Effects of Metabolite Correction for Arterial Input Function on Quantitative Receptor Images with 11C-Flumazenil in Clinical Positron Emission Tomography Studies

Journal of Computer Assisted Tomography

Volumn 28, Issue 3, 2004, Pages 428-435

  Okazawa, Hidehiko ^a,b   Yamauchi, Hiroshi ^b   Sugimoto, Kanji ^b   Magata, Yasuhiro ^c   Kudo, Takashi ^b   Yonekura, Yoshiharu ^a  

^a UNIVERSITY OF FUKUI   (Japan)

^b Shiga Medical Center   (Japan)

^c HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Binding potential; Flumazenil; Input function; Receptor imaging; Statistical parametric mapping

Indexed keywords

BINDING ENERGY; BIOMOLECULES; FUNCTION EVALUATION; MAPPING; POSITRON EMISSION TOMOGRAPHY; POSITRONS;

ACQUISITION TIME; ARTERIAL BLOOD; ARTERIAL INPUT FUNCTION; BINDING POTENTIAL; FLUMAZENIL; HEALTHY VOLUNTEERS; INPUT FUNCTIONS; RECEPTOR IMAGING; STANDARDIZED UPTAKE VALUES; STATISTICAL PARAMETRIC MAPPING;

METABOLITES;

CARBON 11; FLUMAZENIL; FLUMAZENIL C 11; UNCLASSIFIED DRUG;

ADULT; AGED; ARTERIAL BLOOD; ARTICLE; BINDING AFFINITY; BRAIN REGION; CALCULATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; DIAGNOSTIC IMAGING; DIAGNOSTIC VALUE; DOSE TIME EFFECT RELATION; DRUG BINDING; DRUG METABOLISM; EVALUATION; FEMALE; HUMAN; IMAGE ANALYSIS; IMAGE ENHANCEMENT; MALE; METABOLITE; NON INVASIVE MEASUREMENT; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE DIAGNOSIS;

EID: 2342606447     PISSN: 03638715     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004728-200405000-00021     Document Type: Article

References (22)

1. Frey KA, Holthoff VA, Koeppe RA, et al. Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol. 1991; 30:663-672.
2. 11C]flumazenil kinetics for the estimation of ligand transport rate and receptor distribution using positron emission tomography. J Cereb Blood Flow Metab. 1991;11:735-744.
3. 11C]flumazenil and PET: application of the steady-state principle. J Cereb Blood Flow Metab. 1995;15:152-165.
4. Millet P, Delforge J, Mauguiere F, et al. Parameter and index images of benzodiazepine receptor concentration in the brain. J Nucl Med. 1995;36: 1462-1471.
5. 11C-flumazenil metabolite in blood. J Nucl Med. 2003;44:417-421.
6. 11C] Ro 15-1788 (flumazenil) in baboon and human during positron emission tomography studies. Eur J Drug Metab Pharmacokinet. 1991;16:141-152.
7. Logan J, Fowler JS, Volkow ND, et al. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996;16:834-840.
8. Logan J. Graphical analysis of PET data applied to reversible and irreversible tracers. Nucl Med Biol. 2000;27:661-670.
9. Ichise M, Ballinger JR, Golan H, et al. Noninvasive quantification of doparnine D2 receptors with iodine-123-IBF SPECT. J Nucl Med. 1996;37: 513-520.
10. 11C-methyl]-(-)-cocaine PET studies in human subjects. J Cereb Blood Flow Metab. 1990;10:740-747.
11. 11C]flumazenil PET: activity images versus parametric images for the detection of neocortical epileptic foci. J Nucl Med. 1999;40:1985-1991.
12. 11C]flumazenil PET. Ann Nucl Med. 2000;14:193-198.
13. DeGrado TR, Turkington TG, Williams JJ, et al. Performance characteristics of a whole-body PET scanner. J Nucl Med. 1994;35:1398-1406.
14. 11C]Ro 15-1788 (flumazenil) from its metabolites in the blood of rabbits, baboons and humans. Int J Radiat Appl Instrum. 1991; 42:435-439.
15. Woods RP, Mazziotta JC, Cherry SR. MRI-PET registration with automated algorithm. J Comput Assist Tomogr. 1993;17:536-546.
16. Collins DL, Neelin P, Peter TM, et al. Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr. 1994;18:192-205.
17. Talairach J, Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain. New York: Thieme; 1988.
18. Okazawa H, Diksic M. Image generation of serotonin synthesis rates using α-methyl-tryptophan and PET. J Comput Assist Tomogr. 1998;22: 777-785.
19. Friston KJ, Frith CD, Liddle PF, et al. The relationship between global and local changes in PET scans. J Cereb Blood Flow Metab. 1990;10:458-466.
20. Friston KJ, Frith CD, Liddle PF, et al. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab. 1991;11:690-699.
21. Okazawa H, Vafaee M. Effect of vascular radioactivity on regional values of cerebral blood flow: evaluation of methods for oxygen-15-water PET to distinguish cerebral perfusion from blood volume. J Nucl Med. 2001; 42:1032-1039.
22. Abadie P, Baron JC, Bisserbe JC, et al. Central benzodiazepine receptors in human brain: estimation of regional Bmax and KD values with positron emission tomography. Eur J Pharmacol. 1992;213:107-115.