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Volumn 135, Issue 9, 2012, Pages 2817-2825

Decreased carbon-11-flumazenil binding in early Alzheimer's disease

Author keywords

Alzheimer's disease; flumazenil PET; GABA A receptors; MRI

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; FLUMAZENIL C 11; FLUORODEOXYGLUCOSE F 18;

EID: 84866396395     PISSN: 00068950     EISSN: 14602156     Source Type: Journal    
DOI: 10.1093/brain/aws210     Document Type: Article
Times cited : (38)

References (48)
  • 2
    • 34548832230 scopus 로고    scopus 로고
    • A fast diffeomorphic image registration algorithm
    • Ashburner J. A fast diffeomorphic image registration algorithm. Neuroimage 2007; 38: 95-113.
    • (2007) Neuroimage , vol.38 , pp. 95-113
    • Ashburner, J.1
  • 3
    • 33748464610 scopus 로고    scopus 로고
    • Mapping the relative contribution of gray matter activity vs. volume in brain PET: A new approach
    • Berkouk K, Quarantelli M, Prinster A, Landeau B, Alfano B, Baron JC. Mapping the relative contribution of gray matter activity vs. volume in brain PET: a new approach. J Neuroimaging 2006; 16: 224-35.
    • (2006) J Neuroimaging , vol.16 , pp. 224-235
    • Berkouk, K.1    Quarantelli, M.2    Prinster, A.3    Landeau, B.4    Alfano, B.5    Baron, J.C.6
  • 4
    • 0019440757 scopus 로고
    • Regional pattern of degeneration in Alzheimer's disease: Neuronal loss and histopathological grading
    • Brun A, Englund E. Regional pattern of degeneration in Alzheimer's disease: neuronal loss and histopathological grading. Histopathology 1981; 5: 549-64.
    • (1981) Histopathology , vol.5 , pp. 549-564
    • Brun, A.1    Englund, E.2
  • 6
    • 37549004296 scopus 로고    scopus 로고
    • Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease
    • Chetelat G, Desgranges B, Landeau B, Mezenge F, Poline JB, de la Sayette V, et al. Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease. Brain 2008; 131: 60-71.
    • (2008) Brain , vol.131 , pp. 60-71
    • Chetelat, G.1    Desgranges, B.2    Landeau, B.3    Mezenge, F.4    Poline, J.B.5    De La Sayette, V.6
  • 8
    • 0023161657 scopus 로고
    • Cortical GABAB and GABAA receptors in Alzheimer's disease: A quantitative autoradiographic study
    • Chu DC, Penney JB Jr., Young AB. Cortical GABAB and GABAA receptors in Alzheimer's disease: a quantitative autoradiographic study. Neurology 1987; 37: 1454-9.
    • (1987) Neurology , vol.37 , pp. 1454-1459
    • Chu, D.C.1    Penney, Jr.J.B.2    Young, A.B.3
  • 9
    • 0023762975 scopus 로고
    • Clinico-pathologic studies in dementia: Nondemented subjects with pathologically confirmed Alzheimer's disease
    • Crystal H, Dickson D, Fuld P, Masur D, Scott R, Mehler M, et al. Clinico-pathologic studies in dementia: nondemented subjects with pathologically confirmed Alzheimer's disease. Neurology 1988; 38: 1682-7.
    • (1988) Neurology , vol.38 , pp. 1682-1687
    • Crystal, H.1    Dickson, D.2    Fuld, P.3    Masur, D.4    Scott, R.5    Mehler, M.6
  • 10
    • 0028888459 scopus 로고
    • Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol
    • Delforge J, Pappata S, Millet P, Samson Y, Bendriem B, Jobert A, et al. Quantification of benzodiazepine receptors in human brain using PET, [11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 1995; 15: 284-300.
