Epithelial mesenchymal transition traits in honey-driven keratinocyte wound healing: Comparison among different honeys

Wound Repair and Regeneration

Volumn 20, Issue 5, 2012, Pages 778-785

  Ranzato, Elia ^a   Martinotti, Simona ^a   Burlando, Bruno ^a  

^a UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA3 INTEGRIN; BINDING PROTEIN; CALCIUM CHANNEL BLOCKING AGENT; CHEMOATTRACTANT; CYCLIN DEPENDENT KINASE 2; FOCAL ADHESION KINASE; GELATINASE B; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN CDC25C; PROTEIN TYROSINE PHOSPHATASE; RASGAP SH3 BINDING PROTEIN 1; SYNDECAN 4; UNCLASSIFIED DRUG; VASODILATOR STIMULATED PHOSPHOPROTEIN;

ARTICLE; CELL PROLIFERATION; DOWN REGULATION; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIZATION; GENE EXPRESSION; HONEY; HUMAN; HUMAN CELL; KERATINOCYTE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; UPREGULATION; WOUND HEALING;

ACACIA; CDC25 PHOSPHATASES; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FAGOPYRUM; HONEY; HUMANS; INTEGRIN BETA3; KERATINOCYTES; LEPTOSPERMUM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PHENOTYPE; PHOSPHOPROTEINS; PHYTOTHERAPY; POLYMERASE CHAIN REACTION; RE-EPITHELIALIZATION; UP-REGULATION; WOUND HEALING;

EID: 84866492198     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00825.x     Document Type: Article

References (36)

