-
1
-
-
0027905014
-
Altered growth of human colon cancer cell lines disrupted at activated Ki-ras
-
Shirasawa, S., M. Furuse, N. Yokoyama, and T. Sasazuki. 1993. Altered growth of human colon cancer cell lines disrupted at activated Ki-ras. Science 260:85-88.
-
(1993)
Science
, vol.260
, pp. 85-88
-
-
Shirasawa, S.1
Furuse, M.2
Yokoyama, N.3
Sasazuki, T.4
-
2
-
-
0002768524
-
Gene targeting in human cells without isogenic DNA
-
Sedivy, J.M., B. Vogelstein, H.L. Liber, E.A. Hendrickson, and A. Rosmarin. 1999. Gene targeting in human cells without isogenic DNA. Science 283:9a.
-
(1999)
Science
, vol.283
-
-
Sedivy, J.M.1
Vogelstein, B.2
Liber, H.L.3
Hendrickson, E.A.4
Rosmarin, A.5
-
3
-
-
58549095879
-
Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses
-
Di Nicolantonio, F., S. Arena, M. Gallicchio, D. Zecchin, M. Martini, S.E. Flonta, G.M. Stella, S. Lamba, et al. 2008. Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses. Proc. Natl. Acad. Sci. USA 105:20864-20869.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20864-20869
-
-
Di Nicolantonio, F.1
Arena, S.2
Gallicchio, M.3
Zecchin, D.4
Martini, M.5
Flonta, S.E.6
Stella, G.M.7
Lamba, S.8
-
4
-
-
77955288855
-
Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus
-
Di Nicolantonio, F., S. Arena, J. Tabernero, S. Grosso, F. Molinari, T. Macarulla, M. Russo, C. Cancelliere, et al. 2010. Deregulation of the PI3K and KRAS signaling pathways in human cancer cells determines their response to everolimus. J. Clin. Invest. 120:2858-2866.
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 2858-2866
-
-
Di Nicolantonio, F.1
Arena, S.2
Tabernero, J.3
Grosso, S.4
Molinari, F.5
Macarulla, T.6
Russo, M.7
Cancelliere, C.8
-
5
-
-
0031897270
-
Human gene targeting by viral vectors
-
Russell, D.W. and R.K. Hirata. 1998. Human gene targeting by viral vectors. Nat. Genet. 18:325-330.
-
(1998)
Nat. Genet.
, vol.18
, pp. 325-330
-
-
Russell, D.W.1
Hirata, R.K.2
-
6
-
-
0035989649
-
Targeted transgene insertion into human chromosomes by adeno-associated virus vectors
-
Hirata, R., J. Chamberlain, R. Dong, and D.W. Russell. 2002. Targeted transgene insertion into human chromosomes by adeno-associated virus vectors. Nat. Biotechnol. 20:735-738.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 735-738
-
-
Hirata, R.1
Chamberlain, J.2
Dong, R.3
Russell, D.W.4
-
7
-
-
39149117397
-
Genetic knockouts and knockins in human somatic cells
-
Rago, C., B. Vogelstein, and F. Bunz. 2007. Genetic knockouts and knockins in human somatic cells. Nat. Protocols 2:2734-2746.
-
(2007)
Nat. Protocols
, vol.2
, pp. 2734-2746
-
-
Rago, C.1
Vogelstein, B.2
Bunz, F.3
-
8
-
-
38349184853
-
A PCR-based high-throughput screen with multiround sample pooling: Application to somatic cell gene targeting
-
Konishi, H., J. Lauring, J.P. Garay, B. Karakas, A.M. Abukhdeir, J.P. Gustin, Y. Konishi, and B.H. Park. 2007. A PCR-based high-throughput screen with multiround sample pooling: application to somatic cell gene targeting. Nat. Protocols 2:2865-2874.
