Rapid drug extraction from human whole blood using a modified QuEChERS extraction method

Legal Medicine

Volumn 14, Issue 6, 2012, Pages 286-296

  Usui, Kiyotaka ^a   Hayashizaki, Yoshie ^a   Hashiyada, Masaki ^a   Funayama, Masato ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Extraction; Forensic toxicology; LC MS MS; QuEChERS; Whole blood

Indexed keywords

DIAZEPAM; DIPHENHYDRAMINE; MAGNESIUM SULFATE; PESTICIDE RESIDUE; PHENOBARBITAL;

ARTICLE; AUTOPSY; CALIBRATION; CENTRIFUGATION; DEPRESSION; DRUG ISOLATION; DRUG OVERDOSE; FEMALE; HUMAN; HUMAN TISSUE; LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

ADULT; BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, LIQUID; FEMALE; FORENSIC TOXICOLOGY; HUMANS; PHARMACEUTICAL PREPARATIONS; POISONS; TANDEM MASS SPECTROMETRY;

EID: 84866513354     PISSN: 13446223     EISSN: 18734162     Source Type: Journal    
DOI: 10.1016/j.legalmed.2012.04.008     Document Type: Article

References (18)

1. Bogusz M.J. Liquid chromatography-mass spectrometry as a routine method in forensic sciences: a proof of maturity. J Chromatogr B Biomed Sci Appl 2000, 748(1):3-19.
2. Drummer O.H. Chromatographic screening techniques in systematic toxicological analysis. J Chromatogr B Biomed Sci Appl 1999, 733(1-2):27-45.
3. Drummer O.H. Requirements for bioanalytical procedures in postmortem toxicology. Anal Bioanal Chem 2007, 388(7):1495-1503.
4. Herrin G.L., Mccurdy H.H., Wall W.H. Investigation of an LC-MS-MS (QTrap) method for the rapid screening and identification of drugs in postmortem toxicology whole blood samples. J Anal Toxicol 2005, 29(7):599-606.
5. Johnson R.D., Botch S.R. The screening of forensic blood, urine, and tissue specimens for xenobiotics using ion-trap liquid chromatography-tandem mass spectrometry. J Anal Toxicol 2011, 35(2):65-74.
6. Saint-Marcoux F., Lachatre G., Marquet P. Evaluation of an improved general unknown screening procedure using liquid chromatography-electrospray-mass spectrometry by comparison with gas chromatography and high-performance liquid-chromatography-diode array detection. J Am Soc Mass Spectrom 2003, 14(1):14-22.
7. Sanchez De La Torre C., Martinez M.A., Almarza E. Determination of several psychiatric drugs in whole blood using capillary gas-liquid chromatography with nitrogen phosphorus detection: comparison of two solid phase extraction procedures. Forensic Sci Int 2005, 155(2-3):193-204.
8. Sauvage F.L., Picard N., Saint-Marcoux F., Gaulier J.M., Lachatre G., Marquet P. General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: applications and constraints. J Sep Sci 2009, 32(18):3074-3083.
9. Sauve E.N., Langodegard M., Ekeberg D., Oiestad A.M. Determination of benzodiazepines in ante-mortem and post-mortem whole blood by solid-supported liquid-liquid extraction and UPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2012, 883-884:177-188.
10. Anastassiades M., Lehotay S.J., Stajnbaher D., Schenck F.J. Fast and easy multiresidue method employing acetonitrile extraction/partitioning and "dispersive solid-phase extraction" for the determination of pesticide residues in produce. J AOAC Int 2003, 86(2):412-431.
11. Paya P., Anastassiades M., Mack D., Sigalova I., Tasdelen B., Oliva J., et al. Analysis of pesticide residues using the Quick Easy Cheap Effective Rugged and Safe (QuEChERS) pesticide multiresidue method in combination with gas and liquid chromatography and tandem mass spectrometric detection. Anal Bioanal Chem 2007, 389(6):1697-1714.
12. Koesukwiwat U., Lehotay S.J., Leepipatpiboon N. Fast, low-pressure gas chromatography triple quadrupole tandem mass spectrometry for analysis of 150 pesticide residues in fruits and vegetables. J Chromatogr A 2011, 1218(39):7039-7050.
13. Lehotay S.J. QuEChERS sample preparation approach for mass spectrometric analysis of pesticide residues in foods. Methods Mol Biol 2011, 747:65-91.
14. Lehotay S.J., Mastovska K., Lightfield A.R. Use of buffering and other means to improve results of problematic pesticides in a fast and easy method for residue analysis of fruits and vegetables. J AOAC Int 2005, 88(2):615-629.
15. Lehotay S.J., Son K.A., Kwon H., Koesukwiwat U., Fu W., Mastovska K., et al. Comparison of QuEChERS sample preparation methods for the analysis of pesticide residues in fruits and vegetables. J Chromatogr A 2010, 1217(16):2548-2560.
16. Plössl F., Giera M., Bracher F. Multiresidue analytical method using dispersive solid-phase extraction and gas chromatography/ion trap mass spectrometry to determine pharmaceuticals in whole blood. J Chromatogr A 2006, 1135(1):19-26.
17. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Strategies for the assessment of matrix effect in quantitative bioanalytical methods based on HPLC-MS/MS. Anal Chem 2003, 75(13):3019-3030.
18. Carlson M., Thompson R.D. Analyte loss due to membrane filter adsorption as determined by high-performance liquid chromatography. J Chromatogr Sci 2000, 38(2):77-83.