-
1
-
-
0037416141
-
The small-molecule approach to biology
-
Schreiber SL, (2003) The small-molecule approach to biology. Chem Eng News 81: 51-61.
-
(2003)
Chem Eng News
, vol.81
, pp. 51-61
-
-
Schreiber, S.L.1
-
2
-
-
33748195107
-
A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules
-
Banaszynski LA, Chen L-C, Maynard-Smith LA, Ooi AGL, Wandless TJ, (2006) A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004.
-
(2006)
Cell
, vol.126
, pp. 995-1004
-
-
Banaszynski, L.A.1
Chen, L.-C.2
Maynard-Smith, L.A.3
Ooi, A.G.L.4
Wandless, T.J.5
-
3
-
-
53549129978
-
Chemical control of protein stability and function in living mice
-
Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH, (2008) Chemical control of protein stability and function in living mice. Nat Med 14: 1123-1127.
-
(2008)
Nat Med
, vol.14
, pp. 1123-1127
-
-
Banaszynski, L.A.1
Sellmyer, M.A.2
Contag, C.H.3
Wandless, T.J.4
Thorne, S.H.5
-
4
-
-
68349116137
-
Conditional and reversible disruption of essential herpesvirus proteins
-
Glass M, Busche A, Wagner K, Messerle M, Borst EM, (2009) Conditional and reversible disruption of essential herpesvirus proteins. Nat Methods 6: 577-579.
-
(2009)
Nat Methods
, vol.6
, pp. 577-579
-
-
Glass, M.1
Busche, A.2
Wagner, K.3
Messerle, M.4
Borst, E.M.5
-
5
-
-
36749086400
-
An FKBP destabilization domain modulates protein levels in Plasmodium falciparum
-
Armstrong CM, Goldberg DE, (2007) An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods 4: 1007-1009.
-
(2007)
Nat Methods
, vol.4
, pp. 1007-1009
-
-
Armstrong, C.M.1
Goldberg, D.E.2
-
6
-
-
36749062385
-
Rapid control of protein level in the apicomplexan Toxoplasma gondii
-
Herm-Götz A, Agop-Nersesian C, Münter S, Grimley JS, Wandless TJ, et al. (2007) Rapid control of protein level in the apicomplexan Toxoplasma gondii. Nat Methods 4: 1003-1005.
-
(2007)
Nat Methods
, vol.4
, pp. 1003-1005
-
-
Herm-Götz, A.1
Agop-Nersesian, C.2
Münter, S.3
Grimley, J.S.4
Wandless, T.J.5
-
7
-
-
34249664888
-
SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes
-
Berdeaux R, Goebel N, Banaszynski L, Takemori H, Wandless T, et al. (2007) SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes. Nat Med 13: 597-603.
-
(2007)
Nat Med
, vol.13
, pp. 597-603
-
-
Berdeaux, R.1
Goebel, N.2
Banaszynski, L.3
Takemori, H.4
Wandless, T.5
-
8
-
-
66149125717
-
Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins
-
Madeira da Silva L, Owens KL, Murta SMF, Beverley SM, (2009) Regulated expression of the Leishmania major surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins. Proc Natl Acad Sci USA 106: 7583-7588.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 7583-7588
-
-
Madeira da Silva, L.1
Owens, K.L.2
Murta, S.M.F.3
Beverley, S.M.4
-
9
-
-
61449266636
-
Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels
-
Pruett-Miller SM, Reading DW, Porter SN, Porteus MH, (2009) Attenuation of zinc finger nuclease toxicity by small-molecule regulation of protein levels. PLoS Genet 5: e1000376.
-
(2009)
PLoS Genet
, vol.5
-
-
Pruett-Miller, S.M.1
Reading, D.W.2
Porter, S.N.3
Porteus, M.H.4
-
10
-
-
77952378704
-
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes
-
Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, et al. (2010) A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science 328: 910-912.
-
(2010)
Science
, vol.328
, pp. 910-912
-
-
Dvorin, J.D.1
Martyn, D.C.2
Patel, S.D.3
Grimley, J.S.4
Collins, C.R.5
-
11
-
-
84856019643
-
Imaging the impact of chemically inducible proteins on cellular dynamics in vivo
-
Leong HS, Lizardo MM, Ablack A, McPherson VA, Wandless TJ, et al. (2012) Imaging the impact of chemically inducible proteins on cellular dynamics in vivo. PloS one 7: e30177.
