Response of Retinal Blood Flow to Systemic Hyperoxia as Measured with Dual-Beam Bidirectional Doppler Fourier-Domain Optical Coherence Tomography

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Werkmeister, René M ^a   Palkovits, Stefan ^b   Told, Reinhard ^a,b   Gröschl, Martin ^c   Leitgeb, Rainer A ^a   Garhöfer, Gerhard ^b   Schmetterer, Leopold ^a,b  

^a Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c VIENNA UNIVERSITY OF TECHNOLOGY   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

OXYGEN;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD VESSEL DIAMETER; COMPARATIVE STUDY; CORRELATION ANALYSIS; DUAL BEAM BIDIRECTIONAL DOPPLER FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY; ERYTHROCYTE; EYE MOVEMENT; HUMAN; HYPEROXIA; LASER DOPPLER FLOWMETRY; MATHEMATICAL ANALYSIS; NORMAL HUMAN; OPTICAL COHERENCE TOMOGRAPHY; OXYGEN BREATHING; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; VOLUNTEER;

ADULT; ALGORITHMS; BLOOD FLOW VELOCITY; FOURIER ANALYSIS; HUMANS; HYPEROXIA; OXYGEN; RETINAL VESSELS; TOMOGRAPHY, OPTICAL COHERENCE; VASOCONSTRICTION; YOUNG ADULT;

EID: 84866509505     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045876     Document Type: Article

References (65)

