Effect of chronic intracerebroventricluar administration of lipopolysaccharide on connexin43 protein expression in rat hippocampus

Iranian Biomedical Journal

Volumn 16, Issue 1, 2012, Pages 1-8

  Sayyah, Mohammad ^a   Kaviani, Bahar ^a,b   Khoshkholgh Sima, Baharak ^a   Bagheri, Marzieh ^a,c   Olad, Maryam ^a,c   Choopani, Samira ^a   Mahdian, Reza ^a  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c DAMGHAN UNIVERSITY   (Iran)

Author keywords

Connexin36 (Cx36); Connexin43 (Cx43); Interleukin 1 (IL1 )

Indexed keywords

CONNEXIN 36; CONNEXIN 43; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; GAP JUNCTION PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; ENCEPHALITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; EPILEPTOGENESIS; EXCITABILITY; HIPPOCAMPUS; MALE; MOTOR PERFORMANCE; NONHUMAN; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; CELL JUNCTION; DRUG EFFECT; EPILEPSY; GENETICS; INFLAMMATION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS; RATTUS NORVEGICUS;

ANIMALS; CONNEXIN 43; CONNEXINS; EPILEPSY; GAP JUNCTIONS; HIPPOCAMPUS; INFLAMMATION; INFUSIONS, INTRAVENTRICULAR; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, WISTAR; RNA, MESSENGER;

EID: 84866465266     PISSN: 1028852X     EISSN: None     Source Type: Journal    
DOI: 10.6091/IBJ.1030.2012     Document Type: Article

References (37)

