메뉴 건너뛰기




Volumn 31, Issue 10, 2012, Pages 1889-1897

Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal)

Author keywords

13C NMR; Ashwagandha; Isoprenoids biosynthesis; Mevalonate and non mevalonate (DOXP); Withaferin A; Withania somnifera; Withanolides

Indexed keywords

CARBON; GLUCOSE; MEVALONIC ACID; TERPENE; WITHAFERIN A; WITHANOLIDE;

EID: 84866456071     PISSN: 07217714     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00299-012-1302-4     Document Type: Article
Times cited : (99)

References (39)
  • 1
    • 0031798616 scopus 로고    scopus 로고
    • Biosynthesis of the isoprene units of chamomile sesquiterpenes
    • Adam KP, Zapp J (1998) Biosynthesis of the isoprene units of chamomile sesquiterpenes. Phytochemistry 48: 953-959.
    • (1998) Phytochemistry , vol.48 , pp. 953-959
    • Adam, K.P.1    Zapp, J.2
  • 2
    • 27744577599 scopus 로고    scopus 로고
    • Biogenesis, molecular regulation and function of plant isoprenoids
    • Bouvier F, Rahier A, Camara B (2005) Biogenesis, molecular regulation and function of plant isoprenoids. Prog Lipid Res 44: 357-429.
    • (2005) Prog Lipid Res , vol.44 , pp. 357-429
    • Bouvier, F.1    Rahier, A.2    Camara, B.3
  • 4
    • 35348953773 scopus 로고    scopus 로고
    • Leaf ontogenic phase related dynamics of withaferin A and withanone biogenesis in Ashwagandha (Withania somnifera)-an important medicinal herb
    • Chaurasiya ND, Gupta VK, Sangwan RS (2007) Leaf ontogenic phase related dynamics of withaferin A and withanone biogenesis in Ashwagandha (Withania somnifera)-an important medicinal herb. J Plant Biol 50: 508-513.
    • (2007) J Plant Biol , vol.50 , pp. 508-513
    • Chaurasiya, N.D.1    Gupta, V.K.2    Sangwan, R.S.3
  • 5
    • 41149136192 scopus 로고    scopus 로고
    • Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photo diode array and evaporative light scattering detection
    • Chaurasiya ND, Uniyal GC, Lal P, Misra L, Sangwan NS, Tuli R, Sangwan RS (2008) Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photo diode array and evaporative light scattering detection. Phytochem Anal 19: 148-154.
    • (2008) Phytochem Anal , vol.19 , pp. 148-154
    • Chaurasiya, N.D.1    Uniyal, G.C.2    Lal, P.3    Misra, L.4    Sangwan, N.S.5    Tuli, R.6    Sangwan, R.S.7
  • 7
    • 67650915528 scopus 로고    scopus 로고
    • Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants
    • Cordoba E, Salmi M, León P (2009) Unravelling the regulatory mechanisms that modulate the MEP pathway in higher plants. J Exp Bot 60: 2933-2943.
    • (2009) J Exp Bot , vol.60 , pp. 2933-2943
    • Cordoba, E.1    Salmi, M.2    León, P.3
  • 8
    • 0037308195 scopus 로고    scopus 로고
    • Biosynthesis of β-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units
    • De-Eknamkul W, Potduang B (2003) Biosynthesis of β-sitosterol and stigmasterol in Croton sublyratus proceeds via a mixed origin of isoprene units. Phytochemistry 62: 389-398.
    • (2003) Phytochemistry , vol.62 , pp. 389-398
    • De-Eknamkul, W.1    Potduang, B.2
  • 10
    • 12844282432 scopus 로고    scopus 로고
    • Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways
    • Hampel D, Mosandl A, Wüst M (2005) Biosynthesis of mono- and sesquiterpenes in carrot roots and leaves (Daucus carota L.): metabolic cross talk of cytosolic mevalonate and plastidial methylerythritol phosphate pathways. Phytochemistry 66: 305-311.
    • (2005) Phytochemistry , vol.66 , pp. 305-311
    • Hampel, D.1    Mosandl, A.2    Wüst, M.3
  • 12
    • 33644985582 scopus 로고    scopus 로고
    • Morpho-physiological disorders in in vitro culture of plants
    • Hazarika BN (2006) Morpho-physiological disorders in in vitro culture of plants. Sci Hort 108: 105-120.
    • (2006) Sci Hort , vol.108 , pp. 105-120
    • Hazarika, B.N.1
  • 13
    • 84856585187 scopus 로고    scopus 로고
    • A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
    • Hemmerlin A, Harwood JL, Bach TJ (2012) A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis? Prog Lipid Res 51: 95-148.
    • (2012) Prog Lipid Res , vol.51 , pp. 95-148
    • Hemmerlin, A.1    Harwood, J.L.2    Bach, T.J.3
  • 14
    • 17844363245 scopus 로고    scopus 로고
    • Neuritic regeneration and synaptic reconstruction induced by withanolide A
    • Kuboyama T, Tohda C, Komatsu K (2005) Neuritic regeneration and synaptic reconstruction induced by withanolide A. Brit J Pharmacol 144: 961-971.
