메뉴 건너뛰기




Volumn 57, Issue 3, 2008, Pages 306-313

Disruption of gastric barrier function by luminal nitrosative stress: A potential chemical insult to the human gastro-oesophageal junction

Author keywords

[No Author keywords available]

Indexed keywords

DINITROSYL DITHIOLATO IRON COMPLEX; IRON COMPLEX; MANNITOL; OCCLUDIN; REACTIVE NITROGEN SPECIES; TRITIUM; UNCLASSIFIED DRUG;

EID: 39649109685     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.128074     Document Type: Article
Times cited : (23)

References (55)
  • 1
    • 0026028040 scopus 로고
    • Rising incidence of adenocarcinoma of the esophagus and gastric cardia
    • Blot WJ, Devesa SS, Kneller RW, et al. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA 1991;265:1287-9.
    • (1991) JAMA , vol.265 , pp. 1287-1289
    • Blot, W.J.1    Devesa, S.S.2    Kneller, R.W.3
  • 2
    • 33646562518 scopus 로고    scopus 로고
    • Preservation of gastric acid secretion may be important for the development of gastro-esophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status
    • Inomata Y, Koike T, Ohara S, et al. Preservation of gastric acid secretion may be important for the development of gastro-esophageal junction adenocarcinoma in Japanese people, irrespective of the H. pylori infection status. Am J Gastroenterol 2006;101:926-33.
    • (2006) Am J Gastroenterol , vol.101 , pp. 926-933
    • Inomata, Y.1    Koike, T.2    Ohara, S.3
  • 3
    • 0032759696 scopus 로고    scopus 로고
    • Pattern of gastritis in patients with gastroesophageal reflux disease
    • Bowrey DJ, Clark GWB, Williams GT. Pattern of gastritis in patients with gastroesophageal reflux disease. Gut 1999;45:798- 803.
    • (1999) Gut , vol.45 , pp. 798-803
    • Bowrey, D.J.1    Clark, G.W.B.2    Williams, G.T.3
  • 4
    • 0037303287 scopus 로고    scopus 로고
    • Inflammation and intestinal metaplasia at the squamocolumnar junction in young patients with or without Helicobacter pylori infection
    • Oksanen A, Sipponen P, Karttunen R, et al. Inflammation and intestinal metaplasia at the squamocolumnar junction in young patients with or without Helicobacter pylori infection. Gut 2003;52:194-8.
    • (2003) Gut , vol.52 , pp. 194-198
    • Oksanen, A.1    Sipponen, P.2    Karttunen, R.3
  • 5
    • 0032857667 scopus 로고    scopus 로고
    • Inflammation of the gastro-esophageal junction (carditis) in patients with symptomatic gastro-esophageal reflux disease: A prospective study
    • Lembo T, Ippoliti AF, Ramers C, et al. Inflammation of the gastro-esophageal junction (carditis) in patients with symptomatic gastro-esophageal reflux disease: a prospective study. Gut 1999;45:484-8.
    • (1999) Gut , vol.45 , pp. 484-488
    • Lembo, T.1    Ippoliti, A.F.2    Ramers, C.3
  • 6
    • 0344717975 scopus 로고    scopus 로고
    • Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastro-esophageal reflux disease
    • Voutilainen M, Farkkila M, Mecklin JP, et al. Chronic inflammation at the gastroesophageal junction (carditis) appears to be a specific finding related to Helicobacter pylori infection and gastro-esophageal reflux disease. Am J Gastroenterol 1999;94:3175- 80.
    • (1999) Am J Gastroenterol , vol.94 , pp. 3175-3180
    • Voutilainen, M.1    Farkkila, M.2    Mecklin, J.P.3
  • 7
    • 3042836534 scopus 로고    scopus 로고
    • Carditis in patients with gastro-esophageal disease: Results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring
    • Zentilin P, Mastracci L, Dulbecco P, et al. Carditis in patients with gastro-esophageal disease: results of a controlled study based on both endoscopy and 24-h oesophageal pH monitoring. Aliment Pharmacol Ther 2004;19:1285-92.
