Adiponectin and Its Receptors in Preimplantation Embryo Development

Vitamins and Hormones

Volumn 90, Issue , 2012, Pages 211-238

  Čikoš, Štefan ^a  

^a INSTITUTE OF ANIMAL PHYSIOLOGY   (Slovakia)

Author keywords

Adiponectin; Adiponectin receptors; Obesity; Oocyte; Preimplantation embryo

Indexed keywords

EID: 84866625486     PISSN: 00836729     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398313-8.00009-9     Document Type: Chapter

References (128)

1. Abrahamsohn P.A., Zorn T.M. Implantation and decidualization in rodents. The Journal of Experimental Zoology 1993, 266:603-628.
2. Amin R.H., Mathews S.T., Alli A., Leff T. Endogenously produced adiponectin protects cardiomyocytes from hypertrophy by a PPARgamma-dependent autocrine mechanism. American Journal of Physiology. Heart and Circulatory Physiology 2010, 299:690-698.
3. Archanco M., Gómez-Ambrosi J., Tena-Sempere M., Frühbeck G., Burrell M.A. Expression of leptin and adiponectin in the rat oviduct. The Journal of Histochemistry and Cytochemistry 2007, 55:1027-1037.
4. Ardawi M.S.M., Path F.R.C., Rouzi A.A. Plasma adiponectin and insulin resistance in women with polycystic ovary syndrome. Fertility and Sterility 2005, 83:1708-1715.
5. Augustin R., Pocar P., Navarrete-Santos A., Wrenzycki C., Gandolfi F., Niemann H., et al. Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos. Molecular Reproduction and Development 2001, 60:370-376.
6. Barb D., Neuwirth A., Mantzoros C.S., Balk S.P. Adiponectin signals in prostate cancer cells through Akt to activate the mammalian target of rapamycin pathway. Endocrine-Related Cancer 2007, 14:995-1005.
7. Benaitreau D., Dieudonné M.N., Santos E.D., Leneveu M.Ch., de Mazancourt P., Pecquery R. Antiproliferative effects of adiponectin on human trophoblastic cell lines JEG-3 and BeWo. Biology of Reproduction 2009, 80:1107-1114.
8. Berner H.S., Lyngstadaas S.P., Spahr A., Monjo M., Thommesen L., Drevon Ch.A., et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone 2004, 35:842-849.
9. Bersinger N.A., Birkhäuser M.H., Wunder D.M. Adiponectin as a marker of success in intracytoplasmic sperm injection/embryo transfer cycles. Gynecological Endocrinology 2006, 22:479-483.
10. Bersinger N.A., Wunder D.M. Adiponectin isoform distribution in serum and follicular fluid of women undergoing treatment by ICSI. Acta Obstetricia et Gynecologica Scandinavica 2010, 89:782-788.
11. Blomberg L., Hashizume K., Viebahn C. Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation. Reproduction 2008, 135:181-195.
12. Bower N.I., Moser R.J., Hill J.R., Lehnert S.A. Universal reference method for real-time PCR gene expression analysis of preimplantation embryos. BioTechniques 2007, 42:199-206.
13. Bub J.D., Miyazaki T., Iwamoto Y. Adiponectin as a growth inhibitor in prostate cancer cells. Biochemical and Biophysical Research Communications 2006, 340:1158-1166.
14. Buhi W.C., Alvarez I.M., Kouba A.J. Secreted proteins of the oviduct. Cells, Tissues, Organs 2000, 166:165-179.
15. Caminos J.E., Nogueiras R., Gallego R., Bravo S., Tovar S., Garcia-Caballero T., et al. Expression and regulation of adiponectin and receptor in human and rat placenta. The Journal of Clinical Endocrinology and Metabolism 2005, 90:4276-4286.
16. Campos D.B., Palin M.F., Bordignon V., Murphy B.D. The "beneficial" adipokines in reproduction and fertility. International Journal of Obesity 2008, 32:223-231.
