Noncyclam tetraamines inhibit CXC chemokine receptor type 4 and target glioma-initiating cells

Journal of Medicinal Chemistry

Volumn 55, Issue 17, 2012, Pages 7560-7570

  Ros Blanco, Laia ^a   Anido, Judit ^b,c   Bosser, Ramon ^d   Esté, José ^e   Clotet, Bonaventura ^e   Kosoy, Ana ^d   Ruíz Ávila, Luis ^d   Teixidó, Jordi ^a   Seoane, Joan ^b,c   Borrell, José I ^a  

^a INSTITUT QUÍMIC DE SARRIÀ   (Spain)

^b VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d Janus Development SL   (Spain)

^e HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 PIPECOLINE DERIVATIVE; 3 (2 METHYLPIPERIDIN 1 YL) N [4 [[3 (2 METHYLPIPERIDIN 1 YL)PROPYLAMINO]METHYL]BENZYL]PROPAN 1 AMINE TETRAHYDROCHLORIDE; 4 [[3 (2 METHYLPIPERIDIN 1 YL)PROPYLAMINO]METHYL]BENZALDEHYDE; ANTINEOPLASTIC AGENT; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; HERMES ANTIGEN; N (3 AMINOPROPYL) 2 PIPECOLINE; N [3 (2 PIPECOLIN 1 YL)PROPYL]PHTHALIMIDE; N [3(2 PIPECOLIN 1 YL)PROPYL]PHTHALIMIDE; N [4 (DIETHOXYMETHYL)BENZYL] 3 (2 METHYLPIPERIDIN 1 YL)PROPAN 1 AMINE; N,N' [1,4 PHENYLENE BIS(METHYLENE)]BIS[3 (2 METHYLPIPERIDIN 1 YL)PROPAN 1 AMINE]TETRAHYDROCHLORIDE; N,N' [1,4 PHENYLENEBIS(METHYLENE)]BIS[3 (2 METHYLPIPERIDIN 1 YL)PROPAN 1 AMINE]TETRAHYDROCHLORIDE; PLERIXAFOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; CARDIOTOXICITY; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; FEMALE; GLIOMA CELL; GLIOMA INITIATING CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IC 50; IMMUNE DEFICIENCY; MALE; MOUSE; NONHUMAN; STEREOISOMERISM; T LYMPHOCYTE;

AMINES; ANIMALS; ANTIVIRAL AGENTS; BRAIN NEOPLASMS; CHO CELLS; CRICETINAE; CRICETULUS; FLOW CYTOMETRY; GLIOMA; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS, MACROCYCLIC; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTORS, CXCR4; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 84866320588     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300862u     Document Type: Article

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