메뉴 건너뛰기




Volumn 3, Issue , 2011, Pages 81-92

Role of raltegravir in the management of HIV-1 infection

Author keywords

Antiretroviral therapy; HIV; Raltegravir

Indexed keywords

ALANINE AMINOTRANSFERASE; ATAZANAVIR; CREATINE KINASE; INTEGRASE; INTEGRASE INHIBITOR; LAMOTRIGINE; METHADONE; MIDAZOLAM; PLACEBO; PROTON PUMP INHIBITOR; RALTEGRAVIR; RIFAMPICIN; VIRUS DNA;

EID: 84896503763     PISSN: None     EISSN: 11791373     Source Type: Journal    
DOI: 10.2147/HIV.S13985     Document Type: Review
Times cited : (10)

References (80)
  • 1
    • 58149137707 scopus 로고    scopus 로고
    • Accessed December 10, 2010
    • World Health Organization (WHO). Global summary of the HIV/AIDS epidemic. http://www.who.int/hiv/data/en, 2009. Accessed December 10, 2010.
    • (2009) Global summary of the HIV/AIDS epidemic
  • 2
    • 85014425021 scopus 로고    scopus 로고
    • [package insert] Whitehouse Station, NJ: Merck
    • Isentress (raltegravir) [package insert] Whitehouse Station, NJ: Merck, 2007.
    • (2007)
  • 4
    • 0034468560 scopus 로고    scopus 로고
    • Repair of gaps in retroviral DNA integration intermediates
    • Yoder KE, Bushman FD. Repair of gaps in retroviral DNA integration intermediates. J Virol. 2000;74: 11191-11200.
    • (2000) J Virol. , vol.74 , pp. 11191-11200
    • Yoder, K.E.1    Bushman, F.D.2
  • 5
    • 0030812190 scopus 로고    scopus 로고
    • Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase
    • Hazuda DJ, Felock PJ, Hastings JC, et al. Differential divalent cation requirements uncouple the assembly and catalytic reactions of human immunodeficiency virus type 1 integrase. J Virol. 1997; 71: 7005-7011.
    • (1997) J Virol , vol.71 , pp. 7005-7011
    • Hazuda, D.J.1    Felock, P.J.2    Hastings, J.C.3
  • 7
    • 77957040861 scopus 로고    scopus 로고
    • HIV-1 integrase strand transfer inhibitors: Novel insights into their mechanism of action
    • Pandey K, Grandgenett D. HIV-1 integrase strand transfer inhibitors: novel insights into their mechanism of action. Retrovirology. 2008;2: 11-16.
    • (2008) Retrovirology. , vol.2 , pp. 11-16
    • Pandey, K.1    Grandgenett, D.2
  • 8
    • 73549123203 scopus 로고    scopus 로고
    • Strand transfer inhibitors of HIV-1 integrase: Bringing IN a new era of antiretroviral therapy
    • McColl DJ, Chen X. Strand transfer inhibitors of HIV-1 integrase: bringing IN a new era of antiretroviral therapy. Antiviral Res. 2010;85: 101-118.
    • (2010) Antiviral Res. , vol.85 , pp. 101-118
    • McColl, D.J.1    Chen, X.2
  • 9
    • 0037076324 scopus 로고    scopus 로고
    • Diketo acid inhibitor mechanism and HIV-1 integrase: Implications for metal binding in the active site of phosphotransferase enzymes
    • Grobler JA, Stillmock K, Hu B, et al. Diketo acid inhibitor mechanism and HIV-1 integrase: implications for metal binding in the active site of phosphotransferase enzymes. Proc Natl Acad Sci U S A. 2002;99: 6661-6666.
    • (2002) Proc Natl Acad Sci U S A. , vol.99 , pp. 6661-6666
    • Grobler, J.A.1    Stillmock, K.2    Hu, B.3
  • 10
    • 0034723439 scopus 로고    scopus 로고
    • Inhibitors that prevent integration and inhibit HIV-1 replication in cells
    • Hazuda DJ, Felock P, Witmer M, et al. Inhibitors that prevent integration and inhibit HIV-1 replication in cells. Science. 2000;287: 646-650.
