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Volumn 71, Issue 5, 2002, Pages 782-790

The immunosuppressive effects of chronic morphine treatment are partially dependent on corticosterone and mediated by the μ-opioid receptor

Author keywords

Glucocorticoids; Hypothalamic pituitary adrenal axis; Neuroimmunomodulation; Sympathetic nervous system

Indexed keywords

CHLORISONDAMINE; CORTICOSTERONE; GAMMA INTERFERON; GANGLION BLOCKING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 2; MORPHINE; MU OPIATE RECEPTOR; NITRIC OXIDE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0036587745     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (84)

References (52)
  • 1
    • 0029856583 scopus 로고    scopus 로고
    • Effects of opioids on the immune system
    • Roy, S., Loh, H. H. (1996) Effects of opioids on the immune system. Neurochem. Res. 21, 1375-1386.
    • (1996) Neurochem. Res. , vol.21 , pp. 1375-1386
    • Roy, S.1    Loh, H.H.2
  • 4
    • 0028952025 scopus 로고
    • Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages
    • Sedqi, M., Roy, S., Ramakrishnan, S., Elde, R., Loh, H. H. (1995) Complementary DNA cloning of a mu-opioid receptor from rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 209, 563-574.
    • (1995) Biochem. Biophys. Res. Commun. , vol.209 , pp. 563-574
    • Sedqi, M.1    Roy, S.2    Ramakrishnan, S.3    Elde, R.4    Loh, H.H.5
  • 5
    • 0030053922 scopus 로고    scopus 로고
    • Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes
    • Wick, M. J., Minnerath, S. R., Roy, S., Ramakrishnan, S., Loh, H. H. (1996) Differential expression of opioid receptor genes in human lymphoid cell lines and peripheral blood lymphocytes. J. Neuroimmunol. 64, 29-36.
    • (1996) J. Neuroimmunol. , vol.64 , pp. 29-36
    • Wick, M.J.1    Minnerath, S.R.2    Roy, S.3    Ramakrishnan, S.4    Loh, H.H.5
  • 7
    • 0034793410 scopus 로고    scopus 로고
    • Morphine modulates lymph node-derived T lymphocyte function: Role of caspase-3, -8, and nitric oxide
    • Wang, J., Charboneau, R., Balasubramanian, S., Barke, R., Loh, H. H., Roy, S. (2001) Morphine modulates lymph node-derived T lymphocyte function: role of caspase-3, -8, and nitric oxide. J. Leukoc. Biol. 70, 527-536.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 527-536
    • Wang, J.1    Charboneau, R.2    Balasubramanian, S.3    Barke, R.4    Loh, H.H.5    Roy, S.6
  • 8
    • 0026471362 scopus 로고
    • Effects of in vivo and in vitro administration of morphine sulfate upon rhesus macaque polymorphonuclear cell phagocytosis and chemotaxis
    • Liu, Y., Blackbourn, D. J., Chuang, L. F., Killam Jr., K. F., Chuang, R. Y. (1992) Effects of in vivo and in vitro administration of morphine sulfate upon rhesus macaque polymorphonuclear cell phagocytosis and chemotaxis. J. Pharmacol. Exp. Ther. 263, 533-539.
    • (1992) J. Pharmacol. Exp. Ther. , vol.263 , pp. 533-539
    • Liu, Y.1    Blackbourn, D.J.2    Chuang, L.F.3    Killam K.F., Jr.4    Chuang, R.Y.5
  • 11
    • 0027239461 scopus 로고
    • Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages
    • Rojavin, M., Szabo, I., Bussiere, J. L., Rogers, T. J., Adler, W. M., Eisenstein, T. K. (1993) Morphine treatment in vitro or in vivo decreases phagocytic functions of murine macrophages. Life Sci. 53, 997-1006.
    • (1993) Life Sci. , vol.53 , pp. 997-1006
    • Rojavin, M.1    Szabo, I.2    Bussiere, J.L.3    Rogers, T.J.4    Adler, W.M.5    Eisenstein, T.K.6
  • 12
    • 0025858255 scopus 로고
    • Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment
    • Bryant, H. U., Bernton, E. W., Kenner, J. R., Holaday, J.W. (1991) Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment. Endocrinology 128, 3253-3258.
