Retinal Blood Flow in Healthy Young Subjects

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 2, 2012, Pages 698-703

  Garhofer, Gerhard ^a   Werkmeister, Rene ^b   Dragostinoff, Nikolaus ^b   Schmetterer, Leopold ^a,b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Christian Doppler Laboratory for Innovative Optical Imaging and its Translation to Medicine   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTERIOLE; ARTICLE; BLOOD FLOW VELOCITY; DIASTOLIC BLOOD PRESSURE; FEMALE; HEMODYNAMICS; HUMAN; HUMAN EXPERIMENT; INTRAOCULAR PRESSURE; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OPTIC NERVE; PRIORITY JOURNAL; PULSE RATE; RETINA BLOOD FLOW; SYSTOLIC BLOOD PRESSURE; VEIN DIAMETER; VENULE; ADOLESCENT; BLOOD FLOW; MIDDLE AGED; OPTIC DISK; PHYSIOLOGY; REFERENCE VALUE; RETINA ARTERY; RETINA VEIN; VASCULARIZATION;

ADOLESCENT; ADULT; ARTERIOLES; FEMALE; HUMANS; LASER-DOPPLER FLOWMETRY; MALE; MIDDLE AGED; OPTIC DISK; REFERENCE VALUES; REGIONAL BLOOD FLOW; RETINAL ARTERY; RETINAL VEIN; VENULES; YOUNG ADULT;

EID: 84859227680     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8624     Document Type: Article

References (33)