-
(2007)
Nat. Protocols
, vol.2
, pp. 2865-2874
-
-
Konishi, H.1
Lauring, J.2
Garay, J.P.3
Karakas, B.4
Abukhdeir, A.M.5
Gustin, J.P.6
Konishi, Y.7
Park, B.H.8
-
9
-
-
79960046970
-
AAV-mediated gene targeting methods for human cells
-
Khan, I.F., R.K. Hirata, and D.W. Russell. 2011. AAV-mediated gene targeting methods for human cells. Nat. Protocols 6:482-501.
-
(2011)
Nat. Protocols
, vol.6
, pp. 482-501
-
-
Khan, I.F.1
Hirata, R.K.2
Russell, D.W.3
-
10
-
-
0028334223
-
Gene targeting in normal somatic cells: Inactivation of the interferon-gamma receptor in myoblasts
-
Arbones, M.L., H.A. Austin, D.J. Capon, and G. Greenburg. 1994. Gene targeting in normal somatic cells: inactivation of the interferon-gamma receptor in myoblasts. Nat. Genet. 6:90-97.
-
(1994)
Nat. Genet.
, vol.6
, pp. 90-97
-
-
Arbones, M.L.1
Austin, H.A.2
Capon, D.J.3
Greenburg, G.4
-
11
-
-
0033997905
-
Design and packaging of adeno-associated virus gene targeting vectors
-
Hirata, R.K. and D.W. Russell. 2000. Design and packaging of adeno-associated virus gene targeting vectors. J. Virol. 74:4612-4620.
-
(2000)
J. Virol.
, vol.74
, pp. 4612-4620
-
-
Hirata, R.K.1
Russell, D.W.2
-
12
-
-
0038523969
-
Chimeric nucleases stimulate gene targeting in human cells
-
Porteus, M.H. and D. Baltimore. 2003. Chimeric nucleases stimulate gene targeting in human cells. Science 300:763.
-
(2003)
Science
, vol.300
, pp. 763
-
-
Porteus, M.H.1
Baltimore, D.2
-
13
-
-
0036871275
-
Comparison of the EF-1 alpha and the CMV promoter for engineering stable tumor cell lines using recombinant adeno-associated virus
-
Teschendorf, C., K.H. Warrington, Jr., D.W. Siemann, and N. Muzyczka. 2002. Comparison of the EF-1 alpha and the CMV promoter for engineering stable tumor cell lines using recombinant adeno-associated virus. Anticancer Res. 22:3325-3330.
-
(2002)
Anticancer Res.
, vol.22
, pp. 3325-3330
-
-
Teschendorf, C.1
Warrington Jr., K.H.2
Siemann, D.W.3
Muzyczka, N.4
-
14
-
-
0033571986
-
Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: A study using the tetracycline-inducible system in human cancer cells
-
Gopalkrishnan, R.V., K.A. Christiansen, N.I. Goldstein, R.A. DePinho, and P.B. Fisher. 1999. Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Res. 27:4775-4782.
-
(1999)
Nucleic Acids Res.
, vol.27
, pp. 4775-4782
-
-
Gopalkrishnan, R.V.1
Christiansen, K.A.2
Goldstein, N.I.3
DePinho, R.A.4
Fisher, P.B.5
-
15
-
-
0033119849
-
Persistent expression of foreign genes in cultured hepatocytes: Expression vectors
-
Najjar, S.M. and R.E. Lewis. 1999. Persistent expression of foreign genes in cultured hepatocytes: expression vectors. Gene 230:41-45.
-
(1999)
Gene
, vol.230
, pp. 41-45
-
-
Najjar, S.M.1
Lewis, R.E.2
-
16
-
-
28544435657
-
Improved methods for the generation of human gene knockout and knockin cell lines
-
Topaloglu, O., P.J. Hurley, O. Yildirim, C.I. Civin, and F. Bunz. 2005. Improved methods for the generation of human gene knockout and knockin cell lines. Nucleic Acids Res. 33:e158.
-
(2005)
Nucleic Acids Res.