    • (1995) J Cereb Blood Flow Metab , vol.15 , pp. 284-300
    • Delforge, J.1    Pappata, S.2    Millet, P.3    Samson, Y.4    Bendriem, B.5    Jobert, A.6
  • 11
    • 0030967717 scopus 로고    scopus 로고
    • Comparison of iodine-123-iomazenil SPECT and technetium-99 m-HMPAO-SPECT in Alzheimer's disease
    • Fukuchi K, Hashikawa K, Seike Y, Moriwaki H, Oku N, Ishida M, et al. Comparison of iodine-123-iomazenil SPECT and technetium-99 m-HMPAO-SPECT in Alzheimer's disease. J Nucl Med 1997; 38: 467-70.
    • (1997) J Nucl Med , vol.38 , pp. 467-470
    • Fukuchi, K.1    Hashikawa, K.2    Seike, Y.3    Moriwaki, H.4    Oku, N.5    Ishida, M.6
  • 12
    • 0038708285 scopus 로고    scopus 로고
    • Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
    • Giannakopoulos P, Herrmann FR, Bussiere T, Bouras C, Kovari E, Perl DP, et al. Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 2003; 60: 1495-500.
    • (2003) Neurology , vol.60 , pp. 1495-1500
    • Giannakopoulos, P.1    Herrmann, F.R.2    Bussiere, T.3    Bouras, C.4    Kovari, E.5    Perl, D.P.6
  • 13
    • 0344653664 scopus 로고    scopus 로고
    • Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease
    • Gomez-Isla T, Hollister R, West H, Mui S, Growdon JH, Petersen RC, et al. Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease. Ann Neurol 1997; 41: 17-24.
    • (1997) Ann Neurol , vol.41 , pp. 17-24
    • Gomez-Isla, T.1    Hollister, R.2    West, H.3    Mui, S.4    Growdon, J.H.5    Petersen, R.C.6
  • 16
    • 3242781057 scopus 로고    scopus 로고
    • Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: A comparative positron emission tomography/magnetic resonance imaging study in early is-chemic stroke
    • Heiss WD, Sobesky J, Smekal U, Kracht LW, Lehnhardt FG, Thiel A, et al. Probability of cortical infarction predicted by flumazenil binding and diffusion-weighted imaging signal intensity: a comparative positron emission tomography/magnetic resonance imaging study in early is-chemic stroke. Stroke 2004; 35: 1892-8.
    • (2004) Stroke , vol.35 , pp. 1892-1898
    • Heiss, W.D.1    Sobesky, J.2    Smekal, U.3    Kracht, L.W.4    Lehnhardt, F.G.5    Thiel, A.6
  • 18
    • 65649098041 scopus 로고    scopus 로고
    • An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: Relationship to neurofibrillary tangle progression
    • Iwakiri M, Mizukami K, Ikonomovic MD, Ishikawa M, Abrahamson EE, DeKosky ST, et al. An immunohistochemical study of GABA A receptor gamma subunits in Alzheimer's disease hippocampus: relationship to neurofibrillary tangle progression. Neuropathology 2009; 29: 263-9.
    • (2009) Neuropathology , vol.29 , pp. 263-269
    • Iwakiri, M.1    Mizukami, K.2    Ikonomovic, M.D.3    Ishikawa, M.4    Abrahamson, E.E.5    Dekosky, S.T.6
  • 19
    • 0025687708 scopus 로고
    • Alzheimer's disease: Changes in hippocampal N-methyl-D-aspartate, quisqualate, neuroten-sin, adenosine, benzodiazepine, serotonin and opioid receptors-an autoradiographic study
    • Jansen KL, Faull RL, Dragunow M, Synek BL. Alzheimer's disease: changes in hippocampal N-methyl-D-aspartate, quisqualate, neuroten-sin, adenosine, benzodiazepine, serotonin and opioid receptors-an autoradiographic study. Neuroscience 1990; 39: 613-27.
    • (1990) Neuroscience , vol.39 , pp. 613-627
    • Jansen, K.L.1    Faull, R.L.2    Dragunow, M.3    Synek, B.L.4
  • 20
    • 1342284214 scopus 로고    scopus 로고
    • DemTect: A new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia
    • Kalbe E, Kessler J, Calabrese P, Smith R, Passmore AP, Brand M, et al. DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia. Int J Geriatr Psychiatry 2004; 19: 136-43.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 136-143
    • Kalbe, E.1    Kessler, J.2    Calabrese, P.3    Smith, R.4    Passmore, A.P.5    Brand, M.6
  • 21
    • 0034127931 scopus 로고    scopus 로고
    • Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease
    • Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, et al. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol 2000; 47: 430-9.
