Development of a new class of nonimidazole histamine H3 receptor ligands with combined inhibitory histamine N-methyltransferase activity

Journal of Medicinal Chemistry

Volumn 45, Issue 5, 2002, Pages 1128-1141

  Apelt, Joachim ^a   Ligneau, Xavier ^b   Pertz, Heinz H ^a   Arrang, Jean Michel ^c   Ganellin, C Robin ^d   Schwartz, Jean Charles ^c   Schunack, Walter ^a   Stark, Holger ^e  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b Laboratoire Bioprojet   (France)

^c CENTRE PAUL BROCA   (France)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

4 [4 (3 PIPERIDINOPROPOXY)PHENYLAMINO]QUINOLINE; AMINOQUINOLINE DERIVATIVE; AMODIAQUINE; CIPROXIFAN; FUB 649; HISTAMINE H1 RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H3 RECEPTOR; HISTAMINE H3 RECEPTOR ANTAGONIST; HISTAMINE METHYLTRANSFERASE; IODOPROXYFAN; TACRINE; UCL 1972; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME INHIBITION; GUINEA PIG; MOUSE; NEUROTRANSMISSION; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR SENSITIVITY;

ANIMALS; BRAIN; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; GUINEA PIGS; HISTAMINE; HISTAMINE ANTAGONISTS; HISTAMINE N-METHYLTRANSFERASE; HUMANS; ILEUM; LIGANDS; MICE; MUSCLE, SMOOTH; PIPERIDINES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0037186501     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0110845     Document Type: Article

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