The role of nitric oxide in the induction of caudal-type homeobox 2 through epidermal growth factor receptor in the development of Barrett's esophagus

Scandinavian Journal of Gastroenterology

Volumn 47, Issue 10, 2012, Pages 1148-1158

  Kusaka, Gen ^a   Uno, Kaname ^a   Iijima, Katsunori ^a   Endo, Hiroyuki ^a   Asano, Naoki ^a   Koike, Tomoyuki ^a   Imatani, Akira ^a   Shimosegawa, Tooru ^a  

^a TOHOKU UNIVERSITY   (Japan)

Author keywords

Barrett's esophagus; CDX2; EGFR; Esophageal squamous epithelium; Nitric oxide

Indexed keywords

3 NITROTYROSINE; EPIDERMAL GROWTH FACTOR RECEPTOR; LINSIDOMINE; MESSENGER RNA; NITRIC OXIDE; PEROXYNITRITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR CDX2;

AGED; ARTICLE; BARRETT ESOPHAGUS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; DISEASE COURSE; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

BARRETT ESOPHAGUS; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; EPITHELIUM; ESOPHAGOGASTRIC JUNCTION; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOHISTOCHEMISTRY; METAPLASIA; NITRIC OXIDE; PHOSPHORYLATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; TYROSINE;

EID: 84866612727     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.3109/00365521.2012.703232     Document Type: Article

References (46)

