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Volumn 67, Issue 10, 2012, Pages 2494-2500

Risk factors for raltegravir resistance development in clinical practice

Author keywords

Failure; HIV 1; Integrase; Raltegravir; Resistance mutations

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; RALTEGRAVIR; VIRUS RNA;

EID: 84866595664     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks254     Document Type: Article
Times cited : (11)

References (23)
  • 1
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravirbased versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial
    • Lennox JL, DeJesus E, Lazzarin A et al. Safety and efficacy of raltegravirbased versus efavirenz-based combination therapy in treatment-naive patients with HIV-1 infection: a multicentre, double-blind randomised controlled trial. Lancet 2009; 374: 796-806.
    • (2009) Lancet , vol.374 , pp. 796-806
    • Lennox, J.L.1    DeJesus, E.2    Lazzarin, A.3
  • 2
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with optimized background therapy for resistant HIV-1 infection
    • Steigbigel RT, Cooper DA, Kumar PN et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med 2008; 359: 339-54.
    • (2008) N Engl J Med , vol.359 , pp. 339-54
    • Steigbigel, R.T.1    Cooper, D.A.2    Kumar, P.N.3
  • 3
    • 79952669273 scopus 로고    scopus 로고
    • Patterns of resistance development with integrase inhibitors in HIV
    • Mbisa JL, Martin SA, Cane PA. Patterns of resistance development with integrase inhibitors in HIV. Infect Drug Resist 2011; 4: 65-76.
    • (2011) Infect Drug Resist , vol.4 , pp. 65-76
    • Mbisa, J.L.1    Martin, S.A.2    Cane, P.A.3
  • 4
    • 77958015399 scopus 로고    scopus 로고
    • Resistance to integrase inhibitors
    • Métifiot M, Marchand C, Maddali K et al. Resistance to integrase inhibitors. Viruses 2010; 2: 1347-66.
    • (2010) Viruses , vol.2 , pp. 1347-66
    • Métifiot, M.1    Marchand, C.2    Maddali, K.3
  • 5
    • 84896503763 scopus 로고    scopus 로고
    • Role of raltegravir in the management of HIV-1 infection
    • Okeke NL, Hicks C. Role of raltegravir in the management of HIV-1 infection. HIV AIDS (Auckl) 2011; 3: 81-92.
    • (2011) HIV AIDS (Auckl) , vol.3 , pp. 81-92
    • Okeke, N.L.1    Hicks, C.2
  • 6
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper DA, Steigbigel RT, Gatell JM et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med 2008; 359: 355-65.
    • (2008) N Engl J Med , vol.359 , pp. 355-65
    • Cooper, D.A.1    Steigbigel, R.T.2    Gatell, J.M.3
  • 8
    • 62549166235 scopus 로고    scopus 로고
    • Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients
    • Malet I, Delelis O, Soulie C et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1-infected patients. J Antimicrob Chemother 2009; 63: 795-804.
    • (2009) J Antimicrob Chemother , vol.63 , pp. 795-804
    • Malet, I.1    Delelis, O.2    Soulie, C.3
  • 9
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet I, Delelis O, Valantin MA et al. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob Agents Chemother 2008; 52: 1351-8.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 1351-8
    • Malet, I.1    Delelis, O.2    Valantin, M.A.3
  • 10
    • 79954576742 scopus 로고    scopus 로고
    • The SPARTAN study: a pilot study to assess the safety and efficacy of an investigational NRTI- and RTV-sparing regimen of atazanavir (ATV) experimental dose of 300mg BID plus raltegravir (RAL) 400 mg BID (ATV+RAL) in treatment-naive HIV-infected subjects
    • Vienna, Austria Abstract THLBB204
    • Kozal M, Lupo S, DeJesus E et al. The SPARTAN study: a pilot study to assess the safety and efficacy of an investigational NRTI- and RTV-sparing regimen of atazanavir (ATV) experimental dose of 300mg BID plus raltegravir (RAL) 400 mg BID (ATV+RAL) in treatment-naive HIV-infected subjects. In: Abstracts of the Eighteenth International AIDS Conference, Vienna, Austria, 2010. Abstract THLBB204.
    • (2010) Abstracts of the Eighteenth International AIDS Conference
    • Kozal, M.1    Lupo, S.2    DeJesus, E.3
  • 11
    • 75149175071 scopus 로고    scopus 로고
    • Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials
    • Eron JJ, Young B, Cooper DA et al. Switch to a raltegravir-based regimen versus continuation of a lopinavir-ritonavir-based regimen in stable HIV-infected patients with suppressed viraemia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomised controlled trials. Lancet 2010; 375: 396-407
