-
3
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54.
-
(2003)
N Engl J Med
, vol.349
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
4
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-28.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
5
-
-
12144286879
-
Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2α expression during progression of breast cancer
-
Douglas DB, Akiyama Y, Carraway H, Belinsky SA, Esteller M, Gabrielson E, Weitzman S, Williams T, Herman JG, Baylin SB. Hypermethylation of a small CpGuanine-rich region correlates with loss of activator protein-2α expression during progression of breast cancer. Cancer Res 2004;64:1611-20.
-
(2004)
Cancer Res
, vol.64
, pp. 1611-1620
-
-
Douglas, D.B.1
Akiyama, Y.2
Carraway, H.3
Belinsky, S.A.4
Esteller, M.5
Gabrielson, E.6
Weitzman, S.7
Williams, T.8
Herman, J.G.9
Baylin, S.B.10
-
6
-
-
0242552587
-
GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer
-
Akiyama Y, Watkins N, Suzuki H, Jair KW, van Engeland M, Esteller M, Sakai H, Ren CY, Yuasa Y, Herman JG, Baylin SB. GATA-4 and GATA-5 transcription factor genes and potential downstream antitumor target genes are epigenetically silenced in colorectal and gastric cancer. Mol Cell Biol 2003;23:8429-39.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8429-8439
-
-
Akiyama, Y.1
Watkins, N.2
Suzuki, H.3
Jair, K.W.4
van Engeland, M.5
Esteller, M.6
Sakai, H.7
Ren, C.Y.8
Yuasa, Y.9
Herman, J.G.10
Baylin, S.B.11
-
7
-
-
0037077248
-
Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1α
-
Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC. Cloning of the human claudin-2 5′-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1α. J Biol Chem 2002;277:21361-70.
-
(2002)
J Biol Chem
, vol.277
, pp. 21361-21370
-
-
Sakaguchi, T.1
Gu, X.2
Golden, H.M.3
Suh, E.4
Rhoads, D.B.5
Reinecker, H.C.6
-
8
-
-
0037200071
-
Hepatocyte nuclear factor-1α, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene
-
Boudreau F, Rings EH, van Wering HM, Kim RK, Swain GP, Krasinski SD, Moffett J, Grand RJ, Suh ER, Traber PG. Hepatocyte nuclear factor-1α, GATA-4, and caudal related homeodomain protein Cdx2 interact functionally to modulate intestinal gene transcription. Implication for the developmental regulation of the sucrase-isomaltase gene. J Biol Chem 2002;277:31909-17.
-
(2002)
J Biol Chem
, vol.277
, pp. 31909-31917
-
-
Boudreau, F.1
Rings, E.H.2
van Wering, H.M.3
Kim, R.K.4
Swain, G.P.5
Krasinski, S.D.6
Moffett, J.7
Grand, R.J.8
Suh, E.R.9
Traber, P.G.10
-
10
-
-
0036070818
-
Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system
-
Qualtrough D, Hinoi T, Fearon E, Paraskeva C. Expression of CDX2 in normal and neoplastic human colon tissue and during differentiation of an in vitro model system. Gut 2002;51:184-90.
-
(2002)
Gut
, vol.51
, pp. 184-190
-
-
Qualtrough, D.1
Hinoi, T.2
Fearon, E.3
Paraskeva, C.4
-
11
-
-
0033564467
-
Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
-
Tamai Y, Nakajima R, Ishikawa T, Takaku K, Seldin MF, Taketo MM. Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice. Cancer Res 1999;59:2965-70.
