UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming

Journal of Ginseng Research

Volumn 36, Issue 3, 2012, Pages 277-290

  Sun, Bai Shen ^a,b   Xu, Ming Yang ^a   Li, Zheng ^b   Wang, Yi Bo ^a   Sung, Chang Keun ^b  

^a TAIZHOU UNIVERSITY   (China)

^b Chungnam National University   (South Korea)

Author keywords

Black american ginseng; Ginsenosides; Multi steamed Panax quinquefolius; Panax ginseng; UPLC Q TOF MS MS

Indexed keywords

PANAX GINSENG; PANAX QUINQUEFOLIUS;

EID: 84866338703     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.5142/jgr.2012.36.3.277     Document Type: Article

References (43)

1. Chinese Pharmacopeia Commission. Pharmacopeia of the People's Republic of China 2010. Vol. 1. Beijing: China Medical Science Publisher, 2010.
2. Yuan CS, Wang CZ, Wicks SM, Qi LW. Chemical and Pharmacological Studies of Saponins with a Focus on American Ginseng. J Ginseng Res 2010;34:160-167.
3. Li B, Wang CZ, He TC, Yuan CS, Du W. Antioxidants potentiate Amellrican ginseng-induced killing of colorectal cancer cells. Cancer Lett 2010;289:62-70.
4. Yuan HD, Quan HY, Jung MS, Kim SJ, Huang B, Kim DY, Chung SH. Anti-Diabetic Effect of Pectinase-Processed Ginseng Radix (GINST) in High Fat Diet-Fed ICR Mice. J Ginseng Res 2011;35:308-314.
5. Chu SF, Zhang JT. New achievements in ginseng research and its future prospects. Chin J Integr Med 2009;15:403-408.
6. Jia L, Zhao Y. Current evaluation of the millennium phytomedicine. Ginseng (I): etymology, pharmacognosy, phytochemistry, market and regulations. Curr Med Chem 2009;16:2475-2484.
7. Jia L, Zhao Y, Liang XJ. Current evaluation of the millennium phytomedicine. Ginseng (II): collected chemical entities, modern pharmacology, and clinical applications emanated from traditional Chinese medicine. Curr Med Chem 2009;16:2924-2942.
8. Lu JM, Yao Q, Chen C. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol 2009;7:293-302.
9. Luo JZ, Luo L. Ginseng on hyperglycemia: effects and mechanisms. Evid Based Complement Alternat Med 2009;6:423-427.
10. Christensen LP. Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. Adv Food Nutr Res 2009;55:1-99.
11. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol 2008;66:444-450.
12. Lee JH, Shen GN, Kim EK, Shin HJ, Myung CS, Oh HJ, Kim DH, Roh SS, Cho W, Seo YB et al. Preparation of black ginseng and its antitumor activity. Korean J Orient Med Physiol Pathol 2006;20:951-956.
13. Song GY, Oh HJ, Roh SS, Seo YB, Park YJ, Myung CS. Effect of black ginseng on body weight and lipid profiles in male rats fed normal diets. Yakhak Hoeji 2006;50:381-385.
14. Lee SR, Kim MR, Yon JM, Baek IJ, Park CG, Lee BJ, Yun YW, Nam SY. Black ginseng inhibits ethanol-induced teratogenesis in cultured mouse embryos through its effects on antioxidant activity. Toxicol In Vitro 2009;23:47-52.
15. Liu L, Zhu XM, Wang QJ, Zhang DL, Fang ZM, Wang CY, Wang Z, Sun BS, Wu H, Sung CK. Enzymatic preparation of 20(S, R)-protopanaxadiol by transformation of 20(S, R)-Rg3 from black ginseng. Phytochemistry 2010;71:1514-1520.
16. Sun BS, Gu LJ, Fang ZM, Wang CY, Wang Z, Lee MR, Li Z, Li JJ, Sung CK. Simultaneous quantification of 19 ginsenosides in black ginseng developed from Panax ginseng by HPLC-ELSD. J Pharm Biomed Anal 2009;50:15-22.
17. Kim SN, Kang SJ. Effects of black ginseng (9 times-steaming ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process. Korean J Food Sci Technol 2009;41:77-81.
18. n based chemical profiling approach. Biotechnol Bioprocess Eng 2011;16:956-965.
19. Kim AJ, Kang SJ, Lee KH, Lee M, Ha SD, Cha YS, Kim SY. The chemopreventive potential and anti-inflammatory activities of Korean black ginseng in colon 26-M3.1 carcinoma cells and macrophages. J Korean Soc Appl Biol Chem 2010;53:101-105.
20. Qi LW, Wang CZ, Yuan CS. American ginseng: potential structure-function relationship in cancer chemoprevention. Biochem Pharmacol 2010;80:947-954.
21. Chan TW, But PP, Cheng SW, Kwok IM, Lau FW, Xu HX. Differentiation and authentication of Panax ginseng, Panax quinqueflium, and ginseng products by using HPLC/MS. Anal Chem 2000;72:1281-1287.
