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Volumn 13, Issue 14, 2012, Pages 2128-2136

A Novel Approach to the Discovery of Small-Molecule Ligands of CDK2

(6) Martin, Mathew P a Alam, Riazul a Betzi, Stephane a Ingles, Donna J a Zhu, Jin Yi a Schönbrunn, Ernst a

a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE (United States)

Author keywords

Allosteric inhibitors; Chemical probes; Drug discovery; High throughput screening; Protein protein interaction inhibitors

Indexed keywords

8 ANILINO 1 NAPHTHALENESULFONIC ACID; ADENOSINE TRIPHOSPHATE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR; JWS 648; PURPUROGALLIN; SORAFENIB; STAUROSPORINE; SU 9516; SUNITINIB; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; IC 50; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANILINO NAPHTHALENESULFONATES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASE 2; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; PROTEIN BINDING; PROTEIN KINASE INHIBITORS; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 84866449140 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.201200316 Document Type: Article

Times cited : (67)

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