-
(1999)
Cancer Res
, vol.59
, pp. 2965-2970
-
-
Tamai, Y.1
Nakajima, R.2
Ishikawa, T.3
Takaku, K.4
Seldin, M.F.5
Taketo, M.M.6
-
12
-
-
0033594940
-
Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice
-
Beck F, Chawengsaksophak K, Waring P, Playford RJ, Fumess JB. Reprogramming of intestinal differentiation and intercalary regeneration in Cdx2 mutant mice. Proc Natl Acad Sci USA 1999;96:7318-23.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 7318-7323
-
-
Beck, F.1
Chawengsaksophak, K.2
Waring, P.3
Playford, R.J.4
Fumess, J.B.5
-
14
-
-
0034996071
-
Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium
-
Suh E, Wang Z, Swain GP, Tenniswood M, Traber PG. Clusterin gene transcription is activated by caudal-related homeobox genes in intestinal epithelium. Am J Physiol Gastrointest Liver Physiol 2001;280:G149-G156.
-
(2001)
Am J Physiol Gastrointest Liver Physiol
, vol.280
-
-
Suh, E.1
Wang, Z.2
Swain, G.P.3
Tenniswood, M.4
Traber, P.G.5
-
15
-
-
0030032310
-
An intestine-specific homeobox gene regulates proliferation and differentiation
-
Suh E, Traber PG. An intestine-specific homeobox gene regulates proliferation and differentiation. Mol Cell Biol 1996;16:619-25.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 619-625
-
-
Suh, E.1
Traber, P.G.2
-
16
-
-
9144240744
-
-
Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003;278:51549-56.
-
Mesquita P, Jonckheere N, Almeida R, Ducourouble MP, Serpa J, Silva E, Pigny P, Silva FS, Reis C, Silberg D, Van Seuningen I, David L. Human MUC2 mucin gene is transcriptionally regulated by Cdx homeodomain proteins in gastrointestinal carcinoma cell lines. J Biol Chem 2003;278:51549-56.
-
-
-
-
17
-
-
0037462878
-
Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression
-
Yamamoto H, Bai YQ, Yuasa Y. Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression. Biochem Biophys Res Commun 2003;300:813-18.
-
(2003)
Biochem Biophys Res Commun
, vol.300
, pp. 813-818
-
-
Yamamoto, H.1
Bai, Y.Q.2
Yuasa, Y.3
-
18
-
-
29344458031
-
The putative tumor suppressor cdx2 is overexpressed by human colorectal adenocarcinomas
-
Witek ME, Nielsen K, Walters R, Hyslop T, Palazzo J, Schulz S, Waldman SA. The putative tumor suppressor cdx2 is overexpressed by human colorectal adenocarcinomas. Clin Cancer Res 2005;11:8549-56.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8549-8556
-
-
Witek, M.E.1
Nielsen, K.2
Walters, R.3
Hyslop, T.4
Palazzo, J.5
Schulz, S.6
Waldman, S.A.7
-
19
-
-
0035154834
-
The homeobox gene CDX2 in colorectal carcinoma: A genetic analysis
-
Sivagnanasundaram S, Islam I, Talbot I, Drummond F, Walters JR, Edwards YH. The homeobox gene CDX2 in colorectal carcinoma: a genetic analysis. Br J Cancer 2001;84:218-25.
-
(2001)
Br J Cancer
, vol.84
, pp. 218-225
-
-
Sivagnanasundaram, S.1
Islam, I.2
Talbot, I.3
Drummond, F.4
Walters, J.R.5
Edwards, Y.H.6
-
20
-
-
0035190672
-
Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon
-
Hinoi T, Tani M, Lucas PC, Caca K, Dunn RL, Macri E, Loda M, Appelman HD, Cho KR, Fearon ER. Loss of CDX2 expression and microsatellite instability are prominent features of large cell minimally differentiated carcinomas of the colon. Am J Pathol 2001;159:2239-48.