-
(2012)
PloS One
, vol.7
-
-
Leong, H.S.1
Lizardo, M.M.2
Ablack, A.3
McPherson, V.A.4
Wandless, T.J.5
-
12
-
-
80052403213
-
Ligand-switchable substrates for a ubiquitin-proteasome system
-
Egeler EL, Urner LM, Rakhit R, Liu CW, Wandless TJ, (2011) Ligand-switchable substrates for a ubiquitin-proteasome system. J of Biol Chem 286: 31328-31336.
-
(2011)
J of Biol Chem
, vol.286
, pp. 31328-31336
-
-
Egeler, E.L.1
Urner, L.M.2
Rakhit, R.3
Liu, C.W.4
Wandless, T.J.5
-
13
-
-
0030867774
-
The ubiquitin system
-
Varshavsky A, (1997) The ubiquitin system. Trends Biochem Sci 22: 383-387.
-
(1997)
Trends Biochem Sci
, vol.22
, pp. 383-387
-
-
Varshavsky, A.1
-
14
-
-
50149086108
-
Diversity of degradation signals in the ubiquitin-proteasome system
-
Ravid T, Hochstrasser M, (2008) Diversity of degradation signals in the ubiquitin-proteasome system. Nature Reviews Molecular Cell Biology 9: 679-690.
-
(2008)
Nature Reviews Molecular Cell Biology
, vol.9
, pp. 679-690
-
-
Ravid, T.1
Hochstrasser, M.2
-
15
-
-
34250745700
-
The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation)
-
Brodsky JL, (2007) The protective and destructive roles played by molecular chaperones during ERAD (endoplasmic-reticulum-associated degradation). Biochem J 404: 353-363.
-
(2007)
Biochem J
, vol.404
, pp. 353-363
-
-
Brodsky, J.L.1
-
16
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D, Walter P, (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nature reviews Molecular cell biology 8: 519-529.
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
17
-
-
79955664111
-
Mitochondrial protein quality control during biogenesis and aging
-
Baker BM, Haynes CM, (2011) Mitochondrial protein quality control during biogenesis and aging. Trends in biochemical sciences 36: 254-261.
-
(2011)
Trends in Biochemical Sciences
, vol.36
, pp. 254-261
-
-
Baker, B.M.1
Haynes, C.M.2
-
18
-
-
0033617448
-
In vivo mitochondrial import. A comparison of leader sequence charge and structural relationships with the in vitro model resulting in evidence for co-translational import
-
Ni L, Heard TS, Weiner H, (1999) In vivo mitochondrial import. A comparison of leader sequence charge and structural relationships with the in vitro model resulting in evidence for co-translational import. J Biol Chem 274: 12685-12691.
-
(1999)
J Biol Chem
, vol.274
, pp. 12685-12691
-
-
Ni, L.1
Heard, T.S.2
Weiner, H.3
-
19
-
-
33751208345
-
A highly sensitive protein-protein interaction assay based on Gaussia luciferase
-
Remy I, Michnick SW, (2006) A highly sensitive protein-protein interaction assay based on Gaussia luciferase. Nat Methods 3: 977-979.
-
(2006)
Nat Methods
, vol.3
, pp. 977-979
-
-
Remy, I.1
Michnick, S.W.2
-
20
-
-
0036138908
-
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
-
Nagai T, Ibata K, Park ES, Kubota M, Mikoshiba K, et al. (2002) A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications. Nat Biotechnol 20: 87-90.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 87-90
-
-
Nagai, T.1
Ibata, K.2
Park, E.S.3
Kubota, M.4
Mikoshiba, K.5
-
21
-
-
38749112547
-
A secreted luciferase for ex vivo monitoring of in vivo processes
-
Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, et al. (2008) A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods 5: 171-173.
-
(2008)
Nat Methods
, vol.5
, pp. 171-173
-
-
Wurdinger, T.1
Badr, C.2
Pike, L.3
de Kleine, R.4
Weissleder, R.5
-
23
-
-
50249175120
-
Chemical and biological approaches synergize to ameliorate protein-folding diseases
-
Mu T-W, Ong DST, Wang Y-J, Balch WE, Yates JR, et al. (2008) Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 134: 769-781.
-
(2008)
Cell
, vol.134
, pp. 769-781
-
-
Mu, T.-W.1
Ong, D.S.T.2
Wang, Y.-J.3
Balch, W.E.4
Yates, J.R.5
-
24
-
-
36049032748
-
An adaptable standard for protein export from the endoplasmic reticulum
-
Wiseman RL, Powers ET, Buxbaum JN, Kelly JW, Balch WE, (2007) An adaptable standard for protein export from the endoplasmic reticulum. Cell 131: 809-821.
