Imaging the impact of chemically inducible proteins on cellular dynamics in vivo

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Leong, Hon S ^a   Lizardo, Michael M ^a,b   Ablack, Amber ^a   McPherson, Victor A ^a   Wandless, Thomas J ^c   Chambers, Ann F ^a,b   Lewis, John D ^a,b  

^a LONDON REGIONAL CANCER PROGRAM   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

UVOMORULIN; CADHERIN; MORPHOLINE DERIVATIVE; SHIELD 1 COMPOUND; SHIELD-1 COMPOUND; VIMENTIN;

ANIMAL TISSUE; ARTICLE; BIOPHYSICS; BIRD; BREAST CANCER; CANCER CELL; CELL DYNAMICS; CELL FUNCTION; CELL MIGRATION; CELL STRUCTURE; CHIMERA; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DYNAMICS; EMBRYO; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; HUMAN TISSUE; IMAGING AND DISPLAY; IN VITRO STUDY; IN VIVO STUDY; INTRAVITAL IMAGING; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; TUMOR XENOGRAFT; ANIMAL; BREAST TUMOR; DIAGNOSTIC IMAGING; DRUG EFFECT; FEMALE; FLUORESCENCE MICROSCOPY; METABOLISM; PRENATAL DEVELOPMENT; TUMOR CELL LINE; XENOGRAFT;

AVES;

ANIMALS; BIRDS; BREAST NEOPLASMS; CADHERINS; CELL LINE, TUMOR; DIAGNOSTIC IMAGING; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; MORPHOLINES; TRANSPLANTATION, HETEROLOGOUS; VIMENTIN;

EID: 84856019643     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0030177     Document Type: Article

References (32)

1. Kedrin D, Gligorijevic B, Wyckoff J, Verkhusha VV, Condeelis J, et al. (2008) Intravital imaging of metastatic behavior through a mammary imaging window. Nat Methods 5: 1019-1021.
2. Ozduman K, Wollmann G, Piepmeier JM, van den Pol AN, (2008) Systemic vesicular stomatitis virus selectively destroys multifocal glioma and metastatic carcinoma in brain. J Neurosci 28: 1882-1893.
3. Roussos ET, Condeelis JS, Patsialou A, (2011) Chemotaxis in cancer. Nat Rev Cancer 11: 573-587.
4. Gossen M, Bujard H, (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc Natl Acad Sci U S A 89: 5547-5551.
5. Agha-Mohammadi S, O'Malley M, Etemad A, Wang Z, Xiao X, et al. (2004) Second-generation tetracycline-regulatable promoter: repositioned tet operator elements optimize transactivator synergy while shorter minimal promoter offers tight basal leakiness. J Gene Med 6: 817-828.
6. S AM, Alvarez-Vallina L, Ashworth LJ, Hawkins RE, (1997) Delay in resumption of the activity of tetracycline-regulatable promoter following removal of tetracycline analogues. Gene Ther 4: 993-997.
7. Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, et al. (2008) Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 22: 3728-3735.
8. Moses MA, Harper J, Folkman J, (2006) Doxycycline treatment for lymphangioleiomyomatosis with urinary monitoring for MMPs. N Engl J Med 354: 2621-2622.
9. Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, et al. (1992) Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential. Antimicrob Agents Chemother 36: 227-229.
10. Smith GN Jr, Mickler EA, Hasty KA, Brandt KD, (1999) Specificity of inhibition of matrix metalloproteinase activity by doxycycline: relationship to structure of the enzyme. Arthritis Rheum 42: 1140-1146.
11. Hashimoto T, Matsumoto MM, Li JF, Lawton MT, Young WL, (2005) Suppression of MMP-9 by doxycycline in brain arteriovenous malformations. BMC Neurol 5: 1.
12. Banaszynski LA, Chen LC, Maynard-Smith LA, Ooi AG, Wandless TJ, (2006) A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules. Cell 126: 995-1004.
13. Banaszynski LA, Sellmyer MA, Contag CH, Wandless TJ, Thorne SH, (2008) Chemical control of protein stability and function in living mice. Nat Med 14: 1123-1127.
14. Berx G, Cleton-Jansen AM, Nollet F, de Leeuw WJ, van de Vijver M, et al. (1995) E-cadherin is a tumour/invasion suppressor gene mutated in human lobular breast cancers. Embo J 14: 6107-6115.
15. Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, van Roy F, (1991) Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 66: 107-119.
16. Berx G, Becker KF, Hofler H, van Roy F, (1998) Mutations of the human E-cadherin (CDH1) gene. Hum Mutat 12: 226-237.
17. Chen WC, Obrink B, (1991) Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells. J Cell Biol 114: 319-327.
18. Boyer B, Valles AM, Edme N, (2000) Induction and regulation of epithelial-mesenchymal transitions. Biochem Pharmacol 60: 1091-1099.
19. Gotzmann J, Huber H, Thallinger C, Wolschek M, Jansen B, et al. (2002) Hepatocytes convert to a fibroblastoid phenotype through the cooperation of TGF-beta1 and Ha-Ras: steps towards invasiveness. J Cell Sci 115: 1189-1202.
20. Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G, (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190-193.
21. Thiery JP, (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
22. Sarrio D, Perez-Mies B, Hardisson D, Moreno-Bueno G, Suarez A, et al. (2004) Cytoplasmic localization of p120ctn and E-cadherin loss characterize lobular breast carcinoma from preinvasive to metastatic lesions. Oncogene 23: 3272-3283.
23. Mbalaviele G, Dunstan CR, Sasaki A, Williams PJ, Mundy GR, et al. (1996) E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Cancer Res 56: 4063-4070.
24. Born AK, Rottmar M, Lischer S, Pleskova M, Bruinink A, et al. (2009) Correlating cell architecture with osteogenesis: first steps towards live single cell monitoring. Eur Cell Mater 18: 49-60, 61-42; discussion 60.
25. Chi NC, Bussen M, Brand-Arzamendi K, Ding C, Olgin JE, et al. (2010) Cardiac conduction is required to preserve cardiac chamber morphology. Proc Natl Acad Sci U S A 107: 14662-14667.
26. Pincus Z, Theriot JA, (2007) Comparison of quantitative methods for cell-shape analysis. J Microsc 227: 140-156.
27. Xylas J, Alt-Holland A, Garlick J, Hunter M, Georgakoudi I, (2010) Intrinsic optical biomarkers associated with the invasive potential of tumor cells in engineered tissue models. Biomed Opt Express 1: 1387-1400.
28. Zijlstra A, Lewis J, Degryse B, Stuhlmann H, Quigley JP, (2008) The inhibition of tumor cell intravasation and subsequent metastasis via regulation of in vivo tumor cell motility by the tetraspanin CD151. Cancer Cell 13: 221-234.
29. Abramoff MD, Magelhaes PJ, Ram SJ, (2004) Image Processing with ImageJ. Biophotonics International 11: 36-42.
30. Lewis JD, Destito G, Zijlstra A, Gonzalez MJ, Quigley JP, et al. (2006) Viral nanoparticles as tools for intravital vascular imaging. Nat Med 12: 354-360.
31. Maksimov VF, Korostyshevskaya IM, Kurganov SA, (2006) Functional morphology of chorioallantoic vascular network in chicken. Bull Exp Biol Med 142: 367-371.
32. Souter LH, Andrews JD, Zhang G, Cook AC, Postenka CO, et al. (2011) Human 21T breast epithelial cell lines mimic breast cancer progression in vivo and in vitro and show stage-specific gene expression patterns. Lab Invest 90: 1247-1258.