17. Carson D.D., Bagchi I., Dey S.K., Enders A.C., Fazleabas A.T., Lessey B.A., et al. Embryo implantation. Developmental Biology 2000, 223:217-237.
18. Carayannopoulos M.O., Chi M.M., Cui Y., Pingsterhaus J.M., McKnight R.A., Mueckler M., et al. GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst. Proceedings of the National Academy of Sciences of the United States of America 2000, 97:7313-7318.
19. Chabrolle Ch., Tosca L., Dupont J. Regulation of adiponectin and its receptors in rat ovary by human chorionic gonadotrophin treatment and potential involment of adiponectin in granulosa cell steroidogenesis. Reproduction 2007, 133:719-731.
20. Chabrolle Ch., Tosca L., Ramé C., Lecomte P., Royere D., Dupont J. Adiponectin increases insulin-like growth factor I-induced progesterone and estradiol in human granulosa cells. Fertility and Sterility 2009, 92:1988-1996.
21. Chappaz E., Albornoz M.S., Campos D., Che L., Palin M.F.D., Murphy B., et al. Adiponectin enhances in vitro development of swine embryos. Domestic Animal Endocrinology 2008, 35:198-207.
22. Chen H., Montagnani M., Funahashi T., Shimomura I., Quon M.J. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. The Journal of Biological Chemistry 2003, 278:45021-45026.
23. Chen J., Tan B., Karteris E., Zervou S., Digby J., Hillhouse E.W., et al. Secretion of adiponectin by human placenta: Differential modulation of adiponectin and its receptors by cytokines. Diabetologia 2006, 49:1292-1302.
24. Chi M.M., Schlein A.L., Moley K.H. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology 2000, 141:4784-4792.
25. Chi M.M., Pingsterhaus J., Carayannopoulos M., Moley K.H. Decreased glucose transporter expression triggers BAX-dependent apoptosis in the murine blastocyst. The Journal of Biological Chemistry 2000, 275:40252-40257.
26. Čikoš Š., Burkuš J., Bukovská A., Fabian D., Rehák P., Koppel J. Expression of adiponectin receptors and effects of adiponectin isoforms in mouse preimplantation embryos. Human Reproduction 2010, 25:2247-2255.
27. Čikoš Š., Koppel J. Transformation of real-time PCR fluorescence data to target gene quantity. Analytical Biochemistry 2009, 384:1-10.
28. Combs T.P., Berg A.H., Rajala M.W., Klebanov S., Iyengar P., Jimenez-Chillaron J.C., et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003, 52:268-274.
29. Cong L., Gasser J., Zhao J., Yang B., Li F., Zhao A.Z. Human adiponectin inhibits cell growth and induces apoptosis in human endometrial carcinoma cells, HEC-1-A and RL95-2. Endocrine-Related Cancer 2007, 14:713-720.
30. Coope A., Milanski M., Araújo E.P., Tambascia M., Saad M.J., Geloneze B., et al. AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Letters 2008, 582:1471-1476.
31. Corbetta S., Bulfamante G., Cortelazzi D., Barresi V., Cetin I., Mantovani G., et al. Adiponectin expression in human fetal tissues during mid- and late gestation. The Journal of Clinical Endocrinology and Metabolism 2005, 90:2397-2402.
32. Dan-Goor M., Sasson S., Davarashvili A., Almagor M. Expression of glucose transporter and glucose uptake in human oocytes and preimplantation embryos. Human Reproduction 1997, 12:2508-2510.
33. Dal Maso L., Augustin L.S.A., Karalis A., Talamini R., Franceschi S., Trichopoulos D., et al. Circulating adiponectin and endometrial cancer risk. The Journal of Clinical Endocrinology and Metabolism 2004, 89:1160-1163.
34. Deepa S.S., Dong L.Q. APPL1: Role in adiponectin signaling and beyond. American Journal of Physiology. Endocrinology and Metabolism 2009, 296:E22-E36.
