메뉴 건너뛰기




Volumn 222, Issue 1, 2000, Pages 71-83

A large targeted deletion of Hoxb1-Hoxb9 produces a series of single- segment anterior homeotic transformations

Author keywords

Chromosomal engineering; Hox clusters; Large targeted deletion

Indexed keywords

ARTICLE; BRAIN DEVELOPMENT; GENE CLUSTER; GENE CONTROL; GENE DELETION; HETEROZYGOTE; HOMEOBOX; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM;

EID: 0343618784     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.2000.9683     Document Type: Article
Times cited : (61)

References (81)
  • 1
    • 0029151567 scopus 로고
    • Malformations of the heart, kidney, palate, and skeleton in alpha-mhc-hoxb-7 transgenic mice
    • Argao E. A., Kern M. J., Branford W. W., Scott W. J., Potter S. S. Malformations of the heart, kidney, palate, and skeleton in alpha-mhc-hoxb-7 transgenic mice. Mech. Dev. 52:1995;291-303.
    • (1995) Mech. Dev. , vol.52 , pp. 291-303
    • Argao, E.A.1    Kern, M.J.2    Branford, W.W.3    Scott, W.J.4    Potter, S.S.5
  • 2
    • 0030854106 scopus 로고    scopus 로고
    • Phylogenetic reconstruction of vertebrate Hox cluster duplications
    • Bailey W. J., Kin J., Wagner G. P., Ruddle F. H. Phylogenetic reconstruction of vertebrate Hox cluster duplications. Mol. Biol. Evol. 14:1997;843-853.
    • (1997) Mol. Biol. Evol. , vol.14 , pp. 843-853
    • Bailey, W.J.1    Kin, J.2    Wagner, G.P.3    Ruddle, F.H.4
  • 3
    • 0024353975 scopus 로고
    • Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice
    • Balling R., Mutter G., Gruss P., Kessel M. Craniofacial abnormalities induced by ectopic expression of the homeobox gene Hox-1.1 in transgenic mice. Cell. 58:1989;337-347.
    • (1989) Cell , vol.58 , pp. 337-347
    • Balling, R.1    Mutter, G.2    Gruss, P.3    Kessel, M.4
  • 4
    • 0030481054 scopus 로고    scopus 로고
    • Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4
    • Barrow J. R., Capecchi M. R. Targeted disruption of the Hoxb-2 locus in mice interferes with expression of Hoxb-1 and Hoxb-4. Development. 122:1996;3817-3828.
    • (1996) Development , vol.122 , pp. 3817-3828
    • Barrow, J.R.1    Capecchi, M.R.2
  • 5
    • 0029767416 scopus 로고    scopus 로고
    • Function of homeobox genes in skeletal development
    • Capecchi M. R. Function of homeobox genes in skeletal development. Ann. N. Y. Acad. Sci. 785:1996;34-37.
    • (1996) Ann. N. Y. Acad. Sci. , vol.785 , pp. 34-37
    • Capecchi, M.R.1
  • 6
    • 0027249799 scopus 로고
    • Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain
    • Carpenter E. M., Goddard J. M., Chisaka O., Manley N. R., Capecchi M. R. Loss of Hox-A1 (Hox-1.6) function results in the reorganization of the murine hindbrain. Development. 118:1993;1063-1075.
    • (1993) Development , vol.118 , pp. 1063-1075
    • Carpenter, E.M.1    Goddard, J.M.2    Chisaka, O.3    Manley, N.R.4    Capecchi, M.R.5
  • 7
    • 0029155724 scopus 로고
    • Specification of multiple vertebral identities by ectopically expressed Hoxb-8
    • Charite J., de Graaff W., Deschamps J. Specification of multiple vertebral identities by ectopically expressed Hoxb-8. Dev. Dyn. 204:1995;13-21.
    • (1995) Dev. Dyn. , vol.204 , pp. 13-21
    • Charite, J.1    De Graaff, W.2    Deschamps, J.3
  • 8
    • 0031568299 scopus 로고    scopus 로고
    • Targeted mutations in Hoxa-9 and Hoxb-9 reveal synergistic interactions
    • Chen F., Capecchi M. R. Targeted mutations in Hoxa-9 and Hoxb-9 reveal synergistic interactions. Dev. Biol. 181:1997;186-196.