    • (1991) Endocrinology , vol.128 , pp. 3253-3258
    • Bryant, H.U.1    Bernton, E.W.2    Kenner, J.R.3    Holaday, J.W.4
  • 13
    • 0025241225 scopus 로고
    • Suppressive effects of morphine pellet implants on in vivo parameters of immune function
    • Bryant, H. U., Roudebush, R. E. (1990) Suppressive effects of morphine pellet implants on in vivo parameters of immune function. J. Pharmacol. Exp. Ther. 255, 410-414.
    • (1990) J. Pharmacol. Exp. Ther. , vol.255 , pp. 410-414
    • Bryant, H.U.1    Roudebush, R.E.2
  • 15
    • 0028077797 scopus 로고
    • A mechanism of action for morphine-induced immunosuppression: Corticosterone mediates morphine-induced suppression of natural killer cell activity
    • Freier, D. O., Fuchs, B. A. (1994) A mechanism of action for morphine-induced immunosuppression: corticosterone mediates morphine-induced suppression of natural killer cell activity. J. Pharmacol. Exp. Ther. 270, 1127-1133.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 1127-1133
    • Freier, D.O.1    Fuchs, B.A.2
  • 16
    • 0023515416 scopus 로고
    • Opiate receptor mediated regulation of the immune response in vivo
    • Weber, R. J., Ikejiri, B., Rice, K. C., Pert, A., Hagan, A. A. (1987) Opiate receptor mediated regulation of the immune response in vivo. NIDA Res. Monogr. 76, 341-348.
    • (1987) NIDA Res. Monogr. , vol.76 , pp. 341-348
    • Weber, R.J.1    Ikejiri, B.2    Rice, K.C.3    Pert, A.4    Hagan, A.A.5
  • 17
    • 0030607728 scopus 로고    scopus 로고
    • Potential role of the autonomic nervous system in the immunosuppressive effects of acute morphine administration
    • Flores, L. R., Dretchen, K. L., Bayer, B. M. (1996) Potential role of the autonomic nervous system in the immunosuppressive effects of acute morphine administration. Eur. J. Pharmacol. 318, 437-446.
    • (1996) Eur. J. Pharmacol. , vol.318 , pp. 437-446
    • Flores, L.R.1    Dretchen, K.L.2    Bayer, B.M.3
  • 18
    • 0033971408 scopus 로고    scopus 로고
    • Changes in hypothalamic paraventricular nucleus catecholaminergic activity after acute and chronic morphine administration
    • Fuertes, G., Milanes, M. V., Rodriguez-Gago, M., Marin, M. T., Laorden, M. L. (2000) Changes in hypothalamic paraventricular nucleus catecholaminergic activity after acute and chronic morphine administration. Eur. J. Pharmacol. 24, 49-56.
    • (2000) Eur. J. Pharmacol. , vol.24 , pp. 49-56
    • Fuertes, G.1    Milanes, M.V.2    Rodriguez-Gago, M.3    Marin, M.T.4    Laorden, M.L.5
  • 19
    • 0027527788 scopus 로고
    • Alterations of immune status induced by the sympathetic nervous system: Immunomodulatory effects of DMPP alone and in combination with morphine
    • Fecho, K., Maslonek, K. A., Dykstra, L. A., Lysle, D. T. (1993) Alterations of immune status induced by the sympathetic nervous system: immunomodulatory effects of DMPP alone and in combination with morphine. Brain Behav. Immun. 7, 253-270.
    • (1993) Brain Behav. Immun. , vol.7 , pp. 253-270
    • Fecho, K.1    Maslonek, K.A.2    Dykstra, L.A.3    Lysle, D.T.4
  • 20
    • 0028358875 scopus 로고
    • Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo
    • Fecho, K., Maslonek, K. A., Coussons-Read, M. E., Dykstra, L. A., Lysle, D. T. (1994) Macrophage-derived nitric oxide is involved in the depressed concanavalin A responsiveness of splenic lymphocytes from rats administered morphine in vivo. J. Immunol. 152, 5845-5852.