    • (2000) Science. , vol.287 , pp. 646-650
    • Hazuda, D.J.1    Felock, P.2    Witmer, M.3
  • 11
    • 2342541832 scopus 로고    scopus 로고
    • Requirement for integrase during reverse transcription of human immunodeficiency virus type-1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase
    • Zhu K Dobard C, Chow SA. Requirement for integrase during reverse transcription of human immunodeficiency virus type-1 and the effect of cysteine mutations of integrase on its interactions with reverse transcriptase. J Virol. 2004;78: 5045-5055.
    • (2004) J Virol. , vol.78 , pp. 5045-5055
    • Zhu, K.1    Dobard, C.2    Chow, S.A.3
  • 12
    • 3843108916 scopus 로고    scopus 로고
    • A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase
    • Hazuda DJ, Anthony NJ, Gomes RP, et al. A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase. Proc Natl Acad Sci U S A. 2004;101: 11233-11238.
    • (2004) Proc Natl Acad Sci U S A. , vol.101 , pp. 11233-11238
    • Hazuda, D.J.1    Anthony, N.J.2    Gomes, R.P.3
  • 13
    • 52449097240 scopus 로고    scopus 로고
    • Discovery of raltegravir, a potent selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection
    • Summa V, Petrocchi A, Bonelli F, et al. Discovery of raltegravir, a potent selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection. J Med Chem. 2008;51: 5843-5855.
    • (2008) J Med Chem. , vol.51 , pp. 5843-5855
    • Summa, V.1    Petrocchi, A.2    Bonelli, F.3
  • 14
    • 80053271242 scopus 로고    scopus 로고
    • Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor
    • 1-26 Jan, Epub 2011 Jan 5
    • Brainard DM, Wenning LA, Stone JA Stone, et al. Clinical pharmacology profile of raltegravir, an HIV-1 integrase strand transfer inhibitor. J Clin Pharmacol. 1-26 Jan 2011. Epub 2011 Jan 5.
    • (2011) J Clin Pharmacol
    • Brainard, D.M.1    Wenning, L.A.2    Stone, J.A.S.3
  • 15
    • 66149137187 scopus 로고    scopus 로고
    • Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics
    • Iwamoto M, Hanley WD, Petry AS, et al. Lack of a clinically important effect of moderate hepatic insufficiency and severe renal insufficiency on raltegravir pharmacokinetics. Antimicrob Agents Chemother. 2009;53: 1747-1752.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 1747-1752
    • Iwamoto, M.1    Hanley, W.D.2    Petry, A.S.3
  • 16
    • 79953808275 scopus 로고    scopus 로고
    • HIV-2 infection, end stage renal disease and protease inhibitor intolerance: Which salvage regimen?
    • Francisci D, Martinelli L, Weimer LE, et al. HIV-2 infection, end stage renal disease and protease inhibitor intolerance: which salvage regimen? Clin Drug Investig. 2011;31: 345-349.
    • (2011) Clin Drug Investig , vol.31 , pp. 345-349
    • Francisci, D.1    Martinelli, L.2    Weimer, L.E.3
  • 17
    • 77953770958 scopus 로고    scopus 로고
    • Minimal removal of raltegravir by hemodialysis in HIV-infected patients with end stage renal disease
    • Molto J, Sanz-Moreno J, Valle M, et al. Minimal removal of raltegravir by hemodialysis in HIV-infected patients with end stage renal disease. Antimicrob Agents Chemother. 2010;54: 3047-3048.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 3047-3048
    • Molto, J.1    Sanz-Moreno, J.2    Valle, M.3
  • 18
    • 70149119217 scopus 로고    scopus 로고
    • Raltegravir cerebrospinal fluid concentrartions in HIV-1 1 infection
    • Yilmaz A, Gisslen M, Spudich S, et al. Raltegravir cerebrospinal fluid concentrartions in HIV-1 1 infection. PloS One. 2009;4: e6877.
    • (2009) PloS One , vol.4
    • Yilmaz, A.1    Gisslen, M.2    Spudich, S.3
  • 19
    • 38349182976 scopus 로고    scopus 로고
    • Lack of pharmacokinetic effect of raltegravir on midazolam: In vitro/in vivo correlation
    • Iwamoto M, Kassahan K, Matthew D, et al. Lack of pharmacokinetic effect of raltegravir on midazolam: in vitro/in vivo correlation. J Clin Pharmacol. 2008;48: 209-214.
