HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes

Diabetes

Volumn 61, Issue 10, 2012, Pages 2546-2555

  Scotto, Matthieu ^a,b   Afonso, Georgia ^a,b   Østerbye, Thomas ^c   Larger, Etienne ^b,d   Luce, Sandrine ^a,b   Raverdy, Cécile ^b,e   Novelli, Giulia ^f   Bruno, Graziella ^f   Gonfroy Leymarie, Céline ^d   Launay, Odile ^g   Lemonnier, François A ^a,b   Buus, Søren ^c   Carel, Jean Claude ^b,e   Boitard, Christian ^a,b,d   Mallone, Roberto ^a,b,d  

^a université Paris Cité   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d HÔTEL DIEU   (France)

^e HÔPITAL ROBERT DEBRÉ   (France)

^f UNIVERSITY OF TURIN   (Italy)

^g ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; EPITOPE; GAMMA INTERFERON; GLUTAMATE DECARBOXYLASE; HLA A2 ANTIGEN; HLA B7 ANTIGEN; MESSENGER RNA; PREPROINSULIN; TRANSFORMING GROWTH FACTOR BETA;

ADOLESCENT; ADULT; AGED; ALGORITHM; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CELL SPECIFICITY; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETIC PATIENT; DISEASE SEVERITY; DNA IMMUNIZATION; ENZYME LINKED IMMUNOSPOT ASSAY; FEMALE; HLA SYSTEM; HUMAN; HUMAN CELL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS ISLET BETA CELL; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYMERASE CHAIN REACTION; PREDICTION; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; SCHOOL CHILD; SINGLE CELL ANALYSIS; T LYMPHOCYTE; TRANSGENIC MOUSE;

ADOLESCENT; ADULT; AGED; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; EPITOPES; FEMALE; HLA-B7 ANTIGEN; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MIDDLE AGED; TRANSFORMING GROWTH FACTOR BETA;

EID: 84866596202     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db12-0136     Document Type: Article

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