    • (1997) Dev. Biol. , vol.181 , pp. 186-196
    • Chen, F.1    Capecchi, M.R.2
  • 9
    • 0000336513 scopus 로고    scopus 로고
    • Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy
    • Chen F., Capecchi M. R. Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc. Natl. Acad. Sci. USA. 96:1999;541-546.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 541-546
    • Chen, F.1    Capecchi, M.R.2
  • 10
    • 0032171061 scopus 로고    scopus 로고
    • Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae
    • Chen F., Greer J., Capecchi M. R. Analysis of Hoxa7/Hoxb7 mutants suggests periodicity in the generation of the different sets of vertebrae. Mech. Dev. 77:1998;49-57.
    • (1998) Mech. Dev. , vol.77 , pp. 49-57
    • Chen, F.1    Greer, J.2    Capecchi, M.R.3
  • 11
    • 77049140225 scopus 로고
    • Studies on the morphogenesis of the mouse sternum (I. Normal embryonic development)
    • Chen J. M. Studies on the morphogenesis of the mouse sternum (I. Normal embryonic development). J. Anat. 86:1952;373-386.
    • (1952) J. Anat. , vol.86 , pp. 373-386
    • Chen, J.M.1
  • 12
    • 0025797513 scopus 로고
    • Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5
    • Chisaka O., Capecchi M. R. Regionally restricted developmental defects resulting from targeted disruption of the mouse homeobox gene hox-1.5. Nature. 350:1991;473-479.
    • (1991) Nature , vol.350 , pp. 473-479
    • Chisaka, O.1    Capecchi, M.R.2
  • 13
    • 0026599290 scopus 로고
    • Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6
    • Chisaka O., Musci T. S., Capecchi M. R. Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6. Nature. 355:1992;516-520.
    • (1992) Nature , vol.355 , pp. 516-520
    • Chisaka, O.1    Musci, T.S.2    Capecchi, M.R.3
  • 14
    • 0027375604 scopus 로고
    • Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis
    • Condie B. G., Capecchi M. R. Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development. 119:1993;579-595.
    • (1993) Development , vol.119 , pp. 579-595
    • Condie, B.G.1    Capecchi, M.R.2
  • 15
    • 0028124772 scopus 로고
    • Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions
    • Condie B. G., Capecchi M. R. Mice with targeted disruptions in the paralogous genes hoxa-3 and hoxd-3 reveal synergistic interactions. Nature. 370:1994;304-307.
    • (1994) Nature , vol.370 , pp. 304-307
    • Condie, B.G.1    Capecchi, M.R.2
  • 16
    • 0033119868 scopus 로고    scopus 로고
    • Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain
    • Davenne M., Maconochie M. K., Neun R., Pattyn A., Chambon P., Krumlauf R., Rijli F. M. Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron. 22:1999;677-691.
    • (1999) Neuron , vol.22 , pp. 677-691
    • Davenne, M.1    Maconochie, M.K.2    Neun, R.3    Pattyn, A.4    Chambon, P.5    Krumlauf, R.6    Rijli, F.M.7
  • 17
    • 0024341769 scopus 로고
    • The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes
    • Duboule D., Dolle P. The structural and functional organization of the murine HOX gene family resembles that of Drosophila homeotic genes. EMBO J. 8:1989;1497-1505.
    • (1989) EMBO J. , vol.8 , pp. 1497-1505
    • Duboule, D.1    Dolle, P.2
  • 18
    • 0027932522 scopus 로고
    • Colinearity and functional hierarchy among genes of the homeotic complexes
    • Duboule D., Morata G. Colinearity and functional hierarchy among genes of the homeotic complexes. Trends Genet. 10:1994;358-364.
    • (1994) Trends Genet. , vol.10 , pp. 358-364
    • Duboule, D.1    Morata, G.2
  • 20
    • 0029091902 scopus 로고
    • Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus
    • Fiering S., Epner E., Robinson K., Zhuang Y., Telling A., Hu M., Martin D. I., Enver T., Ley T. J., Groudine M. Targeted deletion of 5′HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus. Genes Dev. 9:1995;2203-2213.