    • (2004) Aliment Pharmacol Ther , vol.19 , pp. 1285-1292
    • Zentilin, P.1    Mastracci, L.2    Dulbecco, P.3
  • 8
    • 0035988874 scopus 로고    scopus 로고
    • Carditis: All Helicobacter or is there a role for gastro-esophageal reflux?
    • McNamara D, Buckley M, Crotty P, et al. Carditis: all Helicobacter or is there a role for gastro-esophageal reflux? Scand J Gastroenterol 2002;37:772-7.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 772-777
    • McNamara, D.1    Buckley, M.2    Crotty, P.3
  • 9
    • 0031445618 scopus 로고    scopus 로고
    • Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastro-esophageal reflux disease
    • Oberg S, Peters JH, DeMeester TR, et al. Inflammation and specialized intestinal metaplasia of cardiac mucosa is a manifestation of gastro-esophageal reflux disease. Ann Surg 1997;226:522-32.
    • (1997) Ann Surg , vol.226 , pp. 522-532
    • Oberg, S.1    Peters, J.H.2    DeMeester, T.R.3
  • 10
    • 0031842098 scopus 로고    scopus 로고
    • Intestinal metaplasia at the gastrooesophageal junction: Helicobacter pylori gastritis or gastro-oesophageal reflux disease?
    • Hacklesberger A, Gunther T, Schultze V, et al. Intestinal metaplasia at the gastrooesophageal junction: Helicobacter pylori gastritis or gastro-oesophageal reflux disease? Gut 1998;43:17-21.
    • (1998) Gut , vol.43 , pp. 17-21
    • Hacklesberger, A.1    Gunther, T.2    Schultze, V.3
  • 11
    • 20644452235 scopus 로고    scopus 로고
    • Intestinal metaplasia at the squamocolumnar junction in patients attending for diagnostic gastroscopy
    • Trudgill NJ, Suvarna SK, Kapur KC, et al. Intestinal metaplasia at the squamocolumnar junction in patients attending for diagnostic gastroscopy. Gut 1997;41:585-9.
    • (1997) Gut , vol.41 , pp. 585-589
    • Trudgill, N.J.1    Suvarna, S.K.2    Kapur, K.C.3
  • 12
    • 0028036837 scopus 로고
    • Prevalence of metaplasia at the gastro-oesophageal junction
    • Spechler SJ, Zeroogian JM, Antonioli DA, et al. Prevalence of metaplasia at the gastro-oesophageal junction. Lancet 1994;344:1533-6.
    • (1994) Lancet , vol.344 , pp. 1533-1536
    • Spechler, S.J.1    Zeroogian, J.M.2    Antonioli, D.A.3
  • 13
    • 0033118695 scopus 로고    scopus 로고
    • Specialized columnar epithelium of the esophagogastric junction: Prevalence and associations
    • Voutilainen M, Farkkila M, Juhola M, et al. Specialized columnar epithelium of the esophagogastric junction: prevalence and associations. Am J Gastroenterol 1999;94:913-.
    • (1999) Am J Gastroenterol , vol.94 , pp. 913
    • Voutilainen, M.1    Farkkila, M.2    Juhola, M.3
  • 14
    • 0025599818 scopus 로고
    • Nitrates, nitrites and N-nitroso compounds: A review of the occurrence in food and diet and the toxicological implications
    • Walker R. Nitrates, nitrites and N-nitroso compounds: a review of the occurrence in food and diet and the toxicological implications. Food Add Contam 1990;7:717-68.
    • (1990) Food Add Contam , vol.7 , pp. 717-768
    • Walker, R.1
  • 15
    • 0023933069 scopus 로고
    • The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load
    • Bos PMJ, van den Brandt PA, Wedel M, et al. The reproducibility of the conversion of nitrate to nitrite in human saliva after a nitrate load. Food Chem Toxicol 1988;26:93-7.
    • (1988) Food Chem Toxicol , vol.26 , pp. 93-97
    • Bos, P.M.J.1    van den Brandt, P.A.2    Wedel, M.3
  • 16
    • 0029075644 scopus 로고
    • Chemical generation of nitric oxide in the mouth the enterosalivary circulation of dietary nitrate
    • Duncan C, Dougall H, Johnston P, et al. Chemical generation of nitric oxide in the mouth the enterosalivary circulation of dietary nitrate. Nat Med 1995;1:546-51.