22. Xie GX, Ni Y, Su MM, Zhang YY, Zhao AH, Gao XF, Liu Z, Xiao PG, Jia W. Application of ultra-performance LC-TOF MS metabolite profiling techniques to the analysis of medicinal Panax herbs. Metabolomics 2008;4:248-260.
23. Xie G, Plumb R, Su M, Xu Z, Zhao A, Qiu M, Long X, Liu Z, Jia W. Ultra-performance LC/TOF MS analysis of medicinal Panax herbs for metabolomic research. J Sep Sci 2008;31:1015-1026.
24. Dan M, Xie G, Gao X, Long X, Su M, Zhao A, Zhao T, Zhou M, Qiu Y, Jia W. A rapid ultra-performance liquid chromatography-electrospray Ionisation mass spectrometric method for the analysis of saponins in the adventitious roots of Panax notoginseng. Phytochem Anal 2009;20:68-76.
25. Dan M, Su M, Gao X, Zhao T, Zhao A, Xie G, Qiu Y, Zhou M, Liu Z, Jia W. Metabolite profiling of Panax notoginseng using UPLC-ESI-MS. Phytochemistry 2008;69: 2237-2244.
26. Wang X, Zhao T, Gao X, Dan M, Zhou M, Jia W. Simultaneous determination of 17 ginsenosides in rat urine by ultra performance liquid chromatography-mass spectrometry with solid-phase extraction. Anal Chim Acta 2007;594:265-273.
27. Angelova N, Kong HW, van der Heijden R, Yang SY, Choi YH, Kim HK, Wang M, Hankemeier T, van der Greef J, Xu G et al. Recent methodology in the phytochemical analysis of ginseng. Phytochem Anal 2008;19:2-16.
28. Fuzzati N. Analysis methods of ginsenosides. J Chromatogr B Analyt Technol Biomed Life Sci 2004;812:119-133.
29. Li SL, Song JZ, Choi FF, Qiao CF, Zhou Y, Han QB, Xu HX. Chemical profiling of Radix Paeoniae evaluated by ultra-performance liquid chromatography/photo-diode-array/quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal 2009;49:253-266.
30. Fuzzati N, Gabetta B, Jayakar K, Pace R, Peterlongo F. Liquid chromatography-electrospray mass spectrometric identification of ginsenosides in Panax ginseng roots. J Chromatogr A 1999;854:69-79.
31. Ma X, Xiao H, Liang X. Identification of ginsenosides in Panax quinquefolium by LC-MS. Chromatographia 2006;64:31-36.
32. Liu JH, Wang X, Cai SQ, Komatsu K, Namba T. Analysis of the constituents in the Chinese drug Notoginseng by liquid chromatography-electrospray mass spectrometry. J Chin Pharm Sci 2004;13:225-237.
33. Du XW, Wills RB, Stuart DL. Changes in neutral and malonyl ginsenosides in American ginseng (Panax quinquefolium) during drying, storage and ethanolic extraction. Food Chem 2004;86:155-159.
34. Ren G, Chen F. Degradation of ginsenosides in American ginseng (Panax quinquefolium) extracts during microwave and conventional heating. J Agric Food Chem 1999;47:1501-1505.
35. Lee SA, Jo HK, Im BO, Kim S, Whang WK, Ko SK. Changes in the contents of prosapogenin in the red ginseng (Panax ginseng) depending on steaming batches. J Ginseng Res 2012;36:102-106.
36. An YE, Ahn SC, Yang DC, Park SJ, Kim BY, Baik MY. Chemical conversion of ginsenosides in puffed red ginseng. LWT Food Sci Technol 2011;44:370-374.
37. Li SL, Lai SF, Song JZ, Qiao CF, Liu X, Zhou Y, Cai H, Cai BC, Xu HX. Decocting-induced chemical transformations and global quality of Du-Shen-Tang, the decoction of ginseng evaluated by UPLC-Q-TOF-MS/MS based chemical profiling approach. J Pharm Biomed Anal 2010;53:946-957.
38. Wang Z, Wang H, Chen S. Analysis of ginsenosides in Sheng-Mai-Yin decoction by high performance liquid chromatography-diode array detection-electrospray mass spectrometry. Chin J Chromatogr 2006;24:325-330.
39. Kang KS, Kim HY, Baek SH, Yoo HH, Park JH, Yokozawa T. Study on the hydroxyl radical scavenging activity changes of ginseng and ginsenoside-Rb2 by heat processing. Biol Pharm Bull 2007;30:724-728.
40. Park JD. Recent studies on the chemical constituents of Korean ginseng (Panax ginseng C. A. Meyer). Korean J Ginseng Sci 1996;20:389-415.
41. Park JD, Lee YH, Kim SI. Ginsenoside Rf2, a new dammarane glycoside from Korean red ginseng (Panax ginseng). Arch Pharm Res 1998;21:615-617.
42. Ma XQ, Liang XM, Xu Q, Zhang XZ, Xiao HB. Identification of ginsenosides in roots of Panax ginseng by HPLC-APCI/MS. Phytochem Anal 2005;16:181-187.
43. Park IH, Kim NY, Han SB, Kim JM, Kwon SW, Kim HJ, Park MK, Park JH. Three new dammarane glycosides from heat processed ginseng. Arch Pharm Res 2002;25:428-432.