    • (1995) Genes Dev. , vol.9 , pp. 2203-2213
    • Fiering, S.1    Epner, E.2    Robinson, K.3    Zhuang, Y.4    Telling, A.5    Hu, M.6    Martin, D.I.7    Enver, T.8    Ley, T.J.9    Groudine, M.10
  • 21
    • 0027305095 scopus 로고
    • An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: Analysis of the β-globin locus control region
    • Fiering S., Kim C. G., Epner E. M., Groudine M. An "in-out" strategy using gene targeting and FLP recombinase for the functional dissection of complex DNA regulatory elements: Analysis of the β-globin locus control region. Proc. Natl. Acad. Sci. USA. 90:1993;8469-8473.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8469-8473
    • Fiering, S.1    Kim, C.G.2    Epner, E.M.3    Groudine, M.4
  • 23
    • 0028065237 scopus 로고
    • Archetypal organization of the amphioxus Hox gene cluster
    • García-Fernández J., Holland P. W. H. Archetypal organization of the amphioxus Hox gene cluster. Nature. 370:1994;563-566.
    • (1994) Nature , vol.370 , pp. 563-566
    • García-Fernández, J.1    Holland, P.W.H.2
  • 24
    • 0024273538 scopus 로고
    • Spatially restricted domains of homeo-gene transcripts in mouse embryos: Relation to a segmented body plan
    • Gaunt S., Sharpe P., Duboule D. Spatially restricted domains of homeo-gene transcripts in mouse embryos: Relation to a segmented body plan. Development Suppl. 104:1988;169-179.
    • (1988) Development Suppl. , vol.104 , pp. 169-179
    • Gaunt, S.1    Sharpe, P.2    Duboule, D.3
  • 25
    • 0024432982 scopus 로고
    • Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- And tissue-dependent differences in their regulation
    • Gaunt S. J., Krumlauf R., Duboule D. Mouse homeo-genes within a subfamily, Hox-1.4, -2.6 and -5.1, display similar anteroposterior domains of expression in the embryo, but show stage- and tissue-dependent differences in their regulation. Development. 107:1989;131-141.
    • (1989) Development , vol.107 , pp. 131-141
    • Gaunt, S.J.1    Krumlauf, R.2    Duboule, D.3
  • 26
    • 0031894362 scopus 로고    scopus 로고
    • Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch
    • Gavalas A., Studer M., Lumsden A., Rijli F. M., Krumlauf R., Chambon P. Hoxa1 and Hoxb1 synergize in patterning the hindbrain, cranial nerves and second pharyngeal arch. Development. 125:1998;1123-1136.
    • (1998) Development , vol.125 , pp. 1123-1136
    • Gavalas, A.1    Studer, M.2    Lumsden, A.3    Rijli, F.M.4    Krumlauf, R.5    Chambon, P.6
  • 27
    • 0029824070 scopus 로고    scopus 로고
    • Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve
    • Goddard J. M., Rossei M., Manley N. R., Capecchi M. R. Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve. Development. 122:1996;3217-3228.
    • (1996) Development , vol.122 , pp. 3217-3228
    • Goddard, J.M.1    Rossei, M.2    Manley, N.R.3    Capecchi, M.R.4
  • 28
    • 0031882022 scopus 로고    scopus 로고
    • Hoxc13 mutant mice lack external hair
    • Godwin A., Capecchi M. Hoxc13 mutant mice lack external hair. Genes Dev. 12:1998;11-20.
    • (1998) Genes Dev. , vol.12 , pp. 11-20
    • Godwin, A.1    Capecchi, M.2
  • 29
    • 0031003129 scopus 로고    scopus 로고
    • Positive cross-regulation and enhancer sharing: Two mechanisms for specifying overlapping Hox expression patterns
    • Gould A., Morrison A., Sproat G., White R. A., Krumlauf R. Positive cross-regulation and enhancer sharing: Two mechanisms for specifying overlapping Hox expression patterns. Genes Dev. 11:1997;900-913.
