Applications of hyphenated LC-MS techniques in pharmaceutical analysis

Biomedical Chromatography

Volumn 14, Issue 6, 2000, Pages 373-383

  Ermer, Joachim ^a   Vogel, Martin ^a  

^a SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CHROMATOGRAPHIC ANALYSIS; DRUG DOSAGE; DRUG PRODUCTS; IMPURITIES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; QUALITY CONTROL;

CHROMATOGRAPHIC METHODS; CHROMATOGRAPHIC SEPARATIONS; DOSAGE FORMS; DRUG SUBSTANCES; HYPHENATED TECHNIQUES; IONIZATION PROCESS; PHARMACEUTICAL ANALYSIS; PHARMACEUTICAL DEVELOPMENT; QUALITY AND SAFETIES; SPECTROMETRY TECHNIQUE;

DEGRADATION;

AMINO ACID DERIVATIVE; AMMONIUM ACETATE; CARBON; CARBON MONOXIDE; GLYCEROL; HYDROGEN; NEW DRUG; OXYGEN; TRIPEPTIDE;

AMINO ACID ANALYSIS; CONTROLLED STUDY; DRUG DOSAGE FORM; DRUG IMPURITY; DRUG QUALITY; DRUG STRUCTURE; ENANTIOMER; IONIZATION; LABORATORY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MONITORING; QUALITY CONTROL; REVIEW;

EID: 0033832634     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/1099-0801(200010)14:6<373::AID-BMC29>3.0.CO;2-S     Document Type: Review

References (27)

1. Thermospray interface for liquid chromatography-mass spectrometry
2. 2-(5-fluoro-2,3-dinitrophenyl)-L-amino acid amides
3. Determination of liquid chromatographic peak purity by electrospray ionization mass spectrometry
4. Capillary electrophoresis-mass spectrometry
5. Continuous-Flow Fast Atom Bombardment Mass Spectrometry
6. The use of liquid chromatography combined with a quadrupole time-of-flight analyser for the identification of trace impurities in drug substance
7. A quality concept for impurities during drug development-use of the hyphenated LC-MS technique
8. The use of hyphenated LC-MS technique for characterisation of impurity profiles during drug development
9. Electrospray ionization for mass spectrometry of large biomolecules
10. Liquid chromatography of semi-synthetic ergot preparations. I. Nicergoline
11. A nonempirical method using LC/MS for determination of the absolute configuration of constituent amino acids in a peptide: Combination of Mafey's method with mass spectrometry and its practical application
12. Studies of combined liquid chromatography-mass spectrometry with a moving-belt interface
13. Investigation of online reversed-phase liquid chromatography-gas chromatography-mass spectrometry as a tool for the identification of impurities in drug substances
14. Problem solving in the pharmaceutical industry by the combined application of chromatographic and spectroscopic methods
15. Estimation of impurity profiles of drugs and related materials. Part 19: Theme with variations. Identification of impurities in 3-oxosteroids
16. Atmospheric-pressure ionization and mass spectrometry. Detection for the separation sciences
17. Isolation and identification of process impurities in trimethoprim drug substance by high-performance liquid chromatography, atmospheric-pressure-chemical-ionization liquid chromatography-mass spectrometry and nuclear magnetic resonance sp
18. Assessment of chromatographic peak purity of drugs by multivariate analysis of diode-array and mass spectrometric data
19. Liquid chromatography-mass spectrometry of trace compounds [in almitrine] with a moving-belt interface and multi-dimensional chromatography
20. Investigation of synthetic crude carbetocin by liquid chromatography coupled to electrospray ionization mass spectrometry
21. Active drug substance impurity profiling part II. LC-MS-MS fingerprinting
22. Multidimensional evaluation of impurity profiles for generic cephalexin and cefaclor antibiotics
23. Predictive strategy for the rapid structure elucidation of drug degradants
24. Profiling impurities and degradants of butorphanol tartrate using liquid chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry substructural techniques
25. Electrospray interface for liquid chromatography and mass spectrometers
26. Monodisperse aerosol generation interface for combined liquid chromatography with mass spectrometry