-
(2001)
Am J Pathol
, vol.159
, pp. 2239-2248
-
-
Hinoi, T.1
Tani, M.2
Lucas, P.C.3
Caca, K.4
Dunn, R.L.5
Macri, E.6
Loda, M.7
Appelman, H.D.8
Cho, K.R.9
Fearon, E.R.10
-
21
-
-
21344457214
-
CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
-
Rozek LS, Lipkin SM, Fearon ER, Hanash S, Giordano TJ, Greenson JK, Kuick R, Misek DE, Taylor JM, Douglas JA, Rennert G, Gruber SB. CDX2 polymorphisms, RNA expression, and risk of colorectal cancer. Cancer Res 2005;65:5488-92.
-
(2005)
Cancer Res
, vol.65
, pp. 5488-5492
-
-
Rozek, L.S.1
Lipkin, S.M.2
Fearon, E.R.3
Hanash, S.4
Giordano, T.J.5
Greenson, J.K.6
Kuick, R.7
Misek, D.E.8
Taylor, J.M.9
Douglas, J.A.10
Rennert, G.11
Gruber, S.B.12
-
22
-
-
0242497802
-
Silencing of CDX2 expression in colon cancer via a dominant repression pathway
-
Hinoi T, Loda M, Fearon ER. Silencing of CDX2 expression in colon cancer via a dominant repression pathway. J Biol Chem 2003;278:44608-16.
-
(2003)
J Biol Chem
, vol.278
, pp. 44608-44616
-
-
Hinoi, T.1
Loda, M.2
Fearon, E.R.3
-
23
-
-
4944262384
-
The homeodomain protein CDX2 is an early marker of Barrett's oesophagus
-
Moons LM, Bax DA, Kuipers EJ, Van Dekken H, Haringsma J, Van Vliet AH, Siersema PD, Kusters JG. The homeodomain protein CDX2 is an early marker of Barrett's oesophagus. J Clin Pathol 2004;57:1063-8.
-
(2004)
J Clin Pathol
, vol.57
, pp. 1063-1068
-
-
Moons, L.M.1
Bax, D.A.2
Kuipers, E.J.3
Van Dekken, H.4
Haringsma, J.5
Van Vliet, A.H.6
Siersema, P.D.7
Kusters, J.G.8
-
24
-
-
4744364736
-
Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett's) metaplasia
-
Groisman GM, Amar M, Meir A. Expression of the intestinal marker Cdx2 in the columnar-lined esophagus with and without intestinal (Barrett's) metaplasia. Mod Pathol 2004;17:1282-8.
-
(2004)
Mod Pathol
, vol.17
, pp. 1282-1288
-
-
Groisman, G.M.1
Amar, M.2
Meir, A.3
-
25
-
-
0142200932
-
Cdx2 as a marker of epithelial intestinal differentiation in the esophagus
-
Phillips RW, Frierson HF, Jr, Moskaluk CA. Cdx2 as a marker of epithelial intestinal differentiation in the esophagus. Am J Surg Pathol 2003;27:1442-7.
-
(2003)
Am J Surg Pathol
, vol.27
, pp. 1442-1447
-
-
Phillips, R.W.1
Frierson Jr, H.F.2
Moskaluk, C.A.3
-
26
-
-
27744567515
-
Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma
-
Lord RV, Brabender J, Wickramasinghe K, DeMeester SR, Holscher A, Schneider PM, Danenberg PV, DeMeester TR. Increased CDX2 and decreased PITX1 homeobox gene expression in Barrett's esophagus and Barrett's-associated adenocarcinoma. Surgery 2005;138:924-31.
-
(2005)
Surgery
, vol.138
, pp. 924-931
-
-
Lord, R.V.1
Brabender, J.2
Wickramasinghe, K.3
DeMeester, S.R.4
Holscher, A.5
Schneider, P.M.6
Danenberg, P.V.7
DeMeester, T.R.8
-
27
-
-
0029843950
-
Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
-
Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-6.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
28
-
-
33947536361
-
The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells
-
Benahmed F, Gross I, Guenot D, Jehan F, Martin E, Domon-Dell C, Brabletz T, Kedinger M, Freund JN, Duluc I. The microenvironment controls CDX2 homeobox gene expression in colorectal cancer cells. Am J Pathol 2007;170:733-44.