    • (2008) J Clin Pharmacol. , vol.48 , pp. 209-214
    • Iwamoto, M.1    Kassahan, K.2    Matthew, D.3
  • 20
    • 66949149605 scopus 로고    scopus 로고
    • Effect of rifampin, a potent inducer of drug metabolizing enzymes, on the pharmacokinetics of raltegravir
    • Wenning LA, Hanley WD, Brainard DM, et al. Effect of rifampin, a potent inducer of drug metabolizing enzymes, on the pharmacokinetics of raltegravir. Antimicrob Agents Chemother. 2009;53: 2852-2856.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 2852-2856
    • Wenning, L.A.1    Hanley, W.D.2    Brainard, D.M.3
  • 21
    • 46249087089 scopus 로고    scopus 로고
    • Atazanavir modestly increases plasma levels of raltegravir in healthy adults
    • Iwamoto M, Wenning L, Mistry GC, et al. Atazanavir modestly increases plasma levels of raltegravir in healthy adults. Clin Infect Dis. 2008;47: 137-140.
    • (2008) Clin Infect Dis. , vol.47 , pp. 137-140
    • Iwamoto, M.1    Wenning, L.2    Mistry, G.C.3
  • 23
    • 50949095712 scopus 로고    scopus 로고
    • Lack of significant drug interaction between raltegravir and tenofovir
    • Wenning L, Friedman E, Kost J, et al. Lack of significant drug interaction between raltegravir and tenofovir. Antomicrob Agents Chemother. 2008;52: 3253-3258.
    • (2008) Antomicrob Agents Chemother. , vol.52 , pp. 3253-3258
    • Wenning, L.1    Friedman, E.2    Kost, J.3
  • 24
    • 57049123891 scopus 로고    scopus 로고
    • Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob
    • Iwamoto M, Wenning L, Petry A, et al. Minimal effects of ritonavir and efavirenz on the pharmacokinetics of raltegravir. Antimicrob. Agents Chemother. 2008;52: 4338-4343.
    • (2008) Agents Chemother. , vol.52 , pp. 4338-4343
    • Iwamoto, M.1    Wenning, L.2    Petry, A.3
  • 25
    • 78549245842 scopus 로고    scopus 로고
    • Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment-experience patients
    • Barrail-Tran A, Yazdanpanah Y, Goldwirt L, et al. Pharmacokinetics of etravirine, raltegravir and darunavir/ritonavir in treatment-experience patients. AIDS. 2010;24: 2581-2593.
    • (2010) AIDS. , vol.24 , pp. 2581-2593
    • Barrail-Tran, A.1    Yazdanpanah, Y.2    Goldwirt, L.3
  • 26
    • 79751524627 scopus 로고    scopus 로고
    • Darunavir/ritonavir and raltegravir coadministered in routine clinical practice: Potential role for an unexpected drug interaction
    • Fabbiani M, Di Giambenedetto S, Ragazzoni E, et al. Darunavir/ritonavir and raltegravir coadministered in routine clinical practice: potential role for an unexpected drug interaction. Pharmacol Res. 2011;63: 249-253.
    • (2011) Pharmacol Res. , vol.63 , pp. 249-253
    • Fabbiani, M.1    Di Giambenedetto, S.2    Ragazzoni, E.3
  • 27
    • 33845366857 scopus 로고    scopus 로고
    • Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naïve HIV-1 individuals
    • Markowitz M, Morales-Ramirez JO, Nguyen BY, et al. Antiretroviral activity, pharmacokinetics, and tolerability of MK-0518, a novel inhibitor of HIV-1 integrase, dosed as monotherapy for 10 days in treatment-naïve HIV-1 individuals. J Acquir Immune Defic Syndr. 2006;43: 509-515.
    • (2006) J Acquir Immune Defic Syndr. , vol.43 , pp. 509-515
    • Markowitz, M.1    Morales-Ramirez, J.O.2    Nguyen, B.Y.3
  • 28
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naïve patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Rapid and durable antiretroviral effect of HIV-1 integrase inhibitor raltegravir as part of combination therapy in treatment-naïve patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr. 2007;46: 125-133.
    • (2007) J Acquir Immune Defic Syndr. , vol.46 , pp. 125-133
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 29
    • 70350558421 scopus 로고    scopus 로고
    • Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatmentnaïve patients with HIV-1 infection
    • Markowitz M, Nguyen BY, Gotuzzo E, et al. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatmentnaïve patients with HIV-1 infection. J Acquir Immune Defic Syndr. 2009;52: 350-356.
