Effects of antioxidants (AREDS medication) on ocular blood flow and endothelial function in an endotoxin- induced model of oxidative stress in humans

Investigative Ophthalmology and Visual Science

Volumn 51, Issue 1, 2010, Pages 2-6

  Pemp, Berthold ^a   Polska, Elzbieta ^a   Karl, Katharina ^a   Lasta, Michael ^a   Minichmayr, Alexander ^a   Garhofer, Gerhard ^a   Wolzt, Michael ^a   Schmetterer, Leopold ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CUPRIC OXIDE; ESCHERICHIA COLI ENDOTOXIN; LIPOPOLYSACCHARIDE; OCUVITE PRESERVISION; PLACEBO; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; VITAMIN; ZINC OXIDE; COPPER; ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI;

ADULT; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD VESSEL REACTIVITY; CELL FUNCTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM CELL; EVENING DOSAGE; HUMAN; HUMAN EXPERIMENT; HYPEROXIA; MALE; MORNING DOSAGE; NORMAL HUMAN; OXIDATIVE STRESS; PARALLEL DESIGN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RETINA BLOOD FLOW; RETINA BLOOD VESSEL; VASOCONSTRICTION; VOLUNTEER; ADOLESCENT; BIOLOGICAL MODEL; BLOOD; BLOOD FLOW; BLOOD FLOW VELOCITY; CLINICAL TRIAL; INTRAOCULAR PRESSURE; LASER DOPPLER FLOWMETRY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ADOLESCENT; ADULT; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; BLOOD FLOW VELOCITY; COPPER; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; ENDOTOXINS; HUMANS; HYPEROXIA; INTRAOCULAR PRESSURE; LASER-DOPPLER FLOWMETRY; LIPOPOLYSACCHARIDES; MALE; MODELS, BIOLOGICAL; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; REGIONAL BLOOD FLOW; RETINAL VESSELS; VASOCONSTRICTION; VITAMIN E; YOUNG ADULT; ZINC OXIDE;

EID: 75749153035     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.09-3888     Document Type: Article

References (33)