1. Pournaras CJ, Rungger-Brandle E, Riva CE, Hardarson SH, Stefansson E. Regulation of retinal blood flow in health and disease. Prog Retin Eye Res. 2008;27:284-330.
2. Pemp B, Schmetterer L. Ocular blood flow in diabetes and agerelated macular degeneration. Can J Ophthalmol. 2008;43:295-301.
3. Harris A, Kagemann L, Ehrlich R, Rospigliosi C, Moore D, Siesky B. Measuring and interpreting ocular blood flow and metabolism in glaucoma. Can J Ophthalmol. 2008;43:328-336.
4. Riva CE, Grunwald JE, Sinclair SH, Petrig BL. Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci. 1985;26:1124-1132.
5. Polak K, Dorner GT, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84:1285-1290.
6. Garhofer G, Bek T, Boehm AG, et al. Use of the retinal vessel analyzer in ocular blood flow research. Acta Ophthalmol. 2010; 88:717-722.
7. Riva CE, Grunwald JE, Sinclair SH, O'Keefe K. Fundus camera based retinal LDV. Appl Opt. 1981;20:117-120.
8. Grunwald JE, Riva CE, Baine J, Brucker AJ. Total retinal volumetric blood flow rate in diabetic patients with poor glycemic control. Invest Ophthalmol Vis Sci. 1992;33:356-363.
9. Grunwald JE, DuPont J, Riva CE. Retinal haemodynamics in patients with early diabetes mellitus. Br J Ophthalmol. 1996;80:327-331.
10. Feke GT, Tagawa H, Deupree DM, Goger DG, Sebag J, Weiter JJ. Blood flow in the normal human retina. Invest Ophthalmol Vis Sci. 1989;30:58-65.
11. Garcia JP Jr, Garcia PT, Rosen RB. Retinal blood flow in the normal human eye using the Canon laser blood flowmeter. Ophthalmic Res. 2002;34:295-299.
12. Polska E, Kircher K, Ehrlich P, Vecsei P, Schmetterer L. RI in central retinal artery as assessed by CDI does not correspond to retinal vascular resistance. Am J Physiol Heart Circ Physiol. 2001; 280:H1442-H1447.
13. Pemp B, Polska E, Garhofer G, Bayerle-Eder M, Kautzky-Willer A, Schmetterer L. Retinal blood flow in type 1 diabetic patients with no or mild diabetic retinopathy during euglycemic clamp. Diabetes Care. 2010;33:2038-2042.
14. Riva CE, Feke GT, Eberli B, Benary V. Bidirectional LDV system for absolute measurement of blood speed in retinal vessels. Appl Opt. 1979;18:2301-2306.
15. Logean E, Schmetterer L, Riva CE. Velocity profile of red blood cells in human retinal vessels using confocal scanning laser Doppler velocimetry. Laser Physics. 2003;13:45-51.
16. Murray CD. The physiological principle of minimum work applied to the angle of branching of arteries. J Gen Physiol. 1926;9:835-841.
17. Nguyen TT, Wang JJ, Wong TY. Retinal vascular changes in prediabetes and prehypertension: new findings and their research and clinical implications. Diabetes Care. 2007;30:2708-2715.
18. Nguyen TT, Wong TY. Retinal vascular changes and diabetic retinopathy. Curr Diab Rep. 2009;9:277-283.
19. Sasongko MB, Wang JJ, Donaghue KC, et al. Alterations in retinal microvascular geometry in young type 1 diabetes. Diabetes Care. 2010;33:1331-1336.
20. Panerai RB. Assessment of cerebral pressure autoregulation in humans: a review of measurement methods. Physiol Meas. 1998; 19:305-338.
21. Riva CE, Grunwald JE, Petrig BL. Autoregulation of human retinal blood flow. An investigation with laser Doppler velocimetry. Invest Ophthalmol Vis Sci. 1986;27:1706-1712.
22. Robinson F, Riva CE, Grunwald JE, Petrig BL, Sinclair SH. Retinal blood flow autoregulation in response to an acute increase in blood pressure. Invest Ophthalmol Vis Sci. 1986;27:722-726.
23. Grunwald JE, Riva CE, Brucker AJ, Sinclair SH, Petrig BL. Altered retinal vascular response to 100% oxygen breathing in diabetes mellitus. Ophthalmology. 1984;91:1447-1452.
24. Dumskyj MJ, Eriksen JE, Dore CJ, Kohner EM. Autoregulation in the human retinal circulation: assessment using isometric exercise, laser Doppler velocimetry, and computer-assisted image analysis. Microvasc Res. 1996;51:378-392.
25. Feke GT, Pasquale LR. Retinal blood flow response to posture change in glaucoma patients compared with healthy subjects. Ophthalmology. 2008;115:246-252.
26. Luksch A, Lasta M, Polak K, et al. Twelve-hour reproducibility of retinal and optic nerve blood flow parameters in healthy individuals. Acta Ophthalmol. 2009;87:875-880.
27. Littmann H. Zur Bestimmung der wahren Größe eines Objektes auf dem Hintergrund des lebenden Auges. Klin Monatsbl Augenheilkd. 1982;180:286-289.
28. Bennett AG, Rudnicka AR, Edgar DF. Improvements on Littmann's method of determining the size of retinal features by fundus photography. Graefes Arch Clin Exp Ophthalmol. 1994;232:361-367.
29. Wang Y, Lu A, Gil-Flamer J, Tan O, Izatt JA, Huang D. Measurement of total blood flow in the normal human retina using Doppler Fourier-domain optical coherence tomography. Br J Ophthalmol. 2009;93:634-637.
30. Wang Y, Bower BA, Izatt JA, Tan O, Huang D. Retinal blood flow measurement by circumpapillary Fourier domain Doppler optical coherence tomography. J Biomed Opt. 2008;13:064003.
31. Werkmeister RM, Dragostinoff N, Pircher M, et al. Bidirectional Doppler Fourier-domain optical coherence tomography for measurement of absolute flow velocities in human retinal vessels. Opt Lett. 2008;33:2967-2969.
32. Singh AS, Kolbitsch C, Schmoll T, Leitgeb RA. Stable absolute flow estimation with Doppler OCT based on virtual circumpapillary scans. Biomed Opt Express. 2010;1:1047-1058.
33. Baumann B, Potsaid B, Kraus MF, et al. Total retinal blood flow measurement with ultrahigh speed swept source/Fourier domain OCT. Biomed Opt Express. 2011;2:1539-1552.