Comparison of the antidiabetic activity of Berberis lyceum root extract and berberine in alloxan-induced diabetic Rats

Phytotherapy Research

Volumn 22, Issue 9, 2008, Pages 1208-1212

  Gulfraz, M ^a   Mehmood, S ^a   Ahmad, A ^a   Fatima, N ^a   Praveen, Z ^a   Williamson, E M ^b  

^a PMAS ARID AGRICULTURE UNIVERSITY   (Pakistan)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Berberine; Berberis root extract; Diabetes; Hyperglycaemia

Indexed keywords

BERBERINE; BERBERIS LYCEUM ROOT EXTRACT; GLIBENCLAMIDE; GLUCOSE; LIPID; PLANT EXTRACT; UNCLASSIFIED DRUG;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BERBERIS; BERBERIS LYCEUM; BODY WEIGHT; COMPARATIVE STUDY; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; LIPID BLOOD LEVEL; MALE; NONHUMAN; RAT;

ALLOXAN; ANIMALS; BERBERIS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HYPOGLYCEMIC AGENTS; LIPIDS; MALE; PLANT EXTRACTS; PLANT ROOTS; RATS; RATS, WISTAR;

ANIMALIA; BERBERIS; RATTUS;

EID: 52649114318     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2438     Document Type: Article

References (22)

1. Asif A, Kakub G, Mehmood S, Khunum R, Gulfraz M. 2007. Wound healing activity of root extracts of Berberis lyceum Royle in rats. Phytother Res 21; 589-591.
2. Bailei CJ, Ahamd H. 1981. Determination of plasma insulin. Diabetologia 19: 475-478.
3. Bierman EL, Ameral JAP, Blaknap BH. 1975. Hyperlipidemia and diabetes mellitus. Diabetes 25: 509-515.
4. Cheng Z, Pang T, Gu M et al. 2006. Berberine-stimulated glucose uptake in L6 myotubes involves both AMP and p38 MAPK. Biochim Biophys Acta 11: 1682-1689.
5. Guo YP, Zin JH, Guang JW. 2003. The anti-hyperglycaemic activity of berberine arises from a decrease of glucose adsorption. Planta Med 69: 632-636.
6. Guyatt GH, Osobe D, Wu AW, Wyrwich KW, Noman GR. 2002. Methods to explain the clinical significance of health status measures. Mayo Clin Proc 77: 371-383.
7. Hirsch A, Bartholomas C, Volmer T. 2000. Dimensions of quality of life in people with non insulin dependent diabetes. Qual Life Res 9: 207-218.
8. Huang C, Zhang Y, Gorg Z et al. 2006. Berberine inhibits 3 T3-L 1 adipocyte differentiation through the PPAR gamma pathway. Biochem Biophys Commun 22: 571-578.
9. Ki-Yeon Y, In Koo H, Beong OL et al. 2006. Berberry extract reduces neuronal damage and N-methyl-D-aspartate receptor 1 immunoreactivity in the gerbil hippocampus after transient forebrain ischemia. Biol Pharm Bull 29: 623-628.
10. Ko B-S, Choi SB, Park SK, Jang JS, Kim YE, Park S. 2005. Insulin sensitizing and insulinotropic action of berberine from Cortidis Rhizoma. Biol Pharm Bull 28: 1431-1437.
11. Kulkarni SK, Dhir A. 2007. Possible involvement of L- argininenitric oxide (NO)-cyclic guanosine monophosphate (cGMP) signaling pathway in the antidepressant activity of berberine chloride. Eur J Pharmacol 569: 77-83.
12. Kunst A, Draeger B, Ziegenhorn J. 1984. Methods of Enzymatic Analysis. Verlag Chemie: Weinheim, Germany, 6: 178-185.
13. Lee YS, Kim WS, Kim KH et al. 2006. Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55: 2256-2264.
14. Leng SH, Lu F, Xu LJ. 2004. Therapeutic effect of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 25: 496-502.
15. Lloyd CE, Orchard TJ. 1999. Physical and psychological well being in adults with Type 1 diabetes. Diabet Res Clin Pract 44: 9-19.
16. Ozturk Y, Altan VM, Yildizoglu A. 1996. Effect of experimental diabetes and insulin on smooth muscle functions. Pharmacol Rev 48: 69-112.
17. Pan GY, Huang ZJ, Wang GJ et al. 2003.The antihyperglycaemic activity of berberine arises from a decrease of glucose absorption. Planta Med 69: 632-636.
18. Scholin A, Berne C, Sehvarez E, Karlsoon FA, Bjork E. 1999. Factors predicting clinical remission in adult patients with type 1 diabetes. J Intern Med 245: 155-162.
19. Sudhakar SN, Pattabiraman TN. 1981. Analysis of glycosylated haemoglobin in diabetic rats. Clin Chim Acta 109: 267-270.
20. Tang LQ, Wei W, Chen LM, Liu S. 2006. Effect of berberine on diabetes induced by alloxan and a high-fat/high-cholesterol diet in rats. J Ethnopharmacol 108: 109-115.
21. WHO. 1980. Expert Committee on Diabetes Mellitus Second Report. Technical Report series 646. World Health Organization: Geneva.
22. Zhou L, Yang Y, Wang X et al. 2007. Berberine stimulates glucose transport through a mechanism distinct from insulin. Metabolism 56: 405-412.