    • (1995) Nat Med , vol.1 , pp. 546-551
    • Duncan, C.1    Dougall, H.2    Johnston, P.3
  • 17
    • 0024803178 scopus 로고
    • Nitrate and nitrite concentrations in human saliva: Variations with salivary flow-rate
    • Granli T, Dahl R, Brodin P, et al. Nitrate and nitrite concentrations in human saliva: variations with salivary flow-rate. Food Chem Toxicol 1989;27:675-80.
    • (1989) Food Chem Toxicol , vol.27 , pp. 675-680
    • Granli, T.1    Dahl, R.2    Brodin, P.3
  • 18
    • 10844290642 scopus 로고    scopus 로고
    • When saliva meets acid: Chemical warfare at the oesophagogastric junction
    • McColl KEL. When saliva meets acid: chemical warfare at the oesophagogastric junction. Gut 2005;54:1-3.
    • (2005) Gut , vol.54 , pp. 1-3
    • McColl, K.E.L.1
  • 19
    • 0036237932 scopus 로고    scopus 로고
    • Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastro-oesophageal junction
    • Iijima K, Henry E, Moriya A, et al. Dietary nitrate generates potentially mutagenic concentrations of nitric oxide at the gastro-oesophageal junction. Gastroenterology 2002;122:1248-57.
    • (2002) Gastroenterology , vol.122 , pp. 1248-1257
    • Iijima, K.1    Henry, E.2    Moriya, A.3
  • 20
    • 0345736004 scopus 로고    scopus 로고
    • Studies of nitric oxide generation from salivary nitrite in human gastric juice
    • Iijima K, Fyfe V, McColl KEL. Studies of nitric oxide generation from salivary nitrite in human gastric juice. Scand J Gastroenterol 2003;38:246-52.
    • (2003) Scand J Gastroenterol , vol.38 , pp. 246-252
    • Iijima, K.1    Fyfe, V.2    McColl, K.E.L.3
  • 21
    • 0348149137 scopus 로고    scopus 로고
    • Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-esophageal junction cancers
    • Iijima K, Grant J, McElroy K, et al. Novel mechanism of nitrosative stress from dietary nitrate with relevance to gastro-esophageal junction cancers. Carcinogenesis 2003;24:1951-60.
    • (2003) Carcinogenesis , vol.24 , pp. 1951-1960
    • Iijima, K.1    Grant, J.2    McElroy, K.3
  • 22
    • 0036186660 scopus 로고    scopus 로고
    • In vitro studies indicate that acid catalysed generation of N-nitroso compounds from dietary nitrate will be maximal at the gastrooesophageal junction and cardia
    • Moriya A, Grant J, Williams C, et al. In vitro studies indicate that acid catalysed generation of N-nitroso compounds from dietary nitrate will be maximal at the gastrooesophageal junction and cardia. Scand J Gastroenterol 2002;37:253-61.
    • (2002) Scand J Gastroenterol , vol.37 , pp. 253-261
    • Moriya, A.1    Grant, J.2    Williams, C.3
  • 23
    • 27444444034 scopus 로고    scopus 로고
    • Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux
    • Suzuki H, Iijima K, Scobie G, et al. Nitrate and nitrosative chemistry within Barrett's oesophagus during acid reflux. Gut 2005;54:1527-35.
    • (2005) Gut , vol.54 , pp. 1527-1535
    • Suzuki, H.1    Iijima, K.2    Scobie, G.3
  • 25
    • 22644436276 scopus 로고    scopus 로고
    • Diffusion of cytotoxic concentrations of nitric oxide generated luminally at the gastro-oesophageal junction of rats
    • Asanuma K, Iijima K, Sugata H, et al. Diffusion of cytotoxic concentrations of nitric oxide generated luminally at the gastro-oesophageal junction of rats. Gut 2005;54:1072-7.
    • (2005) Gut , vol.54 , pp. 1072-1077
    • Asanuma, K.1    Iijima, K.2    Sugata, H.3
  • 26
    • 0025370449 scopus 로고
    • Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCI in rats
    • Kitagawa H, Takeda F, Kohei H. Effect of endothelium-derived relaxing factor on the gastric lesion induced by HCI in rats. J Pharmacol Exp Ther 1990;253:1133-7.
