Alpha-momorcharin inhibits HIV-1 replication in acutely but not chronically infected T-lymphocytes

Acta Pharmacologica Sinica

Volumn 20, Issue 3, 1999, Pages 239-243

  Zheng, Yong Tang ^a   Ben, Kun Long ^a   Jin, Shan Wei ^b  

^a KUNMING INSTITUTE OF ZOOLOGY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

momorcharin; Anti HIV agents; Antigen p24; Cytotoxicity; Giant cells; HIV; Ribosome inactivating proteins; T lymphocytes

Indexed keywords

ALPHA MOMORCHARIN; ANTIVIRUS AGENT; GAG PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIGEN; MONOCLONAL ANTIBODY; RIBOSOME INACTIVATING PROTEIN; UNCLASSIFIED DRUG;

ANTIGEN EXPRESSION; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; T LYMPHOCYTE; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELL LINE; HIV CORE PROTEIN P24; HIV-1; HUMANS; PLANT PROTEINS; RIBOSOMAL PROTEINS; T-LYMPHOCYTES; VIRUS REPLICATION;

EID: 0011441255     PISSN: 02539756     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. McGrath MS, Hwang KM, Caldwell SE, Gaston I, Luk KC, Wu P, et al. GLQ223: an inhibitor of human immunodeficiency virus replication in acutely and chronically infected cells of lymphocyte and mononuclear phagocyte lineage. Proc Natl Acad Sci USA 1989; 86: 2844-8.
2. Kahn JO, Gorelick KJ, Gatti G, Arri CJ, Lifson JD, Gambertoglio JG, et al. Safety, activity, and pharmacokinetics of GLQ223 in patients with AIDS and AIDS-related complex. Antimicrob Agents Chemother 1994; 38: 260-7.
3. Lee-Huang S, Huang PL, Kung HF, Li BQ, Huang PL, Huang P, et al. TAP29; an anti-human immunodeficiency virus protein from Trichosanthes kirilowii that is nontoxic to intact cells. Proc Natl Acad Sci USA 1991; 88: 6570-4.
4. Lee-Huang S, Huang PL, Nara PL, Chen HC, Kung HF, Huang P, et al. MAP30; a new inhibitor of HFV-1 infection and replication. FEBS Lett 1990; 272: 12-8.
5. S 30 and 32. FEBS Lett 1991; 291: 139-44.
6. Olson MC, Ramakrishnan S, Anand R. Ribosomal inhibitory proteins from plants inhibit HIV-1 replication in acutely infected peripheral blood mononuclear cells. AIDS Res Hum Retroviruses 1991; 7: 1025-30.
7. Wachinger M, Samtleben R, Gerhauser C, Wagner H, Erfle V. Bryodin, a single-chain ribosome-inactivating protein, selectively inhibits the growth of HIV-1-infected cells and reduces HIV-1 production. Res Exp Med 1993; 193: 1-12.
8. Pu Z, Lu BY, Liu WY, Jin SW. Characterization of the enzymatic mechanism of γ-momorcharin, a novel ribosome-inactivating protein with low molecular weight of 11 500 purified from the seeds of bitter gourd (Momordica charantia). Biochem Biophys Res Commun 1996; 229: 287-94.
9. Lifson J, McGrath MS, Yeung HW, Kuo H, inventors. Method of selectively inhibit HIV. US patent PCT/US88/01794. 1988 Jul 19.
10. Zheng YT, Ben K, Jin SW. Anti-human immunodeficiency virus activities of proteins from 17 species of plants. Viral Sin 1998; 13: in press.
11. Seki J, Ikeda R, Hoshino H. Dimethyl sulfoxide and related polar compounds enhance infection of human T cells with HIV-1 in vitro. Biochem Biophys Res Commun 1996; 227: 724-9.
12. Merluzzi VJ, Hargrave KD, Labadia M, Grozinger K, Skoog M, Wu JC, et al. Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science 1990; 250: 1411-3.
13. Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, et al. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc Natl Acad Sci USA 1987; 84: 8120-4.
14. Kinchington D, Galpin S, Jaroszewski JW, Ghosh K, Subasinghe C, Cohen JS. A comparison of gag, pol and rev antisense oligodeoxynucleotides as inhibitors of HIV-1. Antiviral Res 1992; 17: 53-62.
15. Lee-Huang S, Huang PL, Chen HC, Huang PL, Bourinbaiar A, Huang HI, et al. Anti-HIV and anti-tumor activities of recombinant MAP30 from bitter melon. Gene 1995; 161: 151-6.