    • (1994) J. Immunol. , vol.152 , pp. 5845-5852
    • Fecho, K.1    Maslonek, K.A.2    Coussons-Read, M.E.3    Dykstra, L.A.4    Lysle, D.T.5
  • 21
    • 0035363736 scopus 로고    scopus 로고
    • Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice
    • Roy, S., Wang, J. H., Balasubramanian, S., Sumandeep, S., Charboneau, R., Barke, R., Loh, H. H. (2001) Role of hypothalamic-pituitary axis in morphine-induced alteration in thymic cell distribution using mu-opioid receptor knockout mice. J. Neuroimmunol. 116, 147-155.
    • (2001) J. Neuroimmunol. , vol.116 , pp. 147-155
    • Roy, S.1    Wang, J.H.2    Balasubramanian, S.3    Sumandeep, S.4    Charboneau, R.5    Barke, R.6    Loh, H.H.7
  • 22
    • 0035091540 scopus 로고    scopus 로고
    • Quantitative aspects of stress-induced immunomodulation
    • Pruett, S. B. (2001) Quantitative aspects of stress-induced immunomodulation. Int. Immunopharmacol. 1, 507-520.
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 507-520
    • Pruett, S.B.1
  • 23
    • 0031929367 scopus 로고    scopus 로고
    • Endogenous glucocorticoids induced by a chemical stressor (ethanol) cause apoptosis in the spleen in B6C3F1 female mice
    • Collier, S. D., Wu, W. J., Pruett, S. B. (1998) Endogenous glucocorticoids induced by a chemical stressor (ethanol) cause apoptosis in the spleen in B6C3F1 female mice. Toxicol. Appl. Pharmacol. 148, 176-182.
    • (1998) Toxicol. Appl. Pharmacol. , vol.148 , pp. 176-182
    • Collier, S.D.1    Wu, W.J.2    Pruett, S.B.3
  • 24
    • 0020332537 scopus 로고
    • Corticosteroid-mediated immunoregulation in man
    • Cupps, T. R., Fauci, A. S. (1982) Corticosteroid-mediated immunoregulation in man. Immunol. Rev. 65, 133-155.
    • (1982) Immunol. Rev. , vol.65 , pp. 133-155
    • Cupps, T.R.1    Fauci, A.S.2
  • 25
    • 0035869598 scopus 로고    scopus 로고
    • Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response
    • Fleshner, M., Deak, T., Nguyen, K. T., Watkins, L. R., Maier, S. F. (2001) Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. J. Immunol. 166, 3813-3819.
    • (2001) J. Immunol. , vol.166 , pp. 3813-3819
    • Fleshner, M.1    Deak, T.2    Nguyen, K.T.3    Watkins, L.R.4    Maier, S.F.5
  • 26
    • 0029011165 scopus 로고
    • Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms
    • Dhabhar, F. S., Miller, A. H., McEwen, B. S., Spencer, R. L. (1995) Effects of stress on immune cell distribution. Dynamics and hormonal mechanisms. J. Immunol. 154, 5511-5527.
    • (1995) J. Immunol. , vol.154 , pp. 5511-5527
    • Dhabhar, F.S.1    Miller, A.H.2    McEwen, B.S.3    Spencer, R.L.4
  • 27
    • 0030200747 scopus 로고    scopus 로고
    • Role of glueocorticoids in ethanol-induced decreases in expression of MHC class II molecules on B cells and selective decreases in spleen cell number
    • Weiss, P. A., Collier, S. D., Pruett, S. B. (1996) Role of glueocorticoids in ethanol-induced decreases in expression of MHC class II molecules on B cells and selective decreases in spleen cell number. Toxicol. Appl. Pharmacol. 139, 153-162.
    • (1996) Toxicol. Appl. Pharmacol. , vol.139 , pp. 153-162
    • Weiss, P.A.1    Collier, S.D.2    Pruett, S.B.3
  • 28
    • 0034527778 scopus 로고    scopus 로고
    • Quantitative analysis of the neuroendocrine-immune axis: Linear modeling of the effects of exogenous corticosterone and restraint stress on lymphocyte subpopulations in the spleen and thymus in female B6C3F1 mice
    • Pruett, S. B., Fan, R., Myers, L. P., Wu, W. J., Collier, S. (2000) Quantitative analysis of the neuroendocrine-immune axis: linear modeling of the effects of exogenous corticosterone and restraint stress on lymphocyte subpopulations in the spleen and thymus in female B6C3F1 mice. Brain Behav. Immun. 14, 270-287.