35. DiMascio L., Voermans C., Uqoezwa M., Duncan A., Lu D., Wu J., et al. Identification of adiponectin as a novel hemopoietic stem cell growth factor. Journal of Immunology 2007, 178:3511-3520.
36. Dos Santos E., Benaitreau D., Dieudonne M.N., Leneveu M.Ch., Serazin V., Giudicelli Y., et al. Adiponectin mediates an antiproliferative response in human MDA-MB 231 breast cancer cells. Oncology Reports 2008, 20:971-977.
37. Duranthon V., Watson A.J., Lonergan P. Preimplantation embryo programming: Transcription, epigenetics, and culture environment. Reproduction 2008, 135:141-150.
38. Fedorcsák P., Dale P.O., Storeng R., Ertzeid G., Bjercke S., Oldereid N., et al. Impact of overweight and underweight on assisted reproduction treatment. Human Reproduction 2004, 19:2523-2528.
39. Fischer S., Santos A.N., Thieme R., Ramin N., Fischer B. Adiponectin stimulates glucose uptake in rabbit blastocysts. Biology of Reproduction 2010, 83:859-865.
40. Fleming T.P., Wilkins A., Mears A., Miller D.J., Thomas F., Ghassemifar M.R., et al. Society for Reproductive Biology Founders' Lecture 2003. The making of an embryo: Short-term goals and long-term implications. Reproduction, Fertility, and Development 2004, 16:325-337.
41. Ford S.P., Youngs C.R. Early embryonic development in prolific Meishan pigs. Journal of Reproduction and Fertility. Supplement 1993, 48:271-278.
42. Grossmann M.E., Nkhata K.J., Mizuno N.K., Ray A., Cleary M.P. Effects of adiponectin on breast cancer cell growth and signaling. British Journal of Cancer 2008, 98:370-379.
43. Guérin P., Ménézo Y. Review: Role of tubal environment in preimplantation embryogenesis: Application to co-culture assays. Zygote 2011, 19:47-54.
44. Hada Y., Yamauchi T., Waki H., Tsuchida A., Hara K., Yago H., et al. Selective purification and characterization of adiponectine multimer species from human plasma. Biochemical and Biophysical Research Communications 2007, 356:487-493.
45. Hardy K., Spanos S. Growth factor expression and function in the human and mouse preimplantation embryo. The Journal of Endocrinology 2002, 172:221-236.
46. Haugen F., Drevon Ch. Activation of nuclear factor-κB by high molecular weight and globular adiponectin. Endocrinology 2007, 148:5478-5486.
47. Heikinheimo O., Gibbons W.E. The molecular mechanisms of oocyte maturation and early embryonic development are unveiling new insights into reproductive medicine. Molecular Human Reproduction 1998, 4:745-756.
48. Huggett J., Dheda K., Bustin S., Zumla A. Real-time RT-PCR normalisation; strategies and considerations. Genes and Immunity 2005, 6:279-284.
49. Humblot P. Use of pregnancy specific proteins and progesterone assays to monitor pregnancy and determine the timing, frequencies and sources of embryonic mortality in ruminants. Theriogenology 2001, 56:1417-1433.
50. Jeong Y.J., Choi H.W., Shin H.S., Cui X.S., Kim N.H., Gerton G.L., et al. Optimization of real time RT-PCR methods for the analysis of gene expression in mouse eggs and preimplantation embryos. Molecular Reproduction and Development 2005, 71:284-289.
51. Jiménez-Ayala M., Jiménez-Ayala Portillo B. Cytology of the normal endometrium - cycling and postmenopausal. Endometrial adenocarcinoma: prevention and early diagnosis, Monogr. Clin. Cytol. 2008, Vol. 17:32-39. Karger AG, Basel.
52. Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocrine Reviews 2005, 26:439-451.
