Multidimensional separations in the pharmaceutical arena

Drug Discovery Today

Volumn 9, Issue 3, 2004, Pages 136-144

  Guttman, András ^a   Varoglu, Mustafa ^a   Khandurina, Julia ^a  

^a DIVERSA CORPORATION   (United States)

Author keywords

Biophysics; Capillary electrophoresis; Drug Discovery; Gas chromatography; Liquid chromatography; Microchip electrophoresis; Multidimensional separations; Pharmaceutical Science; Pharmaceuticals; Techniques Methods

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; AMOXICILLIN; ANTINEOPLASTIC AGENT; METYRAPONE; PANTOPRAZOLE; PROTEOME; RETINOIC ACID;

COMPUTER SYSTEM; DESORPTION; DRUG INDUSTRY; GAS CHROMATOGRAPHY; GENOME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MASS SPECTROMETRY; MOLECULAR BIOLOGY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEOMICS; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; REVIEW; SPECTROFLUOROMETRY; TIME OF FLIGHT MASS SPECTROMETRY;

CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, LIQUID; ELECTROPHORESIS, CAPILLARY; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHARMACEUTICAL PREPARATIONS; TECHNOLOGY, PHARMACEUTICAL;

EID: 1042267368     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(03)02972-6     Document Type: Review

References (79)

