Quantitative high-performance liquid chromatography-tandem mass spectrometry impurity profiling methods for the analysis of parenteral infusion solutions for amino acid supplementation containing l-alanyl-l-glutamine

Journal of Chromatography A

Volumn 1259, Issue , 2012, Pages 111-120

  Schiesel, Simone ^a   Lämmerhofer, Michael ^a,b,c   Leitner, Alexander ^a   Lindner, Wolfgang ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ETH ZURICH   (Switzerland)

Author keywords

LC MS MS; Peptides; Stability indicating methods; Stereoisomeric impurities

Indexed keywords

AMINO ACID SUPPLEMENTATION; BIOACTIVE PEPTIDES; CHIRALPAK; EPIMERS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; IMPURITIES IN; IMPURITY PROFILE; IMPURITY PROFILING; ISOBARIC COMPOUNDS; LC-ESI-MS/MS; LC-MS/MS; MULTICOMPONENTS; PHARMACEUTICAL FORMULATION; QUANTITATIVE DATA; SAMPLE SOLUTION; STABILITY INDICATING METHOD; STANDARD ADDITION; STATIONARY PHASE; STRESS TESTING;

AMINO ACIDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERS; MASS SPECTROMETRY; PEPTIDES; STEREOCHEMISTRY;

IMPURITIES;

ACETYLCYSTEINE; ALANINE; ALANYLGLUTAMINE; AMINO ACID; ARGININE; GLYCINE; GLYCYLTYROSINE; HISTIDINE; ISOLEUCINE; LEUCINE; METHIONINE; PHENYLALANINE; PROLINE; SERINE; TAURINE; THREONINE; TRYPTOPHAN; VALINE;

ARTICLE; CALIBRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMER; PRACTICE GUIDELINE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE; STEREOISOMERISM; SUPPLEMENTATION; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIPEPTIDES; DRUG CONTAMINATION; OLIGOPEPTIDES; PARENTERAL NUTRITION SOLUTIONS; REPRODUCIBILITY OF RESULTS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY;

EID: 84866328283     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.01.020     Document Type: Article

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