53. Kadowaki T., Yamauchi T., Kubota N., Hara K., Ueki K., Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. The Journal of Clinical Investigation 2006, 116:1784-1792.
54. Kahn B.B., Alquier T., Carling D., Hardie D.G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metabolism 2005, 1:15-25.
55. Kidder G.M. The genetic program for preimplantation development. Developmental Genetics 1992, 13:319-325.
56. Kierszenbaum A.L. Decidualization and implantation: embryo-uterine bioinformatics at work. Molecular Reproduction and Development 2001, 59:123-125.
57. Kim J.J., Jaffe R.C., Fazleabas A.T. Blastocyst invasion and the stromal response in primates. Human Reproduction 1999, 2:45-55.
58. Kim S.T., Marquard K., Stephens S., Louden E., Allsworth J., Moley K.H. Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus. Human Reproduction 2011, 26:82-95.
59. Kobayashi H., Ouchi N., Kihara S., Walsh K., Kumada M., Abe Y., et al. Selective suppression of endothelial cell apoptosis by the high molecular weight form oj adiponectin. Circulation Research 2004, 94:27-31.
60. Korgun E.T., Demir R., Hammer A., Dohr G., Desoye G., Skofitsch G., et al. Glucose transporter expression in rat embryo and uterus during decidualization, implantation, and early postimplantation. Biology of Reproduction 2001, 65:1364-1370.
61. Körner A., Pazaitou-Panayiotou K., Kelesidis T., Kelesidis I., Williams C.J., Kaprara A., et al. Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. The Journal of Clinical Endocrinology and Metabolism 2007, 92:1041-1048.
62. Kubota N., Terauchi Y., Yamauchi T., Kubota T., Moroi M., Matsui J., et al. Disruption of adiponectin causes insulin resistance and neointimal formation. The Journal of Biological Chemistry 2002, 277:25863-25866.
63. Ledoux S., Campos D.B., Lopes F.L., Dobias-Goff M., Palin M.F., Murphy B.D. Adiponectin induces periovulatory changes in ovarian follicular cells. Endocrinology 2006, 147:5178-5186.
64. Leese H.J. The formation and function of oviduct fluid. Journal of Reproduction and Fertility 1988, 82:843-856.
65. Lord E., Ledoux S., Murphy B.D., Beaudry D., Palin M.F. Expression of adiponectin and its receptors in swine. Journal of Animal Science 2005, 83:565-578.
66. Louden E., Chi M.M., Moley K.H. Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance. Reproduction 2008, 136:335-344.
67. Luo X.H., Guo L.J., Yuan L.Q., Xie H., De Zhou H., Wu X.P., et al. Adiponectin stimulates human osteoblasts proliferation and differentiation via the MAPK signaling pathway. Experimental Cell Research 2005, 309:99-109.
68. Ma K., Cabrero A., Saha P.K., Kojima H., Li L., Chang B.H.J., et al. Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. The Journal of Biological Chemistry 2002, 277:34658-34661.
69. Maddox-Hyttel P., Alexopoulos N.I., Vajta G., Lewis I., Rogers P., Cann L., et al. Immunohistochemical and ultrastructural characterization of the initial post-hatching development of bovine embryos. Reproduction 2003, 125:607-623.
70. Maeda N., Shimomura I., Kishida K., Nishizawa H., Matsuda M., Nagaretani H., et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature Medicine 2002, 8:731-737.
71. Maillard V., Uzbekova S., Guignot F., Perreau Ch., Ramé Ch., Coyral-Castel S., et al. Effect of adiponectin on bovine granulose cell steroidogenesis, oocyte maturation and embryo development. Reproductive Biology and Endocrinology 2010, 8:23.
72. Mamo S., Gal A.B., Bodo S., Dinnyes A. Quantitative evaluation and selection of reference genes in mouse oocytes and embryos cultured in vivo and in vitro. BMC Developmental Biology 2007, 7:14.