1. Phillips J.B., Xu J.Z. Comprehensive multi-dimensional gas chromatography. J. Chromatogr. A. 703:1995;327-334.
2. Dalluge J., et al. Comprehensive two-dimensional gas chromatography: a powerful and versatile analytical tool. J. Chromatogr. A. 1000:2003;69-108.
3. Schomburg G. Two-dimensional gas chromatography: Principles, instrumentation, methods. J. Chromatogr. A. 703:1995;309-325.
4. Liu Z.Y., Phillips J.B. Comprehensive two-dimensional gas chromatography using an on-column thermal modulator interface. J. Chromatogr. Sci. 29:1991;227-231.
5. Marriott P.J., et al. Comparison of thermal sweeper and cryogenic modulator technology for comprehensive gas chromatography. J. High Resolut. Chromatogr. 23:2000;253-258.
6. Ledford, E.B. (2001) Transverse thermal modulation. PCT/US01/01065.
7. Ong R.C.Y., Marriott P.J. A review of basic concepts in comprehensive two-dimensional gas chromatography. J. Chromatogr. Sci. 40:2002;276-291.
8. Beens J., et al. Quantitative aspects of comprehensive two-dimensional gas chromatography (GC×GC). J. High Resolut. Chromatogr. 21:1998;47-54.
9. Korytár P., et al. High-resolution separation of polychlorinated biphenyls by comprehensive two-dimensional gas chromatography. J. Chromatogr. A. 958:2002;203-218.
10. Kueh A.J., et al. Application of comprehensive two-dimensional gas chromatography to drugs analysis in doping control. J. Chromatogr A. 1000:2003;109-124.
11. Shellie R., Marriott P.J. Comprehensive two-dimensional gas chromatography with fast enantioseparation. Anal. Chem. 74:2002;5426-5430.
12. Kitson F.G., et al. Gas Chromatography and Mass Spectrometry, a Practical Guide. 1996;Academic Press.
13. de Hoffmann E., Stroobant V. Mass Spectrometry. 2nd edn :2001;Wiley.
14. Guetens G., et al. Hyphenated techniques in anticancer drug monitoring. II. Liquid chromatography-mass spectrometry and capillary electrophoresis-mass spectrometry. J. Chromatogr. A. 976:2002;239-247.
15. Gimeno P., et al. A contribution to the chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets. Forensic Sci. Int. 127:2002;1-44.
16. Maurer H.H. Role of gas chromatography-mass spectrometry with negative ion chemical ionization in clinical and forensic toxicology, doping control, and biomonitoring. Ther. Drug Monit. 24:2002;247-254.
17. Vandevenne M., et al. Detection time of drugs of abuse in urine. Acta Clin. Belg. 55:2000;323-333.
18. Clayton P.T. Applications of mass spectrometry in the study of inborn errors of metabolism. J. Inherit. Metab. Dis. 24:2001;139-150.
19. Roux C., et al. Role of cholesterol in embryonic development. Am. J. Clin. Nutr. 71:2000;1270S-1279S.
20. Volkman J.F., et al. Microalgal biomarkers: a review of recent research developments. Org. Geochem. 29:1998;1163-1179.
21. Cheng X., Hochlowski J. Current application of mass spectrometry to combinatorial chemistry. Anal. Chem. 74:2002;2679-2690.
22. Lim C-K., Lord G. Current developments in LC-MS for pharmaceutical analysis. Biol. Pharm. Bull. 25:2002;547-557.
23. Kostiainen R., et al. Liquid chromatography/ atmospheric pressure ionization- mass spectrometry in drug metabolism studies. J. Mass Spectrom. 38:2003;357-372.
24. Clarke N., et al. Systematic LC/MS metabolite identification in drug discovery. Anal. Chem. 73:2001;431A-439A.
25. Bushey M.M., Jorgenson J.W. Automated instrumentation for comprehensive two-dimensional high-performance liquid chromatography of proteins. Anal. Chem. 62:1990;161-167.
26. Wehr T. Multidimensional liquid chromatography in proteomic studies. LC GC. 16:2003;154-158.
27. Washburn M.P., et al. Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nat. Biotechnol. 19:2001;242-247.
28. Wagner K., et al. An automated on-line multidimensional hplc system for protein and peptide mapping with integrated sample preparation. Anal. Chem. 74:2002;809-820.
29. Murphy R.E., et al. One- and two-dimensional chromatographic analysis of alcohol ethoxylates. Anal. Chem. 70:1998;4353-4360.
30. Giddings J.C. Sample dimensionality: a predictor of order-disorder in component peak distribution in multidimensional separation. J. Chromatogr. A. 703:1995;3-15.
31. Patrick J., et al. Informational orthogonality of two-dimensional chromatographic separations. Anal. Chem. 68:1996;682-689.
32. Venkatramani C.J., et al. Separation orthogonality in temperature-programmed comprehensive two-dimensional gas chromatography. Anal. Chem. 68:1995;1486-1492.
33. Venkatramani J., Zelechnonok Y. A automated orthogonal two-dimensional liquid chromatograph. Anal. Chem. 75:2003;3452-3462.
34. Gray M., et al. Two dimensional reversed phase reversed phase separations. Isomeric separations incorporating C18 and carbon clad zirconia stationary phases. J. Chromatogr. A. 975:2002;285-297.
35. God R., et al. Online coupling of HPLC and solid phase extraction for preparative chromatography. G. I. T. Laboratory Journal. 3:1999;188-191.
36. Nishino I., et al. Determination of a new oral cephalosporin, cefmatilen, hydrochloride hydrate, and its seven metabolites in human and animal plasma and urine by coupled systems of ion-exchange and reversed phase high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 749:2000;101-110.
37. Yritia M., et al. Quantitation of nifedipine in human plasma by on-line solid-phase extraction and high-performance liquid chromatography. J. Chromatogr. A. 870:2000;115-119.
38. Walles M., et al. Application of restricted access material (RAM) with pre-column switching and matrix solide phase dispersion (MSPD) to the study of the metabolism and pharmacokinetics of verapamil. Anal. Bioanal. Chem. 374:2002;1179-1186.
39. Mislanova C., Stefancova A. Comparison of two different approaches of sample pretreatment for stereoselective determination of (R,S)-propranolol in human plasma. Journal of Trace and Microprobe Techniques. 19:2001;163-170.
40. Xia Y.Q., et al. Automated online dual column extraction coupled with teicoplanin stationary phase for simultaneous determination of (R)- and (S)-propranolol in rat plasma using liquid chromatography-tandem mass spectrometry. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 788:2003;317-329.