    • (1997) Genes Dev. , vol.11 , pp. 900-913
    • Gould, A.1    Morrison, A.2    Sproat, G.3    White, R.A.4    Krumlauf, R.5
  • 30
    • 0024589805 scopus 로고
    • The murine and Drosophila homeobox gene complexes have common features of organization and expression
    • Graham A., Papalopulu N., Krumlauf R. The murine and Drosophila homeobox gene complexes have common features of organization and expression. Cell. 57:1989;367-378.
    • (1989) Cell , vol.57 , pp. 367-378
    • Graham, A.1    Papalopulu, N.2    Krumlauf, R.3
  • 32
    • 0029045063 scopus 로고
    • Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function
    • Horan G., Kovacs E., Behringer R., Featherstone M. Mutations in paralogous Hox genes result in overlapping homeotic transformations of the axial skeleton: Evidence for unique and redundant function. Dev. Biol. 169:1995a;359-372.
    • (1995) Dev. Biol. , vol.169 , pp. 359-372
    • Horan, G.1    Kovacs, E.2    Behringer, R.3    Featherstone, M.4
  • 33
    • 0029143166 scopus 로고
    • Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed
    • Horan G., Ramirez-Solis R., Featherstone M., Wolgemuth D., Bradley A., Behringer R. Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed. Genes Dev. 9:1995b;1667-1677.
    • (1995) Genes Dev. , vol.9 , pp. 1667-1677
    • Horan, G.1    Ramirez-Solis, R.2    Featherstone, M.3    Wolgemuth, D.4    Bradley, A.5    Behringer, R.6
  • 35
    • 0027517719 scopus 로고
    • Specification of axial identity in the mouse: Role of the Hoxa-5 (Hox1.3) gene
    • Jeannotte L., Lemieux M., Charron J., Poirier F., Robertson E. J. Specification of axial identity in the mouse: Role of the Hoxa-5 (Hox1.3) gene. Genes Dev. 7:1993;2085-2096.
    • (1993) Genes Dev. , vol.7 , pp. 2085-2096
    • Jeannotte, L.1    Lemieux, M.2    Charron, J.3    Poirier, F.4    Robertson, E.J.5
  • 36
    • 0024707103 scopus 로고
    • Two steps in the evolution of Antennapedia-class vertebrate homeobox genes
    • Kappen C., Schughart K., Ruddle F. Two steps in the evolution of Antennapedia-class vertebrate homeobox genes. Evolution. 86:1989;5459-5463.
    • (1989) Evolution , vol.86 , pp. 5459-5463
    • Kappen, C.1    Schughart, K.2    Ruddle, F.3
  • 37
    • 0025342695 scopus 로고
    • Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice
    • Kessel M., Balling R., Gruss P. Variations of cervical vertebrae after expression of a Hox-1.1 transgene in mice. Cell. 61:1990;301-308.
    • (1990) Cell , vol.61 , pp. 301-308
    • Kessel, M.1    Balling, R.2    Gruss, P.3
  • 38
    • 0025941823 scopus 로고
    • Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
    • Kessel M., Gruss P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell. 67:1991;89-104.
    • (1991) Cell , vol.67 , pp. 89-104
    • Kessel, M.1    Gruss, P.2
  • 39
    • 0028351367 scopus 로고
    • Hox genes and regionalization of the nervous system
    • Keynes R., Krumlauf R. Hox genes and regionalization of the nervous system. Annu. Rev. Neurosci. 17:1994;109-132.
    • (1994) Annu. Rev. Neurosci. , vol.17 , pp. 109-132
    • Keynes, R.1    Krumlauf, R.2
  • 40
    • 0033617267 scopus 로고    scopus 로고
    • Breaking colinearity in the mouse HoxD complex
    • Kondo T., Duboule D. Breaking colinearity in the mouse HoxD complex. Cell. 97:1999;407-417.
    • (1999) Cell , vol.97 , pp. 407-417
    • Kondo, T.1    Duboule, D.2
  • 41
    • 0000368049 scopus 로고    scopus 로고
    • Control of colinearity in AbdB genes of the mouse HoxD complex
    • Kondo T., Zákány J., Duboule D. Control of colinearity in AbdB genes of the mouse HoxD complex. Mol. Cell. 1:1998;289-300.