1. Cronin J, McAdam E, Danikas A, Tselepis C, Griffiths P, Baxter J, et al. Epidermal growth factor receptor (EGFR) is overexpressed in high-grade dysplasia and adenocarcinoma of the esophagus and may represent a biomarker of histological progression in Barrett's esophagus (BE). Am J Gastroenterol 2011;106:46-56.
2. Shaheen N, Ransohoff DF. Gastroesophageal reflux, Barrett esophagus, and esophageal cancer. JAMA 2002;287: 1972-81. (Pubitemid 34326418)
3. Li Y, Wo JM, Ray MB, Jones W, Su RR, Ellis S, et al. Cyclooxygenase-2 and epithelial growth factor receptor up-regulation during progression of Barrett's esophagus to adenocarcinoma. World J Gastroenterol 2006;12: 928-34.
4. Vaninetti N, Williams L, Geldenhuys L, Porter GA, Guernsey DL, Casson AG. Regulation of CDX2 expression in esophageal adenocarcinoma. Mol Carcinog 2009;48: 965-74.
5. Rahman FB, Kadowaki Y, Ishihara S, Tobita H, Imaoka H, Fukuhara H, et al. Fibroblast-derived HB-EGF promotes Cdx2 expression in esophageal squamous cells. Lab invest 2010;90:1033-48.
6. Takahashi O, Hamada J, Abe M, Hata S, Asano T, Takahashi Y, et al. Dysregulated expression of HOX and ParaHOX genes in human esophageal squamous cell carcinoma. Oncol Rep 2007;17:753-60.
7. McColl KE. When saliva meets acid: Chemical warfare at the oesophagogastric junction. Gut 2005;54:1-3. (Pubitemid 40007208)
8. Burnat G, Rau T, Elshimi E, Hahn EG, Konturek PC. Bile acids induce overexpression of homeobox gene CDX-2 and vascular endothelial growth factor (VEGF) in human Barrett's esophageal mucosa and adenocarcinoma cell line. Scand J Gastroenterol 2007;42:1460-5. (Pubitemid 350125549)
9. Avissar NE, Toia L, Hu Y, Watson TJ, Jones C, Raymond DP, et al. Bile acid alone, or in combination with acid, induces CDX2 expression through activation of the epidermal growth factor receptor (EGFR). J Gastrointest Surg 2009;3:212-12.
10. Clemons NJ, McColl KE, Fitzgerald RC. Nitric oxide and acid induce double-strand DNA breaks in Barrett's esophagus carcinogenesis via distinct mechanisms. Gastroenterology 2007;133:1198-209. (Pubitemid 47494447)
11. Feagins LA, Zhang HY, Zhang X, Hormi-Carver K, Thomas T, Terada LS, et al. Mechanisms of oxidant production in esophageal squamous cell and Barrett's cell lines. Am J Physiol Gastrointest Liver Physiol 2008;295: G411-17. (Pubitemid 351253330)
12. Rantanen TK, Rasanen JV, Sihvo EI, Ahotupa MO, Farkkila MA, Salo JA. The impact of antireflux surgery on oxidative stress of esophageal mucosa caused by gastroesophageal reflux disease: 4-yr follow-up study. Am J Gastroenterol 2006;101:222-8. (Pubitemid 43381659)
13. Clemons NJ, Shannon NB, Abeyratne LR, Walker CE, Saadi A, O'Donovan ML, et al. Nitric oxide mediated invasion in Barrett's high-grade dysplasia and adenocarcinoma. Carcinogenesis 2010;31:1669-75.
14. Iijima K, Grant J, McElroy K, Fyfe V, Preston T, McColl KE. Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-oesophageal junction cancers. Carcinogenesis 2003;24:1951-60. (Pubitemid 38008536)
15. Iijima K, Henry E, Moriyama A, Wirz A, Kelman AW, McColl KE. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastroesophageal junction. Gastroenterology 2002;122:1248-57. (Pubitemid 34465167)
16. Jenkins GJ, D'Souza FR, Suzen SH, Eltahir ZS, James SA, Parry JM, et al. Deoxycholic acid at neutral and acid pH, is genotoxic to oesophageal cells through the induction of ROS: The potential role of antioxidants in Barrett's oesophagus. Carcinogenesis 2007;28: 136-42. (Pubitemid 44942637)
17. Dvorak K, Payne CM, Chavarria M, Ramsey L, Dvorakova B, Bernstein H, et al. Bile acids in combination with low pH induce oxidative stress and oxidative DNA damage: Relevance to the pathogenesis of Barrett's oesophagus. Gut 2007;56:763-71. (Pubitemid 46854189)
18. Jenkins GJ, Cronin J, Alhamdani A, Rawat N, D'Souza F, Thomas T, et al. The bile acid deoxycholic acid has a non-linear dose response for DNA damage and possibly NF-kB activation in oesophageal cells, with a mechanism of action involving ROS. Mutagenesis 2008;23:399- 405.
19. Morelli MP, Cascone T, Troiani T, De Vita F, Orditura M, Laus G, et al. Sequence dependent antiproliferative effects of cytotoxic drugs and epidermal growth factor receptor inhibitors. Ann Oncol 2005;16:61-8.
20. Vaninetti NM, Geldenhuys L, Porter GA, Risch H, Hainaut P, Guernsey DL, et al. Inducible nitric oxide synthase, nitrotyrosine and p53 mutations in the molecular pathogenesis of Barrett's esophagus and esophageal adenocarcinoma. Mol Carcinog 2008;47:275-85. (Pubitemid 351500153)
21. Bae JD, Jung KH, Ahn WS, Bae SH, Jang TJ. Expression of inducible nitric oxide synthase is increased in rat Barrett's esophagus induced by duodenal contents reflux. J Korean Med Sci 2005;20:56-60.
22. Willson KT, Fu S, Ramanujam KS, Meltzer SJ. Increased expression of inducible nitric oxide synthase and cylooxygenase-2 in Barrett's esophagus and associated adenocarcinomas. Cancer Res 1998;58:2929-34. (Pubitemid 28335064)
