Identification of a novel in vitro metabonate from liver microsomal incubations

Drug Metabolism and Disposition

Volumn 34, Issue 6, 2006, Pages 901-905

  Li, Chun ^a   Surapaneni, Sekhar ^a   Zeng, QingPing ^a   Marquez, Brian ^a,b   Chow, David ^a   Kumar, Gondi ^a  

^a AMGEN INC   (United States)

^b PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETALDEHYDE; ACETONITRILE; ALCOHOL; CAFFEINE; CARBON; CELL PROTEIN; DIAMINE DERIVATIVE; DIMETHYL SULFOXIDE; DRUG METABOLITE; FORMALDEHYDE; IMIDAZOLINE; METABONIC ACID; METHANOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG METABOLISM; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; LIVER MICROSOME METABOLISM; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT;

ANIMALS; ARTIFACTS; DRUG EVALUATION, PRECLINICAL; ETHANOL; ETHYLENEDIAMINES; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METHANOL; MICROSOMES, LIVER; MOLECULAR STRUCTURE; RATS; SOLVENTS;

ANIMALIA;

EID: 33646814934     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.008367     Document Type: Article

References (8)

1. Beckett AH, van Dyk JM, Chissick HH, and Gorrod JW (1971) Metabolic oxidation on aliphatic basic nitrogen atoms and their -carbon atoms - some unifying principles. J Pharm Pharmacol 23:809-812.
2. Breck G and Trager WA (1971) Mannich intermediate in the formation of a new metabolite of Lidocaine in man. Science (Wash DC) 173:544-546.
3. Chauret N, Gauthier A, and Nicoll-Griffith DA (1998) Effect of common organic solvents on in vitro cytochrome P450-mediated metabolic activities in human liver microsomes. Drug Metab Dispos 26:1-4.
4. Dawidek-Pietryka K, Szczepaniak S, Dudka J, and Mazur M (1998) In vitro studies of human alcohol dehydrogenase inhibition in the process of methanol and ethylene glycol oxidation. Arch Toxicol 72:604-607.
5. Low CM, Ulgen M, and Gorrod JW (1994) The recognition of a diarylimine as a metabonate produced during incubation of N-benzyl-4-chloroaniline with hepatic microsomal preparations. J Pharm Pharmacol 46:585-590.
6. 3-(2,6-dimethylphenyl)-4- imidazolidinone from the reaction of a metabolite of alcohol with a metabolite of Lidocaine. J Med Chem 16:1106-1112.
7. Thompson BB (1968) The Mannich reaction. Mechanistic and technological considerations. J Pharm Sci 57:715.
8. Yin HQ, Tran P, Greenberg GE, and Fischer V (2001) Methanol solvent may cause increased apparent metabolic instability in in vitro assays. Drug Metab Dispos 29:185-193.