    • (1998) Mol. Cell , vol.1 , pp. 289-300
    • Kondo, T.1    Zákány, J.2    Duboule, D.3
  • 42
    • 0028226038 scopus 로고
    • Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column
    • Kostic D., Capecchi M. R. Targeted disruptions of the murine Hoxa-4 and Hoxa-6 genes result in homeotic transformations of components of the vertebral column. Mech. Dev. 46:1994;231-247.
    • (1994) Mech. Dev. , vol.46 , pp. 231-247
    • Kostic, D.1    Capecchi, M.R.2
  • 43
    • 0027953771 scopus 로고
    • Hox genes in vertebrate development
    • Krumlauf R. Hox genes in vertebrate development. Cell. 78:1994;191-201.
    • (1994) Cell , vol.78 , pp. 191-201
    • Krumlauf, R.1
  • 44
    • 0026602808 scopus 로고
    • Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene
    • Le Mouellic H., Lallemand Y., Brulet P. Homeosis in the mouse induced by a null mutation in the Hox-3.1 gene. Cell. 69:1992;251-264.
    • (1992) Cell , vol.69 , pp. 251-264
    • Le Mouellic, H.1    Lallemand, Y.2    Brulet, P.3
  • 45
    • 0018240421 scopus 로고
    • A gene complex controlling segmentation in Drosophila
    • Lewis E. A gene complex controlling segmentation in Drosophila. Nature. 276:1978;565-570.
    • (1978) Nature , vol.276 , pp. 565-570
    • Lewis, E.1
  • 46
    • 0031770040 scopus 로고    scopus 로고
    • Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11
    • Liu P., Zhang H., McLellan A., Vogel H., Bradley A. Embryonic lethality and tumorigenesis caused by segmental aneuploidy on mouse chromosome 11. Genetics. 150:1998;1155-1168.
    • (1998) Genetics , vol.150 , pp. 1155-1168
    • Liu, P.1    Zhang, H.2    McLellan, A.3    Vogel, H.4    Bradley, A.5
  • 47
    • 0025864268 scopus 로고
    • Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression
    • Lufkin T., Dierich A., LeMeur M., Mark M., Chambon P. Disruption of the Hox-1.6 homeobox gene results in defects in a region corresponding to its rostral domain of expression. Cell. 66:1991a;1105-1119.
    • (1991) Cell , vol.66 , pp. 1105-1119
    • Lufkin, T.1    Dierich, A.2    Lemeur, M.3    Mark, M.4    Chambon, P.5
  • 48
    • 0025941823 scopus 로고
    • Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid
    • Lufkin T., Dierich A., LeMeur M., Mark M., Chambon P. Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid. Cell. 67:1991b;89-104.
    • (1991) Cell , vol.67 , pp. 89-104
    • Lufkin, T.1    Dierich, A.2    Lemeur, M.3    Mark, M.4    Chambon, P.5
  • 49
    • 0026497470 scopus 로고
    • Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene
    • Lufkin T., Mark M., Hart C., Dolle P., Lemeur M., Chambon P. Homeotic transformation of the occipital bones of the skull by ectopic expression of a homeobox gene. Nature. 359:1992;835-841.
    • (1992) Nature , vol.359 , pp. 835-841
    • Lufkin, T.1    Mark, M.2    Hart, C.3    Dolle, P.4    Lemeur, M.5    Chambon, P.6
  • 50
    • 0031573959 scopus 로고    scopus 로고
    • Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures
    • Manley N., Capecchi M. Hox group 3 paralogous genes act synergistically in the formation of somitic and neural crest-derived structures. Dev. Biol. 192:1997;274-288.
    • (1997) Dev. Biol. , vol.192 , pp. 274-288
    • Manley, N.1    Capecchi, M.2
  • 51
    • 0029030722 scopus 로고
    • The role of Hoxa-3 in mouse thymus and thyroid development
    • Manley N. R., Capecchi M. R. The role of Hoxa-3 in mouse thymus and thyroid development. Development. 121:1995;1989-2003.
