Morphine induces splenocyte trafficking into the CNS

Journal of Neuroimmune Pharmacology

Volumn 7, Issue 2, 2012, Pages 436-443

  Olin, Michael ^a   Oh, Seunguk ^b   Roy, Sabita ^b   Peterson, Phillip ^a   Molitor, Thomas ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

In vivo imaging; Lymphocyte trafficking; Opiates

Indexed keywords

DNA; GAMMA INTERFERON; LUCIFERASE; MORPHINE SULFATE; NALTREXONE; PLACEBO; PLASMID DNA; MORPHINE; NARCOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BIOLUMINESCENCE; CELL ACTIVATION; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GENE TRANSFER; IN VIVO STUDY; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SPLEEN CELL; STIMULUS; TRANSGENICS; WILD TYPE; ADOPTIVE TRANSFER; ANIMAL; BRAIN; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; INFLAMMATION; LYMPHOCYTE; NEUTROPHIL CHEMOTAXIS; PLASMID; TRANSGENIC MOUSE;

ADOPTIVE TRANSFER; ANIMALS; BRAIN; CHEMOTAXIS, LEUKOCYTE; INFLAMMATION; INTERFERON-GAMMA; LYMPHOCYTES; MICE; MICE, TRANSGENIC; MORPHINE; NARCOTICS; PLASMIDS; SPLEEN;

EID: 84866520842     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9307-2     Document Type: Article

References (52)

