Degradation kinetics of L-alanyl-L-glutamine and its derivatives in aqueous solution

European Journal of Pharmaceutical Sciences

Volumn 7, Issue 2, 1999, Pages 107-112

  Arii, Kanji ^a   Kai, Toshiya ^a   Kokuba, Yukifumi ^a  

^a SANOFI   (France)

Author keywords

Degradation; Glutamine dipeptide; L Alanyl L glutamine

Indexed keywords

ALANYLGLUTAMINE; DIPEPTIDE; GLYCYLGLUTAMINE; ISOLEUCYLGLUTAMINE; LEUCYLGLUTAMINE; UNCLASSIFIED DRUG; VALYLGLUTAMINE;

AQUEOUS SOLUTION; ARTICLE; DRUG DEGRADATION; DRUG STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; PH; PRIORITY JOURNAL; TEMPERATURE;

DIPEPTIDES; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; SOLUTIONS; TEMPERATURE;

EID: 0032902602     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(98)00012-8     Document Type: Article

References (16)

1. Adibi S.A., Lochs H., Abumrad N.N., Daniel H., Vazques J.A. Removal of glycylglutamine from plasma by individual tissues: Mechanism and impact on amino acid fluxes in postabsorption and starvation. J. Nutr. 123:1993;325-331.
2. Buchman A.L., Moukarzel A.A., Bhuta S., Belle M., Ament M.E., Eckhert C.D., Hollander D., Gornbein J., Kopple J.D., Vijayaroghavan S.R. Parenteral nutrition is associated with intestinal morphologic and functional changes in humans. J. Parenter. Enter. Nutr. 19:1995;453-460.
3. Buchman A.L. Glutamine: Is it a conditionally required nutrient for the human gastrointestinal system? J. Am. Coll. Nutr. 15:1996;199-205.
4. Burrin D.G., Shulman R.J., Langston C., Storm M.C. Supplemental alanylglutamine, organ growth, and nitrogen metabolism in neonatal pigs fed by total parenteral nutrition. J. Parenter. Enter. Nutr. 18:1994;313-319.
5. Deyl Z. Profiling of amino acids in body fluids and tissues by means of liquid chromatography. J. Chromatogr. 379:1986;177-250.
6. Haque S.M.M., Chen K., Usui N., Iiboshi Y., Okuyama H., Masunari A., Cui L., Nezu R., Takagi Y., Okada A. Alanyl-glutamine dipeptide-supplemented parenteral nutrition improves intestinal metabolism and prevents increased permeability in rats. Ann. Surg. 223:1996;334-341.
7. Harned H.S., Hamer W.J. The ionization constant of water and the dissociation of water in potassium chloride solutions from electromotive forces of cells without liquid junction. J. Am. Chem. Soc. 55:1933;2194-2206.
8. Hulst R.R., Meyenfeldt M.F., Deutz N.E., Stockbrugger R.W., Soeters P.B. The effect of glutamine administration on intestinal glutamine content. J. Surg. Res. 61:1996;30-34.
9. Lacey J.M., Wilmore D.W. Is glutamine a conditionally essential amino acid? Nutr. Rev. 48:1990;297-309.
10. Morimura T., Ohno T., Matsukura H., Nobuhara Y. Degradation kinetics of the new antibacterial fluoroquinolone derivative, orbifloxacin, in aqueous solution. Chem. Pharm. Bull. 43:1995;1052-1054.
11. Oreskes I., Kupfer S. Degradation of glutamine at elevated temperatures in ion exchange chromatography. Anal. Chem. 39:1967;397-398.
12. Souba W.W., Smith R.J., Wilmore D.W. Glutamine metabolism by the intestinal tract. J. Parenter. Enter. Nutr. 9:1985;608-617.
13. Takeuchi Y., Sunagawa M., Isobe Y., Hamazume Y., Noguchi T. Stability of a 1β-methylcarbapenem antibiotic, meropenem (SM-7338) in aqueous solution. Chem. Pharm. Bull. 43:1995;689-692.
14. Tremel H., Kienle B., Weilemann L.S., Stehle P., Furst P. Glutamine dipeptides-supplemented parenteral nutrition maintains intestinal function in the critically Ill. Gastroenterology. 107:1994;1595-1601.
15. Whitfield R.E. Steric factors in the chemistry of polypeptides, poly-α-amino acids and proteins. Science. 142:1963;577-579.
16. Windmueller H.G. Glutamine utilization by the small intestine. Adv. Enzymol. Relat. Areas Mol. Biol. 53:1982;201-237.