73. Mao X., Kikani C.K., Riojas R.A., Langlais P., Wang L., Ramos F.J., et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nature Cell Biology 2006, 8:516-523.
74. Maruyama S., Shibata R., Ohashi K., Ohashi T., Daida H., Walsh K., et al. Adiponectin ameliorates doxorubicin-induced cardiotoxicity through Akt protein-dependent mechanism. The Journal of Biological Chemistry 2011, 286:32790-32800.
75. Mazaki-Tovi S., Romero R., Vaisbuch E., Kusanovic J.P., Erez O., Gotsch F., et al. Maternal serum adiponectin multimers in preeclampsia. Journal of Perinatal Medicine 2009, 37:349-363.
76. Mitchell M., Armstrong D.T., Robker R.L., Norman R.J. Adipokines: Implications for female fertility and obesity. Reproduction 2005, 130:583-597.
77. Navarrete Santos A., Tonack S., Kirstein M., Kietz S., Fischer B. Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos. Reproduction 2004, 128:503-516.
78. Navarrete Santos A., Tonack S., Kirstein M., Pantaleon M., Kaye P., Fischer B. Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts. Reproduction 2004, 128:517-526.
79. Nepomnaschy P.A., Welch K.B., McConnell D.S., Low B.S., Strassmann I., England B.G. Cortisol levels and very early pregnancy loss in humans. Proc. Nat. Acad. Sci. U.S.A. 2006, 103:3938-3942.
80. Neumeier M., Weigert J., Schäffler A., Wehrwein G., Müller-Ladner U., Schölmerich J., et al. Different effects of adiponectin isoforms in human monocytic cells. Journal of Leukocyte Biology 2006, 79:803-808.
81. Nishizawa H., Shimomura I., Kishida K., Maeda N., Kuriyama H., Nagaretani H., et al. Androgens decrease plasma adiponectin, an insulin-senzitizing adipocyte-derived protein. Diabetes 2002, 51:2734-2741.
82. Norman R.J., Noakes M., Wu R., Davies M.J., Moran L., Wang J.X. Improving reproductive performance in overweight/obese women with effective weight management. Human Reproduction Update 2004, 10:267-280.
83. Nothias J.Y., Majumder S., Kaneko K.J., DePamphilis M.L. Regulation of gene expression at the beginning of mammalian development. The Journal of Biological Chemistry 1995, 270:22077-22080.
84. Oestrup O., Hall V., Petkov S.G., Wolf X.A., Hyldig S., Hyttel P. From zygote to implantation: Morphological and molecular dynamics during embryo development in the pig. Reproduction in Domestic Animals 2009, 3:39-49.
85. Oh D.K., Ciaraldi T., Henry R.R. Adiponectin in health and disease. Diabetes, Obesity & Metabolism 2007, 9:282-289.
86. Ouchi N., Kobayashi H., Kihara S., Kumada M., Sato K., Inoue T., et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. The Journal of Biological Chemistry 2004, 279:1304-1309.
87. Palanivel R., Fang X., Park M., Eguchi M., Pallan S., De Girolamo S., et al. Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovascular Research 2007, 75:148-1157.
88. Pantaleon M., Kaye P.L. IGF-I and insulin regulate glucose transport in mouse blastocysts via IGF-I receptor. Molecular Reproduction and Development 1996, 44:71-776.
89. Pinto A.B., Carayannopoulos M.O., Hoehn A., Dowd L., Moley K.H. Glucose transporter 8 expression and translocation are critical for murine blastocyst survival. Biology of Reproduction 2002, 66:1729-1733.
90. Riley J.K., Carayannopoulos M.O., Wyman A.H., Chi M., Ratajczak C.K., Moley K.H. The PI3K/Akt pathway is present and functional in the preimplantation mouse embryo. Developmental Biology 2005, 284:377-386.
91. Riley J.K., Carayannopoulos M.O., Wyman A.H., Chi M., Moley K.H. Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts. The Journal of Biological Chemistry 2006, 281:6010-6019.
