Fibroblast-derived HB-EGF promotes Cdx2 expression in esophageal squamous cells

Laboratory Investigation

Volumn 90, Issue 7, 2010, Pages 1033-1048

  Rahman, Farzana B ^a   Kadowaki, Yasunori ^a   Ishihara, Shunji ^a   Tobita, Hiroshi ^a   Imaoka, Hiroshi ^a   Fukuhara, Hiroyuki ^a   Aziz, Md Monowar ^a   Furuta, Kenji ^a   Amano, Yuji ^b   Kinoshita, Yoshikazu ^a  

^a SHIMANE UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b SHIMANE UNIVERSITY HOSPITAL   (Japan)

Author keywords

AP 1; Barrett's esophagus; Cdx2; fibroblast; HB EGF

Indexed keywords

CHEMOKINE; CYTOKERATIN 7; CYTOKINE; GROWTH FACTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR CDX2; VILLIN; CDX2 PROTEIN, HUMAN; HEPARIN-BINDING EGF-LIKE GROWTH FACTOR; HOMEODOMAIN PROTEIN; SIGNAL PEPTIDE;

ARTICLE; BARRETT ESOPHAGUS; CELL STRUCTURE; CELL VIABILITY; CONTROLLED STUDY; ESOPHAGUS BIOPSY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MICROARRAY ANALYSIS; NUCLEOTIDE SEQUENCE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROMOTER REGION; REAL TIME POLYMERASE CHAIN REACTION; REFLUX ESOPHAGITIS; SQUAMOUS CELL; TRANSCRIPTION INITIATION; CELL SURVIVAL; ESOPHAGUS; METABOLISM; METAPLASIA; PATHOLOGY; PHYSIOLOGY; SECRETION; STOMACH ACID; TUMOR CELL LINE;

BARRETT ESOPHAGUS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOKINES; ESOPHAGITIS, PEPTIC; ESOPHAGUS; FIBROBLASTS; GASTRIC ACID; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; METAPLASIA; PARACRINE COMMUNICATION;

EID: 77953548965     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2010.71     Document Type: Article

References (38)