1. Willix DJ, Molan PC, Harfoot CG,. A comparison of the sensitivity of wound-infecting species of bacteria to the antibacterial activity of manuka honey and other honey. J Appl Bacteriol 1992; 73: 388-394.
2. Lev E,. Traditional healing with animals (zootherapy): medieval to present-day Levantine practice. J Ethnopharmacol 2003; 85: 107-118.
3. Lee DS, Sinno S, Khachemoune A,. Honey and wound healing: an overview. Am J Clin Dermatol 2011; 12: 181-190.
4. Langemo DK, Hanson D, Anderson J, Thompson P, Hunter S,. Use of honey for wound healing. Adv Skin Wound Care 2009; 22: 113-118.
5. Molan PC,. The evidence supporting the use of honey as a wound dressing. Int J Low Extrem Wounds 2006; 5: 40-54.
6. Efem SE, Udoh KT, Iwara CI,. The antimicrobial spectrum of honey and its clinical significance. Infection 1992; 20: 227-229.
7. Molan PC,. Potential of honey in the treatment of wounds and burns. Am J Clin Dermatol 2001; 2: 13-19.
8. Al-Waili N, Salom K, Al-Ghamdi AA,. Honey for wound healing, ulcers, and burns; data supporting its use in clinical practice. Sci World J 2011; 11: 766-787.
9. Barui A, Banerjee P, Das RK, Basu SK, Dhara S, Chatterjee J,. Immunohistochemical evaluation of p63, E-cadherin, collagen I and III expression in lower limb wound healing under honey. Evid Based Complement Alternat Med 2011; 2011: 239864.
10. Broughton G, 2nd, Janis JE, Attinger CE,. The basic science of wound healing. Plast Reconstr Surg 2006; 117 (7 Suppl): 12S-34S.
11. Ranzato E, Patrone M, Mazzucco L, Burlando B,. Platelet lysate stimulates wound repair of HaCaT keratinocytes. Br J Dermatol 2008; 159: 537-545.
12. Majtan J, Kovacova E, Bilikova K, Simuth J,. The immunostimulatory effect of the recombinant apalbumin 1-major honeybee royal jelly protein-on TNFalpha release. Int Immunopharmacol 2006; 6: 269-278.
13. Iftikhar F, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M,. Effects of acacia honey on wound healing in various rat models. Phytother Res 2010; 24: 583-586.
14. van den Berg AJ, van den Worm E, van Ufford HC, Halkes SB, Hoekstra MJ, Beukelman CJ,. An in vitro examination of the antioxidant and anti-inflammatory properties of buckwheat honey. J Wound Care 2008; 17: 172-174.
15. Cooper RA, Molan PC, Harding KG,. The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Appl Microbiol 2002; 93: 857-863.
16. Cooper RA, Jenkins L, Henriques AF, Duggan RS, Burton NF,. Absence of bacterial resistance to medical-grade manuka honey. Eur J Clin Microbiol Infect Dis 2010; 29: 1237-1241.
17. Moore OA, Smith LA, Campbell F, Seers K, McQuay HJ, Moore RA,. Systematic review of the use of honey as a wound dressing. BMC Complement Altern Med 2001; 1: 2.
18. Gethin GT, Cowman S, Conroy RM,. The impact of Manuka honey dressings on the surface pH of chronic wounds. Int Wound J 2008; 5: 185-194.
19. Gethin G, Cowman S,. Manuka honey vs. hydrogel-a prospective, open label, multicentre, randomised controlled trial to compare desloughing efficacy and healing outcomes in venous ulcers. J Clin Nurs 2009; 18: 466-474.
20. Boukamp P, Petrussevska RT, Breitkreutz D, Hornung J, Markham A, Fusenig NE,. Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J Cell Biol 1988; 106: 761-771.
21. Ranzato E, Martinotti S, Volante A, Mazzucco L, Burlando B,. Platelet lysate modulates MMP-2 and MMP-9 expression, matrix deposition and cell-to-matrix adhesion in keratinocytes and fibroblasts. Exp Dermatol 2011; 20: 308-313.
22. Ranzato E, Mazzucco L, Patrone M, Burlando B,. Platelet lysate promotes in vitro wound scratch closure of human dermal fibroblasts: different roles of cell calcium, P38, ERK and PI3K/AKT. J Cell Mol Med 2009; 13 (8B): 2030-2038.
23. Smith SE, Roukis TS,. Bone and wound healing augmentation with platelet-rich plasma. Clin Podiatr Med Surg 2009; 26: 559-588.
24. Couchman JR, Chen L, Woods A,. Syndecans and cell adhesion. Int Rev Cytol 2001; 207: 113-150.
25. Neganova I, Zhang X, Atkinson S, Lako M,. Expression and functional analysis of G1 to S regulatory components reveals an important role for CDK2 in cell cycle regulation in human embryonic stem cells. Oncogene 2009; 28: 20-30.
26. Macias E, Miliani de Marval PL, De Siervi A, Conti CJ, Senderowicz AM, Rodriguez-Puebla ML,. CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. Am J Pathol 2008; 173: 526-535.
27. Meng X, Krishnan J, She Y, Ens W, Standing K, Wilkins JA,. Association of rasGAPSH3 binding protein 1, G3BP1, and rasGap120 with integrin containing complexes induced by an adhesion blocking antibody. J Proteome Res 2004; 3: 506-516.
28. Mazzucco L, Medici D, Serra M, Panizza R, Rivara G, Orecchia S, Libener R, Cattana E, Levis A, Betta PG, Borzini P,. The use of autologous platelet gel to treat difficult-to-heal wounds: a pilot study. Transfusion 2004; 44: 1013-1018.
29. Ranzato E, Martinotti S, Burlando B,. Wound healing properties of jojoba liquid wax: an in vitro study. J Ethnopharmacol 2011; 134: 443-449.
30. Kyriakides TR, Wulsin D, Skokos EA, Fleckman P, Pirrone A, Shipley JM, Senior RM, Bornstein P,. Mice that lack matrix metalloproteinase-9 display delayed wound healing associated with delayed reepithelization and disordered collagen fibrillogenesis. Matrix Biol 2009; 28: 65-73.
31. Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ,. A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Dev Cell 2011; 21: 681-693.
32. Majtan J, Kumar P, Majtan T, Walls AF, Klaudiny J,. Effect of honey and its major royal jelly protein 1 on cytokine and MMP-9 mRNA transcripts in human keratinocytes. Exp Dermatol 2010; 19: e73-79.
33. Nakamura M, Tokura Y,. Epithelial-mesenchymal transition in the skin. J Dermatol Sci 2011; 61: 7-13.
34. Hoot KE, Lighthall J, Han G, Lu SL, Li A, Ju W, Kulesz-Martin M, Bottinger E, Wang XJ,. Keratinocyte-specific Smad2 ablation results in increased epithelial-mesenchymal transition during skin cancer formation and progression. J Clin Invest 2008; 118: 2722-2732.
35. Giehl K, Menke A,. Microenvironmental regulation of E-cadherin-mediated adherens junctions. Front Biosci 2008; 13: 3975-3985.
36. Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, Leake D, Godden EL, Albertson DG, Nieto MA, Werb Z, Bissell MJ,. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005; 436: 123-127.