General unknown screening procedure for the characterization of human drug metabolites in forensic toxicology: Applications and constraints

Journal of Separation Science

Volumn 32, Issue 18, 2009, Pages 3074-3083

  Sauvage, François Ludovic ^a   Picard, Nicolas ^a,b   Saint Marcoux, Franck ^a   Gaulier, Jean Michel ^a   Lachâtre, Gérard ^a,b   Marquet, Pierre ^a,b  

^a LIMOGES UNIVERSITY HOSPITAL   (France)

^b UNIVERSITY OF LIMOGES   (France)

Author keywords

Forensic toxicology; Metabolism; Screening; Tandem mass spectrometry

Indexed keywords

ANALYTICAL TOOL; DRUG DISCOVERY; DRUG METABOLITES; FORENSIC SAMPLES; FORENSIC TOXICOLOGY; IN-VITRO; ION SCAN; LC-MS/MS; METABOLISM SCREENING; ROUTINE ANALYSIS; STRUCTURE CONFIRMATION; TANDEM MASS SPECTROMETRY; URINE SAMPLE;

BIOCHEMISTRY; BIOMOLECULES; BODY FLUIDS; MASS SPECTROMETERS; MASS SPECTROMETRY; METABOLITES;

METABOLISM;

3 HYDROXYPRAZEPAM; ANXIOLYTIC AGENT; DIAMORPHINE; DRUG METABOLITE; ETIFOXINE; HYDROXYL GROUP; NOSCAPINE; PRAZEPAM; QUETIAPINE; QUETIAPINE SULFOXIDE; TRAZODONE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANALYTIC METHOD; ARTICLE; CONTROLLED STUDY; DEALKYLATION; DRUG HYDROXYLATION; DRUG STRUCTURE; DRUG USE; ELUTION; FORENSIC TOXICOLOGY; FRAGMENTATION REACTION; HUMAN; HUMAN EXPERIMENT; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; SCREENING TEST; TANDEM MASS SPECTROMETRY; URINALYSIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIBENZOTHIAZEPINES; DRUG DISCOVERY; FORENSIC TOXICOLOGY; HUMANS; NOSCAPINE; OXAZINES; PRAZEPAM; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TANDEM MASS SPECTROMETRY; TRAZODONE;

EID: 70450176003     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200900092     Document Type: Article

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