Cell death features induced in Leishmania major by 1,3,4-thiadiazole derivatives

Experimental Parasitology

Volumn 132, Issue 2, 2012, Pages 116-122

  Ardestani, Sussan K ^a   Poorrajab, Fatemeh ^b   Razmi, Sepideh ^a   Foroumadi, Alireza ^c   Ajdary, Soheila ^d   Gharegozlou, Behnaz ^c   Behrouzi Fardmoghadam, Mina ^c   Shafiee, Abbas ^c  

^a UNIVERSITY OF TEHRAN   (Iran)

^b Shahid Sadouqhi University of Medicinal Science   (Iran)

^c TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^d PASTEUR INSTITUTE OF IRAN   (Iran)

Author keywords

Acid phosphatase; Apoptosis; Leishmania; Necrosis; PolyADP ribose polymerase (PARP)

Indexed keywords

1,3,4 THIADIAZOLE DERIVATIVE; ACID PHOSPHATASE; MEGLUMINE ANTIMONATE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NITROHETEROARYL 1,3,4 THIADIAZOLE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; APOPTOSIS; ARTICLE; CELL DEATH; CELL LOSS; CELL VIABILITY; COLORIMETRY; CONTROLLED STUDY; DNA FRAGMENTATION; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG STRUCTURE; ENZYME ACTIVITY; IC 50; IN VITRO STUDY; LEISHMANIA MAJOR; NICK END LABELING; NONHUMAN; PARASITE DEVELOPMENT; PARASITE VIRULENCE; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN DEGRADATION; PROTEIN LOCALIZATION;

ACID PHOSPHATASE; ANNEXIN A5; DACTINOMYCIN; DNA FRAGMENTATION; FLOW CYTOMETRY; FLUORESCENT DYES; IN SITU NICK-END LABELING; INDICATORS AND REAGENTS; INHIBITORY CONCENTRATION 50; LEISHMANIA MAJOR; POLY(ADP-RIBOSE) POLYMERASES; THIADIAZOLES;

LEISHMANIA MAJOR; MAMMALIA;

EID: 84866415536     PISSN: 00144894     EISSN: 10902449     Source Type: Journal    
DOI: 10.1016/j.exppara.2012.06.002     Document Type: Article

References (45)