    • (2009) J Acquir Immune Defic Syndr. , vol.52 , pp. 350-356
    • Markowitz, M.1    Nguyen, B.Y.2    Gotuzzo, E.3
  • 30
    • 69449101785 scopus 로고    scopus 로고
    • Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment naïve patients with HIV-1 infection: A multicentre, double-blind randomized controlled trial
    • Lennox JL, Dejesus E, Lazzarin A, et al. Safety and efficacy of raltegravir-based versus efavirenz-based combination therapy in treatment naïve patients with HIV-1 infection: a multicentre, double-blind randomized controlled trial. Lancet. 2009;374: 796-806.
    • (2009) Lancet. , vol.374 , pp. 796-806
    • Lennox, J.L.1    Dejesus, E.2    Lazzarin, A.3
  • 31
    • 77956646683 scopus 로고    scopus 로고
    • Raltegravir versus efafirenz regimens in treatment-naïve HIV-1 infected patients: 96-week efficacy, durability, subgroup, safety and metabolic analysis
    • Lennox JL, DeJesus E, Berger DS, et al. Raltegravir versus efafirenz regimens in treatment-naïve HIV-1 infected patients: 96-week efficacy, durability, subgroup, safety and metabolic analysis. J Acquir Immune Defic Syndr. 2010;55: 39-47.
    • (2010) J Acquir Immune Defic Syndr. , vol.55 , pp. 39-47
    • Lennox, J.L.1    DeJesus, E.2    Berger, D.S.3
  • 32
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment- experienced patients with multdrug-resistant virus: A phase II randomized controlled trial
    • Grinstejn B, Nguyen BY, Katlama C, et al. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment- experienced patients with multdrug-resistant virus: a phase II randomized controlled trial. Lancet. 2007;369: 1261-1269.
    • (2007) Lancet. , vol.369 , pp. 1261-1269
    • Grinstejn, B.1    Nguyen, B.Y.2    Katlama, C.3
  • 33
    • 77949381837 scopus 로고    scopus 로고
    • Long term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a phase II study
    • Gatell JM, Katlama C, Grinzstejn B, et al. Long term efficacy and safety of the HIV integrase inhibitor raltegravir in patients with limited treatment options in a phase II study. J Acquir Immune Defic Syndr. 2010;53: 456-463.
    • (2010) J Acquir Immune Defic Syndr. , vol.53 , pp. 456-463
    • Gatell, J.M.1    Katlama, C.2    Grinzstejn, B.3
  • 34
    • 47949120697 scopus 로고    scopus 로고
    • Raltegravir with optimized background therapy for resistant HIV-1 infection
    • Steigbigel R, Cooper D, Kumar P, et al. Raltegravir with optimized background therapy for resistant HIV-1 infection. N Engl J Med. 2008;359: 339-354.
    • (2008) N Engl J Med. , vol.359 , pp. 339-354
    • Steigbigel, R.1    Cooper, D.2    Kumar, P.3
  • 35
    • 75749107023 scopus 로고    scopus 로고
    • Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: Week 96 results of the BENCHMRK 1 and 2 Phase III trials
    • Steigbigel R, Cooper DA, Teppler H, et al. Long-term efficacy and safety of raltegravir combined with optimized background therapy in treatment-experienced patients with drug-resistant HIV infection: week 96 results of the BENCHMRK 1 and 2 Phase III trials. Clin Infect Dis. 2010;50: 605-612.
    • (2010) Clin Infect Dis. , vol.50 , pp. 605-612
    • Steigbigel, R.1    Cooper, D.A.2    Teppler, H.3
  • 36
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper DA, Steigbigel R, Gatell JM, et al. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N Engl J Med. 2008;359: 355-365.
    • (2008) N Engl J Med. , vol.359 , pp. 355-365
    • Cooper, D.A.1    Steigbigel, R.2    Gatell, J.M.3
  • 37
    • 49849103584 scopus 로고    scopus 로고
    • Severe rhabdomyolysis associated with raltegravir use
    • Zembower TR, Gerzenshtein L, Coleman K, et al. Severe rhabdomyolysis associated with raltegravir use. AIDS. 2008;22: 1382-1383.