92. Riley J.K., Moley K.H. Glucose utilization and the PI3-K pathway: Mechanisms for cell survival in preimplantation embryos. Reproduction 2006, 131:823-835.
93. Rodgers R.J., Irving-Rodgers H.F. Formation of the ovarian follicular antrum and follicular fluid. Biology of Reproduction 2010, 82:1021-1029.
94. Schmidt T., Fischer S., Tsikolia N., Santos A.N., Rohrbach S., Ramin N., et al. Expression of adipokines in preimplantation rabbit and mice embryos. Histochemistry and Cell Biology 2008, 129:817-825.
95. Shibata R., Sato K., Pimentel D.R., Takemura Y., Kihara S., Ohashi K., et al. Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2-dependent mechanisms. Nature Medicine 2005, 11:1096-1103.
96. Song H., Chan J., Rovin B.H. Induction of chemokine expression by adiponectin in vitro is isoform dependent. Translational Research 2009, 154:18-26.
97. Steinberg G.R., Kemp B.E. AMPK in Health and Disease. Physiological Reviews 2009, 89:1025-1078.
98. Struwe E., Berzl G.M., Schild R.L., Dötsch J. Gene expression of placental hormones regulating energy balance in small for gestational age neonates. European Journal of Obstetrics, Gynecology, and Reproductive Biology 2009, 142:38-42.
99. Sun Y., Chen X. Effect of adiponectin on apoptosis: Proapoptosis or antiapoptosis?. BioFactors 2010, 36:179-186.
100. Tabandeh M.R., Hosseini A., Saeb M., Kafi M., Saeb S. Changes in the gene expression of adiponectin and adiponectin receptors (AdipoR1 and AdipoR2) in ovarian follicular cells of dairy cow at different stages of development. Theriogenology 2010, 73:659-669.
101. Takemura Y., Osuga Y., Harada M., Hirata T., Koga K., Morimoto Ch., et al. Serum adiponectin concentrations are decreased in women with andometriosis. Human Reproduction 2005, 20:3510-3513.
102. Takemura Y., Osuga Y., Yamauchi T., Kobayashi M., Harada M., Hirata T., et al. Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinolgy 2006, 147:3203-3210.
103. Thellin O., Zorzi W., Lakaye B., De Borman B., Coumans B., Hennen G., et al. Housekeeping genes as internal standards: Use and limits. Journal of Biotechnology 1999, 75:291-295.
104. Tonack S., Fischer B., Navarrete Santos A. Expression of the insulin-responsive glucose transporter isoform 4 in blastocysts of C57/BL6 mice. Anat. Embryol. (Berl) 2004, 208:225-230.
105. Trujillo M.E., Scherer P.E. Adiponectin-journey from an adipocyte secretory protein to biomarker of the metabolic syndrome. Journal of Internal Medicine 2005, 257:167-175.
106. κ B signaling pathway by adipocyte complement-related protein of 30kDa (Acrp30). The Journal of Biological Chemistry 2002, 277:29359-29362.
107. Tsao T.S., Tomas E., Murrey H.E., Hug Ch., Lee D.H., Ruderman N.B., et al. Role of disulfide bonds in Acrp30/Adiponectin structure and signaling specificity. The Journal of Biological Chemistry 2003, 278:50810-50817.
108. Tsuchida A., Yamauchi T., Takekawa S., Hada Y., Ito Y., Maki T., et al. Peroxisome proliferator-activated receptor (PPAR)alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: Comparison of activation of PPARalpha, PPARgamma, and their combination. Diabetes 2005, 54:3358-3370.
109. Van der Steeg J.W., Steures P., Eijkemans M.J.C., Habbema J.D.F., Hompes P.G.A., Burggraaff J.M., et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Human Reproduction 2008, 23:324-328.
110. Varga T., Czimmerer Z., Nagy L. PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochimica et Biophysica Acta 2011, 1812:1007-1022.
