Cyclooxygenase-2, not microsomal prostaglandin E synthase-1, is the mechanism for interleukin-1-β-induced prostaglandin E2 production and inhibition of insulin secretion in pancreatic islets

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 32246-32253

  Parazzoli, Susan ^a   Harmon, Jamie S ^a   Vallerie, Sara N ^a   Zhang, Tao ^a   Zhou, Huarong ^a   Robertson, R Paul ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACIDS; CELL LINES; CYCLOOXYGENASE 2; CYCLOOXYGENASES; ENZYMATIC REACTION; GENE EXPRESSION ANALYSIS; GLUCOSE-STIMULATED INSULIN SECRETIONS; HUMAN ISLETS; INSULIN SECRETION; INTERLEUKIN1; MAMMALIAN TISSUES; MICROSOMAL PROSTAGLANDIN; MPGES-1; MRNA LEVEL; PANCREATIC ISLET; PROSTAGLANDINE; PROTEIN LEVEL; RAT ISLETS; SYNTHASES; TUMOR TISSUES; WHOLE CELL EXTRACTS;

CELL CULTURE; ENZYME INHIBITION; GENE EXPRESSION; GLUCOSE; INSULIN; PROTEINS; RATS; SYNTHESIS (CHEMICAL); TISSUE;

PHYSIOLOGY;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; GLUCOSE; INSULIN; INTERLEUKIN 1BETA; MESSENGER RNA; PROSTAGLANDIN E SYNTHASE; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INHIBITION KINETICS; INSULIN RELEASE; MALE; MICROSOME; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE; WILD TYPE;

ANIMALS; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; INSULIN; INTERLEUKIN-1BETA; INTRAMOLECULAR OXIDOREDUCTASES; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSOMES; MODELS, BIOLOGICAL; PROSTAGLANDINS; RATS;

MAMMALIA; MUS; RATTUS; RODENTIA;

EID: 84866371531     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.364612     Document Type: Article

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