    • (2000) Ann Neurol , vol.47 , pp. 430-439
    • Killiany, R.J.1    Gomez-Isla, T.2    Moss, M.3    Kikinis, R.4    Sandor, T.5    Jolesz, F.6
  • 22
    • 0025329180 scopus 로고
    • Synapses, axonal and dendritic patterns of GABA-immunoreactive neurons in human cerebral cortex
    • Kisvarday ZF, Gulyas A, Beroukas D, North JB, Chubb IW, Somogyi P. Synapses, axonal and dendritic patterns of GABA-immunoreactive neurons in human cerebral cortex. Brain 1990; 113 (Pt 3): 793-812.
    • (1990) Brain , vol.113 , Issue.PART 3 , pp. 793-812
    • Kisvarday, Z.F.1    Gulyas, A.2    Beroukas, D.3    North, J.B.4    Chubb, I.W.5    Somogyi, P.6
  • 25
    • 77949272739 scopus 로고    scopus 로고
    • Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: Preliminary results
    • Klumpers UM, Veltman DJ, Drent ML, Boellaard R, Comans EF, Meynen G, et al. Reduced parahippocampal and lateral temporal GABAA-[11C]flumazenil binding in major depression: preliminary results. Eur J Nucl Med Mol Imaging 2010; 37: 565-74.
    • (2010) Eur J Nucl Med Mol Imaging , vol.37 , pp. 565-574
    • Klumpers, U.M.1    Veltman, D.J.2    Drent, M.L.3    Boellaard, R.4    Comans, E.F.5    Meynen, G.6
  • 26
    • 79955466690 scopus 로고    scopus 로고
    • Where In-vivo imaging meets cytoarchitectonics: The relationship between cortical thickness and neuronal density measured with high-resolution [f-18]flumazenil-pet
    • La Fougere C, Grant S, Kostikov A, Schirrmacher R, Gravel P, Schipper HM, et al. Where in-vivo imaging meets cytoarchitectonics: the relationship between cortical thickness and neuronal density measured with high-resolution [F-18]flumazenil-PET. Neuroimage 2011; 56: 951-60.
    • (2011) Neuroimage , vol.56 , pp. 951-960
    • La Fougere, C.1    Grant, S.2    Kostikov, A.3    Schirrmacher, R.4    Gravel, P.5    Schipper, H.M.6
  • 27
    • 0037054015 scopus 로고    scopus 로고
    • Perirhinal and parahippocampal cortices of the macaque monkey: Projections to the neocortex
    • Lavenex P, Suzuki WA, Amaral DG. Perirhinal and parahippocampal cortices of the macaque monkey: projections to the neocortex. J Comp Neurol 2002; 447: 394-420.
    • (2002) J Comp Neurol , vol.447 , pp. 394-420
    • Lavenex, P.1    Suzuki, W.A.2    Amaral, D.G.3
  • 28
    • 69249220101 scopus 로고    scopus 로고
    • Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke
    • Massaweh G, Schirrmacher E, la Fougere C, Kovacevic M, Wangler C, Jolly D, et al. Improved work-up procedure for the production of [(18)F]flumazenil and first results of its use with a high-resolution research tomograph in human stroke. Nucl Med Biol 2009; 36: 721-7.
    • (2009) Nucl Med Biol , vol.36 , pp. 721-727
    • Massaweh, G.1    Schirrmacher, E.2    La Fougere, C.3    Kovacevic, M.4    Wangler, C.5    Jolly, D.6
  • 29
    • 0021271971 scopus 로고
    • Clinical Diagnosis of Alzheimer's Disease: Report of the NINCDS-ADRDA Work Group under the Auspices of Department of Health and Human Services Task Force on Alzheimer's Disease
    • McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 1984; 34: 939-44.