    • (1995) Development , vol.121 , pp. 1989-2003
    • Manley, N.R.1    Capecchi, M.R.2
  • 52
    • 0032030895 scopus 로고    scopus 로고
    • Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands
    • Manley N. R., Capecchi M. R. Hox group 3 paralogs regulate the development and migration of the thymus, thyroid, and parathyroid glands. Dev. Biol. 195:1998;1-15.
    • (1998) Dev. Biol. , vol.195 , pp. 1-15
    • Manley, N.R.1    Capecchi, M.R.2
  • 54
    • 0027070522 scopus 로고
    • Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice
    • McLain K., Schreiner C., Yager K. L., Stock J. L., Potter S. S. Ectopic expression of Hox-2.3 induces craniofacial and skeletal malformations in transgenic mice. Mech. Dev. 39:1992;3-16.
    • (1992) Mech. Dev. , vol.39 , pp. 3-16
    • McLain, K.1    Schreiner, C.2    Yager, K.L.3    Stock, J.L.4    Potter, S.S.5
  • 55
    • 0030002141 scopus 로고    scopus 로고
    • The molecular basis of hypodactyly (Hd): A deletion in Hoxa13 leads to arrest of digital arch formation
    • Mortlock D. P., Post L. C., Innis J. W. The molecular basis of hypodactyly (Hd): A deletion in Hoxa13 leads to arrest of digital arch formation. Nat. Genet. 13:1996;284-289.
    • (1996) Nat. Genet. , vol.13 , pp. 284-289
    • Mortlock, D.P.1    Post, L.C.2    Innis, J.W.3
  • 56
    • 0029871929 scopus 로고    scopus 로고
    • Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13
    • Muragaki Y., Mundlos S., Upton J., Olsen B. J. Altered growth and branching patterns in synpolydactyly caused by mutations in HOXD13. Science. 272:1996;548-551.
    • (1996) Science , vol.272 , pp. 548-551
    • Muragaki, Y.1    Mundlos, S.2    Upton, J.3    Olsen, B.J.4
  • 57
    • 0030035153 scopus 로고    scopus 로고
    • Genomic structure of HOXD13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families
    • Nurten Akarsu A., Stoilov I., Yilmaz E., Sayli B. S., Sarfarazi M. Genomic structure of HOXD13 gene: A nine polyalanine duplication causes synpolydactyly in two unrelated families. Hum. Mol. Genet. 5:1996;945-952.
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 945-952
    • Nurten Akarsu, A.1    Stoilov, I.2    Yilmaz, E.3    Sayli, B.S.4    Sarfarazi, M.5
  • 58
    • 0027189536 scopus 로고
    • Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments
    • Ramirez Solis R., Zheng H., Whiting J., Krumlauf R., Bradley A. Hoxb-4 (Hox-2.6) mutant mice show homeotic transformation of a cervical vertebra and defects in the closure of the sternal rudiments. Cell. 73:1993;279-294.
    • (1993) Cell , vol.73 , pp. 279-294
    • Ramirez Solis, R.1    Zheng, H.2    Whiting, J.3    Krumlauf, R.4    Bradley, A.5
  • 60
    • 0029562967 scopus 로고
    • Chromosome engineering in mice
    • Ramirez-Solis R., Liu P., Bradley A. Chromosome engineering in mice. Nature. 378:1995;720-724.
    • (1995) Nature , vol.378 , pp. 720-724
    • Ramirez-Solis, R.1    Liu, P.2    Bradley, A.3
  • 62
    • 0028859990 scopus 로고
    • Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation
    • Rancourt D. E., Tsuzuki T., Capecchi M. R. Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation. Genes Dev. 9:1995;108-122.
    • (1995) Genes Dev. , vol.9 , pp. 108-122
    • Rancourt, D.E.1    Tsuzuki, T.2    Capecchi, M.R.3
  • 63
    • 0028606333 scopus 로고
    • Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression
    • Rijli F. M., Dolle P., Fraulob V., LeMeur M., Chambon P. Insertion of a targeting construct in a Hoxd-10 allele can influence the control of Hoxd-9 expression. Dev. Dyn. 201:1994;366-377.
