Prostaglandin G/H synthase-2 is the constitutive and dominant isoform in cultured human lung epithelial cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 271, Issue 1 15-1, 1996, Pages

  Asano, Koichiro ^a   Lilly, Craig M ^a   Drazen, Jeffrey M ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

cyclooxygenase inhibitors; phorbol 12 myristate 13 acetate; prostaglandin E2; smooth muscle cells

Indexed keywords

6 (2,4 DIFLUOROPHENYLTHIO) 5 METHANESULFONAMIDO 1 INDANONE; CYTOKINE; GROWTH FACTOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PHORBOL 13 ACETATE 12 MYRISTATE; PROSTAGLANDIN G; PROSTAGLANDIN SYNTHASE;

ADENOCARCINOMA; ARTICLE; BRONCHUS HYPERREACTIVITY; CELL TRANSFORMATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; HYPEROXIA; INFLAMMATORY CELL; LUNG ALVEOLUS EPITHELIUM; LUNG FUNCTION; MEDIATOR RELEASE; PRIORITY JOURNAL; WATER TRANSPORT;

EID: 0030404174     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1996.271.1.l126     Document Type: Article

References (16)

1. Al-Bazzaz, F., V. P. Yadava, and C. Westenfelder. Modification of Na and Cl transport in canine tracheal mucosa by prostaglandins. Am. J. Physiol. 240 (Renal Fluid Electrolyte Physiol. 9): F101-F105, 1981.
2. Asano, K., C. B. E. Chee, B. Gaston, C. M. Lilly, C. Gerard, J. M. Drazen, and J. S. Stamler. Constitutive and inducible nitric oxide synthase gene expression, regulation, and activity in human lung epithelial cells. Proc. Natl. Acad. Sci. USA 91: 10089-10093, 1994.
3. Boyce, S., C. C. Chan, R. Gordon, C. S. Li, I. W. Rodger, J. K. Webb, N. M. J. Rupniak, and R. G. Hill. L-745,337: a selective inhibitor of cyclooxygenase-2 elicits antinociception but not gastric ulceration in rats. Neuropharmacology 33: 1609-1611, 1994.
4. 2 production. Br. J. Pharmacol. 95: 300-308, 1988.
5. Cozens, A. L., M. J. Yezzi, K. Kunzelmann, T. Ohrui, L. Chin, K. Eng, W. E. Finkbeiner, J. H. Widdicombe, and D. C. Gruenert. CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells. Am. J. Respir. Cell Mol. Biol. 10: 38-47, 1994.
6. Crofford, L. J., R. L. Wilder, A. P. Ristimaki, H. Sano, E. F. Remmers, H. R. Epps, and T. Hla. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J. Clin. Invest. 93: 1095-1101, 1994.
7. Delamere, F., E. Holland, S. Patel, J. Bennett, I. Pavord, and A. Knox. Production of PGE(2) by bovine cultured airway smooth muscle cells and its inhibition by cyclo-oxygenase inhibitors. Br. J. Pharmacol. 111: 983-988, 1994.
8. Dennery, P. A., R. W. Walenga, C. M. Kramer, and S. E. Alpert. Prostaglandin E2 attenuates hyperoxia-induced injury in cultured rabbit tracheal epithelial cells. Pediatr. Res. 32: 87-91, 1992.
9. Devillier, P., G. M. Acker, C. Advenier, J. Marsac, D. Regoli, and N. Frossard. Activation of an epithelial neurokinin NK-1 receptor induces relaxation of rat trachea through release of prostaglandin E2. J. Pharmacol. Exp. Ther. 263: 767-772, 1992.
10. Dewitt, D. L., and E. A. Meade. Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes. Arch. Biochem. Biophys. 306: 94-102, 1993.
11. Futaki, N., I. Arai, Y. Hamasaka, S. Takahashi, S. Higuchi, and S. Otomo. Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation. J. Pharm. Pharmacol. 45: 753-755, 1993.
12. Gierse, J. K., S. D. Hauser, D. P. Creely, C. Koboldt, S. H. Rangwala, P. C. Isakson, and K. Seibert. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem. J. 305: 479-484, 1995.
13. Gray, P. R., F. J. Derksen, R. V. Broadstone, N. E. Robinson, and M. Peters-Golden. Decreased airway mucosal prostaglandin E2 production during airway obstruction in an animal model of asthma. Am. Rev. Respir. Dis. 146: 586-591, 1992.
14. Hamasaki, Y., J. Kitzler, R. Hardman, P. Nettesheim, and T. E. Eling. Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch. Biochem. Biophys. 304: 226-234, 1993.
15. Hansbrough, J. R., A. B. Atlas, J. Turk, and M. J. Holtzman. Arachidonate 12-lipoxygenase and cyclooxygenase: PGE isomerase are predominant pathways for oxygenation in bovine tracheal epithelial cells. Am. J. Respir. Cell Mol. Biol. 1: 237-244, 1989.
16. Harris, R. C., J. A. McKanna, Y. Akai, H. R. Jacobson, R. N. Dubois, and M. D. Breyer. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. J. Clin. Invest. 94: 2504-2510, 1994.