-
(2007)
Cell
, vol.131
, pp. 809-821
-
-
Wiseman, R.L.1
Powers, E.T.2
Buxbaum, J.N.3
Kelly, J.W.4
Balch, W.E.5
-
25
-
-
0035966269
-
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
-
Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K, (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891.
-
(2001)
Cell
, vol.107
, pp. 881-891
-
-
Yoshida, H.1
Matsui, T.2
Yamamoto, A.3
Okada, T.4
Mori, K.5
-
26
-
-
32644432826
-
pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response
-
Yoshida H, Oku M, Suzuki M, Mori K, (2006) pXBP1(U) encoded in XBP1 pre-mRNA negatively regulates unfolded protein response activator pXBP1(S) in mammalian ER stress response. J Cell Biol 172: 565-575.
-
(2006)
J Cell Biol
, vol.172
, pp. 565-575
-
-
Yoshida, H.1
Oku, M.2
Suzuki, M.3
Mori, K.4
-
27
-
-
79959709492
-
Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132
-
Kim HJ, Joo HJ, Kim YH, Ahn S, Chang J, et al. (2011) Systemic analysis of heat shock response induced by heat shock and a proteasome inhibitor MG132. PloS one 6: e20252.
-
(2011)
PloS One
, vol.6
-
-
Kim, H.J.1
Joo, H.J.2
Kim, Y.H.3
Ahn, S.4
Chang, J.5
-
28
-
-
0034505937
-
Protein degradation in mitochondria
-
Käser M, Langer T, (2000) Protein degradation in mitochondria. Semin Cell Dev Biol 11: 181-190.
-
(2000)
Semin Cell Dev Biol
, vol.11
, pp. 181-190
-
-
Käser, M.1
Langer, T.2
-
29
-
-
34249873947
-
Translocation of proteins into mitochondria
-
Neupert W, Herrmann JM, (2007) Translocation of proteins into mitochondria. Annu Rev Biochem 76: 723-749.
-
(2007)
Annu Rev Biochem
, vol.76
, pp. 723-749
-
-
Neupert, W.1
Herrmann, J.M.2
-
30
-
-
27344456466
-
Effect of protein structure on mitochondrial import
-
Wilcox AJ, Choy J, Bustamante C, Matouschek A, (2005) Effect of protein structure on mitochondrial import. Proc Natl Acad Sci USA 102: 15435-15440.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15435-15440
-
-
Wilcox, A.J.1
Choy, J.2
Bustamante, C.3
Matouschek, A.4
-
31
-
-
0034603114
-
Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum
-
Rivera VM, Wang X, Wardwell S, Courage NL, Volchuk A, et al. (2000) Regulation of protein secretion through controlled aggregation in the endoplasmic reticulum. Science 287: 826-830.
-
(2000)
Science
, vol.287
, pp. 826-830
-
-
Rivera, V.M.1
Wang, X.2
Wardwell, S.3
Courage, N.L.4
Volchuk, A.5
-
32
-
-
0036789916
-
An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein
-
Ando R, Hama H, Yamamoto-Hino M, Mizuno H, Miyawaki A, (2002) An optical marker based on the UV-induced green-to-red photoconversion of a fluorescent protein. Proc Natl Acad Sci USA 99: 12651-12656.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12651-12656
-
-
Ando, R.1
Hama, H.2
Yamamoto-Hino, M.3
Mizuno, H.4
Miyawaki, A.5
-
33
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D, (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Molecular cell 5: 897-904.
-
(2000)
Molecular Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
34
-
-
14044250981
-
Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo
-
Tannous BA, Kim D-E, Fernandez JL, Weissleder R, Breakefield XO, (2005) Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther 11: 435-443.
-
(2005)
Mol Ther
, vol.11
, pp. 435-443
-
-
Tannous, B.A.1
Kim, D.-E.2
Fernandez, J.L.3
Weissleder, R.4
Breakefield, X.O.5
-
35
-
-
0021716406
-
A short amino acid sequence able to specify nuclear location
-
Kalderon D, Roberts BL, Richardson WD, Smith AE, (1984) A short amino acid sequence able to specify nuclear location. Cell 39: 499-509.
-
(1984)
Cell
, vol.39
, pp. 499-509
-
-
Kalderon, D.1
Roberts, B.L.2
Richardson, W.D.3
Smith, A.E.4
|