Intrathecal morphine suppresses NK cell activity following abdominal surgery

Canadian Journal of Anesthesia

Volumn 47, Issue 4, 2000, Pages 303-308

  Yokota, T ^a   Uehara, K ^a   Nomoto, Y ^a  

^a KANTO ROSAI HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENALIN; CHROMIUM; HYDROCORTISONE; ISOFLURANE; MORPHINE; NITROUS OXIDE; NORADRENALIN;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; BLOOD SAMPLING; CHROMIUM 51 RELEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYSTERECTOMY; IMMUNE DEFICIENCY; NATURAL KILLER CELL; NAUSEA; NORADRENALIN BLOOD LEVEL; PAIN ASSESSMENT; POSTOPERATIVE PAIN; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT;

ADULT; ANALGESICS, OPIOID; CHROMIUM RADIOISOTOPES; EPINEPHRINE; FEMALE; HUMANS; HYDROCORTISONE; HYSTERECTOMY; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; KILLER CELLS, NATURAL; MIDDLE AGED; MORPHINE; NOREPINEPHRINE; PAIN MEASUREMENT; PAIN, POSTOPERATIVE;

EID: 0033758234     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03020942     Document Type: Article

References (21)

1. Pain relief by intrathecally applied morphine in man
2. Involvement of brain opiate receptors in the immune-suppressive effect of morphine
3. Morphine inhibits spontaneous and cytokine-enhanced natural killer cell cytotoxity in volunteers
4. Role of adrenal cortical activation in the immunosuppressive effects of chronic morphine treatment
5. Immunosuppression by morphine is mediated by central pathways
6. Morphine-induced immune alterations in vivo
7. Effects of opioids on murine antibody responses
8. Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes
9. β-endorphin augments the cytolytic activity and interferon production of natural killer cells
10. The effects of general anesthesia and surgery on basal and interferon stimulated natural killer cell activity of humans
11. Immunosupression after major surgery in normal patients
12. Effect of anaesthesia and surgery on immune status
13. Charactarization of the in vitro effects of glucocorticoids on NK cell activity
14. Sympathetic regulation of T-helper cell function
15. Effect of halothane and nitrous oxide anaesthesia on natural killer lymphocytes from patients with benign and malignant breast disease
16. Intrathecal morphine reduces the minimum alveolar concentration of halothane in humans
17. Postoperative spinal analgesia with morphine
18. Distinction between the in vitro and in vivo inhibitory effects of morphine on lymphocyte proliferation based on agonist sensitivity and naltrexone reversibility
19. Equianalgesic doses of subcutaneous but not intrathecal morphine alter phenotypic expression of cell surface markers and mitogen-induced proliferation in rat lymphocytes
20. Comparison of the time course of morphine's analgesic and immunologic effects
21. Nonrespiratory side effects of epidural morphine