    • (1984) Neurology , vol.34 , pp. 939-944
    • McKhann, G.1    Drachman, D.2    Folstein, M.3    Katzman, R.4    Price, D.5    Stadlan, E.M.6
  • 30
    • 0028910471 scopus 로고
    • Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease
    • Meyer M, Koeppe RA, Frey KA, Foster NL, Kuhl DE. Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease. Arch Neurol 1995; 52: 314-7.
    • (1995) Arch Neurol , vol.52 , pp. 314-317
    • Meyer, M.1    Koeppe, R.A.2    Frey, K.A.3    Foster, N.L.4    Kuhl, D.E.5
  • 31
    • 58149386194 scopus 로고    scopus 로고
    • Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: Results from ADNI
    • Misra C, Fan Y, Davatzikos C. Baseline and longitudinal patterns of brain atrophy in MCI patients, and their use in prediction of short-term conversion to AD: results from ADNI. Neuroimage 2009; 44: 1415-22.
    • (2009) Neuroimage , vol.44 , pp. 1415-1422
    • Misra, C.1    Fan, Y.2    Davatzikos, C.3
  • 33
    • 37849034062 scopus 로고    scopus 로고
    • Partial volume corrected image derived input functions for dynamic PET brain studies: Methodology and validation for [11C]flumazenil
    • Mourik JE, Lubberink M, Klumpers UM, Comans EF, Lammertsma AA, Boellaard R. Partial volume corrected image derived input functions for dynamic PET brain studies: methodology and validation for [11C]flumazenil. Neuroimage 2008; 39: 1041-50.
    • (2008) Neuroimage , vol.39 , pp. 1041-1050
    • Mourik, J.E.1    Lubberink, M.2    Klumpers, U.M.3    Comans, E.F.4    Lammertsma, A.A.5    Boellaard, R.6
  • 34
    • 26644456428 scopus 로고    scopus 로고
    • Cortical efferents of the entorhinal cortex and the adjacent parahippocampal region in the monkey (Macaca fascicularis)
    • Munoz M, Insausti R. Cortical efferents of the entorhinal cortex and the adjacent parahippocampal region in the monkey (Macaca fascicularis). Eur J Neurosci 2005; 22: 1368-88.
    • (2005) Eur J Neurosci , vol.22 , pp. 1368-1388
    • Munoz, M.1    Insausti, R.2
  • 35
    • 0032704843 scopus 로고    scopus 로고
    • Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF
    • Ohyama M, Senda M, Ishiwata K, Kitamura S, Mishina M, Ishii K, et al. Preserved benzodiazepine receptors in Alzheimer's disease measured with C-11 flumazenil PET and I-123 iomazenil SPECT in comparison with CBF. Ann Nucl Med 1999; 13: 309-15.
    • (1999) Ann Nucl Med , vol.13 , pp. 309-315
    • Ohyama, M.1    Senda, M.2    Ishiwata, K.3    Kitamura, S.4    Mishina, M.5    Ishii, K.6
  • 36
    • 2342606447 scopus 로고    scopus 로고
    • Effects of metabolite correction for arterial input function on quantitative receptor images with 11C-flumazenil in clinical positron emission tomography studies
    • Okazawa H, Yamauchi H, Sugimoto K, Magata Y, Kudo T, Yonekura Y. Effects of metabolite correction for arterial input function on quantitative receptor images with 11C-flumazenil in clinical positron emission tomography studies. J Comput Assist Tomogr 2004; 28: 428-35.
    • (2004) J Comput Assist Tomogr , vol.28 , pp. 428-435
    • Okazawa, H.1    Yamauchi, H.2    Sugimoto, K.3    Magata, Y.4    Kudo, T.5    Yonekura, Y.6
  • 37
  • 38
    • 78650417030 scopus 로고    scopus 로고
    • Brain glucose metabolism in vascular white matter disease with dementia: Differentiation from alzheimer disease
    • Pascual B, Prieto E, Arbizu J, Marti-Climent J, Olier J, Masdeu JC. Brain glucose metabolism in vascular white matter disease with dementia: differentiation from Alzheimer disease. Stroke 2010; 41: 2889-93.