1. Mozaffarieh M, Flammer J, (2007) Is there more to glaucoma treatment than lowering IOP? Surv Ophthalmol 52Suppl 2: S174-179.
2. Pemp B, Schmetterer L, (2008) Ocular blood flow in diabetes and age-related macular degeneration. Can J Ophthalmol 43: 295-301.
3. Schmidl D, Garhofer G, Schmetterer L, (2011) The complex interaction between ocular perfusion pressure and ocular blood flow - relevance for glaucoma. Exp Eye Res 93: 141-155.
4. Stalmans I, Vandewalle E, Anderson DR, Costa VP, Frenkel RE, et al. (2011) Use of colour Doppler imaging in ocular blood flow research. Acta Ophthalmol 89: e609-630.
5. Sugiyama T, Araie M, Riva CE, Schmetterer L, Orgul S, (2010) Use of laser speckle flowgraphy in ocular blood flow research. Acta Ophthalmol 88: 723-729.
6. Riva CE, Geiser M, Petrig BL, (2010) Ocular blood flow assessment using continuous laser Doppler flowmetry. Acta Ophthalmol 88: 622-629.
7. Garhofer G, Bek T, Boehm AG, Gherghel D, Grunwald J, et al. (2010) Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol 88: 717-722.
8. Riva C, Ross B, Benedek GB, (1972) Laser Doppler measurements of blood flow in capillary tubes and retinal arteries. Invest Ophthalmol 11: 936-944.
9. Riva CE, Grunwald JE, Sinclair SH, O'Keefe K, (1981) Fundus camera based retinal LDV. Appl Opt 20: 117-120.
10. Riva CE, Grunwald JE, Sinclair SH, Petrig BL, (1985) Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci 26: 1124-1132.
11. Feke GT, Tagawa H, Deupree DM, Goger DG, Sebag J, et al. (1989) Blood flow in the normal human retina. Invest Ophthalmol Vis Sci 30: 58-65.
12. Garhofer G, Werkmeister R, Dragostinoff N, Schmetterer L, (2012) Retinal blood flow in healthy young subjects. Invest Ophthalmol Vis Sci 53: 698-703.
13. Yazdanfar S, Rollins AM, Izatt JA, (2003) In vivo imaging of human retinal flow dynamics by color Doppler optical coherence tomography. Arch Ophthalmol 121: 235-239.
14. Chen Z, Milner TE, Srinivas S, Wang X, Malekafzali A, et al. (1997) Noninvasive imaging of in vivo blood flow velocity using optical Doppler tomography. Opt Lett 22: 1119-1121.
15. Logean E, Schmetterer LF, Riva CE, (2000) Optical Doppler velocimetry at various retinal vessel depths by variation of the source coherence length. Appl Opt 39: 2858-2862.
16. Leitgeb R, Schmetterer L, Drexler W, Fercher A, Zawadzki R, et al. (2003) Real-time assessment of retinal blood flow with ultrafast acquisition by color Doppler Fourier domain optical coherence tomography. Opt Express 11: 3116-3121.
17. Leitgeb RA, Schmetterer L, Hitzenberger CK, Fercher AF, Berisha F, et al. (2004) Real-time measurement of in vitro flow by Fourier-domain color Doppler optical coherence tomography. Opt Lett 29: 171-173.
18. Pedersen CJ, Huang D, Shure MA, Rollins AM, (2007) Measurement of absolute flow velocity vector using dual-angle, delay-encoded Doppler optical coherence tomography. Opt Lett 32: 506-508.
19. Iftimia NV, Hammer DX, Ferguson RD, Mujat M, Vu D, et al. (2008) Dual-beam Fourier domain optical Doppler tomography of zebrafish. Opt Express 16: 13624-13636.
20. Wang Y, Lu A, Gil-Flamer J, Tan O, Izatt JA, et al. (2009) Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. Br J Ophthalmol 93: 634-637.
21. Wang Y, Fawzi AA, Varma R, Sadun AA, Zhang X, et al. (2011) Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases. Invest Ophthalmol Vis Sci 52: 840-845.
22. Singh AS, Kolbitsch C, Schmoll T, Leitgeb RA, (2010) Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans. Biomed Opt Express 1: 1047-1058.
23. Michaely R, Bachmann AH, Villiger ML, Blatter C, Lasser T, et al. (2007) Vectorial reconstruction of retinal blood flow in three dimensions measured with high resolution resonant Doppler Fourier domain optical coherence tomography. J Biomed Opt 12: 041213.
24. Werkmeister RM, Dragostinoff N, Pircher M, Gotzinger E, Hitzenberger CK, et al. (2008) Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels. Opt Lett 33: 2967-2969.
25. Kiss B, Polska E, Dorner G, Polak K, Findl O, et al. (2002) Retinal blood flow during hyperoxia in humans revisited: concerted results using different measurement techniques. Microvasc Res 64: 75-85.
26. Tuchin VV (2005) Optical Clearing of Tissue and Blood: SPIE Publications.
27. Gullstrand A (1924) The dioptrics of the eye. In: Southall J, editor. Helmholtz's Treatise on Physiological Optics: Optical Society of America 351-352.
28. Singh AS, Schmoll T, Leitgeb RA, (2011) Segmentation of Doppler optical coherence tomography signatures using a support-vector machine. Biomed Opt Express 2: 1328-1339.
29. American National Standards Institute American National Standard for Safe Use of Lasers. Orlando, Fl: The Laser Institute of America; 2000. ANSI Z136.1-22000,.
30. Makita S, Hong Y, Yamanari M, Yatagai T, Yasuno Y, (2006) Optical coherence angiography. Opt Express 14: 7821-7840.
31. Schmoll T, Kolbitsch C, Leitgeb RA, (2009) Ultra-high-speed volumetric tomography of human retinal blood flow. Opt Express 17: 4166-4176.
32. Zhong Z, Song H, Chui TY, Petrig BL, Burns SA, (2011) Noninvasive measurements and analysis of blood velocity profiles in human retinal vessels. Invest Ophthalmol Vis Sci 52: 4151-4157.
33. Szkulmowska A, Szkulmowski M, Kowalczyk A, Wojtkowski M, (2008) Phase-resolved Doppler optical coherence tomography - limitations and improvements. Opt Lett 33: 1425-1427.
34. Polak K, Dorner G, Kiss B, Polska E, Findl O, et al. (2000) Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol 84: 1285-1290.
