Simple and precise detection of lipid compounds present within liposomal formulations using a charged aerosol detector

Journal of Chromatography A

Volumn 1216, Issue 5, 2009, Pages 781-786

  Schönherr, Carina ^a,b   Touchene, Sounia ^a   Wilser, Gaston ^a   Peschka Süss, Regine ^b   Francese, Giancarlo ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

^b UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Corona aerosol detector (CAD); HPLC; Lipid detection; Liposomes; Phosphatidylcholine

Indexed keywords

ACCEPTANCE CRITERIONS; ANALYTES; AVERAGE RECOVERIES; CHARGED AEROSOL DETECTORS; CHARGED AEROSOLS; CORONA AEROSOL DETECTOR (CAD); DRUG DELIVERY SYSTEMS; HPLC; HPLC METHODS; LIPOSOMAL FORMULATIONS; NO ABSORPTIONS; PHOSPHATIDYLCHOLINE; REGULATORY AUTHORITIES; UV DETECTIONS;

ATMOSPHERIC AEROSOLS; CHEMICAL PROPERTIES; DETECTORS; DRUG DELIVERY; LAWS AND LEGISLATION; LIPIDS; LIPOSOMES; ORGANIC COMPOUNDS; ORGANIC SOLVENTS; PHOSPHOLIPIDS; ULTRAVIOLET DETECTORS;

AEROSOLS;

LIPID; LIPOSOME; ORGANIC SOLVENT;

ABSORPTION; ACCURACY; AEROSOL; ARTICLE; AUTHORITY; CHEMICAL ANALYSIS; CONTROLLED STUDY; CONVALESCENCE; CORONA CHARGED AEROSOL DETECTION; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID ANALYSIS; PRIORITY JOURNAL; ULTRAVIOLET RADIATION;

AEROSOLS; ALPHA-TOCOPHEROL; CHOLESTEROL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; LIPIDS; LIPOSOMES; PHOSPHATIDYLCHOLINES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY;

EID: 58149114550     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2008.11.080     Document Type: Article

References (18)

1. Bangham A.D., Standish M.M., and Watkins J.C. J. Mol. Biol. 13 (1965) 238
2. Gabizon A., Shmeeda H., and Barenholz Y. Clin. Pharmacokinet. 42 (2003) 419
3. Stano P., Bufali S., and Pisano C. J. Lipos. Res. 14 1 (2004) 87
4. Gabizon A., Meshorer A., and Barenholz Y. J. Natl. Cancer Inst. 77 (1986) 459
5. Allen T.M., and Cullis P.R. Science 303 (2004) 1818
6. Harrington K.J. Expert Opin. Invest. Drugs 10 6 (2001) 1045
7. L. Zhou, Draft Guidance for Industry on Liposome Drug Products, Food and Drug Administration, Center for Drug Evaluation and Research, 2002, http://www.fda.gov/cder/guidance/index.htm.
8. Lee S.H., and Blair I.A. Methods Enzymol. 433 (2007) 159
9. Moreau R.A., Asmann P.T., and Norman H.A. Phytochemistry 29 (1990) 2461
10. R.A. Moreau, in: J.T. Lin, T.A. McKeon (Eds.), The Evaporative Light Scattering Detector, in HPLC of Acryl Lipids, HNB Publ., New York, p. 93.
11. Loughlin J., Phan H., and Wan M. Am. Lab. 39 (2007) 24
12. Gorecki T., Lynen F., and Szucs R. Anal. Chem. 78 (2006) 3186
13. Lu Q., and Koropchak J.A. Anal. Chem. 76 (2004) 5539
14. Gamache P.H., McCarthy R.S., and Freeto S.M. LC-GC Eur. 18 (2005) 345
15. Gamache P.H., McCarthy R.S., and Freeto S.M. LC-GC N. Am. Suppl. S (2005) 101
16. V.P. Torchilin, V. Weissig, Liposomes, Oxford Univ. Press, p. 4.
17. Thomas M.C., and Mitchell T.W. J. Am. Chem. Soc. 128 (2006) 58
18. International Conference on Harmonisation (ICH), Guidance for Industry: Q6A Specifications: Test Procedures and Acceptance Criteria for New Drug Substances and New Drug Products: Chemical Substances, Federal Register 65 (251) (2000) Notices, pp. 83041-83063.