    • (2010) Lancet , vol.375 , pp. 396-407
    • Eron, J.J.1    Young, B.2    Cooper, D.A.3
  • 12
    • 84872650158 scopus 로고    scopus 로고
    • Prise en charge médicale des personnes infectées par le VIH 19 June 2012, date last accessed
    • Yeni P. Prise en charge médicale des personnes infectées par le VIH. 2010. http://www.sante.gouv.fr (19 June 2012, date last accessed).
    • (2010)
    • Yeni, P.1
  • 13
    • 66349126931 scopus 로고    scopus 로고
    • Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility
    • Van Baelen K, Van Eygen V, Rondelez E et al. Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility. AIDS 2008; 22: 1877-80
    • (2008) AIDS , vol.22 , pp. 1877-80
    • Van Baelen, K.1    Van Eygen, V.2    Rondelez, E.3
  • 14
    • 77956887506 scopus 로고
    • A note on a general definition of the coefficient of determination
    • Nagelkerke NJ. A note on a general definition of the coefficient of determination. Biometrika 1991; 78: 691-2.
    • (1991) Biometrika , vol.78 , pp. 691-2
    • Nagelkerke, N.J.1
  • 15
    • 77950264042 scopus 로고    scopus 로고
    • Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection
    • Garrido C, Geretti AM, Zahonero N et al. Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection. J Antimicrob Chemother 2010; 65: 320-6.
    • (2010) J Antimicrob Chemother , vol.65 , pp. 320-6
    • Garrido, C.1    Geretti, A.M.2    Zahonero, N.3
  • 16
    • 41149161847 scopus 로고    scopus 로고
    • The discovery of raltegravir, an integrase inhibitor for the treatment of HIV infection
    • Rowley M. The discovery of raltegravir, an integrase inhibitor for the treatment of HIV infection. Prog Med Chem 2008; 46: 1-28.
    • (2008) Prog Med Chem , vol.46 , pp. 1-28
    • Rowley, M.1
  • 17
    • 37849002059 scopus 로고    scopus 로고
    • Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)
    • Shimura K, Kodama E, Sakagami Y et al. Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137). J Virol 2008; 82: 764-74.
    • (2008) J Virol , vol.82 , pp. 764-74
    • Shimura, K.1    Kodama, E.2    Sakagami, Y.3
  • 18
    • 81855199761 scopus 로고    scopus 로고
    • The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype
    • Malet I, Fourati S, Charpentier C et al. The HIV-1 integrase G118R mutation confers raltegravir resistance to the CRF02_AG HIV-1 subtype. J Antimicrob Chemother 2011; 66: 2827-30.
    • (2011) J Antimicrob Chemother , vol.66 , pp. 2827-30
    • Malet, I.1    Fourati, S.2    Charpentier, C.3
  • 19
    • 77956017859 scopus 로고    scopus 로고
    • Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    • Bar-Magen T, Sloan RD, Donahue DA et al. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J Virol 2010; 84: 9210-6.
    • (2010) J Virol , vol.84 , pp. 9210-6
    • Bar-Magen, T.1    Sloan, R.D.2    Donahue, D.A.3
  • 20
    • 53249087908 scopus 로고    scopus 로고
    • Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants
    • Kobayashi M, Nakahara K, Seki T et al. Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants. Antiviral Res 2008; 80: 213-22.
    • (2008) Antiviral Res , vol.80 , pp. 213-22
    • Kobayashi, M.1    Nakahara, K.2    Seki, T.3
  • 21
    • 65549085822 scopus 로고    scopus 로고
    • Characterization and structural analysis of HIV-1 integrase conservation
    • Ceccherini-Silberstein F, Malet I, D'Arrigo R et al. Characterization and structural analysis of HIV-1 integrase conservation. AIDS Rev 2009; 11: 17-29.
    • (2009) AIDS Rev , vol.11 , pp. 17-29
    • Ceccherini-Silberstein, F.1    Malet, I.2    D'Arrigo, R.3
  • 22
    • 41849083439 scopus 로고    scopus 로고
    • Structural effects of amino acid variations between B and CRF02-AG HIV-1 integrases
    • Malet I, Soulie C, Tchertanov L et al. Structural effects of amino acid variations between B and CRF02-AG HIV-1 integrases. J Med Virol 2008; 80: 754-61.
    • (2008) J Med Virol , vol.80 , pp. 754-61
    • Malet, I.1    Soulie, C.2    Tchertanov, L.3
  • 23
    • 52749086245 scopus 로고    scopus 로고
    • Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors
    • Rhee SY, Liu TF, Kiuchi M et al. Natural variation of HIV-1 group M integrase: implications for a new class of antiretroviral inhibitors. Retrovirology 2008; 5: 74.
    • (2008) Retrovirology , vol.5 , pp. 74
    • Rhee, S.Y.1    Liu, T.F.2    Kiuchi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.