[11C]Flumazenil PET in temporal lobe epilepsy: Do we need an arterial input function or kinetic modeling?

Journal of Cerebral Blood Flow and Metabolism

Volumn 28, Issue 1, 2008, Pages 207-216

  Hammers, Alexander ^a,b,c,d   Panagoda, Prasan ^a   Heckemann, Rolf A ^a   Kelsch, Wolfgang ^b,c   Turkheimer, Federico E ^a   Brooks, David J ^a   Duncan, John S ^b,c   Koepp, Matthias J ^a,b,c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c EPILEPSY SOCIETY   (United Kingdom)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Clinical studies; Human; Input functions; Neuroreceptor imaging; Quantitative assessment; Receptor density measurements; Simplified reference tissue model; Spectral analysis

Indexed keywords

FLUMAZENIL; FLUMAZENIL C 11; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; CARBON;

ARTERIAL BLOOD; ARTICLE; CLINICAL ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DIAGNOSTIC VALUE; EPILEPTIC FOCUS; HIPPOCAMPAL SCLEROSIS; HIPPOCAMPUS; HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; TEMPORAL LOBE EPILEPSY; ADULT; BIOLOGICAL MODEL; BRAIN CIRCULATION; FEMALE; KINETICS; MALE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PREDICTION AND FORECASTING; SCINTISCANNING; SCLEROSIS;

ADULT; CARBON ISOTOPES; CEREBROVASCULAR CIRCULATION; EPILEPSY, TEMPORAL LOBE; FEMALE; FLUMAZENIL; GABA MODULATORS; HIPPOCAMPUS; HUMANS; KINETICS; MALE; MIDDLE AGED; MODELS, BIOLOGICAL; POSITRON-EMISSION TOMOGRAPHY; PREDICTIVE VALUE OF TESTS; SCLEROSIS;

EID: 37549051373     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600515     Document Type: Article

References (41)

