Short-term subcutaneous insulin treatment delays but does not prevent diabetes in NOD mice

European Journal of Immunology

Volumn 42, Issue 6, 2012, Pages 1553-1561

  Brezar, Vedran ^a,b   Culina, Slobodan ^a,b   Gagnerault, Marie Claude ^a,b   Mallone, Roberto ^a,b,c  

^a Cochin/Saint Vincent de Paul Hospital ^*  (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c HÔTEL DIEU   (France)

Author keywords

Insulin; NOD mouse; Prevention; T cells; Type 1 diabetes

Indexed keywords

C PEPTIDE; GAMMA INTERFERON; GLUCOSE; GLUCOSE 6 PHOSPHATASE; INSULIN GLARGINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COMPOSITION; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DRUG EFFICACY; DRUG MEGADOSE; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; INSULITIS; LOW DRUG DOSE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL; PRIORITY JOURNAL; SHORT COURSE THERAPY; TREATMENT DURATION;

ANIMALS; BLOOD GLUCOSE; C-PEPTIDE; CD8-POSITIVE T-LYMPHOCYTES; DIABETES MELLITUS, TYPE 1; HYPOGLYCEMIC AGENTS; INJECTIONS, SUBCUTANEOUS; INSULIN; INTERFERON-GAMMA; MICE; MICE, INBRED NOD;

EID: 84862122042     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242394     Document Type: Article

References (34)