    • (1990) J Pharmacol Exp Ther , vol.253 , pp. 1133-1137
    • Kitagawa, H.1    Takeda, F.2    Kohei, H.3
  • 27
    • 0037251950 scopus 로고    scopus 로고
    • Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat
    • Miyoshi M, Kasahara E, Park AM, et al. Dietary nitrate inhibits stress-induced gastric mucosal injury in the rat. Free Radic Res 2003;37:85-90.
    • (2003) Free Radic Res , vol.37 , pp. 85-90
    • Miyoshi, M.1    Kasahara, E.2    Park, A.M.3
  • 28
    • 85047693682 scopus 로고    scopus 로고
    • Nitrite in saliva increases gastric mucosal blood flow and mucus thickness
    • Bjorne H, Petersson J, Phillipson M, et al. Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest 2004;113:106-14.
    • (2004) J Clin Invest , vol.113 , pp. 106-114
    • Bjorne, H.1    Petersson, J.2    Phillipson, M.3
  • 29
    • 0036304508 scopus 로고    scopus 로고
    • Gastric nitric oxide synthase expression during endotoxemia: Implications in mucosal defense in rats
    • Helmer KS, West SD, Shipley GL, et al. Gastric nitric oxide synthase expression during endotoxemia: implications in mucosal defense in rats. Gastroenterology 2002;123:173-86.
    • (2002) Gastroenterology , vol.123 , pp. 173-186
    • Helmer, K.S.1    West, S.D.2    Shipley, G.L.3
  • 30
    • 0030783158 scopus 로고    scopus 로고
    • Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats
    • Unno N, Wang H, Menconi MJ, et al. Inhibition of inducible nitric oxide synthase ameliorates endotoxin-induced gut mucosal barrier dysfunction in rats. Gastroenterology 1997;113:1246-57.
    • (1997) Gastroenterology , vol.113 , pp. 1246-1257
    • Unno, N.1    Wang, H.2    Menconi, M.J.3
  • 31
    • 2642576322 scopus 로고    scopus 로고
    • Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice
    • Han X, Fink MP, Yang R, et al. Increased iNOS activity is essential for intestinal epithelial tight junction dysfunction in endotoxemic mice. Shock 2004;21:261-70.
    • (2004) Shock , vol.21 , pp. 261-270
    • Han, X.1    Fink, M.P.2    Yang, R.3
  • 32
    • 0033033928 scopus 로고    scopus 로고
    • Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Ussing chamber
    • Mishima S, Xu D, Deitch EA. Increase in endotoxin-induced mucosal permeability is related to increased nitric oxide synthase activity using the Ussing chamber. Crit Care Med 1999;27:880-6.
    • (1999) Crit Care Med , vol.27 , pp. 880-886
    • Mishima, S.1    Xu, D.2    Deitch, E.A.3
  • 33
    • 0041669658 scopus 로고    scopus 로고
    • Applicability of the ussing chamber technique to permeability determinations in functionally distinct regions of gastrointestinal tract in the rat
    • Bajka BH, Gillespie CM, Steeb CB, et al. Applicability of the ussing chamber technique to permeability determinations in functionally distinct regions of gastrointestinal tract in the rat. Scand J Gastroentrol 2003;38:732-41.
    • (2003) Scand J Gastroentrol , vol.38 , pp. 732-741
    • Bajka, B.H.1    Gillespie, C.M.2    Steeb, C.B.3
  • 34
    • 0021001377 scopus 로고
    • Role of tight-junctional pathways in bile salt-induced increases in colonic permeability
    • Freel RW, Hatch M, Earnest DL, et al. Role of tight-junctional pathways in bile salt-induced increases in colonic permeability. Am J Physiol 1983;245:G816-23.
    • (1983) Am J Physiol , vol.245
    • Freel, R.W.1    Hatch, M.2    Earnest, D.L.3
  • 35
    • 0011128977 scopus 로고
    • Source of the gastric potential difference
    • Forte JG, Adams PH, Davies RE. Source of the gastric potential difference. Nature 1963;2:874-6.
