Effects of ACTH, dexamethasone, and adrenalectomy on 11β-hydroxylase (CYP11B1) and aldosterone synthase (CYP11B2) gene expression in the rat central nervous system

Journal of Endocrinology

Volumn 196, Issue 2, 2008, Pages 305-311

  Ye, Ping ^a   Kenyon, Christopher J ^b   MacKenzie, Scott M ^a   Nichol, Katherine ^b   Seckl, Jonathan R ^b   Fraser, Robert ^a   Connell, John M C ^a   Davies, Eleanor ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE SYNTHASE; CORTICOTROPIN; DEXAMETHASONE; MESSENGER RNA; STEROID 11BETA MONOOXYGENASE;

ADRENAL GLAND; ADRENALECTOMY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; HORMONAL REGULATION; HYPOTHALAMUS; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION;

ADRENAL GLANDS; ADRENALECTOMY; ADRENOCORTICOTROPIC HORMONE; ALDOSTERONE SYNTHASE; ANIMALS; BRAIN; DEXAMETHASONE; GENE EXPRESSION; GLUCOCORTICOIDS; INFUSION PUMPS; MALE; RATS; RATS, INBRED WKY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROID 11-BETA-HYDROXYLASE;

EID: 39749156335     PISSN: 00220795     EISSN: 14796805     Source Type: Journal    
DOI: 10.1677/JOE-07-0439     Document Type: Article

References (24)

1. Abayasekara DR, Onyezili NI, Whitehouse BJ, Laird SM & Vinson GP 1993 Effects of chronic corticotrophin treatment on aldosterone metabolism in the rat. Journal of Endocrinology 137 445-455.
2. Adan RAH & Gispen WH 1997 Brain melanocortin receptors: from cloning to function. Peptides 18 1279-1287.
3. Banks WA, Kastin AJ, Olson GA & Olson RD 1993 Permeability of the blood-brain barrier and blood testis barrier to LH, FSH, and albumin in younger and older mice. Neuroendocrinology Letters 15 177-182.
4. Chikhale EG, Ng K, Burton PS & Borchardt RT 1994 Hydrogen bonding potential as a determinant of the in vitro and in situ blood-brain barrier permeability of peptides. Pharmacological Research 11 412-419.
5. Davies E & MacKenzie SM 2003 Extra-adrenal production of corticosteroids. Clinical and Experimental Pharmacology and Physiology 30 437-445.
6. Furukawa A, Miyatake A, Ohnishi T & Ichikawa Y 1998 Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: colocalization of StAR, cytochrome P-450SCC (CYP XIA1), and 3β-hydroxysteroid dehydrogenase in the rat brain. Journal of Neurochemistry 71 2231-2238.
7. Ganong W 2000 Circumventricular organs: definition and role in the regulation of endocrine and autonomic function. Clinical and Experimental Pharmacology and Physiology 27 422-427.
8. Gomez-Sanchez EP 1986 Intracerebroventricular infusion of aldosterone induces hypertension in rats. Endocrinology 118 819-823.
9. Gomez-Sanchez CE, Zhou MY, Cozza EN, Morita H, Eddleman FC & Gomez-Sanchez EP 1996 Corticosteroid synthesis in the central nervous system. Endocrine Research 22 463-470.
10. Gomez-Sanchez CE, Zhou MY, Cozza EN, Morita H, Foecking MF & Gomez-Sanchez EP 1997 Aldosterone biosynthesis in the rat brain. Endocrinology 138 3369-3373.
11. Gomez-Sanchez EP, Ahmad N, Romero DG & Gomez-Sanchez CE 2005 Is aldosterone synthesized within the rat brain? American Journal of Physiology. Endocrinology and Metabolism 288 E342-E346.
12. Holland OB & Carr B 1993 Modulation of aldosterone synthase messenger ribonucleic acid levels by dietary sodium and potassium and by adrenocorticotropin. Endocrinology 132 2666-2673.
13. Karssen AM, Meijer OC, van der Sant ICJ, Lucassen PJ, de Lange ECM, e Boer AG & e Kloet ER 2001 Multidrug resistance P-glycoprotein hampers the access of cortisol but not of corticosterone to mouse and human brain. Endocrinology 142 2686-2694.
14. Kastin AJ, Zadina JE, Banks WA & Graf MV 1984 Misleading concepts in the field of brain peptides. Peptides 5 (Suppl 1) 249-253.
15. MacKenzie SM, Clark CJ, Fraser R, Gomez-Sanchez CE, Connell JM & Davies E 2000a Expression of 11β-hydroxylase and aldosterone synthase genes in the rat brain. Journal of Molecular Endocrinology 24 321-328.
16. MacKenzie SM, Clark CJ, Ingram MC, Lai M, Seckl J, Gomez-Sanchez CE, Fraser R, Connell JM & Davies E 2000b Corticosteroid production by fetal rat hippocampal neurons. Endocrine Research 26 531-535.
17. MacKenzie SM, Lai M, Clark CJ, Fraser R, Gómez-S-acanchez CE, Seckl JR, Connell JMC & Davies E 2002 11β-Hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons. Journal of Molecular Endocrinology 29 319-325.
18. Mazzocchi G, Malendowicz LK, Rebuffat P, Robba C, Gottardo G & Nussdorfer GG 1986 Short- and long-term effects of ACTH on the adrenal zona glomerulosa of the rat. A coupled stereological and enzymological study. Cell and Tissue Research 243 303-310.
19. Mitani F, Miyamoto H, Mukai K & Ishimura Y 1996 Effects of long term stimulation of ACTH and angiotensin II-secretions on the rat adrenal cortex. Endocrine Research 22 421-431.
20. Mueller M, Atanasov A, Cima I, Corazza N, Schoonjans K & Brunner T 2007 Differential regulation of glucocorticoid synthesis in routine intestinal epithelial versus adrenocortical cell lines. Endocrinology 148 1445-1453.
21. Pihl L & Hau J 2003 Faecal corticosterone and immunoglobulin A in young adult rats. Laboratory Animals 37 166-171.
22. Robson AC, Leckie CM, Seckl JR & Holmes MC 1998 11β-Hydroxysteroid, dehydrogenase type 2 in the postnatal and adult rat brain. Molecular Brain Research 61 1-10.
23. Ye P, Kenyon CJ, MacKenzie SM, Seckl JR, Fraser R, Connell JMC & Davies E 2003 Regulation of aldosterone synthase gene expression in the rat adrenal gland and central nervous system by sodium and angiotensin II. Endocrinology 144 3321-3328.
24. Ye P, Kenyon C, MacKenzie SM, Jong AS, Miller C, Gray GA, Wallace AM, Ryding ADS, Mullins JJ, McBride MW et al. 2005 The aldosterone synthase (CYP11B2) and 11β-hydroxylase (CYP11B1) genes are not expressed in the rat heart. Endocrinology 146 5287-5293.