Telomere shortening occurs early during gastrocarcinogenesis

Medical Oncology

Volumn 29, Issue 2, 2012, Pages 893-898

  Mu, Yunchuan ^a   Zhang, Qing ^a   Mei, Linhang ^a   Liu, Xiaosun ^a   Yang, Weili ^a   Yu, Jiren ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Gastric carcinoma; Real time PCR; Telomerase; Telomere shortening

Indexed keywords

ADULT; AGED; ARTICLE; CANCER STAGING; CARCINOGENESIS; FEMALE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STOMACH CARCINOMA; STOMACH MUCOSA; TELOMERE SHORTENING; ADENOCARCINOMA; CANCER GRADING; CANCER INVASION; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; SIGNET RING CARCINOMA; STOMACH; STOMACH TUMOR; TELOMERE;

DNA;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SIGNET RING CELL; DNA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; PROGNOSIS; REAL-TIME POLYMERASE CHAIN REACTION; STOMACH; STOMACH NEOPLASMS; TELOMERE; TELOMERE SHORTENING; YOUNG ADULT;

EID: 84866301532     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-011-9866-3     Document Type: Article

References (23)

1. Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374(9688):477-90.
2. Catalano V, et al. Gastric cancer. Crit Rev Oncol Hematol. 2009;71(2):127-64.
3. Milne AN, Carneiro F, O'Morain C, Offerhaus GJ. Nature meets nurture: molecular genetics of gastric cancer. Hum Genet. 2009; 126(5):615-28.
4. Tahara E. Molecular mechanism of stomach carcinogenesis. J Cancer Res Clin Oncol. 1993;119(5):265-72.
5. Bornschein J, Kandulski A, Selgrad M, Malfertheiner P. From gastric inflammation to gastric cancer. Dig Dis. 2010;28(4-5): 609-14.
6. Chin L, et al. p53 deficiency rescues the advance effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell. 1999;97(4):527-38.
7. Aida J, et al. Telomere length variations in 6 mucosal cell types of gastric tissue observed using a novel quantitative fluorescence in situ hybridization method. Hum Pathol. 2007;38(8):1192-200.
8. Sobin LH, Wittekind CH. TNM classification of malignant tumors. 6th ed. New York, NY, USA: Wiley; 2002.
9. Canela A, Klatt P, Blasco MA. Telomere length analysis. Methods Mol Biol. 2007;371:45-72.
10. Cawthon RM. Telomere measurement by quantitative PCR. Nucleic Acids Res. 2002;30(10):e47.
11. Blackbum EH. Structure and function of telomeres. Nature. 1991;350:569-73.
12. Djojosubroto MW, Choi YS, Lee HW, Rudolph KL. Telomeres and telomerase in aging, regeneration, and cancer. Mol Cells. 2003;15(2):164-75.
13. Furugori E, et al. Telomere shortening in gastric carcinoma with aging despite telomerase activation. J Cancer Res Clin Oncol. 2000;126(8):481-5.
14. Nakamura K, et al. Correlation of telomere lengths in normal and cancers tissue in the large bowel. Cancer Lett. 2000;158: 179-84.
15. Gumus-Akay G, et al. Telomerase activity could be used as a marker for neoplastic transformation in gastric adenocarcinoma: but it does not have a prognosyic significance. Genet Mol Res. 2007;6(1):41-9.
16. Nakamura Y, Tahara E, Tahara H, Yasui W, Ide T. Quantitative reevaluation of telomerase activity in cancerous and noncancerous gastrointestinal tissues. Mol Carcinog. 1999;16(4):312-20.
17. Liu XN, et al. Constitutive telomere length and gastric cancer risk: case-control analysis in Chinese Han population. Cancer Sci. 2009;100(7):1300-5.
18. Blackburn EH. Telomeres and telomerase: their mechanism of action and the effects of action and the effects of altering their functions. FEBS Lett. 2005;579:859-62.
19. Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB. Telomere end-replication problem and cell aging. J Mol Biol. 1992;225(4):951-60.
20. Artandi SE, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature. 2000;406: 641-5.
21. Cosme-Blanco W, Chang S. Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis. Exp Cell Res. 2008;314:1973-9.
22. Gertler R, et al. Telomere length and human telomerase reverse transcriptase expression as markers for progression and prognosis of colorectal carcinoma. J Clin Oncol. 2004;22:1807-14.
23. Kim NW, et al. Specific association of human telomerase activity with immortal cells and cancer. Science. 1994;266:2011.