    • (1994) Dev. Dyn. , vol.201 , pp. 366-377
    • Rijli, F.M.1    Dolle, P.2    Fraulob, V.3    Lemeur, M.4    Chambon, P.5
  • 64
    • 0027739813 scopus 로고
    • A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene
    • Rijli F. M., Mark M., Lakkaraju S., Dierich A., Dolle P., Chambon P. A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene. Cell. 75:1993;1333-1349.
    • (1993) Cell , vol.75 , pp. 1333-1349
    • Rijli, F.M.1    Mark, M.2    Lakkaraju, S.3    Dierich, A.4    Dolle, P.5    Chambon, P.6
  • 66
    • 0029936703 scopus 로고    scopus 로고
    • Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process
    • Saegusa H., Takahashi N., Noguchi S., Suemori H. Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process. Dev. Biol. 174:1996;55-64.
    • (1996) Dev. Biol. , vol.174 , pp. 55-64
    • Saegusa, H.1    Takahashi, N.2    Noguchi, S.3    Suemori, H.4
  • 67
    • 0026520839 scopus 로고
    • Analysis of the murine Hox-2.7 gene: Conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions
    • Sham M. H., Hunt P., Nonchev S., Papalopulu N., Graham A., Boncinelli E., Krumlauf R. Analysis of the murine Hox-2.7 gene: Conserved alternative transcripts with differential distributions in the nervous system and the potential for shared regulatory regions. EMBO J. 11:1992;1825-1836.
    • (1992) EMBO J. , vol.11 , pp. 1825-1836
    • Sham, M.H.1    Hunt, P.2    Nonchev, S.3    Papalopulu, N.4    Graham, A.5    Boncinelli, E.6    Krumlauf, R.7
  • 68
    • 0032536818 scopus 로고    scopus 로고
    • Selectivity, sharing and competitive interactions in the regulation of Hoxb genes
    • Sharpe J., Nonchev S., Gould A., Whiting J., Krumlauf R. Selectivity, sharing and competitive interactions in the regulation of Hoxb genes. EMBO J. 17:1998;1788-1798.
    • (1998) EMBO J. , vol.17 , pp. 1788-1798
    • Sharpe, J.1    Nonchev, S.2    Gould, A.3    Whiting, J.4    Krumlauf, R.5
  • 69
    • 0027131262 scopus 로고
    • Homeotic transformations and limb defects in Hox A11 mutant mice
    • Small K. M., Potter S. S. Homeotic transformations and limb defects in Hox A11 mutant mice. Genes Dev. 7:1993;2318-2328.
    • (1993) Genes Dev. , vol.7 , pp. 2318-2328
    • Small, K.M.1    Potter, S.S.2
  • 70
    • 0025971766 scopus 로고
    • A deficiency of the homeotic complex in the beetle Tribolium
    • Stuart J. J., Brown S. J., Beeman R. W., Denell R. E. A deficiency of the homeotic complex in the beetle Tribolium. Nature. 350:1991;72-74.
    • (1991) Nature , vol.350 , pp. 72-74
    • Stuart, J.J.1    Brown, S.J.2    Beeman, R.W.3    Denell, R.E.4
  • 71
    • 0030447736 scopus 로고    scopus 로고
    • Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1
    • Studer M., Lumsden A., Ariza-McNaughton L., Bradley A., Krumlauf R. Altered segmental identity and abnormal migration of motor neurons in mice lacking Hoxb-1. Nature. 384:1996;630-634.
    • (1996) Nature , vol.384 , pp. 630-634
    • Studer, M.1    Lumsden, A.2    Ariza-Mcnaughton, L.3    Bradley, A.4    Krumlauf, R.5
  • 72
    • 0029035611 scopus 로고
    • Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs
    • Suemori H., Takahashi N., Noguchi S. Hoxc-9 mutant mice show anterior transformation of the vertebrae and malformation of the sternum and ribs. Mech. Dev. 51:1995;265-273.
    • (1995) Mech. Dev. , vol.51 , pp. 265-273
    • Suemori, H.1    Takahashi, N.2    Noguchi, S.3
  • 73
    • 0030604724 scopus 로고    scopus 로고
    • Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls
    • van der Hoeven F., Zakany J., Duboule D. Gene transpositions in the HoxD complex reveal a hierarchy of regulatory controls. Cell. 85:1996;1025-1035.