    • (2000) Brain Behav. Immun. , vol.14 , pp. 270-287
    • Pruett, S.B.1    Fan, R.2    Myers, L.P.3    Wu, W.J.4    Collier, S.5
  • 29
    • 13144279307 scopus 로고    scopus 로고
    • Restraint stress causes tissue-specific changes in the immune cell distribution
    • Sudo, N., Yu, X. N., Sogawa, H., Kubo, C. (1997) Restraint stress causes tissue-specific changes in the immune cell distribution. Neuroimmunomodulation 4, 113-119.
    • (1997) Neuroimmunomodulation , vol.4 , pp. 113-119
    • Sudo, N.1    Yu, X.N.2    Sogawa, H.3    Kubo, C.4
  • 31
    • 0030267521 scopus 로고    scopus 로고
    • Immune regulation in Cushing's syndrome: Relationship to hypothalamic-pituitary-adrenal axis hormones
    • Kronfol, Z., Starkman, M., Schteingartm, D. E., Singh, V., Zhang, Q., Hill, E. (1996) Immune regulation in Cushing's syndrome: relationship to hypothalamic-pituitary-adrenal axis hormones. Psychoneuroendocrinology 21, 599-608.
    • (1996) Psychoneuroendocrinology , vol.21 , pp. 599-608
    • Kronfol, Z.1    Starkman, M.2    Schteingartm, D.E.3    Singh, V.4    Zhang, Q.5    Hill, E.6
  • 32
    • 0030802018 scopus 로고    scopus 로고
    • Glucocorticoids and immune function: Unknown dimensions and new frontiers
    • Wilckens, T., De Rijk, R. (1997) Glucocorticoids and immune function: unknown dimensions and new frontiers. Immunol. Today 18, 418-424.
    • (1997) Immunol. Today , vol.18 , pp. 418-424
    • Wilckens, T.1    De Rijk, R.2
  • 33
    • 0028686656 scopus 로고
    • Glucocorticoids and stress: Permissive and suppressive actions
    • Munck, A., Naray-Fejes-Toth, A. (1994) Glucocorticoids and stress: permissive and suppressive actions. Ann. N. Y. Acad. Sci. 746, 115-130.
    • (1994) Ann. N. Y. Acad. Sci. , vol.746 , pp. 115-130
    • Munck, A.1    Naray-Fejes-Toth, A.2
  • 34
    • 0029037126 scopus 로고
    • The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation
    • Chrousos, G. P. (1995) The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 332, 1351-1362.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 1351-1362
    • Chrousos, G.P.1
  • 35
    • 0028926159 scopus 로고
    • Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver
    • Liao, J., Keiser, J. A., Scales, W. E., Kunkel, S. L., Kluger, M. J. (1995) Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver. Am. J. Physiol. 268, R699-R706.
    • (1995) Am. J. Physiol. , vol.268
    • Liao, J.1    Keiser, J.A.2    Scales, W.E.3    Kunkel, S.L.4    Kluger, M.J.5
  • 36
    • 0028979136 scopus 로고
    • Glucocorticoids and immune function: Physiological relevance and pathogenic potential of hormonal dysfunction
    • Wilckens, T. (1995) Glucocorticoids and immune function: physiological relevance and pathogenic potential of hormonal dysfunction. Trends Pharmacol. Sci. 16, 193-197.
    • (1995) Trends Pharmacol. Sci. , vol.16 , pp. 193-197
    • Wilckens, T.1
  • 38
    • 0032582829 scopus 로고    scopus 로고
    • MU-opioid receptor-knockout mice: Role of μ-opioid receptor in morphine mediated immune functions
    • Roy, S., Barke, R. A., Loh, H. H. (1998) MU-opioid receptor-knockout mice: role of μ-opioid receptor in morphine mediated immune functions. Brain Res. Mol. Brain Res. 61, 190-194.
