PARP inhibitors attenuate chemotherapy-induced painful neuropathy

Journal of the Peripheral Nervous System

Volumn 17, Issue 3, 2012, Pages 324-330

  Brederson, Jill Desiree ^a   Joshi, Shailen K ^a   Browman, Kaitlin E ^a   Mikusa, Joseph ^a   Zhong, Chengmin ^a   Gauvin, Donna ^a   Liu, Xuesong ^a   Shi, Yan ^a   Penning, Thomas D ^a   Shoemaker, Alex R ^a   Giranda, Vincent L ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

cancer; chemotherapy; CIPN; neuropathy; pain; poly(ADP ribose)

Indexed keywords

[2 (2 METHYLPYRROLIDIN 2 YL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE]; [6 FLUORO 2 (2 METHYLPYRROLIDIN 2 YL) 1H BENZIMIDAZOLE 4 CARBOXAMIDE]; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; UNCLASSIFIED DRUG; VELIPARIB; VINCRISTINE;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATTENUATION; CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG INDUCED DISEASE; DRUG MEGADOSE; ENZYME ACTIVATION; ENZYME INHIBITION; LOW DRUG DOSE; MALE; NONHUMAN; PERIPHERAL NEUROPATHY; PRIORITY JOURNAL; RAT;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; BENZIMIDAZOLES; ENZYME INHIBITORS; MALE; NEURALGIA; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84866387667     PISSN: 10859489     EISSN: 15298027     Source Type: Journal    
DOI: 10.1111/j.1529-8027.2012.00413.x     Document Type: Article

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