1. Grattagliano I, Vendemiale G, Boscia F, Micelli-Ferrari T, Cardia L, Altomare E. Oxidative retinal products and ocular damage in diabetic patients. Free Radic Biol Med. 1998;25(3):369-372.
2. van Reyk DM, Gillies MC, Davies MJ. The retina: oxidative stress and diabetes. Redox Rep. 2003;8(4):187-192.
3. Spector A. Oxidative stress-induced cataract: mechanism of action. FASEB J. 1995;9(12):1173-1182.
4. Rao NA, Wu GS. Free radical mediated photoreceptor damage in uveitis. Prog Retin Eye Res. 2000;19(1):41-68.
5. Dani C, Cecchi A, Bertini G. Role of oxidative stress as physiopathologic factor in the preterm infant. Minerva Pediatr. 2004; 56(4):381-394.
6. Baskol G, Karakucuk S, Oner AO, et al. Serum paraoxonase 1 activity and lipid peroxidation levels in patients with age-related macular degeneration. Ophthalmologica. 2006;220(1):12-16.
7. Moreno MC, Campanelli J, Sande P, Sanez DA, Keller Sarmiento MI, Rosenstein RE. Retinal oxidative stress induced by high intraocular pressure. Free Radic Biol Med. 2004;37(6):803-812.
8. Juhl B, Klein F, Christiansen JS. Vitamin C treatment reduces transcapillary escape rate of albumin in type 1 diabetes. Eur J Intern Med. 2004;15(7):428-435.
9. Kukner AS, Kukner A, Naziroǧlu M, et al. Protective effects of intraperitoneal vitamin C, aprotinin and melatonin administration on retinal edema during experimental uveitis in the guinea pig. Cell Biochem Funct. 2004;22(5):299-305.
10. Bosch-Morell F, Roma J, Marin N, et al. Role of oxygen and nitrogen species in experimental uveitis: anti-inflammatory activity of the synthetic antioxidant ebselen. Free Radic Biol Med. 2002; 33(5):669-675.
11. Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001;119(10):1417-1436.
12. Kolodjaschna J, Berisha F, Lasta M, Polska E, Fuchsjäger-Mayrl G, Schmetterer L. Reactivity of retinal blood flow to 100% oxygen breathing after lipopolysaccharide administration in healthy subjects. Exp Eye Res. 2008;87(2):131-136.
13. Ramalho PS, Dollery CT. Hypertensive retinopathy. Caliber changes in retinal blood vessels following blood-pressure reduction and inhalation of oxygen. Circulation. 1968;37(4):580-588.
14. Riva CE, Grunwald JE, Sinclair SH. Laser Doppler Velocimetry study of the effect of pure oxygen breathing on retinal blood flow. Invest Ophthalmol Vis Sci. 1983;24(1):47-51.
15. Kiss B, Polska E, Dorner G, et al. Retinal blood flow during hyperoxia in humans revisited: concerted results using different measurement techniques. Microvasc Res. 2002;64(1):75-85.
16. Gilmore ED, Hudson C, Venkataraman ST, Preiss D, Fisher J. Comparison of different hyperoxic paradigms to induce vasoconstriction: implications for the investigation of retinal vascular reactivity. Invest Ophthalmol Vis Sci. 2004;45(9):3207-3212.
17. Polak K, Dorner G, Kiss B, et al. Evaluation of the Zeiss retinal vessel analyser. Br J Ophthalmol. 2000;84(11):1285-1290.
18. Riva CE, Grunwald JE, Sinclair SH, Petrig BL. Blood velocity and volumetric flow rate in human retinal vessels. Invest Ophthalmol Vis Sci. 1985;26(8):1124-1132.
19. Trepels T, Zeiher AM, Fichtlscherer S. The endothelium and inflammation. Endothelium. 2006;13(6):423-429.
20. Suffredini AF, Hochstein HD, McMahon FG. Dose-related inflammatory effects of intravenous endotoxin in humans: evaluation of a new clinical lot of Escherichia coli O:113 endotoxin. J Infect Dis. 1999;179(5):1278-1282.
21. Pleiner J, Mittermayer F, Schaller G, MacAllister RJ, Wolzt M. High doses of vitamin C reverse Escherichia coli endotoxin-induced hyporeactivity to acetylcholine in the human forearm. Circulation. 2002;106(12):1460-1464.
22. Droy-Lefaix MT, Drouet Y, Geraud G, Hosford D, Braquet P. Superoxide dismutase (SOD) and the PAF-antagonist (BN 52021) reduce small intestinal damage induced by ischemia-reperfusion. Free Radic Res Commun. 1991;12-13:725-735.
23. Zhu Y, Park TS, Gidday JM. Mechanisms of hyperoxia-induced reductions in retinal blood flow in newborn pig. Exp Eye Res. 1998;67(3):357-369.
24. Takagi C, King GL, Takagi H, Lin YW, Clermont AC, Bursell SE. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996;37(10):2099-2109.
25. Dallinger S, Dorner GT, Wenzel R, et al. Endothelin-1 contributes to hyperoxia-induced vasoconstriction in the human retina. Invest Ophthalmol Vis Sci. 2000;41(3):864-869.
26. Lip PL, Blann AD, Hope-Ross M, Gibson JM, Lip GY. Age-related macular degeneration is associated with increased vascular endothelial growth factor, hemorheology and endothelial dysfunction. Ophthalmology. 2001;108(4):705-710.
27. Omenn GS, Goodman GE, Thornquist MD, et al. Risk factors for lung cancer and for intervention effects in CARET, the beta-carotene and retinol efficacy trial. J Natl Cancer Inst. 1996;88(21): 1550-1559.
28. Fairfield KM, Fletcher RH. Vitamins for chronic disease prevention in adults: scientific review. JAMA. 2002;287(23):3116-3126.
29. Evans JR. Antioxidant vitamin and mineral supplements for slowing the progression of age-related macular degeneration. Cochrane Database Syst Rev. 2006;(2):CD000254.
30. Jin XH, Ohgami K, Shiratori K, et al. Inhibitory effects of lutein on endotoxin-induced uveitis in Lewis rats. Invest Ophthalmol Vis Sci. 2006;47(6):2562-2568.
31. Koto T, Nagai N, Mochimaru H, et al. Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice. Invest Ophthalmol Vis Sci. 2007;48(9):4328-4334.
32. Seddon JM, Ajani UA, Sperduto RD, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration: Eye Disease Case-Control Study Group. JAMA. 1994; 272(18):1413-1420.
33. Seddon JM, Rosner B, Sperduto RD, et al. Dietary fat and risk for advanced age-related macular degeneration. Arch Ophthalmol. 2001;119(8):1191-1199.