The kinetic isotope effect in the search for deuterated drugs

Drug News and Perspectives

Volumn 23, Issue 6, 2010, Pages 398-404

  Shao, Liming ^a   Hewitt, Michael C ^a  

^a DAINIPPON SUMITOMO PHARMA CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; ARFORMOTEROL; ATAZANAVIR; C 20081; C 21246; CTP 347; CTP 518; CYTOCHROME P450; DEUTERIUM; DEUTERIUM OXIDE; ESZOPICLONE; HYDROGEN; ISOTOPE; LEVALBUTEROL; MELATONIN; MK 0641; MK 0642; MORPHINE; NIFEDIPINE; NORADRENALIN; PAROXETINE; PHENAZONE; POLIOMYELITIS VACCINE; RITONAVIR; SALBUTAMOL; SEROTONIN; SUCCINIMIDE; TRAMADOL; TRYPTOPHAN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANXIETY DISORDER; CHEMICAL BOND; CHEMICAL REACTION; CHEMISTRY; CHRONIC KIDNEY DISEASE; CLINICAL TRIAL; DRUG HALF LIFE; DRUG INDUSTRY; DRUG METABOLISM; DRUG RESEARCH; DRUG STRUCTURE; ELECTRON; EPILEPSY; GASTROINTESTINAL TOXICITY; GENERALIZED ANXIETY DISORDER; HEPATITIS C; HOT FLUSH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; IN VITRO STUDY; INFECTION; KINETICS; LD 50; MAJOR DEPRESSION; MICROSOME; NEUTRON; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PAIN; PANIC; POLIOMYELITIS; POSTTRAUMATIC STRESS DISORDER; REVIEW; DRUG DEVELOPMENT;

DEUTERIUM; DRUG DISCOVERY; KINETICS;

EID: 77957885594     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2010.23.6.1426638     Document Type: Review

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