    • (2005) Brit J Pharmacol , vol.144 , pp. 961-971
    • Kuboyama, T.1    Tohda, C.2    Komatsu, K.3
  • 15
    • 0033513375 scopus 로고    scopus 로고
    • 1-deoxy-d-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants
    • Lichtenthaler HK (1999) 1-deoxy-d-xylulose-5-phosphate pathway of isoprenoid biosynthesis in plants. Annu Rev Plant Physiol Plant Mol Biol 50: 47-65.
    • (1999) Annu Rev Plant Physiol Plant Mol Biol , vol.50 , pp. 47-65
    • Lichtenthaler, H.K.1
  • 16
    • 33847659963 scopus 로고    scopus 로고
    • Purification and physico-kinetic characterization of 3β-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response
    • Madina BR, Sharman LK, Chaturvedi P, Sangwan RS, Tuli R (2007) Purification and physico-kinetic characterization of 3β-hydroxy specific sterol glucosyltransferase from Withania somnifera (L) and its stress response. Biochim Biophys Acta 1774: 392-402.
    • (2007) Biochim Biophys Acta , vol.1774 , pp. 392-402
    • Madina, B.R.1    Sharman, L.K.2    Chaturvedi, P.3    Sangwan, R.S.4    Tuli, R.5
  • 17
    • 56349141560 scopus 로고    scopus 로고
    • Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through mitochondrial death cascade
    • Mandal C, Dutta A, Mallick A, Chandra S, Misra L, Sangwan RS, Mandal C (2008) Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through mitochondrial death cascade. Apoptosis 13: 1450-1464.
    • (2008) Apoptosis , vol.13 , pp. 1450-1464
    • Mandal, C.1    Dutta, A.2    Mallick, A.3    Chandra, S.4    Misra, L.5    Sangwan, R.S.6    Mandal, C.7
  • 20
    • 77956469863 scopus 로고    scopus 로고
    • Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    • Mondal S, Mandal C, Sangwan RS, Chandra S, Mandal C (2010) Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer 9: 239-255.
    • (2010) Mol Cancer , vol.9 , pp. 239-255
    • Mondal, S.1    Mandal, C.2    Sangwan, R.S.3    Chandra, S.4    Mandal, C.5
  • 21
    • 35148849576 scopus 로고    scopus 로고
    • Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia
    • Munoz-Bertomeu J, Sales E, Ros R, Arrillaga I (2007) Up-regulation of an N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase enhances production of essential oils and sterols in transgenic Lavandula latifolia. Plant Biotech J 5: 746-758.
    • (2007) Plant Biotech J , vol.5 , pp. 746-758
    • Munoz-Bertomeu, J.1    Sales, E.2    Ros, R.3    Arrillaga, I.4
  • 22
    • 84982358134 scopus 로고
    • A revised medium for rapid growth and bioassays Tobacco tissue culture
    • Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays Tobacco tissue culture. Physiol Plant 15: 473-497.
    • (1962) Physiol Plant , vol.15 , pp. 473-497
    • Murashige, T.1    Skoog, F.2
  • 23
    • 0037422234 scopus 로고    scopus 로고
    • Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata
    • Palazón J, Cusidó RM, Bonfill M, Morales C, Piñol MT (2003) Inhibition of paclitaxel and baccatin III accumulation by mevinolin and fosmidomycin in suspension cultures of Taxus baccata. J Biotechnol 10: 157-163.
    • (2003) J Biotechnol , vol.10 , pp. 157-163
    • Palazón, J.1    Cusidó, R.M.2    Bonfill, M.3    Morales, C.4    Piñol, M.T.5
  • 24
    • 62949236615 scopus 로고    scopus 로고
    • Leaf anatomy during leaf development of photoautotrophically in vitro-grown tobacco plants as affected by growth irradiance
    • Radochova B, Ticha L (2009) Leaf anatomy during leaf development of photoautotrophically in vitro-grown tobacco plants as affected by growth irradiance. Biol Plant 53: 21-27.
    • (2009) Biol Plant , vol.53 , pp. 21-27
    • Radochova, B.1    Ticha, L.2
  • 25
    • 0037313208 scopus 로고    scopus 로고
    • Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis elucidation and distribution
    • Rohmer M (2003) Mevalonate-independent methylerythritol phosphate pathway for isoprenoid biosynthesis elucidation and distribution. Pure Appl Chem 75: 375-387.
    • (2003) Pure Appl Chem , vol.75 , pp. 375-387
    • Rohmer, M.1
  • 27
    • 79954706260 scopus 로고    scopus 로고
    • Biotransformation of withanolides by cell suspension cultures of Withania somnifera (Dunal.)
    • Sabir F, Sangwan RS, Singh J, Misra LN, Pathak N, Sangwan NS (2011) Biotransformation of withanolides by cell suspension cultures of Withania somnifera (Dunal.). Plant Biotech Rep 5: 127-134.
