Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole

Journal of Biological Chemistry

Volumn 287, Issue 38, 2012, Pages 32096-32102

  Lovering, Andrew L ^a,c   Gretes, Michael C ^a,d   Safadi, Susan S ^a   Danel, Franck ^b   De Castro, Liza ^a   Page, Malcolm G P ^b   Strynadka, Natalie C J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b BASILEA PHARMACEUTICA INTERNATIONAL LTD   (Switzerland)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d OREGON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIRST LOOK; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PEPTIDOGLYCANS; S. AUREUS; STAPHYLOCOCCUS AUREUS; STRUCTURAL INSIGHTS;

ANTIBIOTICS; BACTERIA;

ENZYME INHIBITION;

CEFALOTIN; CEFTOBIPROLE; IMIPENEM; NITROCEFIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN G; PIPERACILLIN;

ACYLATION; ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG PROTEIN BINDING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICHAEL ADDITION; PRIORITY JOURNAL; PROTEIN STABILITY; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYTIC DOMAIN; CEPHALOSPORINS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 84866344574     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.355644     Document Type: Article

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