Downregulation of nucleoporin 88 and 214 induced by oridonin may protect OCIM2 acute erythroleukemia cells from apoptosis through regulation of nucleocytoplasmic transport of NF-κB

International Journal of Molecular Medicine

Volumn 30, Issue 4, 2012, Pages 877-883

  Yi, Sha ^a   Chen, Yan ^a   Wen, Lu ^a   Yang, Lijing ^a   Cui, Guohui ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Acute erythroleukemia; Apoptosis; NF B; Nucleoporin 88 214; Oridonin

Indexed keywords

CASPASE 3; CASPASE 6; CASPASE 9; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEOPORIN; NUCLEOPORIN 214; NUCLEOPORIN 88; ORIDONIN; PROTEIN BAX; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL NUCLEUS; CELL PROLIFERATION; CELL PROTECTION; CONTROLLED STUDY; CYTOPLASM; DOWN REGULATION; ENZYME ACTIVATION; ERYTHROLEUKEMIA; ERYTHROLEUKEMIA CELL; HUMAN; HUMAN CELL; IC 50; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES, KAURANE; DOWN-REGULATION; DRUG RESISTANCE, NEOPLASM; HUMANS; LEUKEMIA, ERYTHROBLASTIC, ACUTE; NF-KAPPA B; NUCLEAR PORE COMPLEX PROTEINS;

EID: 84866502482     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2012.1067     Document Type: Article

References (22)

1. Santos FP, Bueso-Ramos CE and Ravandi F: Acute erythroleukemia: diagnosis and management. Expert Rev Hematol 3: 705-718, 2010.
2. Hayden MS and Ghosh S: Shared principles in NF-kappaB signaling. Cell 132: 344-362, 2008.
3. Ryan KM, Ernst MK, Rice NR and Vousden KH: Role of NF-kappaB in p53-mediated programmed cell death. Nature 404: 892-897, 2000. (Pubitemid 30230343)
4. Baud V and Karin M: Is NF-kappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 8: 33-40, 2009.
5. Perkins ND and Gilmore TD: Good cop, bad cop: the different faces of NF-kappaB. Cell Death Differ 13: 759-772, 2006.
6. Weis K: Nucleocytoplasmic transport: cargo trafficking across the border. Curr Opin Cell Biol 14: 328-335, 2002.
7. Gould VE, Orucevic A, Zentgraf H, Gattuso P, Martinez N and Alonso A: Nup88 (karyoporin) in human malignant neoplasms and dysplasias: correlations of immunostaining of tissue sections, cytologic smears, and immunoblot analysis. Hum Pathol 33: 536-544, 2002. (Pubitemid 34747874)
8. Gould VE, Martinez N, Orucevic A, Schneider J and Alonso A: A novel, nuclear pore-associated, widely distributed molecule overexpressed in oncogenesis and development. Am J Pathol 157: 1605-1613, 2000.
9. Emterling A, Skoglund J, Arbman G, et al: Clinicopathological significance of Nup88 expression in patients with colorectal cancer. Oncology 64: 361-369, 2003. (Pubitemid 36682949)
10. Fornerod M, Ohno M, Yoshida M and Mattaj IW: CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060, 1997. (Pubitemid 27408519)
11. Gao F, Tang Q, Yang P, Fang Y, Li W and Wu Y: Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells. Int J Lab Hematol 32: e114-e122, 2010.
12. Zhou GB, Chen SJ, Wang ZY and Chen Z: Back to the future of oridonin: again, compound from medicinal herb shows potent antileukemia efficacies in vitro and in vivo. Cell Res 17: 274-276, 2007.
13. Gao FH, Liu F, Wei W, et al: Oridonin induces apoptosis and senescence by increasing hydrogen peroxide and glutathione depletion in colorectal cancer cells. Int J Mol Med 29: 649-655, 2012.
14. Ji Z, Tang QJ, Zhang JS, Yang Y, Liu YF and Pan YJ: Oridonin-induced apoptosis in SW620 human colorectal adenocarcinoma cells. Oncol Lett 2: 1303-1307, 2011.
15. Ghosh S and Karin M: Missing pieces in the NF-kappaB puzzle. Cell 109 (Suppl): S81-S96, 2002.
16. Kirkin V, Joos S and Zornig M: The role of Bcl-2 family members in tumorigenesis. Biochim Biophys Acta 1644: 229-249, 2004. (Pubitemid 38281277)
17. Thornberry NA: Caspases: key mediators of apoptosis. Chem Biol 5: R97-R103, 1998.
18. Bernad R, Engelsma D, Sanderson H, Pickersgill H and Fornerod M: Nup214-Nup88 nucleoporin subcomplex is required for CRM1-mediated 60 S preribosomal nuclear export. J Biol Chem 281: 19378-19386, 2006. (Pubitemid 44035443)
19. Hutten S and Kehlenbach RH: Nup214 is required for CRM1-dependent nuclear protein export in vivo. Mol Cell Biol 26: 6772-6785, 2006. (Pubitemid 44387628)
20. Uv AE, Roth P, Xylourgidis N, Wickberg A, Cantera R and Samakovlis C: members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation. Genes Dev 14: 1945-1957, 2000. (Pubitemid 30639527)
21. Roth P, Xylourgidis N, Sabri N, Uv A, Fornerod M and Samakovlis C: The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export. J Cell Biol 163: 701-706, 2003. (Pubitemid 37517877)
22. Xylourgidis N, Roth P, Sabri N, Tsarouhas V and Samakovlis C: The nucleoporin Nup214 sequesters CRM1 at the nuclear rim and modulates NFkappaB activation in Drosophila. J Cell Sci 119: 4409-4419, 2006. (Pubitemid 44830640)