    • (2008) AIDS. , vol.22 , pp. 1382-1383
    • Zembower, T.R.1    Gerzenshtein, L.2    Coleman, K.3
  • 38
    • 75649112262 scopus 로고    scopus 로고
    • A case of rhabdomyolysis associated with raltegravir use
    • Dori L, Buonomoni AR, Viscione M, et al. A case of rhabdomyolysis associated with raltegravir use. AIDS. 2010;24: 473-474.
    • (2010) AIDS. , vol.24 , pp. 473-474
    • Dori, L.1    Buonomoni, A.R.2    Viscione, M.3
  • 39
    • 78650825831 scopus 로고    scopus 로고
    • Severe raltegravir-associated rhabdomyolysis: A case report and review of the literature
    • Croce F, Vitello P, Pria D, et al. Severe raltegravir-associated rhabdomyolysis: a case report and review of the literature. Intl J STD AIDS. 2010;21: 783-785.
    • (2010) Intl J STD AIDS. , vol.21 , pp. 783-785
    • Croce, F.1    Vitello, P.2    Pria, D.3
  • 40
    • 77955049938 scopus 로고    scopus 로고
    • Severe acute renal failure associated with rhabdomyolysis during treatment with raltegravir: A call for caution
    • Masia M. Severe acute renal failure associated with rhabdomyolysis during treatment with raltegravir: a call for caution. J Infect. 2010;61: 189-196.
    • (2010) J Infect. , vol.61 , pp. 189-196
    • Masia, M.1
  • 41
    • 0031949592 scopus 로고    scopus 로고
    • Effects of mutations in residues near the active site of human immunodeficiency virus type I integrase on specific enzyme-substrate interactions
    • Gerton J, Ohgi S, Olsen M, et al. Effects of mutations in residues near the active site of human immunodeficiency virus type I integrase on specific enzyme-substrate interactions. J Virol. 1998;72: 5046-5055.
    • (1998) J Virol. , vol.72 , pp. 5046-5055
    • Gerton, J.1    Ohgi, S.2    Olsen, M.3
  • 42
    • 78951476418 scopus 로고    scopus 로고
    • Resistance to inhibitors of the human immunodeficiency virus type 1 integration
    • Hazuda DJ. Resistance to inhibitors of the human immunodeficiency virus type 1 integration. Brazil J Infect Dis. 2010;14: 513-518.
    • (2010) Brazil J Infect Dis. , vol.14 , pp. 513-518
    • Hazuda, D.J.1
  • 43
    • 10744226580 scopus 로고    scopus 로고
    • Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations
    • Fikkert V, Van Maele B, Vercammen J, et al. Development of resistance against diketo derivatives of human immunodeficiency virus type 1 by progressive accumulation of integrase mutations. J Virol. 2003;77: 11459-11470.
    • (2003) J Virol. , vol.77 , pp. 11459-11470
    • Fikkert, V.1    Van Maele, B.2    Vercammen, J.3
  • 44
    • 7744240084 scopus 로고    scopus 로고
    • Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360
    • Fikkert V, Hombrouck A, Van Remoortel B, et al. Multiple mutations in human immunodeficiency virus-1 integrase confer resistance to the clinical trial drug S-1360. AIDS. 2004;18: 2019-2028.
    • (2004) AIDS. , vol.18 , pp. 2019-2028
    • Fikkert, V.1    Hombrouck, A.2    Van Remoortel, B.3
  • 45
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
    • Fransen S, Gupta S, Danovich R. Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways. J Virol. 2009;83: 11440-114446.
    • (2009) J Virol. , vol.83 , pp. 11440-114446
    • Fransen, S.1    Gupta, S.2    Danovich, R.3
  • 46
    • 77956412031 scopus 로고    scopus 로고
    • The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to raltegravir and impact the enzyme functions
    • Reigadas S, Anies G, Maquelier B, et al. The HIV-1 integrase mutations Y143C/R are an alternative pathway for resistance to raltegravir and impact the enzyme functions. PloS One. 2010;5: e10311.
    • (2010) PloS One , vol.5
    • Reigadas, S.1    Anies, G.2    Maquelier, B.3
  • 47
    • 73849095055 scopus 로고    scopus 로고
    • Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo
    • Delelis O, Thierry S, Subra F, et al. Impact of Y143 HIV-1 integrase mutations on resistance to raltegravir in vitro and in vivo. Antimicrob Agents Chemother. 2010;54: 491-501.