1. Aragon V., Kurtz S., Cianciotto N.P. Legionella pneumophila major acid phosphatase and its role in intracellular infection. Infect. Immun. 2001, 69:177-185.
2. Aravinda S., Gopalakrishnan B., Dey C.S., Totey S.M., Pawshe C.H., Salunke D., Kaur K., Shaha C. A testicular protein important for fertility has glutathione S-transferase activity and is localized extracellularly in the seminiferous tubules. J. Biol. Chem. 1995, 270:15675-15685.
3. Arnoult D., Akarid K., Grodet A., Petit P.X., Estaquier J., Ameisen J.C. On the evolution of programmed cell death: apoptosis of the unicellular eukaryote Leishmania major involves cysteine proteinase activation and mitochondrion permeabilization. Cell Death Differ. 2002, 9:65-81.
4. Bailey M.S., Lockwood D.N. Cutaneous leishmaniasis. Clin. Dermatol. 2007, 25:203-211.
5. Bailly C. Topoisomerase I poisons and suppressors as anticancer drugs. Curr. Med. Chem. 2000, 7:39-58.
6. Behrouzi-Fardmoghadam M., Poorrajab F., Ardestani S.K., Emami S., Shafiee A., Foroumadi A. Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines. Bioorg. Med. Chem. 2008, 16:4509-4515.
7. Besteiro S., Williams R.A., Coombs G.H., Mottram J.C. Protein turnover and differentiation in Leishmania. Int. J. Parasitol. 2007, 37:1063-1075.
8. Bodley A.L., McGarry M.W., Shapiro T.A. Drug cytotoxicity assay for African trypanosomes and Leishmania species. J. Infect. Dis. 1995, 172:1157-1159.
9. Brouckaert G., Kalai M., Krysko D.V., Saelens X., Vercammen D., Ndlovu M., Haegeman G., D'Herde K., Vandenabeele P. Phagocytosis of necrotic cells by macrophages is phosphatidylserine dependent and does not induce inflammatory cytokine production. Mol. Biol. Cell 2004, 15:1089-1100.
10. Cocco R.E., Ucker D.S. Distinct modes of macrophage recognition for apoptotic and necrotic cells are not specified exclusively by phosphatidylserine exposure. Mol. Biol. Cell 2001, 12:919-930.
11. Croft S.L., Yardley V. Chemotherapy of leishmaniasis. Curr. Pharm. Des. 2002, 8:319-342.
12. Das B.B., Sengupta T., Ganguly A., Majumder H.K. Topoisomerases of kinetoplastid parasites: why so fascinating?. Mol. Microbiol. 2006, 62:917-927.
13. Das M., Mukherjee S.B., Shaha C. Hydrogen peroxide induces apoptosis-like death in Leishmania donovani promastigotes. J. Cell Sci. 2001, 114:2461-2469.
14. Debrabant A., Lee N., Bertholet S., Duncan R., Nakhasi H.L. Programmed cell death in trypanosomatids and other unicellular organisms. Int. J. Parasitol. 2003, 33:257-267.
15. Elmore S. Apoptosis: a review of programmed cell death. Toxicol. Pathol. 2007, 35:495-516.
16. Festjens N., Vanden Berghe T., Vandenabeele P. Necrosis, a well-orchestrated form of cell demise: signalling cascades, important mediators and concomitant immune response. Biochim. Biophys. Acta 2006, 1757:1371-1387.
17. Fiers W., Beyaert R., Declercq W., Vandenabeele P. More than one way to die: apoptosis, necrosis and reactive oxygen damage. Oncogene 1999, 18:7719-7730.
18. Katakura K., Kobayashi A. Acid phosphatase activity of virulent and avirulent clones of Leishmania donovani promastigotes. Infect. Immun. 1988, 56:2856-2860.
19. Laemmli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
20. Laskay T., van Z.G., Solbach W. Neutrophil granulocytes as host cells and transport vehicles for intracellular pathogens: apoptosis as infection-promoting factor. Immunobiology 2008, 213:183-191.
21. Lee N., Bertholet S., Debrabant A., Muller J., Duncan R., Nakhasi H.L. Programmed cell death in the unicellular protozoan parasite Leishmania. Cell Death Differ. 2002, 9:53-64.
22. Lee N., Gannavaram S., Selvapandiyan A., Debrabant A. Characterization of metacaspases with trypsin-like activity and their putative role in programmed cell death in the protozoan parasite Leishmania. Eukaryot. Cell 2007, 6:1745-1757.
23. Leist M., Jaattela M. Four deaths and a funeral: from caspases to alternative mechanisms. Nat. Rev. Mol. Cell Biol. 2001, 2:589-598.
24. Olivier M., Badaro R., Medrano F.J., Moreno J. The pathogenesis of Leishmania/HIV co-infection: cellular and immunological mechanisms. Ann. Trop. Med. Parasitol. 2003, 97(Suppl 1):79-98.