    • (2011) Plant Biotech Rep , vol.5 , pp. 127-134
    • Sabir, F.1    Sangwan, R.S.2    Singh, J.3    Misra, L.N.4    Pathak, N.5    Sangwan, N.S.6
  • 28
    • 84868339242 scopus 로고    scopus 로고
    • Salt stress-induced responses in growth and metabolism in callus cultures and differentiating in vitro shoots of Indian ginseng (Withania somnifera Dunal)
    • (in press, doi: 10. 1007/s00344-012-9264-x)
    • Sabir F, Sangwan RS, Kumar R, Sangwan NS (2012) Salt stress-induced responses in growth and metabolism in callus cultures and differentiating in vitro shoots of Indian ginseng (Withania somnifera Dunal). J Plant Growth Regul (in press, doi: 10. 1007/s00344-012-9264-x).
    • (2012) J Plant Growth Regul
    • Sabir, F.1    Sangwan, R.S.2    Kumar, R.3    Sangwan, N.S.4
  • 29
    • 70449338387 scopus 로고    scopus 로고
    • Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants
    • Samina A, Husaini AM, Abdin MZ, Rather GM (2009) Overexpression of the HMG-CoA reductase gene leads to enhanced artemisinin biosynthesis in transgenic Artemisia annua plants. Plant Med 75: 1453-1458.
    • (2009) Plant Med , vol.75 , pp. 1453-1458
    • Samina, A.1    Husaini, A.M.2    Abdin, M.Z.3    Rather, G.M.4
  • 30
    • 34548682302 scopus 로고    scopus 로고
    • Withanolide A biogeneration in in vitro shoot cultures of Ashwagandha (Withania somnifera Dunal)-a main medicinal plant of Ayurveda
    • Sangwan RS, Chaurasiya ND, Lal P, Misra L, Uniyal GC, Tuli R, Sangwan NS (2007) Withanolide A biogeneration in in vitro shoot cultures of Ashwagandha (Withania somnifera Dunal)-a main medicinal plant of Ayurveda. Chem Pharm Bull 55: 1371-1375.
    • (2007) Chem Pharm Bull , vol.55 , pp. 1371-1375
    • Sangwan, R.S.1    Chaurasiya, N.D.2    Lal, P.3    Misra, L.4    Uniyal, G.C.5    Tuli, R.6    Sangwan, N.S.7
  • 31
    • 43149118590 scopus 로고    scopus 로고
    • Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera)
    • Sangwan RS, Chaurasiya ND, Lal P, Misra L, Tuli R, Sangwan NS (2008) Withanolide A is inherently de novo biosynthesized in roots of the medicinal plant Ashwagandha (Withania somnifera). Physiol Plant 133: 278-287.
    • (2008) Physiol Plant , vol.133 , pp. 278-287
    • Sangwan, R.S.1    Chaurasiya, N.D.2    Lal, P.3    Misra, L.4    Tuli, R.5    Sangwan, N.S.6
  • 32
    • 0042158199 scopus 로고    scopus 로고
    • Biosynthesis of the triterpenoids, botryococcenes and tetramethylsqualene in the B race of Botryococcus braunii via the non-mevalonate pathway
    • Sato Y, Ito Y, Okada S, Murakami M, Abe H (2003) Biosynthesis of the triterpenoids, botryococcenes and tetramethylsqualene in the B race of Botryococcus braunii via the non-mevalonate pathway. Tetrahed Lett 44: 7035-7037.
    • (2003) Tetrahed Lett , vol.44 , pp. 7035-7037
    • Sato, Y.1    Ito, Y.2    Okada, S.3    Murakami, M.4    Abe, H.5
  • 35
    • 33947593377 scopus 로고    scopus 로고
    • Molecular cloning and characterization of one member of 3β-hydroxy sterol glucosyltransferase gene family in Withania somnifera
    • Sharma LK, Madina BR, Chaturvedi P, Sangwan RS, Tuli R (2007) Molecular cloning and characterization of one member of 3β-hydroxy sterol glucosyltransferase gene family in Withania somnifera. Arch Biochem Biophys 460: 48-55.
    • (2007) Arch Biochem Biophys , vol.460 , pp. 48-55
    • Sharma, L.K.1    Madina, B.R.2    Chaturvedi, P.3    Sangwan, R.S.4    Tuli, R.5
  • 37
    • 36448939464 scopus 로고    scopus 로고
    • Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways
    • Towler MJ, Weathers PJ (2007) Evidence of artemisinin production from IPP stemming from both the mevalonate and the nonmevalonate pathways. Plant Cell Rep 26: 2129-2136.
    • (2007) Plant Cell Rep , vol.26 , pp. 2129-2136
    • Towler, M.J.1    Weathers, P.J.2
  • 39
    • 0141940212 scopus 로고    scopus 로고
    • Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route
    • van Klink J, Becker H, Anderson S, Boland W (2003) Biosynthesis of anthecotuloide, an irregular sesquiterpene lactone from Anthemis cotula L. (Asteraceae) via a non-farnesyl diphosphate route. Org Biomol Chem 1: 1503-1508.
    • (2003) Org Biomol Chem , vol.1 , pp. 1503-1508
    • van Klink, J.1    Becker, H.2    Anderson, S.3    Boland, W.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.