    • (2010) Antimicrob Agents Chemother. , vol.54 , pp. 491-501
    • Delelis, O.1    Thierry, S.2    Subra, F.3
  • 48
    • 62549166235 scopus 로고    scopus 로고
    • Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1 infected patients
    • Malet I, Delelis O, Soulie C, et al. Quasispecies variant dynamics during emergence of resistance to raltegravir in HIV-1 infected patients. J Antimicrob Chemother. 2009;63: 795-804.
    • (2009) J Antimicrob Chemother. , vol.63 , pp. 795-804
    • Malet, I.1    Delelis, O.2    Soulie, C.3
  • 49
    • 70349272200 scopus 로고    scopus 로고
    • Selective advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes
    • Quercia R, Dam E, Perez-Bercoff D, et al. Selective advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes. J Virol. 2009;83: 10245-10249.
    • (2009) J Virol. , vol.83 , pp. 10245-10249
    • Quercia, R.1    Dam, E.2    Perez-Bercoff, D.3
  • 50
    • 77957310350 scopus 로고    scopus 로고
    • Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness
    • Hu Z, Kuritzkes D. Effect of raltegravir resistance mutations in HIV-1 integrase on viral fitness. J Acquir Immune Defic Syndr. 2010;55: 148-155.
    • (2010) J Acquir Immune Defic Syndr. , vol.55 , pp. 148-155
    • Hu, Z.1    Kuritzkes, D.2
  • 51
    • 77955504896 scopus 로고    scopus 로고
    • Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy
    • Hatano H, Lampiris H, Fransen S, et al. Evolution of integrase resistance during failure of integrase inhibitor-based antiretroviral therapy. J Acquir Immune Defic Syndr. 2010;54: 389-393.
    • (2010) J Acquir Immune Defic Syndr. , vol.54 , pp. 389-393
    • Hatano, H.1    Lampiris, H.2    Fransen, S.3
  • 52
    • 70349337790 scopus 로고    scopus 로고
    • Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure
    • Fransen S, Karmochkine M, Huang W, et al. Longitudinal analysis of raltegravir susceptibility and integrase replication capacity of human immunodeficiency virus type 1 during virologic failure. Antimicrob Agents Chemother. 2009;53: 4522-4524.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 4522-4524
    • Fransen, S.1    Karmochkine, M.2    Huang, W.3
  • 53
    • 77950264042 scopus 로고    scopus 로고
    • Integrase variability and susceptibility to HIV integrase inhibitors: Impact of subtypes, antiretroviral experience and duration of HIV infection
    • Garrido C, Geretti A, Zahonero N, et al. Integrase variability and susceptibility to HIV integrase inhibitors: impact of subtypes, antiretroviral experience and duration of HIV infection. J Antimicrob Chemother. 2010;65: 320-326.
    • (2010) J Antimicrob Chemother. , vol.65 , pp. 320-326
    • Garrido, C.1    Geretti, A.2    Zahonero, N.3
  • 54
    • 78650238190 scopus 로고    scopus 로고
    • Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure
    • Codoner F, Pou C, Thielen A, et al. Dynamic escape of pre-existing raltegravir-resistant HIV-1 from raltegravir selection pressure. Antiviral Res. 2010;88: 281-286.
    • (2010) Antiviral Res. , vol.88 , pp. 281-286
    • Codoner, F.1    Pou, C.2    Thielen, A.3
  • 55
    • 70349320511 scopus 로고    scopus 로고
    • Natural polymorphisms of human immunodeficiency virus type I integrase and inherent susceptibilities to a panel of integrase inhibitors
    • Low A, Prada N. Topper M, et al. Natural polymorphisms of human immunodeficiency virus type I integrase and inherent susceptibilities to a panel of integrase inhibitors. Antimicrob Agents Chemother. 2009;53: 4275-4282.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 4275-4282
    • Low, A.1    Prada, N.2    Topper, M.3
  • 56
    • 77957875432 scopus 로고    scopus 로고
    • Specific HIV-1 integrase polymorphism change their prevalence in untreated versus antiretroviral-treated HIV-1 infected patients, all naïve to integrase inhibitors
    • Sliberstein-Ceccherini F, Malet I, Fabeni L, et al. Specific HIV-1 integrase polymorphism change their prevalence in untreated versus antiretroviral-treated HIV-1 infected patients, all naïve to integrase inhibitors. J Antimicrob Chemother. 2010;65: 2305-2318.