41. Cass Q.B., et al. Determination of amoxycillin in human plasma by direct injection and coupled-column high-performance liquid chromatography. J. Chromatogr. A. 987:2003;235-241.
42. Cassiano N.M., et al. Determination of the plasma levels of metyrapone and its enantiomeric metyrapol metabolites by direct plasma injection and multidimensional achiral-chiral chromatography. Chirality. 14:2002;731-735.
43. Cass Q.B., et al. Enantiomeric determination of pantoprazole in human plasma by multidimensional high-performance liquid chromatography. J. Chromatogr. B. Analyt Technol Biomed. Life Sci. 766:2001;153-160.
44. Itoh M., Kominami G. On-line immunoaffinity extraction followed by high-performance liquid chromatography and radioimmunoassay for a novel reinobenzoic acid, AM-80, in human plasma. J. Immunoassay Immunochem. 22:2001;213-223.
45. Wang T., et al. A new ultra-high throughput method for characterizaing combinatorial libraries incorporating a multiple probe autosampler coupled with flow injection mass spectrometry analysis. Rapid Commun. Mass Spectrum. 12:1998;1123-1129.
46. Zeng L., Kassel D.B. Development of a fully automated parallel HPLC/ mass spectrometry system for the analytical characterization and preparative purification of combinatorial libraries. Anal. Chem. 70:1998;4380-4388.
47. Morrison D., et al. An evaluation of a four-channel multiplexed electrospray tandem mass spectrometry for higher throughput quantitative analysis. Anal. Chem. 74:2002;1896-1902.
48. Rongda D., et al. High-throughput mass-directed parallel purification incorporating a multiplexed single quadrapole mass spectrometer. Anal. Chem. 74:2002;3055-3062.
49. Ripka W.C., et al. High-throughput purification of compound libraries. Drug Discov. Today. 6:2001;471-477.
50. Rathore, A. and Guttman, A. eds (2003) Electrokinetic Phenomena, Marcel Dekker.
51. Fenn J.B., et al. Electrospray ionization for mass spectrometry of large biomolecules. Science. 246:1989;64-71.
52. Choudhary G., et al. Use of on-line mass spectrometric detection in capillary electyrochromatography. J. Chromatogr. A. 887:2000;85-101.
53. Smith R.D., et al. Improved electrospray ionization interface for capillary zone electrophoresis-mass spectrometry. Anal. Chem. 60:1988;1948-1952.
54. Lee E.D., et al. On-line capillary zone electrophoresis-ion spray tandem mass spectrometry for the determination of dynorphins. J. Chromatogr. 458:1988;313-321.
55. Janini G.M., et al. A sheathless nanoflow electrospray interface for on-line capillary electrophoresis mass spectrometry. Anal. Chem. 75:2003;1615-1619.
56. Olivares J.A., et al. On-line mass spectrometric detection for capillary zone electrophoresis. Anal. Chem. 59:1987;1230-1232.
57. van Brocke A., et al. Recent advances in capillary electrophoresis/ electrospray-mass spectrometry. Electrophoresis. 22:2001;1251-1266.
58. Khandurina J., Guttman A. Microchip based HTS analysis of combinatorial libraries. Curr. Opin. Chem. Biol. 6:2002;359-366.
59. Gottschlich N., et al. Two-dimensional electrochromatography/capillary electrophoresis on a microchip. Anal. Chem. 73:2001;2669-2674.
60. Rocklin R.D., et al. A microfabricated fluidic device for performing two-dimensional liquid-phase separations. Anal. Chem. 72:2000;5244-5249.
61. Chen X., et al. A prototype two-dimensional capillary electrophoresis system fabricated in poly(dimethylsiloxane). Anal. Chem. 74:2002;1772-1778.
62. Li J., et al. Integration of microfabricated devices to capillary electrophoresis-electrospray mass spectrometry using a low dead volume connection: application to rapid analyses of proteolytic digests. Anal. Chem. 71:1999;3036-3045.
63. Zhang B., et al. Microfabricated devices for capillary electrophoresis-electrospray mass spectrometry. Anal. Chem. 71:1999;3258-3264.
64. Lazar I.M., et al. Novel microfabricated device for electrokinetically induced pressure flow and electrospray ionization mass spectrometry. J. Chromatogr. A. 892:2000;195-201.
65. Zhang B., et al. High-throughput microfabricated CE/ESI-MS: automated sampling from a microwell plate. Anal. Chem. 73:2001;2675-2681.
66. Lion N., et al. Integration of a membrane-based desalting step in a microfabricated disposable polymer injector for mass spectrometric protein analysis. Electrophoresis. 23:2002;3583-3588.
67. Gorby V., et al. Microfabricated polymer injector for direct mass spectrometry coupling. Proteomics. 2:2002;405-412.
68. Mohan D., Lee C.S. On-line coupling of capillary isoelectric focusing with transient isotachophoresis-zone electrophoresis: a two-dimensional separation system for proteomics. Electrophoresis. 23:2002;3160-3167.
69. Karas M. Matrix-assisted ultraviolet laser desorption of non-volatile compounds. Int. J. Mass Spectrom. Ion Process. 78:1987;53-63.
70. Rejtar T., et al. Off-line coupling of high-resolution capillary electrophoresis to MALDI-TOF and TOF/TOF MS. J. Proteome Res. 1:2002;171-179.
71. Preiser J., et al. On-line MALDI-TOF MS using a continuous vacuum deposition interface. Anal. Chem. 70:1998;5278-5287.
72. Ekstrom S., et al. Integrated microanalytical technology enabling rapid and automated protein identification. Anal. Chem. 72:2000;286-293.
73. Litborn E., et al. Parallel reactions in open chip-based nanovials with continuous compensation for solvent evaporation. Electrophoresis. 21:2000;91-99.
74. Watt A.T., et al. Metabolite identification in drug discovery. Curr. Opin. Drug Discov. Devel. 6:2003;57-65.
75. Concoran O., Spraul M. LC-NMR-MS in drug discovery. Drug Discov. Today. 8:2003;624-631.
76. Wu N., et al. Nanoliter volume sample cells for 1H NMR: application to online detection in capillary electrophoresis. J. Am. Chem. Soc. 116:1994;7929-7930.
77. Pusecker K., et al. On-line coupling of capillary electrophochromatography, capillary electrophoresis and capillary HPLC with NMR spectroscopy. Anal. Chem. 70:1998;3280-3285.
78. Kautz R.A., et al. Sample concentration and separation for nanoliter volume NMR spectroscopy using capillary esotachophoresis. J. Am. Chem. Soc. 123:2001;3159-3160.
79. Jayawickrama, D.A. et al. (2003) NMR detection in capillary electrophoresis and capillary electrochromatography. In Electrokinetic Phenomena (Rathore, A. and Guttman, A.), Marcel Dekker (in press).