1. Benard A, Cavailles P, Boue J, Chapey E, Bayry J, Blanpied C, Meyer N, Lamant L, Kaveri S, Brousset P, Dietrich N (2010) μ-Opioid Receptor is induced by IL-13 within lymph nodes from patients with Sézary Syndrome. J Invest Dermatol 433:1-8
2. Borner C, Kraus J, Bedini A et al (2008) T-cell receptor/CD28- mediated activation of human T lymphocytes induces expression of functional mu-opioid receptors. Mol Pharmacol 74:496-504
3. Bryant HU, Bernton EW, Kenner JR, Holaday JW (1991) Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology 128:3253-3258
4. Carriters MD, Visintin I, Viret C, Janeway CA (2002) Role of genetic back ground in P selection-dependent immune surveillance of the central nervous system. J Neuroimmunol 129:51-57 (Pubitemid 34874909)
5. Chen Y, Mestek A, Liu J, Yu L (1993) Molecular cloning of a rat opioid receptor reveals sequence similar to the μ and opioid receptors. Biochem J 295:625-632
6. Donahoe R, Falck A (1990) Neuroimmunodulation by opiates and other drugs of abuse: relationship to HIV infection and AIDS. Adv Biochem Psychopharmacol 44:145-158
7. Eisenstein TK, Hilburger ME (1998) Opioid modulation of immune responses: effects on phagocyte and lymphoid cell populations. J Neuroimmunol 83:36-44 (Pubitemid 28280949)
8. Flores LR, Wahl SM, Bayer BM (1995) Mechanisms of morphineinduced immunosuppression: effect of acute morphine administration on lymphocyte trafficking. J Pharmacol Exp Ther 3:1246-1251
9. Friedman H, Eisenstein TK (2004) Neurological basis of drug dependence and its effects on the immune system. J Neuroimmunol 147:106-108 (Pubitemid 38114957)
10. Friedman H, Newton C, Klein TW (2003) Microbial infections, immunomodulation, and drugs of abuse. Clin Microbiol Rev 16:209-219 (Pubitemid 36519808)
11. Gavériaux-Ruff C, Matthes HWD, Peluso J et al (1998) Abolition of morphine-immunosuppression in mice lacking the μ-opioid receptor gene. Proc Natl Acad Sci USA 95:6326-6330 (Pubitemid 28249011)
12. Gomez-Flores R, Weber RJ (1999) Inhibition of interleukin-2 production and down regulation of IL-2 and transferrin receptors on rat splenic lymphocytes following PAG morphine administration: a role in natural killer and T cell suppression. J Interferon Cytokine Res 6:625-630 (Pubitemid 29331315)
13. Heagy W, Laurance M, Cohen E, Finberg R (1990) Neurohormones regulate T cell function. J Exp Med 171:1625-1633 (Pubitemid 20167555)
14. Hickey WF (1999) Leukocyte traffic in the central nervous system: the participants and their roles. Semin Immunol 11:125-137 (Pubitemid 29201818)
15. Hickey WF, Kimura H (1988) Perivascular microglial cells of the CNS are bone marrow-derived and present antigen. Science 239:290-292 (Pubitemid 18061496)
16. Hickey WF, Hsu BL, Kimura H (1991) T Lymphocyte entry into the central nervous system. J Neurosci Res 28:254-260
17. Hilburger M, Adler M, Truant A, Meissler J, Satishchandran V, Rogers T, Eisenstein TK (1997) Morphine induces sepsis in mice. J Infect Dis 176:183-188 (Pubitemid 27272867)
18. Jaume M, Laffont S, Chapey E et al (2007) Opioid receptor blockade increases the number of lymphocytes without altering T cell response in draining lymph nodes in vivo. J Neuroimmunol 188:95-102 (Pubitemid 47103219)
19. Jordan CA, Watkins BA, Kufta C, Dubois-Dalcq M (1991) Infection of brain microglial cells by human immunodeficiency virus type 1 is CD4 dependent. J Virol 65:736-742
20. Kraus J, Borner C, Giannini E et al (2001) Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J Biol Chem 276:43901-43908
21. Lassmann H, Schmied M, Vass K, Hickey WF (1993) Bone marrow derived elements and resident microglia in brain inflammation. Glia 7:19-24
22. Li S, Zhu J, Chen C, Chen YW, Deriel JK, Ashby B, Liu-Chen LY (1993) Molecular cloning and expression of a rat opioid receptor. Biochem J 295:629-634
23. Mace G, Jaume M, Blanpied C et al (2002) Anti-mu-opioid-receptor IgG antibodies are commonly present in serum from healthy blood donors: evidence for a role in apoptotic immune cell death. Blood 100:3261-3268 (Pubitemid 35217076)
24. Madden JJ, Whaley WL, Ketelsen D et al (2001) The morphinebinding site on human activated T-cells is not related to the mu opioid receptor. Drug Alcohol Depend 62:131-139 (Pubitemid 32195503)
25. Nguyen K, Miller BC (2002) CD28 costimulation induces delta opioid receptor expression during anti-CD3 activation of T cells. J Immunol 168:4440-4445 (Pubitemid 34441345)
26. Niwa H, Yamamura K, Miyazaki J (1991) Efficient selection for highexpression transfectants with a novel eukaryotic vector. Gene 108:193-199
27. Ohlfest JR, Lobitz PD, Perkinson SG, Largaespada DA (2004) Integration and long-term expression in xenografted human glioblastoma cells using a plasmid-based transposon system. Mol Ther 10:260-268 (Pubitemid 39117872)