25. Olivier M., Gregory D.J., Forget G. Subversion mechanisms by which Leishmania parasites can escape the host immune response: a signaling point of view. Clin. Microbiol. Rev. 2005, 18:293-305.
26. Ouellette M., Drummelsmith J., Papadopoulou B. Leishmaniasis: drugs in the clinic, resistance and new developments. Drug Resist. Updat. 2004, 7:257-266.
27. Palchaudhuri R., Hergenrother P.J. DNA as a target for anticancer compounds: methods to determine the mode of binding and the mechanism of action. Curr. Opin. Biotechnol. 2007, 18:497-503.
28. Paris C., Loiseau P.M., Bories C., Breard J. Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes. Antimicrob. Agents Chemother. 2004, 48:852-859.
29. Pasquau F., Ena J., Sanchez R., Cuadrado J.M., Amador C., Flores J., Benito C., Redondo C., Lacruz J., Abril V., Onofre J. Leishmaniasis as an opportunistic infection in HIV-infected patients: determinants of relapse and mortality in a collaborative study of 228 episodes in a Mediterreanean region. Eur. J. Clin. Microbiol. Infect. Dis. 2005, 24:411-418.
30. Pommier Y., Pourquier P., Fan Y., Strumberg D. Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzyme. Biochim. Biophys. Acta 1998, 1400:83-105.
31. Poorrajab F., Ardestani S.K., Emami S., Behrouzi-Fardmoghadam M., Shafiee A., Foroumadi A. Nitroimidazolyl-1,3,4-thiadiazole-based anti-leishmanial agents: synthesis and in vitro biological evaluation. Eur. J. Med. Chem. 2009, 44:1758-1762.
32. Poorrajab F., Ardestani S.K., Foroumadi A., Emami S., Kariminia A., Behrouzi-Fardmoghadam M., Shafiee A. Selective leishmanicidal effect of 1,3,4-thiadiazole derivatives and possible mechanism of action against Leishmania species. Exp. Parasitol. 2009, 121:323-330.
33. Proskuryakov S.Y., Konoplyannikov A.G., Gabai V.L. Necrosis: a specific form of programmed cell death?. Exp. Cell Res. 2003, 283:1-16.
34. Rocha N.A., Silva G.B., Oliveira M.J., Abreu K.L., Franco L.F., Silva M.P., Garcia A.V., Daher E.F. Visceral leishmaniasis in children: a cohort of 120 patients in a metropolitan city of Brazil. Turk. J. Pediatr. 2011, 53(2):154-160.
35. Sen N., Das B.B., Ganguly A., Mukherjee T., Tripathi G., Bandyopadhyay S., Rakshit S., Sen T., Majumder H.K. Camptothecin induced mitochondrial dysfunction leading to programmed cell death in unicellular hemoflagellate Leishmania donovani. Cell Death Differ. 2004, 11:924-936.
36. Sereno D., Holzmuller P., Mangot I., Cuny G., Ouaissi A., Lemesre J.L. Antimonial-mediated DNA fragmentation in Leishmania infantum amastigotes. Antimicrob. Agents Chemother. 2001, 45:2064-2069.
37. Sundar S., Chatterjee M. Visceral leishmaniasis - current therapeutic modalities. Indian J. Med. Res. 2006, 123:345-352.
38. Tentori L., Graziani G. Chemopotentiation by PARP inhibitors in cancer therapy. Pharmacol. Res. 2005, 52:25-33.
39. van Z.G., Bollinger A., Wenzel A., Kamhawi S., Voll R., Klinger M., Muller A., Holscher C., Herrmann M., Sacks D., Solbach W., Laskay T. Leishmania disease development depends on the presence of apoptotic promastigotes in the virulent inoculum. Proc. Natl. Acad. Sci. USA 2006, 103:13837-13842.
40. Vannier-Santos M.A., Martiny A., de S.W. Cell biology of Leishmania spp.: invading and evading. Curr. Pharm. Des. 2002, 8:297-318.
41. Verma N.K., Dey C.S. Possible mechanism of miltefosine-mediated death of Leishmania donovani. Antimicrob. Agents Chemother. 2004, 48:3010-3015.
42. Wanderley J.L., Moreira M.E., Benjamin A., Bonomo A.C., Barcinski M.A. Mimicry of apoptotic cells by exposing phosphatidylserine participates in the establishment of amastigotes of Leishmania (L) amazonensis in mammalian hosts. J. Immunol. 2006, 176:1834-1839.
43. Werbovetz K.A. Target-based drug discovery for malaria, leishmaniasis, and trypanosomiasis. Curr. Med. Chem. 2000, 7:835-860.
44. Wilson W.D., Tanious F.A., Mathis A., Tevis D., Hall J.E., Boykin D.W. Antiparasitic compounds that target DNA. Biochimie 2008, 90:999-1014.
45. Zangger H., Mottram J.C., Fasel N. Cell death in Leishmania induced by stress and differentiation: programmed cell death or necrosis?. Cell Death Differ. 2002, 9:1126-1139.