    • (1963) Nature , vol.2 , pp. 874-876
    • Forte, J.G.1    Adams, P.H.2    Davies, R.E.3
  • 36
    • 0037371387 scopus 로고    scopus 로고
    • The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans
    • Pannala A, Mani AR, Spencer JP, et al. The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans. Free Radic Biol Med 2003;34:576-84.
    • (2003) Free Radic Biol Med , vol.34 , pp. 576-584
    • Pannala, A.1    Mani, A.R.2    Spencer, J.P.3
  • 37
    • 0031055821 scopus 로고    scopus 로고
    • Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans
    • McKnight GM, Smith LM, Drummond RS, et al. Chemical synthesis of nitric oxide in the stomach from dietary nitrate in humans. Gut 1997;40:211-4.
    • (1997) Gut , vol.40 , pp. 211-214
    • McKnight, G.M.1    Smith, L.M.2    Drummond, R.S.3
  • 38
    • 34249715269 scopus 로고    scopus 로고
    • Fe-S cluster proteins are intracellular targets for nitric oxide generated luminally at the gastro-oesophageal junction
    • Asanuma K, Iijima K, Ara N, et al. Fe-S cluster proteins are intracellular targets for nitric oxide generated luminally at the gastro-oesophageal junction. Nitric Oxide 2007;16:395-402.
    • (2007) Nitric Oxide , vol.16 , pp. 395-402
    • Asanuma, K.1    Iijima, K.2    Ara, N.3
  • 39
    • 0021259247 scopus 로고
    • Gastric surface cell function: Potential difference and mucosal barrier
    • McGreevy JM. Gastric surface cell function: potential difference and mucosal barrier. Am J Physiol 1984;247:G79-87.
    • (1984) Am J Physiol , vol.247
    • McGreevy, J.M.1
  • 40
    • 0029167043 scopus 로고
    • Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium
    • Ballard ST, Hunter JH, Taylor AE. Regulation of tight-junction permeability during nutrient absorption across the intestinal epithelium. Annu Rev Nutr 1995;15:35-55.
    • (1995) Annu Rev Nutr , vol.15 , pp. 35-55
    • Ballard, S.T.1    Hunter, J.H.2    Taylor, A.E.3
  • 41
    • 0026686356 scopus 로고    scopus 로고
    • Lancaster JrJ, Langrehr JM, Berbonia HA, et al. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J Biol Chem 1992;267:10994-8.
    • Lancaster JrJ, Langrehr JM, Berbonia HA, et al. EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft. J Biol Chem 1992;267:10994-8.
  • 42
    • 0028575311 scopus 로고
    • Apical acidification induces paracellular injury in canine gastric mucosal monolayers
    • Chen MC, Chang A, Buhl T, et al. Apical acidification induces paracellular injury in canine gastric mucosal monolayers. Am J Physiol 1994;267:G1012-20.
    • (1994) Am J Physiol , vol.267
    • Chen, M.C.1    Chang, A.2    Buhl, T.3
  • 43
    • 0030787772 scopus 로고    scopus 로고
    • Expression of occludin, tight-junction associated protein, in human digestive tract
    • Kimura Y, Shiozaki H, Hirano M, et al. Expression of occludin, tight-junction associated protein, in human digestive tract. Am J Pathol 1997;151:45-54.
    • (1997) Am J Pathol , vol.151 , pp. 45-54
    • Kimura, Y.1    Shiozaki, H.2    Hirano, M.3
  • 44
    • 0032999451 scopus 로고    scopus 로고
    • Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice
    • Mowat C, Carswell A, Wirz A, et al. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology 1999;116:813-22.
    • (1999) Gastroenterology , vol.116 , pp. 813-822
    • Mowat, C.1    Carswell, A.2    Wirz, A.3
  • 45
    • 0038298414 scopus 로고    scopus 로고
    • Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia
    • Suzuki H, Iijima K, Moriya A, et al. Conditions for acid catalysed luminal nitrosation are maximal at the gastric cardia. Gut 2003;52:1095-101.
    • (2003) Gut , vol.52 , pp. 1095-1101
    • Suzuki, H.1    Iijima, K.2    Moriya, A.3
  • 46
    • 0027483941 scopus 로고
    • Mutagens, N-nitroso compounds and their precursors in gastric juice from patients with or without precancerous lesion of the stomach
    • Pignatelli B, Malaveille C, Rogatko A, et al. Mutagens, N-nitroso compounds and their precursors in gastric juice from patients with or without precancerous lesion of the stomach. Eur J Cancer 1993;29A:2031-9.
