High-performance liquid chromatography-mass spectrometry analysis of diltiazem and 11 of its phase I metabolites in human plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 33, Issue 2, 2003, Pages 275-285

  Molden, Espen ^a   Bøe, Grethe Helen ^a   Christensen, Hege ^a   Reubsaet, Leon ^a  

^a UNIVERSITY OF OSLO   (Norway)

Author keywords

Atmospheric pressure chemical ionization; Diltiazem; High performance liquid chromatography; Mass spectrometry; Metabolites; Pharmacokinetics

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CODEINE; DILTIAZEM; DRUG METABOLITE;

ACCURACY; ANALYTIC METHOD; ARTICLE; ATMOSPHERIC PRESSURE; BLOOD SAMPLING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; IONIZATION; NORMAL HUMAN; PLASMA; PRIORITY JOURNAL; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 0041825163     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00259-0     Document Type: Article

References (30)

1. Sugawara Y., Ohashi M., Nakamura S., Usuki S., Suzuki T., Ito Y., Kume T., Harigaya S., Nakao A., Gaino M., et al. J. Pharmacobiodyn. 11:1988;211-223.
2. Yeung P.K., Prescott C., Haddad C., Montague T.J., McGregor C., Quilliam M.A., Xei M., Li R., Farmer P., Klassen G.A. Eur. J. Drug Metab. Pharmacokinet. 18:1993;199-206.
3. Narita H., Otsuka M., Yabana H., Nagao T. J. Pharmacobiodyn. 9:1986;547-553.
4. Yeung P.K., Feng J.D., Buckley S.J. J. Pharm. Pharmacol. 50:1998;1247-1253.
5. Yabana H., Nagao T., Sato M. J. Cardiovasc. Pharmacol. 7:1985;152-157.
6. Kiyomoto A., Sasaki Y., Odawara A., Morita T. Circ. Res. 52:1983;I115-I119.
7. Sutton D., Butler A.M., Nadin L., Murray M. J. Pharmacol. Exp. Ther. 282:1997;294-300.
8. Lamberg T.S., Kivisto K.T., Neuvonen P.J. Clin. Pharmacol. Ther. 63:1998;640-645.
9. Shaughnessy A.F., Mosley M.R. Neurology. 42:1992;937-938.
10. Thomas A.R., Chan L.N., Bauman J.L., Olopade C.O. Pharmacotherapy. 18:1998;381-385.
11. Asberg A., Christensen H., Hartmann A., Carlson E., Molden E., Berg K.J. Eur. J. Clin. Pharmacol. 55:1999;383-387.
12. Azie N.E., Brater D.C., Becker P.A., Jones D.R., Hall S.D. Clin. Pharmacol. Ther. 64:1998;369-377.
13. Backman J.T., Olkkola K.T., Aranko K., Himberg J.J., Neuvonen P.J. Br. J. Clin. Pharmacol. 37:1994;221-225.
14. Mousa O., Brater D.C., Sunblad K.J., Hall S.D. Clin. Pharmacol. Ther. 67:2000;267-274.
15. Hansson L., Hedner T., Lund-Johansen P., Kjeldsen S.E., Lindholm L.H., Syvertsen J.O., Lanke J., de Faire U., Dahlof B., Karlberg B.E. Lancet. 356:2000;359-365.
16. Verghese C., Smith M.S., Aanonsen L., Pritchett E.L., Shand D.G. J. Chromatogr. 272:1983;149-155.
17. Abernethy D.R., Schwartz J.B., Todd E.L. J. Chromatogr. 342:1985;216-220.
18. Goebel K.J., Kolle E.U. J. Chromatogr. 345:1985;355-363.
19. Hoglund P., Nilsson L.G. J. Chromatogr. 414:1987;109-120.
20. Ascalone V., Flaminio L. J. Chromatogr. 495:1989;358-360.
21. Zhao H., Chow M.S. Pharm. Res. 6:1989;428-430.
22. Yeung P.K., Montague T.J., Tsui B., McGregor C. J. Pharm. Sci. 78:1989;592-597.
23. Boulieu R., Bonnefous J.L., Ferry S. J. Chromatogr. 528:1990;542-546.
24. Ververs F.F., Schaefer H.G., Lefevre J.F., Lopez L.M., Derendorf H. J. Pharm. Biomed. Anal. 8:1990;535-539.
25. Rutledge D.R., Abadi A.H., Lopez L.M., Beaudreau C.A. J. Chromatogr. 615:1993;111-116.
26. Ascalone V., Locatelli M., Malavasi B. J. Chromatogr. B Biomed. Appl. 657:1994;133-140.
27. Christensen H., Carlson E., Asberg A., Schram L., Berg K.J. Clin. Chim. Acta. 283:1999;63-75.
28. Molden E., Johansen P.W., Boe G.H., Bergan S., Christensen H., Rugstad H.E., Rootwelt H., Reubsaet L., Lehne G. Clin. Pharmacol. Ther. 72:2002;333-342.
29. Li R., Farmer P.S., Xie M., Quilliam M.A., Pleasance S., Howlett S.E., Yeung P.K. J. Med. Chem. 35:1992;3246-3253.
30. Yeung P.K., Mosher S.J., Klassen G.A., McGilveray I.J. Ther. Drug Monit. 13:1991;369-374.