, vol.33
-
-
Topaloglu, O.1
Hurley, P.J.2
Yildirim, O.3
Civin, C.I.4
Bunz, F.5
-
17
-
-
34548710863
-
Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation
-
Konishi, H., B. Karakas, A.M. Abukhdeir, J. Lauring, J.P. Gustin, J.P. Garay, Y. Konishi, E. Gallmeier, et al. 2007. Knock-in of mutant K-ras in nontumorigenic human epithelial cells as a new model for studying K-ras mediated transformation. Cancer Res. 67:8460-8467.
-
(2007)
Cancer Res.
, vol.67
, pp. 8460-8467
-
-
Konishi, H.1
Karakas, B.2
Abukhdeir, A.M.3
Lauring, J.4
Gustin, J.P.5
Garay, J.P.6
Konishi, Y.7
Gallmeier, E.8
-
18
-
-
0024118441
-
Homologous integration in mammalian cells without target gene selection
-
Jasin, M. and P. Berg. 1988. Homologous integration in mammalian cells without target gene selection. Genes Dev. 2:1353-1363.
-
(1988)
Genes Dev.
, vol.2
, pp. 1353-1363
-
-
Jasin, M.1
Berg, P.2
-
19
-
-
0038658494
-
Positive genetic selection for gene disruption in mammalian cells by homologous recombination
-
Sedivy, J.M. and P.A. Sharp. 1989. Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proc. Natl. Acad. Sci. USA 86:227-231.
-
(1989)
Proc. Natl. Acad. Sci. USA
, vol.86
, pp. 227-231
-
-
Sedivy, J.M.1
Sharp, P.A.2
-
20
-
-
0035880772
-
Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs
-
Hennecke, M., M. Kwissa, K. Metzger, A. Oumard, A. Kroger, R. Schirmbeck, J. Reimann, and H. Hauser. 2001. Composition and arrangement of genes define the strength of IRES-driven translation in bicistronic mRNAs. Nucleic Acids Res. 29:3327-3334.
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 3327-3334
-
-
Hennecke, M.1
Kwissa, M.2
Metzger, K.3
Oumard, A.4
Kroger, A.5
Schirmbeck, R.6
Reimann, J.7
Hauser, H.8
-
21
-
-
0030751962
-
Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins
-
Borman, A.M., P. Le Mercier, M. Girard, and K.M. Kean. 1997. Comparison of picornaviral IRES-driven internal initiation of translation in cultured cells of different origins. Nucleic Acids Res. 25:925-932.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 925-932
-
-
Borman, A.M.1
Le Mercier, P.2
Girard, M.3
Kean, K.M.4
-
22
-
-
0031956963
-
Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins
-
Roberts, L.O., R.A. Seamons, and G.J. Belsham. 1998. Recognition of picornavirus internal ribosome entry sites within cells; influence of cellular and viral proteins. RNA 4:520-529.
-
(1998)
RNA
, vol.4
, pp. 520-529
-
-
Roberts, L.O.1
Seamons, R.A.2
Belsham, G.J.3
-
23
-
-
66849089596
-
Toward a structural understanding of IRES RNA function
-
Filbin, M.E. and J.S. Kieft. 2009. Toward a structural understanding of IRES RNA function. Curr. Opin. Struct. Biol. 19:267-276.
-
(2009)
Curr. Opin. Struct. Biol.
, vol.19
, pp. 267-276
-
-
Filbin, M.E.1
Kieft, J.S.2
-
24
-
-
79551554217
-
Cellular IRES-mediated translation: The war of ITAFs in pathophysiological states
-
Komar, A.A. and M. Hatzoglou. 2011. Cellular IRES-mediated translation: the war of ITAFs in pathophysiological states. Cell Cycle 10:229-240.