    • (1993) Eur J Cancer , vol.29 A , pp. 2031-2039
    • Pignatelli, B.1    Malaveille, C.2    Rogatko, A.3
  • 47
    • 0030982059 scopus 로고    scopus 로고
    • Hyperpermeability of intestinal epithelial monolayers is induced by NO: Effect of low extracellular pH
    • Unno N, Menconi MJ, Smith M, et al. Hyperpermeability of intestinal epithelial monolayers is induced by NO: effect of low extracellular pH. Am J Physiol 1997;272:G923-34.
    • (1997) Am J Physiol , vol.272
    • Unno, N.1    Menconi, M.J.2    Smith, M.3
  • 48
    • 0028955892 scopus 로고
    • Nitric oxide dilates tight junction and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers
    • Salzman AL, Mencoli MJ, Unno N, et al. Nitric oxide dilates tight junction and depletes ATP in cultured Caco-2BBe intestinal epithelial monolayers. Am J Physiol 1995;268:G361-73.
    • (1995) Am J Physiol , vol.268
    • Salzman, A.L.1    Mencoli, M.J.2    Unno, N.3
  • 49
    • 0033395025 scopus 로고    scopus 로고
    • NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge
    • Dickinson E, Tuncer R, Nadler E, et al. NOX, a novel nitric oxide scavenger, reduces bacterial translocation in rats after endotoxin challenge. Am J Physiol 1999;277:G1281-7.
    • (1999) Am J Physiol , vol.277
    • Dickinson, E.1    Tuncer, R.2    Nadler, E.3
  • 50
    • 0036479890 scopus 로고    scopus 로고
    • Nitric oxide impairs intestinal barrier function
    • Xu DZ, Lu Q, Deitch. Nitric oxide impairs intestinal barrier function. Shock 2002;17:139-45.
    • (2002) Shock , vol.17 , pp. 139-145
    • Xu, D.Z.1    Lu, Q.2    Deitch3
  • 51
    • 0035198046 scopus 로고    scopus 로고
    • Modulation of intestinal permeability by nitric oxide donors: Implication in intestinal delivery of poorly absorbable drugs
    • Yamamoto A, Tatsumi H, Maruyama M, et al. Modulation of intestinal permeability by nitric oxide donors: implication in intestinal delivery of poorly absorbable drugs. J Phramacol Exp Ther 2001;296:84-90.
    • (2001) J Phramacol Exp Ther , vol.296 , pp. 84-90
    • Yamamoto, A.1    Tatsumi, H.2    Maruyama, M.3
  • 52
    • 0031425958 scopus 로고    scopus 로고
    • Phosphorylation of occludin correlates with occludin localization and function at the tight junction
    • Wong V. Phosphorylation of occludin correlates with occludin localization and function at the tight junction. Am J Physiol 1997;273:C1859-67.
    • (1997) Am J Physiol , vol.273
    • Wong, V.1
  • 53
    • 0141957168 scopus 로고    scopus 로고
    • Proinflammatory cytokines cause NO-dependent and -independent changes in expression and location of tight junction proteins in intestinal epithelial cells
    • Han X, Fink MP, Delude RL. Proinflammatory cytokines cause NO-dependent and -independent changes in expression and location of tight junction proteins in intestinal epithelial cells. Shock 2003;19:229-37.
    • (2003) Shock , vol.19 , pp. 229-237
    • Han, X.1    Fink, M.P.2    Delude, R.L.3
  • 54
    • 0031581874 scopus 로고    scopus 로고
    • Evidence for the involvement of a muscarinic receptor in ascorbic acid secretion in the rat stomach
    • Muto N, Ohta T, Suzuki T, et al. Evidence for the involvement of a muscarinic receptor in ascorbic acid secretion in the rat stomach. Biochem Pharmacol 1997;53:553-9.
    • (1997) Biochem Pharmacol , vol.53 , pp. 553-559
    • Muto, N.1    Ohta, T.2    Suzuki, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.