    • (1996) Cell , vol.85 , pp. 1025-1035
    • Van Der Hoeven, F.1    Zakany, J.2    Duboule, D.3
  • 74
    • 0026684136 scopus 로고
    • Expression and modification of Hox-2.1 protein in mouse embryos
    • Wall N. A., Jones C. M., Hogan B. L. M., Wright C. V. E. Expression and modification of Hox-2.1 protein in mouse embryos. Mech. Dev. 37:1992;111-120.
    • (1992) Mech. Dev. , vol.37 , pp. 111-120
    • Wall, N.A.1    Jones, C.M.2    Hogan, B.L.M.3    Wright, C.V.E.4
  • 75
    • 0026005506 scopus 로고
    • Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression
    • Whiting J., Marshall H., Cook M., Krumlauf R., Rigby P. W. J., Stott D., Allemann R. K. Multiple spatially specific enhancers are required to reconstruct the pattern of Hox-2.6 gene expression. Genes Dev. 5:1991;2048-2059.
    • (1991) Genes Dev. , vol.5 , pp. 2048-2059
    • Whiting, J.1    Marshall, H.2    Cook, M.3    Krumlauf, R.4    Rigby, P.W.J.5    Stott, D.6    Allemann, R.K.7
  • 76
    • 0027445532 scopus 로고
    • Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts
    • Wilkinson D. G., Nieto M. A. Detection of messenger RNA by in situ hybridization to tissue sections and whole mounts. Methods Enzymol. 225:1993;361-373.
    • (1993) Methods Enzymol. , vol.225 , pp. 361-373
    • Wilkinson, D.G.1    Nieto, M.A.2
  • 77
    • 0024544976 scopus 로고
    • Transgenic mice overexpressing the mouse homeobox-containing gene Hox-1.4 exhibit abnormal gut development
    • Wolgemuth D. J., Behringer R. R., Mostoller M. P., Brinster R. L., Palmiter R. D. Transgenic mice overexpressing the mouse homeobox-containing gene Hox-1.4 exhibit abnormal gut development. Nature. 337:1989;464-467.
    • (1989) Nature , vol.337 , pp. 464-467
    • Wolgemuth, D.J.1    Behringer, R.R.2    Mostoller, M.P.3    Brinster, R.L.4    Palmiter, R.D.5
  • 78
    • 0024436103 scopus 로고
    • Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord
    • Wright C. V. E., Cho K. W. Y., Hardwicke J., Collins R. H., De Robertis E. M. Interference with function of a homeobox gene in Xenopus embryos produces malformations of the anterior spinal cord. Cell. 59:1989;81-93.
    • (1989) Cell , vol.59 , pp. 81-93
    • Wright, C.V.E.1    Cho, K.W.Y.2    Hardwicke, J.3    Collins, R.H.4    De Robertis, E.M.5
  • 79
    • 0029854152 scopus 로고    scopus 로고
    • Synpolydactyly in mice with a targeted deficiency in the HoxD complex
    • Zakany J., Duboule D. Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Nature. 384:1996;69-71.
    • (1996) Nature , vol.384 , pp. 69-71
    • Zakany, J.1    Duboule, D.2
  • 80
    • 0342872062 scopus 로고    scopus 로고
    • Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum
    • Zakany J., Gerard M., Favier B., Duboule D. Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 16:1997;4393-4402.
    • (1997) EMBO J. , vol.16 , pp. 4393-4402
    • Zakany, J.1    Gerard, M.2    Favier, B.3    Duboule, D.4
  • 81
    • 0029840724 scopus 로고    scopus 로고
    • Hoxb-13: A new Hox gene in a distant region of the HOXB cluster maintains colinearity
    • Zeltser L., Desplan C., Heintz N. Hoxb-13: A new Hox gene in a distant region of the HOXB cluster maintains colinearity. Development. 122:1996;2475-2484.
    • (1996) Development , vol.122 , pp. 2475-2484
    • Zeltser, L.1    Desplan, C.2    Heintz, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.