    • (2010) J Antimicrob Chemother. , vol.65 , pp. 2305-2318
    • Sliberstein-Ceccherini, F.1    Malet, I.2    Fabeni, L.3
  • 57
    • 55249105017 scopus 로고    scopus 로고
    • Resistance mutations in human immunodeficiency virus type 1 selected with elvitegavir confer reduced susceptibility to a wide range of integrase inhibitors
    • Goethals O, Clayton R, Van Ginderen M, et al. Resistance mutations in human immunodeficiency virus type 1 selected with elvitegavir confer reduced susceptibility to a wide range of integrase inhibitors. J Virol. 2008;82: 10366-10374.
    • (2008) J Virol. , vol.82 , pp. 10366-10374
    • Goethals, O.1    Clayton, R.2    Van Ginderen, M.3
  • 58
    • 75149175071 scopus 로고    scopus 로고
    • Switch to a raltegravir-based regimen versus continuation of a lopinavir/ritonavir-based regimen in stable HIV-infected patients with suppressed viremia (SWITCHMRK 1 and 2): Two multicentre, double-blind, randomized controlled trials
    • Eron JJ, Young B, Cooper DA, et al. Switch to a raltegravir-based regimen versus continuation of a lopinavir/ritonavir-based regimen in stable HIV-infected patients with suppressed viremia (SWITCHMRK 1 and 2): two multicentre, double-blind, randomized controlled trials. Lancet. 2010;375: 396-407.
    • (2010) Lancet. , vol.375 , pp. 396-407
    • Eron, J.J.1    Young, B.2    Cooper, D.A.3
  • 59
    • 77954348583 scopus 로고    scopus 로고
    • Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: The SPIRAL study group
    • Martinez E, Larrousse M, Llibre JM, et al. Substitution of raltegravir for ritonavir-boosted protease inhibitors in HIV-infected patients: the SPIRAL study group. AIDS. 2010;24: 1697-1707.
    • (2010) AIDS. , vol.24 , pp. 1697-1707
    • Martinez, E.1    Larrousse, M.2    Llibre, J.M.3
  • 60
    • 68049148420 scopus 로고    scopus 로고
    • Virologic outcomes of changing enfurvitide to raltgravir in HIV-1 patients well controlled on an enfurvitide based regimen: 24 week results of the CHEER study
    • Towner W, Klein D, Kerrigan HL, et al. Virologic outcomes of changing enfurvitide to raltgravir in HIV-1 patients well controlled on an enfurvitide based regimen: 24 week results of the CHEER study. J Acquir Immune Defic Syndr. 2009;51: 367-373.
    • (2009) J Acquir Immune Defic Syndr. , vol.51 , pp. 367-373
    • Towner, W.1    Klein, D.2    Kerrigan, H.L.3
  • 61
    • 78149492207 scopus 로고    scopus 로고
    • Integrase inhibitors in the treatment of HIV-1 infection
    • Powderly WG. Integrase inhibitors in the treatment of HIV-1 infection. J Antimicrob Chemother. 2010;65: 2485-2488.
    • (2010) J Antimicrob Chemother. , vol.65 , pp. 2485-2488
    • Powderly, W.G.1
  • 65
    • 79953043112 scopus 로고    scopus 로고
    • Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model
    • Neff CP, Ndolo T, Tandon A, et al. Oral pre-exposure prophylaxis by anti-retrovirals raltegravir and maraviroc protects against HIV-1 vaginal transmission in a humanized mouse model. PLoS One. 2010;5: e15257.
    • (2010) PLoS One , vol.5
    • Neff, C.P.1    Ndolo, T.2    Tandon, A.3
  • 66
    • 77956856393 scopus 로고    scopus 로고
    • The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: A randomized controlled trial
    • Gandhi R, Zheng Lu, Bosch R, et al. The effect of raltegravir intensification on low-level residual viremia in HIV-infected patients on antiretroviral therapy: a randomized controlled trial. PloS One. 2010;7: e1000321.
    • (2010) PloS One , vol.7
    • Gandhi, R.1    Lu, Z.2    Bosch, R.3
  • 67
    • 77749277080 scopus 로고    scopus 로고
    • Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy
    • McMahon D, Jones J, Wiegand A, et al. Short-course raltegravir intensification does not reduce persistent low-level viremia in patients with HIV-1 suppression during receipt of combination antiretroviral therapy. Clin Infect Dis. 2010;50: 912-919.