35. Pemp B, Polska E, Karl K, Lasta M, Minichmayr A, et al. (2010) Effects of antioxidants (AREDS medication) on ocular blood flow and endothelial function in an endotoxin-induced model of oxidative stress in humans. Invest Ophthalmol Vis Sci 51: 2-6.
36. Garcia JP Jr, Garcia PT, Rosen RB, (2002) Retinal blood flow in the normal human eye using the canon laser blood flowmeter. Ophthalmic Res 34: 295-299.
37. Polska E, Kircher K, Ehrlich P, Vecsei PV, Schmetterer L, (2001) RI in central retinal artery as assessed by CDI does not correspond to retinal vascular resistance. Am J Physiol Heart Circ Physiol 280: H1442-1447.
38. Grunwald JE, DuPont J, Riva CE, (1996) Retinal haemodynamics in patients with early diabetes mellitus. Br J Ophthalmol 80: 327-331.
39. Grunwald JE, Riva CE, Baine J, Brucker AJ, (1992) Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control. Invest Ophthalmol Vis Sci 33: 356-363.
40. Logean E, Schmetterer L, Riva CE, (2003) Velocity profile of red blood cells in human retinal vessels using confocal scanning laser Doppler velocimetry. Laser Physics 13: 45-51.
41. Pemp B, Polska E, Garhofer G, Bayerle-Eder M, Kautzky-Willer A, et al. (2010) Retinal blood flow in type 1 diabetic patients with no or mild diabetic retinopathy during euglycemic clamp. Diabetes Care 33: 2038-2042.
42. Feke GT, Buzney SM, Ogasawara H, Fujio N, Goger DG, et al. (1994) Retinal circulatory abnormalities in type 1 diabetes. Invest Ophthalmol Vis Sci 35: 2968-2975.
43. Yoshida A, Feke GT, Mori F, Nagaoka T, Fujio N, et al. (2003) Reproducibility and clinical application of a newly developed stabilized retinal laser Doppler instrument. Am J Ophthalmol 135: 356-361.
44. Nagaoka T, (2006) [Physiological mechanism for the regulation of ocular circulation]. Nihon Ganka Gakkai Zasshi 110: 872-878.
45. Riva CE, Grunwald JE, Sinclair SH, (1983) Laser Doppler Velocimetry study of the effect of pure oxygen breathing on retinal blood flow. Invest Ophthalmol Vis Sci 24: 47-51.
46. Gilmore ED, Hudson C, Nrusimhadevara RK, Harvey PT, Mandelcorn M, et al. (2007) Retinal arteriolar diameter, blood velocity, and blood flow response to an isocapnic hyperoxic provocation in early sight-threatening diabetic retinopathy. Invest Ophthalmol Vis Sci 48: 1744-1750.
47. Bower BA, Zhao M, Zawadzki RJ, Izatt JA, (2007) Real-time spectral domain Doppler optical coherence tomography and investigation of human retinal vessel autoregulation. J Biomed Opt 12: 041214.
48. Linsenmeier RA, Braun RD, (1992) Oxygen distribution and consumption in the cat retina during normoxia and hypoxemia. J Gen Physiol 99: 177-197.
49. Baumann B, Potsaid B, Kraus MF, Liu JJ, Huang D, et al. (2011) Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT. Biomed Opt Express 2: 1539-1552.
50. Bachmann AH, Villiger ML, Blatter C, Lasser T, Leitgeb RA, (2007) Resonant Doppler flow imaging and optical vivisection of retinal blood vessels. Opt Express 15: 408-422.
51. Zotter S, Pircher M, Torzicky T, Bonesi M, Gotzinger E, et al. (2011) Visualization of microvasculature by dual-beam phase-resolved Doppler optical coherence tomography. Opt Express 19: 1217-1227.
52. Tao YK, Kennedy KM, Izatt JA, (2009) Velocity-resolved 3D retinal microvessel imaging using single-pass flow imaging spectral domain optical coherence tomography. Opt Express 17: 4177-4188.
53. Schmoll T, Singh AS, Blatter C, Schriefl S, Ahlers C, et al. (2011) Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension. Biomed Opt Express 2: 1159-1168.
54. Resch H, Garhofer G, Fuchsjager-Mayrl G, Hommer A, Schmetterer L, (2009) Endothelial dysfunction in glaucoma. Acta Ophthalmol 87: 4-12.
55. Flammer J, Orgul S, Costa VP, Orzalesi N, Krieglstein GK, et al. (2002) The impact of ocular blood flow in glaucoma. Prog Retin Eye Res 21: 359-393.
56. Schmetterer L, Wolzt M, (1999) Ocular blood flow and associated functional deviations in diabetic retinopathy. Diabetologia 42: 387-405.
57. Garhofer G, Zawinka C, Resch H, Kothy P, Schmetterer L, et al. (2004) Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes. Br J Ophthalmol 88: 887-891.
58. Mandecka A, Dawczynski J, Blum M, Muller N, Kloos C, et al. (2007) Influence of flickering light on the retinal vessels in diabetic patients. Diabetes Care 30: 3048-3052.
59. Nguyen TT, Kawasaki R, Wang JJ, Kreis AJ, Shaw J, et al. (2009) Flicker light-induced retinal vasodilation in diabetes and diabetic retinopathy. Diabetes Care 32: 2075-2080.
60. Pemp B, Garhofer G, Weigert G, Karl K, Resch H, et al. (2009) Reduced retinal vessel response to flicker stimulation but not to exogenous nitric oxide in type 1 diabetes. Invest Ophthalmol Vis Sci 50: 4029-4032.
61. Nguyen TT, Kawasaki R, Kreis AJ, Wang JJ, Shaw J, et al. (2009) Correlation of light-flicker-induced retinal vasodilation and retinal vascular caliber measurements in diabetes. Invest Ophthalmol Vis Sci 50: 5609-5613.
62. Attwell D, Buchan AM, Charpak S, Lauritzen M, Macvicar BA, et al. (2010) Glial and neuronal control of brain blood flow. Nature 468: 232-243.
63. Metea MR, Newman EA, (2006) Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling. J Neurosci 26: 2862-2870.
64. Riva CE, Logean E, Falsini B, (2005) Visually evoked hemodynamical response and assessment of neurovascular coupling in the optic nerve and retina. Prog Retin Eye Res 24: 183-215.
65. Wang Y, Fawzi AA, Tan O, Zhang X, Huang D, (2011) Flicker-induced changes in retinal blood flow assessed by Doppler optical coherence tomography. Biomed Opt Express 2: 1852-1860.