-
(2007)
Am J Pathol
, vol.170
, pp. 733-744
-
-
Benahmed, F.1
Gross, I.2
Guenot, D.3
Jehan, F.4
Martin, E.5
Domon-Dell, C.6
Brabletz, T.7
Kedinger, M.8
Freund, J.N.9
Duluc, I.10
-
29
-
-
0032578509
-
Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis
-
Belinsky SA, Nikula KJ, Palmisano WA, Michels R, Saccomanno G, Gabrielson E, Baylin SB, Herman JG. Aberrant methylation of p16(INK4a) is an early event in lung cancer and a potential biomarker for early diagnosis. Proc Natl Acad Sci USA 1998;95:11891-6.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 11891-11896
-
-
Belinsky, S.A.1
Nikula, K.J.2
Palmisano, W.A.3
Michels, R.4
Saccomanno, G.5
Gabrielson, E.6
Baylin, S.B.7
Herman, J.G.8
-
30
-
-
13444305417
-
Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients
-
Yuasa Y, Nagasaki H, Akiyama Y, Sakai H, Nakajima T, Ohkura Y, Takizawa T, Koike M, Tani M, Iwai T, Sugihara K, Imai K et al. Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients. Carcinogenesis 2005;26:193-200.
-
(2005)
Carcinogenesis
, vol.26
, pp. 193-200
-
-
Yuasa, Y.1
Nagasaki, H.2
Akiyama, Y.3
Sakai, H.4
Nakajima, T.5
Ohkura, Y.6
Takizawa, T.7
Koike, M.8
Tani, M.9
Iwai, T.10
Sugihara, K.11
Imai, K.12
-
31
-
-
15044346790
-
Promoter methylation downregulates CDX2 expression in colorectal carcinomas
-
Kawai H, Tomii K, Toyooka S, Yano M, Murakami M, Tsukuda K, Shimizu N. Promoter methylation downregulates CDX2 expression in colorectal carcinomas. Oncol Rep 2005;13:547-51.
-
(2005)
Oncol Rep
, vol.13
, pp. 547-551
-
-
Kawai, H.1
Tomii, K.2
Toyooka, S.3
Yano, M.4
Murakami, M.5
Tsukuda, K.6
Shimizu, N.7
-
32
-
-
0035838585
-
Regulation of the intestinal mucin MUC2 gene expression in vivo: Evidence for the role of promoter methylation
-
Gratchev A, Siedow A, Bumke-Vogt C, Hummel M, Foss HD, Hanski ML, Kobalz U, Mann B, Lammert H, Mansmann U, Stein H, Riecken EO et al. Regulation of the intestinal mucin MUC2 gene expression in vivo: evidence for the role of promoter methylation. Cancer Lett 2001;168:71-80.
-
(2001)
Cancer Lett
, vol.168
, pp. 71-80
-
-
Gratchev, A.1
Siedow, A.2
Bumke-Vogt, C.3
Hummel, M.4
Foss, H.D.5
Hanski, M.L.6
Kobalz, U.7
Mann, B.8
Lammert, H.9
Mansmann, U.10
Stein, H.11
Riecken, E.O.12
-
33
-
-
23844445282
-
Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing
-
Hamada T, Goto M, Tsutsumida H, Nomoto M, Higashi M, Sugai T, Nakamura S, Yonezawa S. Mapping of the methylation pattern of the MUC2 promoter in pancreatic cancer cell lines, using bisulfite genomic sequencing. Cancer Lett 2005;227:175-84.
-
(2005)
Cancer Lett
, vol.227
, pp. 175-184
-
-
Hamada, T.1
Goto, M.2
Tsutsumida, H.3
Nomoto, M.4
Higashi, M.5
Sugai, T.6
Nakamura, S.7
Yonezawa, S.8
|