1. Ashburner J, Andersson JL, Friston KJ (2000) Image registration using a symmetric prior - in three dimensions. Hum Brain Mapp 9:212-25
2. Ashburner J, Friston KJ (2005) Unified segmentation. Neuroimage 26:839-51
3. 11C]flumazenil-PET study. Brain 128:1330-43
4. Bruton CJ (1988) The Neuropathology of Temporal Lobe Epilepsy. Oxford: Oxford University Press
5. Cunningham VJ, Jones T (1993) Spectral analysis of dynamic PET studies. J Cereb Blood Flow Metab 13:15-23
6. 123I-iomazenil SPECT in presurgical evaluation of temporal lobe epilepsy? J Neurol Neurosurg Psychiatry 62:141-50
7. 11C]flumazenil, and a single-experiment protocol. J Cereb Blood Flow Metab 15:284-300
8. Delforge J, Spelle L, Bendriem B, Samson Y, Syrota A (1997) Parametric images of benzodiazepine receptor concentration using a partial-saturation injection. J Cereb Blood Flow Metab 17:343-55
9. Engel JJ (1987) Outcome with respect to seizures. In: Engel JJ (ed), Surgical Treatment of the Epilepsies. New York: Raven Press pp 553-72
10. Frey KA, Holthoff VA, Koeppe RA, Jewett DM, Kilbourn MR, Kuhl DE (1991) Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol 30:663-72
11. Gunn RN, Lammertsma AA, Hume SP, Cunningham VJ (1997) Parametric imaging of ligand-receptor binding in PET using a simplified reference region model. Neuroimage 6:279-87
12. Hammers A, Allom R, Koepp MJ, Free SL, Myers R, Lemieux L, Mitchell TN, Brooks DJ, Duncan JS (2003a) Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum Brain Mapp 19:224-47
13. Hammers A, Koepp MJ, Brooks DJ, Duncan JS (2005) Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis. Epilepsia 46:944-8
14. 11C] flumazenil binding in temporal lobe epilepsy with normal MRI. Brain 125:2257-71
15. 11C]-flumazenil PET in mesial temporal lobe epilepsy. Neurology 56:897-906
16. Hammers A, Koepp MJ, Richardson MP, Hurlemann R, Brooks DJ, Duncan JS (2003b) Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI. A PET study of 44 patients. Brain 126:1300-18
17. Henry TR, Frey KA, Sackellares JC, Gilman S, Koeppe RA, Brunberg JA, Ross DA, Berent S, Young AB, Kuhl DE (1993) In vivo cerebral metabolism and central benzodiazepine-receptor binding in temporal lobe epilepsy. Neurology 43:1998-2006
18. Juhász C, Chugani DC, Muzik O, Shah A, Shah J, Watson C, Canady A, Chugani HT (2001) Relationship of flumazenil and glucose PET abnormalities to neocortical epilepsy surgery outcome. Neurology 56:1650-8
19. Juhász C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT (2000) Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 55:825-34
20. 11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 53:2037-45
21. 11C-flumazenil PET in patients with refractory temporal lobe epilepsy and normal MRI. Neurology 54:332-9
22. 11C]flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. Brain 120:1865-76
23. Koepp MJ, Richardson MP, Brooks DJ, Poline JB, Van Paesschen W, Friston KJ, Duncan JS (1996) Cerebral benzodiazepine receptors in hippocampal sclerosis. An objective in vivo analysis. Brain 119:1677-87
24. 11C-flumazenil PET, volumetric MRI, and quantitative pathology in mesial temporal lobe epilepsy. Neurology 49:764-73
25. Lammertsma AA, Hume SP (1996) Simplified reference tissue model for PET receptor studies. NeuroImage 4:153-8
26. 11C]Flumazenil binding in the medial temporal lobe in patients with temporal lobe epilepsy. Correlation with hippocampal MR volumetry, T2 relaxometry, and neuropathology. Neurology 54:2252-60
27. Millet P, Delforge J, Mauguière F, Pappata S, Cinotti L, Frouin V, Samson Y, Bendriem B, Syrota A (1995) Parameter and index images of benzodiazepine receptor concentration in the brain. J Nucl Med 36:1462-71
28. 11C] flumazenil PET. Ann Nucl Med 14:193-8
29. Muzik O, da Silva EA, Juhasz C, Chugani DC, Shah J, Nagy F, Canady A, von Stockhausen H-M, Herholz K, Gates J, Frost M, Ritter F, Watson C, Chugani HT (2000) Intracranial EEG versus flumazenil and glucose PET in children with extratemporal lobe epilepsy. Neurology 54:171-9
30. 11C]flumazenil PET: activity images versus parametric images for the detection of neocortical epileptic foci. J Nucl Med 40:1985-91
31. 11C-flumazenil in clinical positron emission tomography studies. J Comput Assist Tomogr 28:428-35
32. 11C- flumazenil PET in neocortical epilepsy. Neurology 51:485-92
33. 18F] fluorodeoxyglucose-PET and MRI in refractory partial epilepsy. A prospective study in 100 patients. Brain 121:2067-81
34. Ryvlin P, Bouvard S, Le Bars D, Mauguière F (1999) Transient and falsely lateralizing flumazenil-PET asymmetries in temporal lobe epilepsy. Neurology 53:1882-5
35. 11C-flumazenil and 18F-FDG as PET markers of epileptic foci. J Neurol Neurosurg Psychiatry 56:615-21
36. 11C]Flumazenil positron emission tomography visualises frontal epileptogenic regions. Epilepsia 36:1225-32
37. Szelies B, Weber-Luxenburger G, Mielke R, Pawlik G, Kessler J, Pietrzyk U, Bauer B, Heiss WD (2000) Interictal hippocampal benzodiazepine receptors in temporal lobe epilepsy: comparison with coregistered hippocampal metabolism and volumetry. Eur J Neurol 7:393-400
38. Szelies B, Weber-Luxenburger G, Pawlik G, Kessler J, Holthoff V, Mielke R, Herholz K, Bauer B, Wienhard K, Heiss WD (1996) MRI-guided flumazenil- and FDG-PET in temporal lobe epilepsy. NeuroImage 3:109-18
39. 11C]flumazenil brain PET. Eur J Nucl Med Mol Imaging 31:846-51
40. Van Paesschen W, Connelly A, King MD, Jackson GD, Duncan JS (1997) The spectrum of hippocampal sclerosis: a quantitative magnetic resonance imaging study. Ann Neurol 41:41-51
41. 11C-flumazenil at tracer concentrations. Br J Clin Pharmacol 60:477-85