-
(2011)
Cell Cycle
, vol.10
, pp. 229-240
-
-
Komar, A.A.1
Hatzoglou, M.2
-
25
-
-
33645151413
-
Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells
-
So, S., Y. Nomura, N. Adachi, Y. Kobayashi, T. Hori, Y. Kurihara, and H. Koyama. 2006. Enhanced gene targeting efficiency by siRNA that silences the expression of the Bloom syndrome gene in human cells. Genes Cells 11:363-371.
-
(2006)
Genes Cells
, vol.11
, pp. 363-371
-
-
So, S.1
Nomura, Y.2
Adachi, N.3
Kobayashi, Y.4
Hori, T.5
Kurihara, Y.6
Koyama, H.7
-
26
-
-
26444493181
-
Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors
-
Ohbayashi, F., M.A. Balamotis, A. Kishimoto, E. Aizawa, A. Diaz, P. Hasty, F.L. Graham, C.T. Caskey, and K. Mitani. 2005. Correction of chromosomal mutation and random integration in embryonic stem cells with helper-dependent adenoviral vectors. Proc. Natl. Acad. Sci. USA 102:13628-13633.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 13628-13633
-
-
Ohbayashi, F.1
Balamotis, M.A.2
Kishimoto, A.3
Aizawa, E.4
Diaz, A.5
Hasty, P.6
Graham, F.L.7
Caskey, C.T.8
Mitani, K.9
-
27
-
-
0029822592
-
Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine
-
Swann, P.F., T.R. Waters, D.C. Moulton, Y.Z. Xu, Q. Zheng, M. Edwards, and R. Mace. 1996. Role of postreplicative DNA mismatch repair in the cytotoxic action of thioguanine. Science 273:1109-1111.
-
(1996)
Science
, vol.273
, pp. 1109-1111
-
-
Swann, P.F.1
Waters, T.R.2
Moulton, D.C.3
Xu, Y.Z.4
Zheng, Q.5
Edwards, M.6
Mace, R.7
-
28
-
-
79951711771
-
Zinc-finger nucleases: A panoramic view
-
Carroll, D. 2011. Zinc-finger nucleases: a panoramic view. Curr. Gene Ther. 11:2-10.
-
(2011)
Curr. Gene Ther.
, vol.11
, pp. 2-10
-
-
Carroll, D.1
-
29
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller, J.C., S. Tan, G. Qiao, K.A. Barlow, J. Wang, D.F. Xia, X. Meng, D.E. Paschon, et al. 2011. A TALE nuclease architecture for efficient genome editing. Nat. Biotechnol. 29:143-148.
-
(2011)
Nat. Biotechnol.
, vol.29
, pp. 143-148
-
-
Miller, J.C.1
Tan, S.2
Qiao, G.3
Barlow, K.A.4
Wang, J.5
Xia, D.F.6
Meng, X.7
Paschon, D.E.8
-
30
-
-
84865513069
-
TALE nucleases: Tailored genome engineering made easy
-
Feb 17. [Epub ahead of print]
-
Mussolino, C. and T. Cathomen. 2012. TALE nucleases: tailored genome engineering made easy. Curr. Opin. Biotechnol. Feb 17. [Epub ahead of print]
-
(2012)
Curr. Opin. Biotechnol.
-
-
Mussolino, C.1
Cathomen, T.2
-
31
-
-
48549084778
-
A syngeneic variance library for functional annotation of human variation: Application to BRCA2
-
Hucl, T., C. Rago, E. Gallmeier, J.R. Brody, M. Gorospe, and S.E. Kern. 2008. A syngeneic variance library for functional annotation of human variation: application to BRCA2. Cancer Res. 68:5023-5030.
-
(2008)
Cancer Res.