1. +T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes 2007. 56: 613-621.
2. Brezar, V., Carel, J. C., Boitard, C. and Mallone, R., Beyond the hormone: insulin as an autoimmune target in type 1 diabetes. Endocr. Rev. 2011. 32: 623-669.
3. Chandra, J., Zhivotovsky, B., Zaitsev, S., Juntti-Berggren, L., Berggren, P. O. and Orrenius, S., Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes 2001. 50(Suppl 1): S44-S47.
4. Skowera, A., Ellis, R. J., Varela-Calvino, R., Arif, S., Huang, G. C., Van-Krinks, C., Zaremba, A. et al., CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J. Clin. Invest. 2008. 118: 3390-3402.
5. Miller, S. D., Turley, D. M. and Podojil, J. R., Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease. Nat. Rev. Immunol. 2007. 7: 665-677.
6. Atkinson, M. A., Maclaren, N. K. and Luchetta, R., Insulitis and diabetes in NOD mice reduced by prophylactic insulin therapy. Diabetes 1990. 39: 933-937.
7. Diabetes Prevention Trial-Type 1 Diabetes Study Group, Effects of insulin in relatives of patients with type 1 diabetes mellitus. N. Engl. J. Med. 2002. 346: 1685-1691.
8. Carel, J. C., Landais, P. and Bougneres, P., Therapy to prevent type 1 diabetes mellitus. N. Engl. J. Med. 2002. 347: 1115-1116.
9. Mallone, R. and van Endert, P., T cells in the pathogenesis of type 1 diabetes. Curr. Diab. Rep. 2008. 8: 101-106.
10. + cytotoxic T cells in the destruction of pancreatic beta-cells in nonobese diabetic mice. J. Immunol. 1994. 152: 2042-2050.
11. Wong, F. S., Visintin, I., Wen, L., Flavell, R. A. and Janeway, C. A., Jr., CD8 T cell clones from young nonobese diabetic (NOD) islets can transfer rapid onset of diabetes in NOD mice in the absence of CD4 cells. J. Exp. Med. 1996. 183: 67-76.
12. Verdaguer, J., Schmidt, D., Amrani, A., Anderson, B., Averill, N. and Santamaria, P., Spontaneous autoimmune diabetes in monoclonal T cell nonobese diabetic mice. J. Exp. Med. 1997. 186: 1663-1676.
13. Wong, F. S., Siew, L. K., Scott, G., Thomas, I. J., Chapman, S., Viret, C. and Wen, L., Activation of insulin-reactive CD8 T cells for development of autoimmune diabetes. Diabetes 2009. 58: 1156-1164.
14. Trudeau, J. D., Kelly-Smith, C., Verchere, C. B., Elliott, J. F., Dutz, J. P., Finegood, D. T., Santamaria, P. et al., Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J. Clin. Invest. 2003. 111: 217-223.
15. Fourlanos, S., Perry, C., Gellert, S. A., Martinuzzi, E., Mallone, R., Butler, J., Colman, P. G. et al., Evidence that nasal insulin induces immune tolerance to insulin in adults with autoimmune diabetes. Diabetes 2011. 60: 1237-1245.
16. Achenbach, P., Barker, J. and Bonifacio, E., Modulating the natural history of type 1 diabetes in children at high genetic risk by mucosal insulin immunization. Curr. Diab. Rep. 2008. 8: 87-93.
17. Atkinson, M. A., ADA Outstanding Scientific Achievement Lecture 2004. Thirty years of investigating the autoimmune basis for type 1 diabetes: why can't we prevent or reverse this disease? Diabetes 2005. 54: 1253-1263.
18. Pozzilli, P., Pitocco, D., Visalli, N., Cavallo, M. G., Buzzetti, R., Crino, A., Spera, S. et al., No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia 2000. 43: 1000-1004.
19. Skyler, J. S., Krischer, J. P., Wolfsdorf, J., Cowie, C., Palmer, J. P., Greenbaum, C., Cuthbertson, D. et al., Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1. Diabetes Care 2005. 28: 1068-1076.
20. Culina, S., Boitard, C. and Mallone, R., Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Clin. Dev. Immunol. 2011. 2011: 286248.
21. Vehik, K., Cuthbertson, D., Ruhlig, H., Schatz, D. A., Peakman, M. and Krischer, J. P., Long-term outcome of individuals treated with oral insulin: Diabetes Prevention Trial-Type 1 (DPT-1) oral insulin trial. Diabetes Care 2011. 34: 1585-1590.
22. Guery, J. C., Galbiati, F., Smiroldo, S. and Adorini, L., Selective development of T helper (Th)2 cells induced by continuous administration of low dose soluble proteins to normal and beta(2)-microglobulin-deficient BALB/c mice. J. Exp. Med. 1996. 183: 485-497.
23. Karounos, D. G., Bryson, J. S. and Cohen, D. A., Metabolically inactive insulin analog prevents type I diabetes in prediabetic NOD mice. J. Clin. Invest. 1997. 100: 1344-1348.
24. Volund, A., Brange, J., Drejer, K., Jensen, I., Markussen, J., Ribel, U., Sorensen, A. R. et al., In vitro and in vivo potency of insulin analogues designed for clinical use. Diabet. Med. 1991. 8: 839-847.
25. Bowman, M. A., Campbell, L., Darrow, B. L., Ellis, T. M., Suresh, A. and Atkinson, M. A., Immunological and metabolic effects of prophylactic insulin therapy in the NOD-scid/scid adoptive transfer model of IDDM. Diabetes 1996. 45: 205-208.
26. Thivolet, C. H., Goillot, E., Bedossa, P., Durand, A., Bonnard, M. and Orgiazzi, J., Insulin prevents adoptive cell transfer of diabetes in the autoimmune non-obese diabetic mouse. Diabetologia 1991. 34: 314-319.
27. Muir, A., Peck, A., Clare-Salzler, M., Song, Y. H., Cornelius, J., Luchetta, R., Krischer, J. et al., Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription. J. Clin. Invest. 1995. 95: 628-634.
28. Daniel, D. and Wegmann, D. R., Protection of nonobese diabetic mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23). Proc. Natl. Acad. Sci. USA 1996. 93: 956-960.
29. Abiru, N., Maniatis, A. K., Yu, L., Miao, D., Moriyama, H., Wegmann, D. and Eisenbarth, G. S., Peptide and major histocompatibility complex-specific breaking of humoral tolerance to native insulin with the B9-23 peptide in diabetes-prone and normal mice. Diabetes 2001. 50: 1274-1281.
30. Orban, T., Farkas, K., Jalahej, H., Kis, J., Treszl, A., Falk, B., Reijonen, H. et al., Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J. Autoimmun. 2010. 34: 408-415.
31. Zhang, Z. J., Davidson, L., Eisenbarth, G. and Weiner, H. L., Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc. Natl. Acad. Sci. USA 1991. 88: 10252-10256.
32. Harrison, L. C., Dempsey-Collier, M., Kramer, D. R. and Takahashi, K., Aerosol insulin induces regulatory CD8 gamma delta T cells that prevent murine insulin-dependent diabetes. J. Exp. Med. 1996. 184: 2167-2174.
33. Diana, J., Brezar, V., Beaudoin, L., Dalod, M., Mellor, A., Tafuri, A., von Herrath, M. et al., Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J. Exp. Med. 2011. 208: 729-745.
34. Jarchum, I., Takaki, T. and DiLorenzo, T. P., Efficient culture of CD8(+) T cells from the islets of NOD mice and their use for the study of autoreactive specificities. J. Immunol. Methods 2008. 339: 66-73.