23. Benjamin N, O'Driscoll F, Dougall H, Duncan D, Smith L, Golden M, et al. Stomach NO synthesis. Nature 1994;368:502.
24. Lundberg JO, Weitzberg E, Lundberg JM, Alving K. Intragastric nitric oxide production in humans: Measurements in expelled air. Gut 1994;35:1543-6. (Pubitemid 24339249)
25. McKnight GM, Smith LM, Drummond RS, Duncan CW, Golden M, Benjamin N. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut 1997;40: 211-14. (Pubitemid 27093095)
26. Pannala AS, Mani AR, Spencer JP, Skinner V, Bruckdorfer KR, Moore KP, et al. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 2003;34:576-84. (Pubitemid 36254831)
27. Mukaia H, Toi M, Hirai T, Yamashita Y, Toge T. Clinical significance of the expression of epidermal growth factor and its receptor in esophageal cancer. Cancer 1991;68:142-8.
28. Suzuki H, Iijima K, Scobie G, Fyfe V, McColl KE. Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut 2005;54:1527-35. (Pubitemid 41531765)
29. Ishiyama F, Iijima K, Asanuma K, Ara N, Yoshitake J, Abe Y, et al. Exogenous luminal nitric oxide exacerbates esophagus tissue damage in a reflux esophagitis model of rats. Scand J Gastroenterol 2009;44:527-37.
30. Ara N, Iijima K, Asanuma K, Yoshitake J, Ohara S, Shimosegawa T, et al. Disruption of gastric barrier function by luminal nitrosative stress: A potential chemical insult to human gastro-oesophageal junction. Gut 2008;57:306-13. (Pubitemid 351288095)
31. Ito H, Iijima K, Ara N, Asanuma K, Endo H, Asano N, et al. Reactive nitrogen oxide species induce dilatation of the intercellular space of rat esophagus. Scand J Gastroenterol 2010;45:282-91.
32. Endo H, Iijima K, Asanuma K, Ara N, Ito H, Asano N, et al. Exogenous luminal nitric oxide exposure accelerates columnar transformation of rat esophagus. Int J Cancer 2010;127: 2009-19.
33. Asanuma K, Iijima K, Sugata H, Ohara S, Shimosegawa T, Yoshimura T. Diffusion of cytotoxic concentration of nitric oxide generated luminally at the gastro-oesophageal junction of rat. Gut 2005;54:1072-7. (Pubitemid 41025897)
34. Hyung-Chahn L, An S, Lee H, Woo S, Jin H, Seo S, et al. Activation of epidermal growth factor receptor and its downstream signaling pathway by nitric oxide in response to ionizing radiation. Mol Cancer Res 2008;6:996-1002.
35. Ruano MJ, Hernandez-Hernando S, Jimenez A, Estrada C, Villalobo A. Nitric oxide-induced epidermal growth factordependent phosphorylations in A431 tumor cells. Eur J Biochem 2003;270:1828-37. (Pubitemid 36534483)
36. Andl CD, Mizushima T, Nakagawa H, Oyama K, Harada H, Chruma K, et al. Epidermal growth factor receptor mediates increased cell proliferation, migration, and aggregation in esophageal keratinocytes in Vitro and in Vivo. J Biol Chem 2003;278:1824-30. (Pubitemid 36801419)
37. Hanawa M, Suzuki S, Dobashi Y, Yamane T, Kono K, Enomoto N, et al. EGFR protein overexpression and gene amplification in squamous cell carcinomas of the esophagus. Int J Cancer 2006;118:1173-80. (Pubitemid 43185604)
38. Goldman A, Chen HD, Roesly HB, Hill KA, Tome ME, Dvorak B, et al. Characterization of squamous esophageal cells resistant to bile acids at acidic pH: Implication for Barrett-s esophagus pathogenesis. Am J Physiol Gastrointest Liver Physiol 2011;300:G292-302.
39. Kii T, Takiuchi H, Kawabe S, Gotoh M, Ohta S, Tanaka T, et al. Evaluation of prognostic factors of esophageal squamous cell carcinoma (stage II-III) after concurrent chemoradiotherapy using biopsy specimens. Jpn J Clin Oncol 2007;37:583-9. (Pubitemid 351790801)
40. Freedman ND, Park Y, Subar AF, Hollenbeck AR, Leitzmann MF, Schatzkin A, et al. Fruit and vegetable intake and esophageal cancer in a large prospective cohort study. Int J Cancer 2007;121:2753-60. (Pubitemid 350136423)
41. Asonuma S, Imatani A, Asano N, Oikawa T, Konishi H, Iijima K, et al. Helicobacter pyroli induces gastric mucosal intestinal metaplasia through the inhibition of interleukin-4- mediated HMG box protein Sox2 expression. Am J Physiol Gastrointest Liver Physiol 2009;297:G312-22.
42. Winter SC, Stephenson SA, Subramaniam SK, Paleri V, Ha K, Marnane C, et al. Long term survival following the detection of circulating tumor cells in head and neck squamous carcinoma. BMC Cancer 2009;9:424.
43. Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, et al. The microenvironment controls CDX2 homobox gene expression in colorectal cancer cells. Am J Pathol 2007;170:733-44. (Pubitemid 47339407)
44. Zhang P, Wang Y, Kagan E, Bonner JC. Peroxinitrite targets the epidermal growth factor receptor, Raf-1, and MEK independently to activate MAPK. J Biol Chem 2000;275: 22479-86. (Pubitemid 30621836)
45. Guo M, House MG, Suzuki H, Ye Y, Brock MV, Lu F, et al. Epigenetic silencing of CDX2 is a feature of squamous esophageal cancer. Int J Cancer 2007;121: 1219-26. (Pubitemid 47293788)
46. Pande AU, Lyer RV, Rani A, Maddipatla S, Yang GY, Nwogu CE, et al. Epidermal growth factor receptordirected therapy in esophageal cancer. Oncology 2007;73: 281-9. (Pubitemid 351862017)