111. Vejlsted M., Du Y., Vajta G., Maddox-Hyttel P. Post-hatching development of the porcine and bovine embryo-defining criteria for expected development in vivo and in vitro. Theriogenology 2006, 65:153-165.
112. Viebahn C., Mayer B., Hrabé de Angelis M. Signs of the principle body axes prior to primitive streak formation in the rabbit embryo. Anat. Embryol. (Berl) 1995, 192:159-169.
113. Vona-Davis L., Rose D.P. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocrine-Related Cancer 2007, 14:189-206.
114. Wang Y., Lam K.S.L., Xu J.Y., Lu G., Xu L.Y., Cooper G.J.S., et al. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. The Journal of Biological Chemistry 2005, 280:18341-18347.
115. Wang Y., Lam K.S.L., Yau M.H., Xu A. Post-translational modifications of adiponectin: Mechanisms and functional implications. The Biochemical Journal 2008, 409:623-633.
116. Watson R.T., Pessin J.E. Intracellular organization of insulin signaling and GLUT4 translocation. Recent Progress in Hormone Research 2001, 56:175-193.
117. Welsh G.I., Hers I., Berwick D.C., Dell G., Wherlock M., Birkin R., et al. Role of protein kinase B in insulin-regulated glucose uptake. Biochemical Society Transactions 2005, 33:346-349.
118. Whitehead J.P., Richards A.A., Hickman I.J., Macdonald G.A., Prins J.B. Adiponectin-a key adipokine in the metabolic syndrome. Diabetes, Obesity & Metabolism 2006, 8:264-280.
119. Whitworth K.M., Agca C., Kim J.G., Patel R.V., Springer G.K., Bivens N.J., et al. Transcriptional profiling of pig embryogenesis by using a 15-K member unigene set specific for pig reproductive tissues and embryos. Biology of Reproduction 2005, 72:1437-1451.
120. Wijesekara N., Krishnamurthy M., Bhattacharjee A., Suhail A., Sweeney G., Wheeler M.B. Adiponectin-induced ERK and Akt phosphorylation protects against pancreatic beta cell apoptosis and increases insulin gene expression and secretion. The Journal of Biological Chemistry 2010, 285:33623-33631.
121. Wong G.W., Wang J., Hug C., Tsao T.S., Lodish H.F. A family of Acrp30/adiponectin structural and functional paralogs. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:10302-10307.
122. Xiao X., Dong Y., Zhong J., Cao R., Zhao X., Wen G., et al. Adiponectin protects endothelial cells from the damages induced by the intermittent high level of glucose. Endocrine 2011, 40:386-393.
123. Yamauchi T., Kamon J., Waki H., Terauchi Y., Kubota N., Hara K., et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 2001, 7:941-946.
124. Yamauchi T., Kamon J., Minokoshi Y., Ito Y., Waki H., Uchida S., et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Medicine 2002, 8:1288-1295.
125. Yamauchi T., Kamon J., Ito Y., Tsuchida A., Yokomizo T., Kita S., et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003, 423:762-768.
126. Yoon M.J., Lee G.Y., Chung J.J., Ahn Y.H., Hong S.H., Kim J.B. Adiponectin increases fatty acid oxidation in skeletal muscle cells by sequential activation of AMP-activated protein kinase, p38 mitogen-activated protein kinase, and peroxisome proliferator-activated receptor alpha. Diabetes 2006, 55:2562-2570.
127. Zavalza-Gómez A.B., Anaya-Prado R., Rincón-Sánchez A.R., Mora-Martínez J.M. Adipokines and insulin resistance during pregnancy. Diabetes Research and Clinical Practice 2008, 80:8-15.
128. Zhou Y., Sun X., Jin L., Stringfield T., Lin L., Chen Y. Expression profiles of adiponectin receptors in mouse embryos. Gene Expression Patterns 2005, 5:711-715.