, vol.68
, pp. 5023-5030
-
-
Hucl, T.1
Rago, C.2
Gallmeier, E.3
Brody, J.R.4
Gorospe, M.5
Kern, S.E.6
-
32
-
-
62449130185
-
Knockin of mutant PIK3CA activates multiple oncogenic pathways
-
Gustin, J.P., B. Karakas, M.B. Weiss, A.M. Abukhdeir, J. Lauring, J.P. Garay, D. Cosgrove, A. Tamaki, et al. 2009. Knockin of mutant PIK3CA activates multiple oncogenic pathways. Proc. Natl. Acad. Sci. USA 106:2835-2840.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 2835-2840
-
-
Gustin, J.P.1
Karakas, B.2
Weiss, M.B.3
Abukhdeir, A.M.4
Lauring, J.5
Garay, J.P.6
Cosgrove, D.7
Tamaki, A.8
-
33
-
-
70349331678
-
Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
-
Yun, J., C. Rago, I. Cheong, R. Pagliarini, P. Angenendt, H. Rajagopalan, K. Schmidt, J.K. Willson, et al. 2009. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 325:1555-1559.
-
(2009)
Science
, vol.325
, pp. 1555-1559
-
-
Yun, J.1
Rago, C.2
Cheong, I.3
Pagliarini, R.4
Angenendt, P.5
Rajagopalan, H.6
Schmidt, K.7
Willson, J.K.8
-
34
-
-
70350539589
-
Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells
-
Vitolo, M.I., M.B. Weiss, M. Szmacinski, K. Tahir, T. Waldman, B.H. Park, S.S. Martin, D.J. Weber, and K.E. Bachman. 2009. Deletion of PTEN promotes tumorigenic signaling, resistance to anoikis, and altered response to chemotherapeutic agents in human mammary epithelial cells. Cancer Res. 69:8275-8283.
-
(2009)
Cancer Res.
, vol.69
, pp. 8275-8283
-
-
Vitolo, M.I.1
Weiss, M.B.2
Szmacinski, M.3
Tahir, K.4
Waldman, T.5
Park, B.H.6
Martin, S.S.7
Weber, D.J.8
Bachman, K.E.9
-
35
-
-
77649230740
-
Cdk2 is required for p53-independent G2/M checkpoint control
-
Chung, J.H. and F. Bunz. 2010. Cdk2 is required for p53-independent G2/M checkpoint control. PLoS Genet. 6:e1000863.
-
(2010)
PLoS Genet.
, vol.6
-
-
Chung, J.H.1
Bunz, F.2
-
36
-
-
77649225150
-
Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells
-
Fattah, F., E.H. Lee, N. Weisensel, Y. Wang, N. Lichter, and E.A. Hendrickson. 2010. Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells. PLoS Genet. 6:e1000855.
-
(2010)
PLoS Genet.
, vol.6
-
-
Fattah, F.1
Lee, E.H.2
Weisensel, N.3
Wang, Y.4
Lichter, N.5
Hendrickson, E.A.6
-
37
-
-
80051874823
-
Mutational inactivation of STAG2 causes aneuploidy in human cancer
-
Solomon, D.A., T. Kim, L.A. Diaz-Martinez, J. Fair, A.G. Elkahloun, B.T. Harris, J.A. Toretsky, S.A. Rosenberg, et al. 2011. Mutational inactivation of STAG2 causes aneuploidy in human cancer. Science 333:1039-1043.
-
(2011)
Science
, vol.333
, pp. 1039-1043
-
-
Solomon, D.A.1
Kim, T.2
Diaz-Martinez, L.A.3
Fair, J.4
Elkahloun, A.G.5
Harris, B.T.6
Toretsky, J.A.7
Rosenberg, S.A.8
-
38
-
-
80055077133
-
Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells
-
Konishi, H., M. Mohseni, A. Tamaki, J.P. Garay, S. Croessmann, S. Karnan, A. Ota, H.Y. Wong, et al. 2011. Mutation of a single allele of the cancer susceptibility gene BRCA1 leads to genomic instability in human breast epithelial cells. Proc. Natl. Acad. Sci. USA 108:17773-17778.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 17773-17778
-
-
Konishi, H.1
Mohseni, M.2
Tamaki, A.3
Garay, J.P.4
Croessmann, S.5
Karnan, S.6
Ota, A.7
Wong, H.Y.8
|