1. Kielian T. Glial connexins and gap junctions in CNS inflammation and disease. J Neurochem. 2008; 106: 1000-16.
2. Vezzani M, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nat Rev Neurol. 2011; 7: 31-40.
3. Ambrosini A, Louin G, Croci N, Plotkine M, Jafarian Tehrani M. Characterization of a rat model to study acute neuroinflammation on histopathological, bio-chemical and functional outcomes. J Neurosci Methods. 2005; 144: 183-91.
4. Meme W, Calvo CF, Froger N, Ezan P, Amigou E, Koulakoff A, Giaume C. Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by beta-amyloid. FASEB J. 2006; 20: 494-6.
5. Retamal MA, Froger N, Palacios-Prado N, Ezan P, Saez PJ, Saez JC, Giaume C. Cx43 hemichannels and gap junction channels in astrocytes are regulated oppositely by proinflammatory cytokines released from activated microglia. J Neurosci. 2007; 27: 13781-92.
6. Liao C, Wang S, Chen Y, Wang H, Wu J. Lipopolysaccharide-induced inhibition of connexin43 gap junction communication in astrocytes is mediated by downregulation of caveolin-3. Int J Biochem Cell Biol. 2010; 42: 762-70.
7. Karpuk N, Burkovetskaya M, Fritz T, Angle A, Kielian T. Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J Neurosci. 2011; 31: 414-25.
8. Sayyah M, Toubeihaye Najafabadi I, Beheshti S, Majzoob S. Lipopolysaccharide retards development of amygdala kindling but does not affect fully-kindled seizures in rats. Epilepsy Res. 2003; 57: 175-80.
9. LeBeau FE, Traub RD, Monyer H, Whittington MA, Buhl EH. The role of electrical signaling via gap junctions in the generation of fast network oscillations. Brain Res Bull. 2003; 62: 3-13.
10. Traub RD, Cunningham MO, Whittington MA. Chemical synaptic and gap junctional interactions between principal neurons: Partners in epileptogenesis. Neural Netw. 2011; 24: 515-25.
11. Fukuda T, Kosaka T. Gap junctions linking the dendritic network of GABAergic interneurons in the hippocampus. J Neurosci. 2000; 20: 1519-28.
12. Venance L, Rozov A, Blatow M, Burnashev N, Feldmeyer D, Monyer H. Connexin expression in electrical coupled postnatal rat brain neurons. Proc Natl. Acad Sci USA., 2000; 97: 10260-65.
13. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976; 72: 248-54.
14. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K. Short protocols in molecular biology. New York: Wiley; 2002.
15. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T) Method. Methods. 2001; 25: 402-8.
16. Vaerman JL, Saussoy P, Ingargiola I. Evaluation of realtime PCR data. J Biol Regul Homeost Agents. 2004; 18: 212-14.
17. Klein SL, Nelson RJ. Activation of the immuneendocrine system with lipopolysaccharide reduces affiliative behaviors in voles. Behav Neurosci. 1999; 113: 1042-48.
18. West MA, Heagy W. Endotoxin tolerance: a review. Crit Care Med. 2002; 30: S64-S73.
19. Chen R, Zhou H, Beltran J, Malellari L, Chang SL. Differential expression of cytokines in the brain and serum during endotoxin tolerance. J Neuroimmunol. 2005; 163: 53-72.
20. Haghikia A, Ladage K, Lafenetre P, Hinkerohe D, Smikalla D, Haase CG, Dermietzel R, et al. Intracellular application of TNF-alpha impairs cell to cell communication via gap junctions in glioma cells. J. Neuroendocrinol. 2008; 86: 143-52.
21. Hinkerohe D, Smikalla D, Schoebel A, Haghikia A, Zoidl G, Haase CG, Schlegel U, et al. Dexamethasone prevents LPS-induced microglial activation and astroglial impairment in an experimental bacterial meningitis co-culture model. Brain Res. 2010; 1329: 45-54.
22. Frantseva MV, Kokarovtseva L, Naus CG, Carlen PL, MacFabe D, Perez Velazquez JL. Specific gap junctions enhance the neuronal vulnerability to brain trauma injury. J. Neurosci. 2002; 22: 644-53.
23. de Pina-Benabou MH, Szostak V, Kyrozis A, Rempe D, Uziel D, Urban-Maldonado M, Benabou S, et al. Blockade of gap junctions in vivo provides neuroprotection after perinatal global ischemia. Stroke 2005; 36: 2232-37.
24. Froger N, Orellana JA, Calvo C, Amigou E, Kozoriz MG, Naus CC, Saez JC, et al. Inhibition of cytokineinduced connexin43 hemichannel activity in astrocytes is neuroprotective. Mol Cell Neurosci. 2010; 45: 37-46.
25. Nakase T, Fushiki S, Naus CC. Astrocytic gap junctions composed of connexin43 reduces apoptotic neuronal damage in cerebral ischemia. Stroke 2003; 34: 1987-93.
26. Nakase T, Sohl G, Theis M, Willecke K, Naus CC. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am J Pathol. 2004; 164: 2067-75.
27. Kofuji P, Newman EA. Potassium buffering in the central nervous system. Neuroscience 2004; 129: 1043-54.
28. Binder DK, Steinhauser C. Functional changes in astroglial cells in epilepsy. Glia 2006; 54: 358-68.
29. Wallraff A, Kohling R, Hinemann U, Theis M, Willecke K, Steinhauser C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J Neurosci. 2006; 26: 5438-47.
30. Pannasch U, Vargova L, Reingruber J, Ezan, P, Holcman D, Giaume C. Astroglial networks scale synaptic activity and plasticity. Proc Natl Acad Sci USA. 2011; 108: 8467-72.
31. Akarsu ES, Ozdayi S, Algan E, Ulupinar F. The neuronal excitability time-dependently changes after lipopolysaccharide administration in mice: possible role of cyclooxygenase-2 induction. Epilepsy Res. 2006; 71: 181-87.
32. Arican N, Kaya M, Kalayci R, Uzun H, Ahishali B, Bilgic B, Elmas I, et al. Effect of lipopolysaccharide on blood-brain barrier permeability during pentylenetetrazole-induced epileptic seizures in rats. Life Sci. 2006; 79: 1-7.
33. Mirrione MM, Konomos DH, Gravanis I, Dewey SL, Aguzzi A, Heppner FL, Tsirka SE. Microglial ablation and lipopolysaccharide preconditioning affects pilo carpine-induced seizures in mice. Neurobiol Dis. 2010; 39: 85-97.
34. Samoilova M, Wentlandt K, Adamchick Y, Velumian AF, Carlen PL. Connexin43 mimetic peptides inhibit spontaneous epileptiform activity in organotypic hippocampal slice cultures. Exp Neurol. 2008; 210: 762-75.
35. Yoon JJ, Green CR, O'Carroll SJ, Nicholson, LFB. Dose-dependent protective effect of connexin43 mimetic peptide against neurodegeneration in an ex vivo model of epileptiform lesion. Epilepsy Res. 2010; 92: 153-62.
36. Oguro K, Jover T, Tanaka H, Lin Y, Kojima T, Oguro N, Grooms SN, et al. Global ischemia-induced increases in the gap junctional proteins connexin32 (Cx32) and Cx36 in hippocampus and enhanced vulnerability of Cx32 knock-out mice. J Neurosci. 2001; 21: 7534-42.
37. Schock SC, LeBlanc D, Hakim AM, Thompson CS. ATP release by way of connexin36 hemichannels mediates ischemic tolerance in vitro. Biochem Biophys Res Commun. 2008; 368: 138-44.