28. Ohlfest JR, Demorest ZL, Motooka Y, Vengco I, Oh S, Chen E, Scappaticci FA, Saplis RJ, Ekker SC, Low WC, Freese AB, Largaespada DA (2005) Combinatorial antiangiogenic gene therapy by nonviral gene transfer using the sleeping beauty transposon causes tumor regression and improves survival in mice bearing intracranial human glioblastoma. Mol Ther J Am Soc Gene Ther 12:778-788 (Pubitemid 41614473)
29. Olin MR, Choi K, Lee J, Molitor TW (2004) gd T-lymphocytes cytolytic activity against Mycobacterium tuberculosis analyzed by flow cytometry. J Immunol Meth 297:1-11
30. Olin MR, Choi K, Lee J, Peterson PK, Molitor TW (2007) Morphine modulates gammadelta lymphocytes cytolytic activity following BCG vaccination. Brain Behav Immun 21:195-201 (Pubitemid 46038910)
31. Philippe D, Dubuquoy L, Groux H et al (2003) Anti-inflammatory properties of the mu-opioid receptor support its use in the treatment of colon inflammation. J Clin Invest 111:1329-1338 (Pubitemid 36554703)
32. Rauch D, Gross S, Harding J, Bokhari S, Niewiesk S, Lairmore M, Plwnica-Worms D, Ratner L (2009) T-cell activation promotes tumorigenesis in inflammation-associated cancer. Retrovirology 6:116-126
33. Roy S, Ge BL, Ramakrishnan S, Lee NM, Loh HH (1991) 3H] morphine binding is enhanced by IL-1-stimulated thymocyte proliferation. FEBS Lett 287(1-2):93-96
34. Roy S, Cain KJ, Charboneau RG, Barke RA (1999) Morphine accelerates the progression of sepsis in an experimental sepsis model. Adv Exp Med Biol 437:21-31
35. Roy S, Wang JH, Sumandeep G, Charboneau RG, Loh HH, Barke RA (2004) Chronic Morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T bet. J Neuroimmunol 147:78-81 (Pubitemid 38114951)
36. Roy S, Wang J, Charboneau R, Loh HH, Barke RA (2005) Morphine induces CD4+ T cell IL-4 expression through an adenylyl cyclase mechanism independent of the protein kinase A pathway. J Immunol 175:6361-6367 (Pubitemid 41598876)
37. Shacklett BL, Cox CA, Wilkens DT, Karl Karlsson R, Nilsson A, Nixon DF, Price RW (2004) Increased adhesion molecule and chemokine receptor expression on CD8+ T cells trafficking to cerebrospinal fluid in HIV-1 infection. J Infect Dis 189:2202-2212 (Pubitemid 38757192)
38. Shavit Y, Lewis J, Terman G et al (1984) Opioid peptides mediate the suppressive effect of stress on natural killer cell cytotoxicity. Science 223:188-190 (Pubitemid 14212071)
39. Svenningsson A, Anderson O, Edsbagge M, Stemme S (1995) Lymphocyte phenotype and subset distribution in normal cerebrospinal fluid. J Neuroimmunol 63:39-46
40. Sweeney TJ, Mailander V, Tucker AA, Olomu AB, Zhang W, Cao Y, Negrin RS, Contag CH (1999) Visualizing the kinetics of tumorcell clearance in living animals. Proc Natl Acad Sci USA 96:12044-12049 (Pubitemid 29502855)
41. Szabo I, Rojavin M, Bussiere J, Eisenstein TK, Alder MW, Rogers TJ (1995) Suppression of peritoneal macrophage phagocytes of Candida albicans by opioids. J Pharmacol Expt Therap 267:703-706
42. Von Andrian UH, Mackay CR (2000) T-cell function and migration - two sides of the same coin. N Engl J Med 343:1020-1026
43. Wang JB, Johnson PS, Imai Y, Persico AM, Ozenberger BA, Eppler CM, Uhl GR (1994) cDNA cloning of an orphan opiate receptor gene family member and its splice variant. FEBS Lett 348:75-79 (Pubitemid 24223037)
44. Wang J, Charboneau R, Barke RA et al (2002a) Mu-opioid receptor mediates chronic restraint stress-induced lymphocyte apoptosis. J Immunol 169:3630-3636
45. Wang J, Charboneau R, Balasubramanian S et al (2002b) The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the muopioid receptor. J Leukoc Biol 71:782-790
46. Wekerle H, Fierz W (1985) T cell approach to demyelinating diseases. Springer Semin Immunopathol 8:97-110 (Pubitemid 15101535)
47. Wiley CA, Schrier RD, Nelson JA, Lampert PW, Oldstone MBA (1986) Cellular localization of human immunodeficiency virus infection within the brains of acquired immunodeficiency syndrome patients. Proc Natl Acad Sci USA 83:7089-7093
48. Wu DY, Woodman SE, Weiss JM, McManus CM, D'Aversa TG, Hesselgesser J, Major EO, Nath A, Berman JW (2000) Mechanisms of leukocyte trafficking into the CNS. J Neurovirol Suppl 1:S82-85 (Pubitemid 30342781)
49. Wu A, Oh S, Ericson K, Demorest ZL, Vengco I, Gharagozlou S, Chen W, Low WC, Ohlfest JR (2007) Transposon-based interferon gamma gene transfer overcomes limitations of episomal plasmid for immunogene therapy of glioblastoma. Canc Gene Ther 14:550-560 (Pubitemid 46788330)
50. Yasuda K, Raynor K, Kong H, Breder CD, Takeda J, Reisine T, Bell GI (1993) Cloning and functional comparison of and opioid receptors from mouse brain. Proc Natl Acad Sci USA 90:6736-6748
51. Yin D, Mufson A, Wang R et al (1999) Fas-mediated cell death promoted by opioids. Nature 397:218
52. Yokota T, Uehara K, Nomota Y (2000) Intrathecal morphine suppresses NK cell activity following abdominal surgery. Can J Anaesth 47:303-308