    • (1998) Brain Res. Mol. Brain Res. , vol.61 , pp. 190-194
    • Roy, S.1    Barke, R.A.2    Loh, H.H.3
  • 39
    • 0024510945 scopus 로고
    • Inadequate blockade by hexamethonium of the baroreceptor heart rate response in anesthetized and conscious rats
    • Abdel-Rahman, A. R. (1989) Inadequate blockade by hexamethonium of the baroreceptor heart rate response in anesthetized and conscious rats. Arch. Int. Pharmacodyn. Ther. 297, 68-85.
    • (1989) Arch. Int. Pharmacodyn. Ther. , vol.297 , pp. 68-85
    • Abdel-Rahman, A.R.1
  • 40
    • 0028215569 scopus 로고
    • The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion
    • Clarke, P. B., Chaudieu, I., el-Bizri, H., Boksa, P., Quik, M., Esplin, B. A., Capek, R. (1994) The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion. Br. J. Pharmacol. 111, 397-405.
    • (1994) Br. J. Pharmacol. , vol.111 , pp. 397-405
    • Clarke, P.B.1    Chaudieu, I.2    El-Bizri, H.3    Boksa, P.4    Quik, M.5    Esplin, B.A.6    Capek, R.7
  • 41
    • 0028046222 scopus 로고
    • Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine
    • el-Bizri, H., Clarke, P. B. (1994.) Regulation of nicotinic receptors in rat brain following quasi-irreversible nicotinic blockade by chlorisondamine and chronic treatment with nicotine. Br. J. Pharmacol. 113, 917-925.
    • (1994) Br. J. Pharmacol. , vol.113 , pp. 917-925
    • El-Bizri, H.1    Clarke, P.B.2
  • 42
    • 0035907001 scopus 로고    scopus 로고
    • Oxidized glucocorticoids counteract GC-induced apoptosis in murine thymocytes in vitro
    • Hirano, T., Horigome, H., Ishishita, H., Uda, S., Oka, K. (2001) Oxidized glucocorticoids counteract GC-induced apoptosis in murine thymocytes in vitro. Life Sci. 68, 2905-2916.
    • (2001) Life Sci. , vol.68 , pp. 2905-2916
    • Hirano, T.1    Horigome, H.2    Ishishita, H.3    Uda, S.4    Oka, K.5
  • 43
    • 0031171641 scopus 로고    scopus 로고
    • In vitro studies of spontaneous and corticosteroid-induced apoptosis of lymphocyte populations from metamorphosing frogs/RU486 inhibition
    • Barker, K. S., Davis, A. T., Li, B., Rollins-Smith, L. A. (1997) In vitro studies of spontaneous and corticosteroid-induced apoptosis of lymphocyte populations from metamorphosing frogs/RU486 inhibition. Brain Behav. Immun. 11, 119-131.
    • (1997) Brain Behav. Immun. , vol.11 , pp. 119-131
    • Barker, K.S.1    Davis, A.T.2    Li, B.3    Rollins-Smith, L.A.4
  • 44
    • 0035869598 scopus 로고    scopus 로고
    • Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response
    • Fleshner, M., Deak, T., Nguyen, K. T., Watkins, L. R., Maier, S. F. (2001) Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response. J. Immunol. 166, 3813-3819.
    • (2001) J. Immunol. , vol.166 , pp. 3813-3819
    • Fleshner, M.1    Deak, T.2    Nguyen, K.T.3    Watkins, L.R.4    Maier, S.F.5
  • 45
    • 0034330368 scopus 로고    scopus 로고
    • The effect of surgical stress on the endotoxin-induced interferon-γ response
    • Esguerra, L. E. O., Beno, D. W. A., Deriy, L., Kimura, R. E., Uhing, M. R. (2000) The effect of surgical stress on the endotoxin-induced interferon-γ response. Shock 14, 561-564.
    • (2000) Shock , vol.14 , pp. 561-564
    • Esguerra, L.E.O.1    Beno, D.W.A.2    Deriy, L.3    Kimura, R.E.4    Uhing, M.R.5
  • 46
    • 0034669996 scopus 로고    scopus 로고
    • Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats
    • Bakker, J. M., Kavelaars, A., Kamphuis, P. J., Cobelens, P. M., van Vugt, H. H., van Bel, F., Heijnen, C. J. (2000) Neonatal dexamethasone treatment increases susceptibility to experimental autoimmune disease in adult rats. J. Immunol. 165, 5932-5937.