1. Jankowski JA, Rebecca FH, Ian P, et al. Barrett's metaplasia. Lancet 2000;356:2079-2085.
2. Pera M, Cameron AJ, Trastek VF, et al. Increasing incidence of adenocarcinoma of the esophagus and esophagogastric junction. Gastroenterology 1993;104:510-513.
3. Lagergren J, Berqstrom R, Lindgren A, et al. Symptomatic gastroesophageal reflux as a risk factor for esophageal adenocarcinoma. N Engl J Med 1999;340:825-831.
4. Wild CP, Hardie LJ. Reflux, Barrett's oesophagus and adenocarcinoma: burning questions. Nat Rev Cancer 2003;3:676-684.
5. Fitzgerald RC, Omary MB, Triadafilopoulos G. Dynamic effects of acid on Barrett's esophagus. An ex vivo proliferation and differentiation model. J Clin Inves 1996;98:2120-2128.
6. Bremner RM, Crookes PF, DeMeester TR, et al. Concentration of refluxed acid and esophageal mucosal injury. Am J Surg 1992;164:522-526.
7. Stanciu C, Hoare RC, Bennett JR. Correlation between manometric and pH tests for gastro-esophageal reflux. Gut 1977;18:536-540.
8. Jang TJ, Min SK, Bae JD, et al. Expression of cyclooxygenase 2, microsomal prostaglandin E synthase 1, and EP receptors is increased in rat oesophageal squamous cell dysplasia and Barrett's metaplasia induced by duodenal contents reflux. Gut 2004;53:27-33.
9. Souza RF, Shewmake K, Terada LS, et al. Acid exposure activates the mitogen-activated protein kinase pathways in Barrett's Esophagus. Gastroenterology 2002;122:299-307.
10. Eda A, Osawa H, Satoh K, et al. Aberrant expression of CDX2 in Barrett's epithelium and inflamed esophageal mucosa. J Gastroenterology 2003;38:14-22.
11. Kazumori H, Ishihara S, Rumi MA, et al. Bile acids directly augment caudal related homeobox gene Cdx2 expression in oesophageal keratinocytes in Barrett's epithelium. Gut 2006;55:16-25.
12. Bissell MJ, Radisky D. Putting tumors in context. Nat Rev Cancer 2001;1:46-54.
13. Tlsty TD, Hein PW. Know thy neighbor: stromal cells can contribute oncogenic signals. Curr Opin Genet De 2001;11:5459.
14. Camps JL, Chang SM, Hsu TC, et al. Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA 1990;87:75-79.
15. Sari A, Reidar G, Stina S. Fibroblasts can modulate the phenotype of malignant epithelial cells in vitro. Exp Cell Res 1997;235:180-187.
16. Okawa T, Michaylira CZ, Kalabis J, et al. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev 2007;21:2788-2803.
17. Hodges GM, Hicks RM, Spacey GD. Epithelial-stromal interactions in normal and chemical carcinogen-treated adult bladder. Cancer Res 1977;37:3720-3730.
18. Sakakura T, Sakagami Y, Nishizuka Y. Accelerated mammary cancer development by fetal salivary mesenchyma isografted to adult mouse mammary epithelium. J Natl Cancer Ins 1981;66:953-959.
19. Smola H, Thiekötter G, Fusenig NE. Mutual induction of growth factor gene expression by epidermal-dermal cell interaction. J Cell Biol 1993;122:417-429.
20. Bhowmick NA, Neilson EG, Moses HL. Stromal fibroblast in cancer initiation and progression. Nature 2004;432:332-337.
21. Isomoto H, Wang A, Mizuta Y, et al. Elevated levels of chemokines in esophageal mucosa of patients with reflux esophagitis. Am J Gastroenterol 2003;98:551-556.
22. Isomoto H, Saenko VA, Kanazawa Y, et al. Enhanced expression of interleukin-8 and activation of nuclear factor kappa-B in endoscopy negative gastroesophageal reflux disease. Am J Gastroenterol 2004;99:589-597.
23. Rogler G, Gelbmann CM, Vogl D, et al. Differential activation of cytokines secretion in primary colonic fibroblast/myofibroblast cultures. Scand J Gastroenterol 2001;36:389-398.
24. Van Baal JW, Bozikas A, Pronk R, et al. Cytokeratin and CDX2 expression in Barrett's esophagus. Scand J Gastroenterol 2008;43:132-140.
25. El-Assal ON, Besner GE. HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation. Gastroenterology 2005;129:609-625.
26. Coussens LM, Werb Z. Inflammation and cancer. Nature 2002;420:860-867.
27. Odze RD. Update on the diagnosis and treatment of Barrett esophagus and related neoplastic precursor lesions. Arch Pathol Lab Med 2008;132:1577-1585.
28. Kazumori H, Ishihara S, Kinoshita Y. Roles of caudal-related homeobox gene Cdx1 in oesophageal epithelial cells in Barrett's epithelium development. Gut 2009;58:620-628.
29. Silberg DG, Swain GP, Suh ER, et al. Cdx1 and Cdx2 expression during intestinal development. Gastroenterology 2000;119: 961-971.
30. Eda A, Osawa H, Satoh K, et al. Aberrant expression of CDX2 in Barrett's epithelium and inflammatory esophageal mucosa. J Gastroenterol 2003;38:14-22.
31. Phillips RW, Frierson Jr HF, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27:1442-1447.
32. Moll R, Franke WW, Schiller DL, et al. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultures cells. Cell 1982;31:11-24.
33. Ormsby AH, Goldblum JR, Rice TW, et al. Cytokeratin subsets can reliably distinguish Barrett esophagus from intestinal metaplasia of the stomach. Hum Pathol 1999;30:288-294.
34. Bretscher A, Weber K. Villin is a major protein of microvillus cytoskeleton which binds G and F actin in a calcium-dependent manner. Cell 1980;20:839-847.
35. Kumble S, Omary MB, Fajardo LF, et al. Multifocal heterogeneity in villin and Ep-cam expression in Barrett's esophagus. Int J Cancer 1996;66:48-54.
36. Moran E. DNA tumor virus transforming proteins and the cell cycle. Curr Opin Genet Dev 1993;3:63-70.
37. Ali SH, DeCaprio JA. Cellular transformation by SV40 large T antigen: interaction with host proteins. Semin Cancer Biol 2001;11:15-23.
38. Khaled A, Mounir T, Sonia Z, et al. Presence of simian virus 40 DNA sequences in diffuse large B-cell lymphomas in Tunisia correlates with aberrant promoter hypermethylation of multiple tumor suppressor genes. Int J Cancer 2007;121:2693-2702.