Synthesis of stable isotope labelled internal standards for drug-drug interaction (DDI) studies

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 18, 2012, Pages 5658-5667

  Atzrodt, J ^a   Blankenstein, J ^b   Brasseur, D ^b   Calvo Vicente, S ^b   Denoux, M ^b   Derdau, V ^a   Lavisse, M ^b   Perard, S ^b   Roy, S ^b   Sandvoss, M ^a   Schofield, J ^b   Zimmermann, J ^a  

^a Sanofi R and D   (Germany)

^b SANOFI   (France)

Author keywords

1 Hydroxymidazolam; Dextrorphan; Diclofenac; H D exchange; Internal standard; Midazolam; Testosterone

Indexed keywords

1 (2,6 DICHLOROPHENYL) 1,3 DIHYDRO INDOL 2 ONE [3,3,5,7 D 4]; 1 (2,6 DICHLOROPHENYL[4 D]) 1,3 DIHYDRO INDOL 2 ONE [3,3,4,5,6,7 D 6]; 17 METHYL 9A,13,14A MORPHINAN 3 OL D 9; 3 METHOXY 17 METHYLMORPHINAN D 10; 4' HYDROXYDICLOFENAC; 6BETA HYDROXYTESTOSTERONE; 8 CHLORO 6 (2 FLUORO PHENYL) 1 METHYL 4H 2,5,10B TRIAZA BENZO[E]AZULENE D 8; [8 CHLORO 6 (2 FLUORO PHENYL) 4H 2,5,10B TRIAZA BENZO[E]AZULEN 1 YL]METHANOL D 5; [8 CHLORO 6 (2 FLUORO PHENYL) 4H 2,5,10B TRIAZA BENZO[E]AZULEN 1 YL]METHANOL D 8; ALPHA HYDROXYMIDAZOLAM; ANDROST 4 EN 17BETA OL 3 ONE [2,2,4,6,6 D 5]; ANDROST 4 EN 6ALPHA,17BETA DIOL 3 ONE [2,2,4,6BETA D 4]; ANDROST 4 EN 6BETA,17BETA DIOL 3 ONE [2,2,4,6ALPHA D 4]; CYTOCHROME P450; CYTOCHROME P450 3A; DEUTERIUM; DEXTROMETHORPHAN; DEXTRORPHAN; DICLOFENAC; MIDAZOLAM; RADIOPHARMACEUTICAL AGENT; TESTOSTERONE; TRANSITION ELEMENT; UNCLASSIFIED DRUG;

ARTICLE; BIOCATALYSIS; CATALYSIS; CHEMICAL REACTION; COST CONTROL; DRUG HYDROXYLATION; DRUG ISOLATION; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME ACTIVITY; H D EXCHANGE REACTION; IN VITRO STUDY; INTERMETHOD COMPARISON; ISOTOPE LABELING; MICROWAVE IRRADIATION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; STANDARD; TIME;

CYTOCHROME P-450 ENZYME SYSTEM; DEUTERIUM EXCHANGE MEASUREMENT; DICLOFENAC; ISOTOPE LABELING; MICROWAVES; MIDAZOLAM; MOLECULAR STRUCTURE; PHARMACEUTICAL PREPARATIONS; REFERENCE STANDARDS;

EID: 84866256859     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.06.052     Document Type: Article

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