    • (2000) J. Immunol. , vol.165 , pp. 5932-5937
    • Bakker, J.M.1    Kavelaars, A.2    Kamphuis, P.J.3    Cobelens, P.M.4    Van Vugt, H.H.5    Van Bel, F.6    Heijnen, C.J.7
  • 47
    • 0029062148 scopus 로고
    • In vitro production of type 1 and type 2 cytokines by peripheral blood mononuelear cells from high-risk HIV-negative intravenous drug users
    • Barcellini, W., Rizzardi, G. P., Velati, C., Borghi, M. O., Fain, C., Lazzarin, A., Meroni, P. L. (1995) In vitro production of type 1 and type 2 cytokines by peripheral blood mononuelear cells from high-risk HIV-negative intravenous drug users. AIDS 9, 691-694.
    • (1995) AIDS , vol.9 , pp. 691-694
    • Barcellini, W.1    Rizzardi, G.P.2    Velati, C.3    Borghi, M.O.4    Fain, C.5    Lazzarin, A.6    Meroni, P.L.7
  • 48
    • 0033008602 scopus 로고    scopus 로고
    • Comparison between a whole blood interferon-gamma release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure
    • Kimura, M., Converse, P., Astemborski, J. J., Rothel, J. S., Vlahov, D., Comstock, G. W., Graham, N. M., Chaisson, R. E., Bishai, W. R. (1999) Comparison between a whole blood interferon-gamma release assay and tuberculin skin testing for the detection of tuberculosis infection among patients at risk for tuberculosis exposure. J. Infect. Dis. 179, 1297-1300.
    • (1999) J. Infect. Dis. , vol.179 , pp. 1297-1300
    • Kimura, M.1    Converse, P.2    Astemborski, J.J.3    Rothel, J.S.4    Vlahov, D.5    Comstock, G.W.6    Graham, N.M.7    Chaisson, R.E.8    Bishai, W.R.9
  • 49
    • 0033756333 scopus 로고    scopus 로고
    • Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages
    • Peng, X., Mosser, D. M., Adler, M. W., Rogers, T. J., Meissler Jr., J. J., Eisenstein, T. K. (2000) Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages. J. Leukoc. Biol. 68, 723-728.
    • (2000) J. Leukoc. Biol. , vol.68 , pp. 723-728
    • Peng, X.1    Mosser, D.M.2    Adler, M.W.3    Rogers, T.J.4    Meissler J.J., Jr.5    Eisenstein, T.K.6
  • 50
    • 0028288178 scopus 로고
    • Acute immunosuppressive effects of morphine: Lack of involvement of pituitary and adrenal factors
    • Flores, L. R., Hernandez, M. C., Bayer, B. M. (1994) Acute immunosuppressive effects of morphine: lack of involvement of pituitary and adrenal factors. J. Pharmacol. Exp. Ther. 268, 1129-1134.
    • (1994) J. Pharmacol. Exp. Ther. , vol.268 , pp. 1129-1134
    • Flores, L.R.1    Hernandez, M.C.2    Bayer, B.M.3
  • 51
    • 0035314077 scopus 로고    scopus 로고
    • Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine
    • Mellon, R. D., Bayer, B. M. (2001) Reversal of acute effects of high dose morphine on lymphocyte activity by chlorisondamine. Drug Alcohol Depend. 62, 141-147.
    • (2001) Drug Alcohol Depend. , vol.62 , pp. 141-147
    • Mellon, R.D.1    Bayer, B.M.2
  • 52
    • 0030607728 scopus 로고    scopus 로고
    • Potential role of the autonomic nervous system in the immunosuppressive effects of acute morphine administration
    • Flores, L. R., Dretchen, K. L., Bayer, B. M. (1996) Potential role of the autonomic nervous system in the immunosuppressive effects of acute morphine administration. Eur. J. Pharmacol. 318, 437-446.
    • (1996) Eur. J. Pharmacol. , vol.318 , pp. 437-446
    • Flores, L.R.1    Dretchen, K.L.2    Bayer, B.M.3


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