    • (2010) Clin Infect Dis. , vol.50 , pp. 912-919
    • McMahon, D.1    Jones, J.2    Wiegand, A.3
  • 68
    • 77950537810 scopus 로고    scopus 로고
    • HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAARTsuppressed subjects
    • Buzon MJ, Massanella M, Llibre J, et al. HIV-1 replication and immune dynamics are affected by raltegravir intensification of HAARTsuppressed subjects. Nat Med. 2010;16: 460-466.
    • (2010) Nat Med. , vol.16 , pp. 460-466
    • Buzon, M.J.1    Massanella, M.2    Llibre, J.3
  • 69
    • 77953308545 scopus 로고    scopus 로고
    • Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome
    • Singh IR, Gorzynski JE, Drobysheva D, et al. Raltegravir is a potent inhibitor of XMRV, a virus implicated in prostate cancer and chronic fatigue syndrome. PloS One. 2010;5: e9948.
    • (2010) PloS One , vol.5
    • Singh, I.R.1    Gorzynski, J.E.2    Drobysheva, D.3
  • 72
    • 77749267991 scopus 로고    scopus 로고
    • Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV type 1: Results of a phase 2, randomized, controlled, dose-ranging clinical trial
    • Zolopa AR, Berger DS, Lampiris H, et al. Activity of elvitegravir, a once-daily integrase inhibitor, against resistant HIV type 1: results of a phase 2, randomized, controlled, dose-ranging clinical trial. J Infect Dis. 2010;201: 814-822.
    • (2010) J Infect Dis. , vol.201 , pp. 814-822
    • Zolopa, A.R.1    Berger, D.S.2    Lampiris, H.3
  • 75
    • 78751697293 scopus 로고    scopus 로고
    • In vitro antiretroviral properties of S/GSK1349572 a next generation HIV integrase inhibitor
    • Kobayashi M, Yoshinaga T, Seki T, et al. In vitro antiretroviral properties of S/GSK1349572 a next generation HIV integrase inhibitor. Antimicrob Agents Chemother. 2011;55: 813-821.
    • (2011) Antimicrob Agents Chemother. , vol.55 , pp. 813-821
    • Kobayashi, M.1    Yoshinaga, T.2    Seki, T.3
  • 76
    • 67649573353 scopus 로고    scopus 로고
    • Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Available at, Accessed December 28
    • DHHS Panel-Office of AIDS Research Advisory Council. US Department of Health and Human Services 2009. Guidelines for the use of antiretroviral agents in HIV-1 infected adults and adolescents. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdoslescentGL. pdf. Accessed December 28, 2010.
    • (2010) US Department of Health and Human Services 2009
  • 77
    • 79951558288 scopus 로고    scopus 로고
    • Long-term successful control of super-multidrug-resistant human immunodeficiency virus type 1 infection by a novel combination therapy of raltegravir, etravirine and boosted darunavir
    • Nakamura H, Miyazaki N, Hosoya N, et al. Long-term successful control of super-multidrug-resistant human immunodeficiency virus type 1 infection by a novel combination therapy of raltegravir, etravirine and boosted darunavir. J Infect Chemother. 2011;17: 105-110.
    • (2011) J Infect Chemother. , vol.17 , pp. 105-110
    • Nakamura, H.1    Miyazaki, N.2    Hosoya, N.3
  • 78
    • 66949126977 scopus 로고    scopus 로고
    • Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir
    • Hanley WD, Wenning LA, Moreau, et al. Effect of tipranavir-ritonavir on pharmacokinetics of raltegravir. Antimicrob Agents Chemother. 2009;53: 2752-2755.
    • (2009) Antimicrob Agents Chemother. , vol.53 , pp. 2752-2755
    • Hanley, W.D.1    Wenning, L.A.2    Moreau3
  • 80
    • 57049148690 scopus 로고    scopus 로고
    • Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleotide reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects
    • Anderson MS, Kakuda TN, Hanley W, et al. Minimal pharmacokinetic interaction between the human immunodeficiency virus nonnucleotide reverse transcriptase inhibitor etravirine and the integrase inhibitor raltegravir in healthy subjects. Antimicrob Agents Chemother. 2008;52: 4228-4232.
    • (2008) Antimicrob Agents Chemother. , vol.52 , pp. 4228-4232
    • Anderson, M.S.1    Kakuda, T.N.2    Hanley, W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.