    • (2010) Stroke , vol.41 , pp. 2889-2893
    • Pascual, B.1    Prieto, E.2    Arbizu, J.3    Marti-Climent, J.4    Olier, J.5    Masdeu, J.C.6
  • 39
    • 4544335597 scopus 로고    scopus 로고
    • Mild cognitive impairment as a diagnostic entity
    • Petersen RC. Mild cognitive impairment as a diagnostic entity. J Intern Med 2004; 256: 183-94.
    • (2004) J Intern Med , vol.256 , pp. 183-194
    • Petersen, R.C.1
  • 40
    • 74149088935 scopus 로고    scopus 로고
    • Evaluation of spatial resolution of a pet scanner through the simulation and experimental measurement of the recovery coefficient
    • Prieto E, Marti-Climent JM, Arbizu J, Garrastachu P, Dominguez I, Quincoces G, et al. Evaluation of spatial resolution of a PET scanner through the simulation and experimental measurement of the recovery coefficient. Comp Biol Med 2010; 40: 75-80.
    • (2010) Comp Biol Med , vol.40 , pp. 75-80
    • Prieto, E.1    Marti-Climent, J.M.2    Arbizu, J.3    Garrastachu, P.4    Dominguez, I.5    Quincoces, G.6
  • 41
    • 1542504654 scopus 로고    scopus 로고
    • Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction
    • Quarantelli M, Berkouk K, Prinster A, Landeau B, Svarer C, Balkay L, et al. Integrated software for the analysis of brain PET/SPECT studies with partial-volume-effect correction. J Nucl Med 2004; 45: 192-201.
    • (2004) J Nucl Med , vol.45 , pp. 192-201
    • Quarantelli, M.1    Berkouk, K.2    Prinster, A.3    Landeau, B.4    Svarer, C.5    Balkay, L.6
  • 42
    • 4444314610 scopus 로고    scopus 로고
    • Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment
    • Rissman RA, Bennett DA, Armstrong DM. Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment. J Chem Neuroanat 2004; 28: 17-25.
    • (2004) J Chem Neuroanat , vol.28 , pp. 17-25
    • Rissman, R.A.1    Bennett, D.A.2    Armstrong, D.M.3
  • 43
    • 0344552488 scopus 로고    scopus 로고
    • Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: A study in baboons
    • Rocher AB, Chapon F, Blaizot X, Baron JC, Chavoix C. Resting-state brain glucose utilization as measured by PET is directly related to regional synaptophysin levels: a study in baboons. Neuroimage 2003; 20: 1894-8.
    • (2003) Neuroimage , vol.20 , pp. 1894-1898
    • Rocher, A.B.1    Chapon, F.2    Blaizot, X.3    Baron, J.C.4    Chavoix, C.5
  • 44
    • 0031955835 scopus 로고    scopus 로고
    • Correction for partial volume effects in PET: Principle and validation
    • Rousset OG, Ma Y, Evans AC. Correction for partial volume effects in PET: principle and validation. J Nucl Med 1998; 39: 904-11.
    • (1998) J Nucl Med , vol.39 , pp. 904-911
    • Rousset, O.G.1    Ma, Y.2    Evans, A.C.3
  • 47
    • 0023896012 scopus 로고
    • Changes in benzodiazepine receptors in Alzheimer-type dementia
    • Shimohama S, Taniguchi T, Fujiwara M, Kameyama M. Changes in benzodiazepine receptors in Alzheimer-type dementia. Ann Neurol 1988; 23: 404-6.
    • (1988) Ann Neurol , vol.23 , pp. 404-406
    • Shimohama, S.1    Taniguchi, T.2    Fujiwara, M.3    Kameyama, M.4
  • 48
    • 0029796805 scopus 로고    scopus 로고
    • Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses
    • Soricelli A, Postiglione A, Grivet-Fojaja MR, Mainenti PP, Discepolo A, Varrone A, et al. Reduced cortical distribution volume of iodine-123 iomazenil in Alzheimer's disease as a measure of loss of synapses. Eur J Nucl Med 1996; 23: 1323-8.
    • (1996) Eur J Nucl Med , vol.23 , pp. 1323-1328
    • Soricelli, A.1    Postiglione, A.2    Grivet-Fojaja, M.R.3    Mainenti, P.P.4    Discepolo, A.5    Varrone, A.6


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